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3. FPR2 DNA Aptamers for Targeted Therapy of Wound Repair

Author

María del Carmen de Arriba, Gerónimo Fernández, Esteban Chacón-Solano, Manuel Mataix, Lucía Martínez-Santamaría, Nuria Illera, Rebeca Carrión-Marchante, María Elena Martín, Fernando Larcher, Victor M. González, Marcela Del Río, and Marta Carretero

Subjects
Mice, Wound Healing, Animals, Humans, Cell Biology, Dermatology, Aptamers, Nucleotide, Receptors, Lipoxin, Ligands, Molecular Biology, Biochemistry, Receptors, Formyl Peptide
Abstract

Chronic wounds represent a major health problem worldwide. Some of the available therapies based on recombinant proteins usually fail owing to the hostile environment found at the wound bed. Aptamers appear as an attractive alternative to recombinant factors owing in part to their stability, sensitivity, specificity, and low-cost production. In this study, the Cell-Systematic Evolution of Ligands by EXponential Enrichment technology was employed to generate aptamers that specifically recognize and modulate the function of the FPR2, a receptor expressed in a variety of cells involved in wound repair. Three aptamers were obtained that specifically bound to FPR2 stable transfectants generated in HaCaT cells. The targeted aptamers were shown to act as FPR2 agonists in different in vitro functional assays, including wound healing assays, and elicited a similar pattern of response to that obtained with other known FPR2 peptide agonists, such as the human LL37 cathelicidin. We have also obtained in vivo evidence for the prohealing activities of one of these FPR2 aptamers in a skin-humanized mouse model developed by us, previously shown to accurately recreate the main phases of physiological human wound repair process. In conclusion, we provide evidence of the potential therapeutic value of FPR2 aptamers for cutaneous repair.

Published
2020

4. Contributors

Author

Teresa Alonso-Rasgado, Saeid Amini-Nik, Mohammed Ashrafi, Mohamed Baguneid, Jeremy Baskin, Ardeshir Bayat, Audrey Bélanger, François-Xavier Bernard, Manuel Berning, Katia Boniface, Charbel Bouez, Petra Boukamp, Nicholas Boulais, Jennifer Bourland, Virginie Buhé, Muriel Cario-André, Jean-Luc Carré, Mariana T. Cerqueira, Esteban Chacón-Solano, David Y.S. Chau, Vivien Chen, Lin Chen, Jérémy Chéret, José Cotovio, Stephen C. Davis, Marcela Del Río, Maria L. Dell'Anna, Marianne Deslauriers, Luisa A. DiPietro, Stefan Drakulich, Alexandra Duque-Fernandez, Julie Fradette, Jonathan A. Garlick, Behzad Gerami-Naini, George D. Glinos, Olivier Gouin, Sara Guerrero-Aspizua, Adam Hague, Kyle Hewitt, Victoria Hutter, Marc G. Jeschke, Olga Kashpur, Stewart B. Kirton, Ana Korosec, Dagmar Kulms, Manuela E.L. Lago, Fernando Larcher, Christelle Le Gall-Ianotto, Raphaële Le Garrec, Nicolas Lebonvallet, Raphaël Leschiera, Killian L'Hérondelle, Liang Liang, Beate M. Lichtenberger, Isabelle Lorthois, Maxim Maheux, Alexandra P. Marques, Lucía Martínez-Santamaría, Louis-Charles Masson, Stephanie H. Mathes, Friedegund Meier, Laurent Misery, Alexandre Morin, Nailia Mukhamedshina, Deborah G. Nguyen, Christian N. Parker, Irena Pastar, Elizabeth Pavez Loriè, Christian Pellevoisin, Ulysse Pereira, Rogério P. Pirraco, Roxane Pouliot, Rui L. Reis, Kelsey N. Retting, Geneviève Rioux, Bryan Roy, Mehdi Sakka, Andrew P. Sawaya, Megan Schrementi, Julien Seneschal, Yulia Shamis, Mélissa Simard, Philippe Simard, Avi Smith, Hans-Jürgen Stark, Olivera Stojadinovic, Alain Taieb, Matthieu Talagas, Marjana Tomic-Canic, Tongyu Cao Wikramanayake, and Yusef Yousuf

Published
2018
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