9 results on '"Federico Porporato"'
Search Results
2. AA-amyloidosis in cats (Felis catus) housed in shelters
- Author
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Filippo Ferri, Silvia Ferro, Federico Porporato, Carolina Callegari, Chiara Guglielmetti, Maria Mazza, Marta Ferrero, Chiara Crinò, Enrico Gallo, Michele Drigo, Luigi M. Coppola, Gabriele Gerardi, Tim Paul Schulte, Stefano Ricagno, Monique Vogel, Federico Storni, Martin F. Bachmann, Anne-Cathrine Vogt, Serena Caminito, Giulia Mazzini, Francesca Lavatelli, Giovanni Palladini, Giampaolo Merlini, Eric Zini, and University of Zurich
- Subjects
Multidisciplinary ,10253 Department of Small Animals ,Histology ,630 Agriculture ,610 Medicine & health ,Kidneys ,Amyloidosis ,FIV ,Domestic animals ,Settore BIO/10 - Biochimica ,Cats ,Bile ,Spleen ,570 Life sciences ,biology - Abstract
Systemic AA-amyloidosis is a protein-misfolding disease characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs in humans and many animal species. Fibril deposits originate from abnormally high serum levels of SAA during chronic inflammation. A high prevalence of AA-amyloidosis has been reported in captive cheetahs and a horizontal transmission has been proposed. In domestic cats, AA-amyloidosis has been mainly described in predisposed breeds but only rarely reported in domestic short-hair cats. Aims of the study were to determine AA-amyloidosis prevalence in dead shelter cats. Liver, kidney, spleen and bile were collected at death in cats from 3 shelters. AA-amyloidosis was scored. Shedding of amyloid fibrils was investigated with western blot in bile and scored. Descriptive statistics were calculated. In the three shelters investigated, prevalence of AA-amyloidosis was 57.1% (16/28 cats), 73.0% (19/26) and 52.0% (13/25), respectively. In 72.9% of cats (35 in total) three organs were affected concurrently. Histopathology and immunofluorescence of post-mortem extracted deposits identified SAA as the major protein source. The duration of stay in the shelters was positively associated with a histological score of AA-amyloidosis (B = 0.026, CI95% = 0.007–0.046; p = 0.010). AA-amyloidosis was very frequent in shelter cats. Presence of SAA fragments in bile secretions raises the possibility of fecal-oral transmission of the disease. In conclusion, AA-amyloidosis was very frequent in shelter cats and those staying longer had more deposits. The cat may represent a natural model of AA-amyloidosis.
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- 2023
3. Thyroidectomy in dogs with thyroid tumors: Survival analysis in 144 cases (1994-2018)
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Daniela Enache, Livia Ferro, Emanuela M. Morello, Federico Massari, Giorgio Romanelli, Stefano Nicoli, Stefano Guazzetti, Federico Porporato, Eric Zini, University of Zurich, and Zini, Eric
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surgery ,10253 Department of Small Animals ,630 Agriculture ,General Veterinary ,3400 General Veterinary ,follicular ,competing risks analysis ,570 Life sciences ,biology ,canine, carcinoma, competing risks analysis, follicular, metastasis, surgery ,canine ,metastasis ,carcinoma - Published
- 2023
4. Correction to: Gastrointestinal ultrasonographic findings in cats with Feline panleukopenia: a case series
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Marco Pesaresi, Barbara Contiero, Stefano Ciccarelli, Eric Zini, Luigi Michele Coppola, Daniela Enache, Filippo Ferri, Federico Porporato, Swan Specchi, Edoardo Auriemma, and Rosaria Isaya
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Male ,Pathology ,medicine.medical_specialty ,lcsh:Veterinary medicine ,CATS ,General Veterinary ,biology ,business.industry ,Feline Panleukopenia ,Correction ,General Medicine ,Feline panleukopenia ,biology.organism_classification ,Gastroenteritis ,Abdomen ,Cats ,lcsh:SF600-1100 ,Medicine ,Animals ,Female ,Intestinal Mucosa ,business ,Ultrasonography - Abstract
Feline panleukopenia virus (FPV) is very resistant and highly contagious and infects domestic cats and other felids. FPV is particularly widespread among sheltered cats, and is associated with high morbidity and mortality, causing severe gastroenteritis characterized by anorexia, lethargy, fever, dehydration, hemorrhagic diarrhea, and vomiting. There is currently no data on the ultrasonographic features of cats affected with FPV. This case series describes abdominal ultrasonographic findings in shelter cats with naturally-occurring FPV, and assesses whether are associated with clinical and laboratory findings. Cats affected by FPV were enrolled in the study if an abdominal ultrasound was performed within 12 hours of diagnosis. Clinical, laboratory and