1. Comparison of three methods of diagnosis of plasma unmeasured anions in critically ill patients
- Author
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Lautrette A, Fejjal M, Ali AIT HSSAIN, Tn, Phan, Caillot N, Fogli A, Souweine B, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Souweine, Bertrand, and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA)
- Subjects
Acid-Base Equilibrium ,Adult ,Aged, 80 and over ,Anions ,Male ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Adolescent ,Critical Care ,Critical Illness ,Acid-Base Imbalance ,Middle Aged ,Intensive Care Units ,Plasma ,Young Adult ,Humans ,Female ,Prospective Studies ,Child ,Blood Chemical Analysis ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Aged - Abstract
International audience; Background: The measurement of plasma unmeasured anions (PUA) is paramount in assessing metabolic acid base disorders. The aim of this study was to compare the accuracy of three methods in diagnosing abnormal PUA values: standard base excess (SBE), the albumin corrected anion gap (AGc), and the Stewart-Figge approach, based on unidentified anions (XAc-). Methods: Acid-base variables were prospectively collected in ICU patients admitted January-September 2008. Whatever the method, PUA values measured two standard deviations above or below the mean of those in control subjects were considered as abnormal. Results: Of the 205 consecutives patients included, 179 had an abnormal PUA value. The accuracy of AGc and XAc- in diagnosing abnormal PUA values was comparable (AUC: 0.89±0.03 and 0.89±0.03, P=0.82) but greater than that of SBE (0.67±0.06, P
- Published
- 2013