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8 results on '"Forrest M. Stewart"'

1. Post-Transplantation Sinusoidal Obstruction Syndrome in Adult Patients with B Cell Acute Lymphoblastic Leukemia Treated with Pretransplantation Inotuzumab

Author

Vaibhav Agrawal, Hoda Pourhassan, Ni-Chun Tsai, Dat Ngo, Paul Koller, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian Ball, Salman Otoukesh, Idoroenyi Amanam, Andrew Artz, Dupinder Singh, Pamela S. Becker, Forrest M. Stewart, Eileen P. Smith, Peter Curtin, Anthony S. Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Vinod Pullarkat, and Ibrahim Aldoss

Subjects
Transplantation, Molecular Medicine, Immunology and Allergy, Cell Biology, Hematology
Published
2023
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2. High response rates and transition to transplant after novel targeted and cellular therapies in adults with relapsed/refractory acute lymphoblastic leukemia with <scp>Philadelphia‐like</scp> fusions

Author

Ibrahim Aldoss, Michelle Afkhami, Dongyun Yang, Zhaohui Gu, Sally Mokhtari, Shilpa Shahani, Hoda Pourhassan, Vaibhav Agrawal, Paul Koller, Shukaib Arslan, Vanina Tomasian, Monzr M. Al Malki, Andrew Artz, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Brian Ball, Salman Otoukesh, Idoroenyi Amanam, Pamela S. Becker, Forrest M. Stewart, Peter Curtin, Eileen Smith, Milhan Telatar, Anthony S. Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, and Vinod Pullarkat

Subjects
Hematology
Published
2023
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3. Outcomes Post-Allogeneic Hematopoietic Cell Transplantation Relapse in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Author

Tamer Othman, Ibrahim Aldoss, Ni-Chun Tsai, Hoda Pourhassan, Vaibhav Agrawal, Salman Otoukesh, Idoroenyi Amanam, Dat Ngo, Jason Chen, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Forrest M. Stewart, Peter T. Curtin, Andrew S. Artz, David S Snyder, Guido Marcucci, Stephen J Forman, Anthony S. Stein, Ryotaro Nakamura, Vinod A. Pullarkat, Matthew Mei, and Paul B. Koller

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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4. Novel Salvage Therapies Are Highly Effective in Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) with Philadelphia (Ph)-like Fusions

Author

Ibrahim Aldoss, Dongyun Yang, Michelle Afkhami, Zhaohui Gu, Sally Mokhtari, Shilpa Shahani, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Vanina Tomasian, Milhan Telatar, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Peter T. Curtin, Raju Pillai, Eileen P. Smith, Guido Marcucci, Anthony S. Stein, Stephen J Forman, Ryotaro Nakamura, and Vinod A. Pullarkat

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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5. Evaluation of 5-Day Vs. 10-Day Decitabine in Combination with Venetoclax in Newly Diagnosed AML Patients Ineligible for Induction Chemotherapy

Author

Jorge M. Ramos Perez, Jose Tinajero, Dat Ngo, Jianying Zhang, Paul B. Koller, Vaibhav Agrawal, Hoda Pourhassan, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Eileen P. Smith, Peter Curtin, Stephen J Forman, Ryotaro Nakamura, Vinod A. Pullarkat, Guido Marcucci, Anthony S. Stein, Ibrahim Aldoss, and Brian J Ball

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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6. Sinusoidal Obstruction Syndrome in Adult Patients with B-Cell Acute Lymphoblastic Leukemia Treated with Inotuzumab Prior to Hematopoietic Stem Cell Transplantation

Author

Vaibhav Agrawal, Hoda Pourhassan, Ni-Chun Tsai, Dat Ngo, Paul B. Koller, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Eileen P. Smith, Peter T. Curtin, Anthony S. Stein, Guido Marcucci, Stephen J Forman, Ryotaro Nakamura, Vinod A. Pullarkat, and Ibrahim Aldoss

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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7. Long Term Outcomes of Patients with Chronic Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation in the Era of Oral Tyrosine Kinase Inhibitors

Author

Paul B. Koller, Haoyue Shan, Joycelynne Palmer, Peter T. Curtin, Karamjeet S. Sandhu, Vaibhav Agrawal, Ricardo Spielberger, Joshua Mansour, Amanda Blackmon, Salman Otoukesh, Shukaib Arslan, Idoroenyi Amanam, Eileen P. Smith, Forrest M. Stewart, Brian J Ball, Amandeep Salhotra, Ahmed Aribi, Ibrahim Aldoss, Vinod A. Pullarkat, Anthony S. Stein, Andrew S. Artz, Guido Marcucci, Stephen J Forman, Ryotaro Nakamura, Monzr M. Al Malki, David S Snyder, and Haris Ali

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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8. Outcomes of allogeneic hematopoietic cell transplantation in adults with fusions associated with Ph-like ALL

Author

Ibrahim Aldoss, Dongyun Yang, Vanina Tomasian, Sally Mokhtari, Ryan Jackson, Zhaohui Gu, Milhan Telatar, Hooi Yew, Monzr M. Al Malki, Amandeep Salhotra, Samer Khaled, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Matthew Mei, Shukaib Arslan, Paul Koller, Andrew Artz, Patricia Aoun, Dongqing Gu, David Snyder, Forrest M. Stewart, Peter Curtin, Anthony S. Stein, Raju Pillai, Guido Marcucci, Stephen J. Forman, Vinod Pullarkat, Ryotaro Nakamura, and Michelle Afkhami

Subjects
Adult, Philadelphia, Recurrence, Acute Disease, Hematopoietic Stem Cell Transplantation, Humans, Transplantation, Homologous, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, In Situ Hybridization, Fluorescence, Retrospective Studies
Abstract

Allogenic hematopoietic cell transplantation (alloHCT) is a well-established curative modality for acute lymphoblastic leukemia (ALL), yet large amounts of data describing alloHCT outcomes in Philadelphia (Ph)-like ALL are lacking. We retrospectively analyzed archived DNA samples from consecutive adults with B-cell Ph-negative ALL who underwent alloHCT in complete remission (CR) (n = 127) at our center between 2006 and 2020. Identification of fusions associated with Ph-like ALL was performed using cumulative results from RNA-seq, conventional cytogenetics, fluorescence in situ hybridization, and whole genome array studies. Fusions associated with Ph-like ALL were detected in 56 (44%) patients, of whom 38 were carrying CRLF2r. Compared with other non–Ph-like ALL (n = 71), patients with fusions associated with Ph-like ALL were more frequently Hispanic (P = .008), were less likely to carry high-risk cytogenetics (P < .001), and were more likely to receive blinatumomab prior to HCT (P = .019). With the median followup of 3.5 years, patients with Ph-like ALL fusions had comparable posttransplant outcomes compared with other B-cell ALL: 3-year relapse-free survival (RFS) (41% vs 44%; P = .36), overall survival (OS) (51% vs 50%; P = .59), and relapse (37% vs 31%; P = .47). In multivariable analysis, age (P = .023), disease status at the time of transplant (P < .001), and donor type (P = .015) influenced OS. RFS (primary endpoint) was significantly influenced by disease status (P < .001) and conditioning regimen intensity (P = .014). In conclusion, our data suggest that alloHCT consolidation results in similarly favorable survival outcomes in adult patients with Ph-like fusions and other high-risk B-cell ALL.

Published
2022

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