survival data were collected from medical records. Ultrasonographic examinations were reviewed for gastrointestinal abnormalities and their associations with the above data were explored.Twenty-one cats were included. Nine cats (42.9%) died and 12 (57.1%) recovered. Based on ultrasonography, the duodenum and jejunum showed thinning of the mucosal layer in 70.6% and 66.6% of cats, thickening of the muscular layer in 52.9% and 57.1% of cats, and hyperechogenicity of the mucosa in 41.2% and 33.3%. Jejunal hyperechoic mucosal band paralleling the submucosa and irregular luminal surface were both observed in 33.3% of the cats. Survival was positively associated with increased jejunal mucosal echogenicity (P = 0.003) and hyperechoic mucosal band (P = 0.003). Peritoneal free fluid was positively associated with vomiting (P = 0.002).This study provides ultrasonographic features of naturally-occurring FPV in cats, which, as expected, are compatible with gastroenteropathy. The most frequent findings were diffuse small intestine mucosal layer thinning, muscular layer thickening and mucosal hyperechogenicity, jejunal hyperechoic mucosal band and irregular luminal surface. Ultrasonographic features may be useful to complete the clinical picture and assess the severity of the gastroenteropathy in FPV cats. Prospective studies are needed to confirm ultrasonographic prognostic factors.
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- 2021
5. Gastrointestinal Ultrasonographic Findings In Cats With Feline Panleukopenia: A Case Series
- Author
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Eric Zini, Luigi Michele Coppola, Filippo Ferri, Marco Pesaresi, Daniela Enache, Edoardo Auriemma, Rosaria Isaya, Stefano Ciccarelli, Federico Porporato, Swan Specchi, Barbara Contiero, and University of Zurich
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medicine.medical_specialty ,10253 Department of Small Animals ,040301 veterinary sciences ,3400 General Veterinary ,FPV ,Feline panleukopenia ,Gastroenterology ,0403 veterinary science ,Jejunum ,Muscular layer ,Lethargy ,Gastrointestinal tract ,Submucosa ,Internal medicine ,Ultrasound ,Medicine ,lcsh:Veterinary medicine ,CATS ,630 Agriculture ,General Veterinary ,biology ,business.industry ,0402 animal and dairy science ,Cat ,04 agricultural and veterinary sciences ,General Medicine ,biology.organism_classification ,040201 dairy & animal science ,medicine.anatomical_structure ,Vomiting ,Duodenum ,570 Life sciences ,lcsh:SF600-1100 ,medicine.symptom ,business ,Research Article - Abstract
Background Feline panleukopenia virus (FPV) is very resistant and highly contagious and infects domestic cats and other felids. FPV is particularly widespread among sheltered cats, and is associated with high morbidity and mortality, causing severe gastroenteritis characterized by anorexia, lethargy, fever, dehydration, hemorrhagic diarrhea, and vomiting. There is currently no data on the ultrasonographic features of cats affected with FPV. This case series describes abdominal ultrasonographic findings in shelter cats with naturally-occurring FPV, and assesses whether are associated with clinical and laboratory findings. Cats affected by FPV were enrolled in the study if an abdominal ultrasound was performed within 12 hours of diagnosis. Clinical, laboratory and survival data were collected from medical records. Ultrasonographic examinations were reviewed for gastrointestinal abnormalities and their associations with the above data were explored. Results Twenty-one cats were included. Nine cats (42.9%) died and 12 (57.1%) recovered. Based on ultrasonography, the duodenum and jejunum showed thinning of the mucosal layer in 70.6% and 66.6% of cats, thickening of the muscular layer in 52.9% and 57.1% of cats, and hyperechogenicity of the mucosa in 41.2% and 33.3%. Jejunal hyperechoic mucosal band paralleling the submucosa and irregular luminal surface were both observed in 33.3% of the cats. Survival was positively associated with increased jejunal mucosal echogenicity (P = 0.003) and hyperechoic mucosal band (P = 0.003). Peritoneal free fluid was positively associated with vomiting (P = 0.002). Conclusions This study provides ultrasonographic features of naturally-occurring FPV in cats, which, as expected, are compatible with gastroenteropathy. The most frequent findings were diffuse small intestine mucosal layer thinning, muscular layer thickening and mucosal hyperechogenicity, jejunal hyperechoic mucosal band and irregular luminal surface. Ultrasonographic features may be useful to complete the clinical picture and assess the severity of the gastroenteropathy in FPV cats. Prospective studies are needed to confirm ultrasonographic prognostic factors.
