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18 results on '"Fragola, P."'

6. The problem of ventricular tachycardia with torsade de pointes and of its rational treatment

Author

Fragola, P, Capria, A, Autore, C, and Sangiorgi, M

Subjects
Settore MED/09 - Medicina Interna, lidocaine, magnesium sulfate, mexiletine, phenytoin, heart arrhythmia, heart ventricle tachycardia, human, intravenous drug administration, review, torsade des pointes, electrocardiography, pathophysiology, tachycardia, Electrocardiography, English Abstract, Human, Magnesium Sulfate, Tachycardia
Published
1988

14. Autoantibodies in myotonic dystrophy

Author

Fiorito, S., Pocobelli, D., Antonini, G., Picelli, A., Fragola, P. V., camillo autore, Magrini, L., and Cannata, D.

Subjects
Adult, Male, Adolescent, Humans, Immunoglobulins, Myotonic Dystrophy, Female, Complement System Proteins, Middle Aged, Autoantibodies
Abstract

We evaluated some immunological parameters in a group of 24 patients affected with myotonic dystrophy (MD). IgG, IgA, IgM immunoglobulin serum levels resulted decreased in most of the patients. Anti-smooth-muscle antibodies have been found in 10 out of 24 patients (45.5%). Moreover in some of them decreased C3 and C4 complement fraction serum levels have been found. Our data confirm the existence of some immunological abnormalities in a great number of subjects affected with the disease. Besides, these data evidence for most of the subjects the presence of autoantibodies non-organ-specific direct against myocellular antigens. These autoantibodies could be considered the expression of suffering of muscular fibres.

15. Clinical relevance of the electrocardiogram in relatives of patients with hypertrophic cardiomyopathy

Author

Fragola, P. V., camillo autore, Ruscitti, G., Picelli, A., Borzi, M., Cannata, D., and Sangiorgi, M.

Subjects
Adult, Male, Electrocardiography, Humans, Female, Cardiomyopathy, Hypertrophic, Middle Aged, Aged
Abstract

Eighty-nine first-degree relatives of 22 patients with an established diagnosis of hypertrophic cardiomyopathy underwent electrocardiographic and echocardiographic screening. Scalar electrocardiogram was abnormal in 30/89 (33.7%) relatives. Of these thirty, eleven had definite evidence of hypertrophic cardiomyopathy at echo; one had borderline hypertrophy and was considered neither affected nor unaffected; four had questionable signs of hypertrophy. The remaining 14 relatives had normal echo-cardiograms. Fifty-nine relatives (66.3%) had normal electrocardiograms; at echo 3 were considered to have borderline hypertrophy, 16 had questionable signs of hypertrophy and 40 were normal. In relatives of patients with hypertrophic cardiomyopathy an abnormal electrocardiogram may reflect different morphologic conditions: a real hypertrophic cardiomyopathy or a myocardial hypertrophy of uncertain significance. Furthermore, in these categories of subjects, an abnormal electrocardiogram with normal echo must be considered with caution.

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