- Published
- 2020
6. Gastrointestinal Ultrasonographic Findings In Cats With Feline Panleukopenia Virus: A Case Series
- Author
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Rosaria Isaya, Stefano Ciccarelli, Daniela Enache, Swan Specchi, Marco Pesaresi, Filippo Ferri, Federico Porporato, Edoardo Auriemma, Barbara Contiero, Luigi M Coppola, and Eric Zini
- Abstract
BackgroundFeline panleukopenia virus (FPV) is very resistant and highly contagious and infects domestic cats and other felids. FPV is particularly widespread among sheltered cats, and is associated with high morbidity and mortality, causing severe gastroenteritis characterized by anorexia, lethargy, fever, dehydration, hemorrhagic diarrhea, and vomiting. There is currently no data on the ultrasonographic features of cats affected with FPV. This case series describes abdominal ultrasonographic findings in shelter cats with naturally-occurring FPV, and assesses whether are associated with clinical and laboratory findings. Cats affected by FPV were enrolled in the study if an abdominal ultrasound was performed within 12 hours of diagnosis. Clinical, laboratory and survival data were collected from medical records. Ultrasonographic examinations were reviewed for gastrointestinal abnormalities and their associations with the above data were explored.ResultsTwenty-one cats were included. Nine cats (42.9%) died and 12 (57.1%) recovered. Based on ultrasonography, the duodenum and jejunum showed thinning of the mucosal layer in 70.6% and 66.6% of cats, thickening of the muscular layer in 52.9% and 57.1% of cats, and hyperechogenicity of the mucosa in 41.2% and 33.3%. Jejunal hyperechoic mucosal band paralleling the submucosa and irregular luminal surface were both observed in 33.3% of the cats. Survival was positively associated with increased jejunal mucosal echogenicity ( P =0.003) and hyperechoic mucosal band ( P =0.003). Peritoneal free fluid was positively associated with vomiting ( P =0.002).ConclusionThis study provides ultrasonographic features of naturally-occurring FPV in cats, which, as expected, are compatible with gastroenteropathy. The most frequent findings were diffuse small intestine mucosal layer thinning, muscular layer thickening and mucosal hyperechogenicity, and jejunal hyperechoic mucosal band and irregular luminal surface. At diagnosis, ultrasonographic features may be useful to assess survival.
- Published
- 2020
7. Treatment with Class A CpG Oligodeoxynucleotides in Cats with Naturally Occurring Feline Parvovirus Infection: A Prospective Study
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Barbara Contiero, Luigi Michele Coppola, Filippo Ferri, Chiara Crinò, Francesco Rossi, Neda Ranjbar Kohan, Regina Hofmann-Lehmann, Gabriele Gerardi, Daniela Enache, Carolina Callegari, Hans Lutz, Federico Porporato, Eric Zini, Marina L. Meli, University of Zurich, and Ferri, Filippo
- Subjects
Male ,0301 basic medicine ,10253 Department of Small Animals ,Feline Panleukopenia ,viruses ,lcsh:QR1-502 ,Cell Count ,lcsh:Microbiology ,0403 veterinary science ,hemic and lymphatic diseases ,Leukocytes ,Medicine ,Prospective Studies ,11434 Center for Clinical Studies ,CATS ,Leukopenia ,treatment ,biology ,virus diseases ,04 agricultural and veterinary sciences ,antiviral ,Infectious Diseases ,Oligodeoxyribonucleotides ,11404 Department of Clinical Diagnostics and Services ,Female ,medicine.symptom ,Antibody ,feline parvovirus ,040301 veterinary sciences ,CpG Oligodeoxynucleotide ,cat ,610 Medicine & health ,Viremia ,macromolecular substances ,Placebo ,Article ,03 medical and health sciences ,Virology ,Mx protein ,otorhinolaryngologic diseases ,Animals ,Survival rate ,business.industry ,2725 Infectious Diseases ,Type I interferon production ,medicine.disease ,030104 developmental biology ,Immunology ,Cats ,CpG-A ,2406 Virology ,biology.protein ,Antiviral ,Cat ,Feline parvovirus ,Treatment ,Feline Panleukopenia Virus ,business - Abstract
Feline parvovirus (FPV) causes severe gastroenteritis and leukopenia in cats, the outcome is poor. Information regarding specific treatments is lacking. Class A CpG oligodeoxynucleotides (CpG-A) are short single-stranded DNAs, stimulating type I interferon production. In cats, CpG-A induced an antiviral response in vivo and inhibited FPV replication in vitro. The aim was to prospectively investigate the effects of CpG-A on survival, clinical score, hematological findings, antiviral response (cytokines), viremia, and fecal shedding (real-time qPCR) in cats naturally infected with FPV. Forty-two FPV-infected cats were randomized to receive 100 µ, g/kg of CpG-A (n = 22) or placebo (n = 20) subcutaneously, on admission and after 48 h. Blood and fecal samples were collected on admission, after 1, 3, and 7 days. All 22 cats showed short duration pain during CpG-A injections. The survival rate, clinical score, leukocyte and erythrocyte counts, viremia, and fecal shedding at any time-point did not differ between cats treated with CpG-A (50%) and placebo (40%). Antiviral myxovirus resistance (Mx) gene transcription increased in both groups from day 1 to 3 (p = 0.005). Antibodies against FPV on admission were associated with survival in cats (p = 0.002). In conclusion, CpG-A treatment did not improve the outcome in cats with FPV infection. FPV infection produced an antiviral response.
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- 2020
8. Survival estimates and outcome predictors for shelter cats with feline panleukopenia virus infection
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Regina Hofmann-Lehmann, Paola Rocchi, Tommaso Vezzosi, Barbara Contiero, Federico Porporato, Gabriele Gerardi, Hans Lutz, Marian C. Horzinek, Edoardo Auriemma, Eric Zini, Filippo Ferri, University of Zurich, and Porporato, Federico
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,10253 Department of Small Animals ,Feline Panleukopenia ,040301 veterinary sciences ,3400 General Veterinary ,Physical examination ,Feline panleukopenia ,Animal Welfare ,Disease Outbreaks ,Cohort Studies ,0403 veterinary science ,03 medical and health sciences ,Lethargy ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,Animals ,Medicine ,Survival analysis ,Retrospective Studies ,CATS ,Leukopenia ,630 Agriculture ,General Veterinary ,biology ,medicine.diagnostic_test ,business.industry ,Retrospective cohort study ,04 agricultural and veterinary sciences ,Prognosis ,biology.organism_classification ,Survival Analysis ,030104 developmental biology ,Italy ,chemistry ,Cats ,11404 Department of Clinical Diagnostics and Services ,570 Life sciences ,Veterinary (all) ,Female ,Feline Panleukopenia Virus ,medicine.symptom ,business ,Maropitant - Abstract
OBJECTIVE To determine survival estimates and outcome predictors for shelter cats with feline panleukopenia virus (FPV) infection. DESIGN Retrospective cohort study. ANIMALS 177 shelter cats with FPV infection. PROCEDURES Medical records of cats treated for FPV infection from 2011 through 2013 were reviewed to collect information pertaining to signalment; history; results of physical examination, CBC, serum biochemical analysis, and blood gas analysis; and treatments (antimicrobials, antiparasitics, antivirals, antiemetics, analgesics, crystalloid or colloid solutions, and blood products). Survival time and outcome predictors were determined by means of Kaplan-Meier estimation, logistic regression, and mixed-model ANOVA. RESULTS Median survival time after hospital admission was 3 days; 20.3% (36/177) of cats survived to discharge from the hospital. Risk of nonsurvival was greater in cats with (vs without) signs of lethargy, rectal temperature < 37.9°C (I00.2°F), or low body weight at hospital admission. Lower (vs higher) leukocyte count on days 3,4, and 7 of hospitalization, but not at admission, was associated with nonsurvival. Amoxicillin–clavulanic acid, antiparasitics, and maropitant but not interferon-ω were associated with survival, whereas glucose infusion was associated with nonsurvival. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that FPV infection carried a poor prognosis for shelter cats. Several variables measured at admission or during hospitalization were associated with outcome. Remarkably and contrary to the existing literature, leukopenia at admission had no association with outcome, possibly owing to early prevention of complications.
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- 2018
9. Diagnostic accuracy of a smartphone electrocardiograph in dogs: Comparison with standard 6-lead electrocardiography
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Federico Porporato, Rosalba Tognetti, Tommaso Vezzosi, Oriol Domenech, Eric Zini, Federica Marchesotti, Carlotta Buralli, University of Zurich, and Vezzosi, T
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Bradycardia ,Tachycardia ,Male ,medicine.medical_specialty ,10253 Department of Small Animals ,040301 veterinary sciences ,3400 General Veterinary ,Diagnostic accuracy ,Arrhythmias ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,Canine ,0403 veterinary science ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Dogs ,Heart Rate ,Internal medicine ,Heart rate ,Validation ,medicine ,Animals ,Sinus rhythm ,Single-Blind Method ,cardiovascular diseases ,Dog Diseases ,Prospective Studies ,Lead (electronics) ,Smartphone ,Animal Science and Zoology ,Veterinary (all) ,630 Agriculture ,General Veterinary ,medicine.diagnostic_test ,business.industry ,Arrhythmias, Cardiac ,04 agricultural and veterinary sciences ,Female ,Cardiology ,570 Life sciences ,biology ,1103 Animal Science and Zoology ,medicine.symptom ,business ,Cardiac ,Standard ECG - Abstract
The diagnostic accuracy of a smartphone electrocardiograph (ECG) in evaluating heart rhythm and ECG measurements was evaluated in 166 dogs. A standard 6-lead ECG was acquired for 1 min in each dog. A smartphone ECG tracing was simultaneously recorded using a single-lead bipolar ECG recorder. All ECGs were reviewed by one blinded operator, who judged if tracings were acceptable for interpretation and assigned an electrocardiographic diagnosis. Agreement between smartphone and standard ECG in the interpretation of tracings was evaluated. Sensitivity and specificity for the detection of arrhythmia were calculated for the smartphone ECG. Smartphone ECG tracings were interpretable in 162/166 (97.6%) tracings. A perfect agreement between the smartphone and standard ECG was found in detecting bradycardia, tachycardia, ectopic beats and atrioventricular blocks. A very good agreement was found in detecting sinus rhythm versus non-sinus rhythm (100% sensitivity and 97.9% specificity). The smartphone ECG provided tracings that were adequate for analysis in most dogs, with an accurate assessment of heart rate, rhythm and common arrhythmias. The smartphone ECG represents an additional tool in the diagnosis of arrhythmias in dogs, but is not a substitute for a 6-lead ECG. Arrhythmias identified by the smartphone ECG should be followed up with a standard ECG before making clinical decisions.
- Published
- 2016
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