Author: "Fred, A" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

149,614 results on '"Fred, A"'

1. Asociación entre Niveles de Vitamina D y Preeclampsia Severa en Pacientes con Embarazo Único a Término

Author: Alan Rigoberto Carvajal-Sepúlveda, Fred Valentín Morgan-Ruiz, Perla Yareli Gutiérrez-Arzapalo, Everardo Quevedo-Castro, Guadalupe López-Manjarrez, Saúl Armando Beltrán-Ontiveros, Josefina Báez-Barraza, and Fred Morgan-Ortiz
Subjects: General Medicine
Abstract: Objetivo: Determinar la frecuencia de hipovitaminosis D en pacientes con preeclampsia con datos de severidad y embarazo a término con producto único vivo. Material y métodos: Se llevó a cabo un estudio de casos y controles, en el cual se consideró como “caso” a toda embarazada con cifras tensionales igual o mayor a 160/110 y cualquier otro criterio de severidad y se definió como “control” a la embarazada con presión arterial normal, sin comorbilidades adicionales y embarazo único. Las variables analizadas fueron las características generales y los niveles promedios de vitamina D entre los dos grupos. Se utilizó la prueba t de student y la prueba exacta de Fisher para la comparación de variables numéricas y categóricas respectivamente. --- Resultados: Se analizaron 60 paciente (30 en el grupo de casos y 30 en el grupo control). El promedio de edad fue similar entre los grupos de estudio (25.8 vs 25.6 años; p=0.917). Ambos grupos presentaron características clínicas y epidemiológicas similares, a excepción del índice de masa corporal, que fue significativamente mayor en el grupo de casos (p= 0.035). En lo que respecta al número de gestas, paridad, número de cesáreas y abortos fueron similares entre los grupos Las parejas sexuales para cada grupo de estudio fueron de 1.83 y 1.90 respectivamente, sin diferencias significativas (p=0.821). El nivel sérico promedio de 25-hidroxivitamina D fue similar entre los grupos siendo de 24 ng/ml (DE: 6.214) para grupo control y un valor de 21.5 ng/ml (DE: 6.731). para el grupo de casos. 27 pacientes presentaron hipovitaminosis D en el grupo caso), y 25 pacientes con hipovitaminosis en el grupo control (p =0.153) --- Conclusiones: No se encontró asociación entre los niveles séricos de vitamina D y el desarrollo de preeclampsia. Palabras Clave: Preeclampsia, vitamina D, hipovitaminosis D, embarazo.
Published: 2023
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2. MEASURING PERCEPTIONS AND THE DRIVERS OF MEMBERSHIP COMMITMENT OF COCOA FARMERS’ COOPERATIVE SOCIETIES IN ATWIMA MPONUA DISTRICT, GHANA

Author: Justice Frimpong-Manso, Enoch Kwame Tham-Agyekum, David Boansi, Fred Ankuyi, Evans Antwi, John-Eudes Andivi Bakang, Frederick Osei Tawiah, and Fred Nimoh
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: Limited studies exist on the commitment of members to cooperative societies. Therefore, the study sought to measure perceptions of membership and the drivers of membership commitment of cocoa farmers' cooperative societies in the Atwima Mponua District of Ashanti Region, Ghana. Data was collected from a sample of 400 cocoa farmers through a multi-stage sampling technique. Descriptive statistics (mean and standard deviation) and inferential statistics (binary logit regression) were used in analyzing the data. Results show that cocoa farmers agree that they benefit from the cooperative and they appreciate the management, marketing and business, internal dynamics and public interest of their cooperatives. The study also discovered that farm age, access to extension service, farming experience, farmer status, cooperative benefits and internal dynamics are critical to obtaining commitment in cooperative societies. The study shows the need for the Ghana Cocoa Board to improve farmers’ access to extension services so as to improve their commitment in cooperative societies. Cooperative organizations are encouraged to consider the perceptions of the cocoa farmers and their socio-economic characteristics in order to elicit the desired commitment.
Published: 2023
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3. Responsive strategic oscillation for solving the disjunctively constrained knapsack problem

Author: Zequn Wei, Jin-Kao Hao, Jintong Ren, and Fred Glover
Subjects: Information Systems and Management, General Computer Science, Modeling and Simulation, Management Science and Operations Research, Industrial and Manufacturing Engineering
Published: 2023
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4. NOV03 for Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction: The Randomized Phase 3 MOJAVE Study

Author: John D. Sheppard, Fred Kurata, Alice T. Epitropoulos, Sonja Krösser, and Jason L. Vittitow
Subjects: Ophthalmology
Published: 2023
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5. Correcting Gain Drift in TES Detectors for Future X-Ray Satellite Missions

Author: Stephen J. Smith, Michael C. Witthoeft, Joseph S. Adams, Simon R. Bandler, Sophie Beaumont, James A. Chervenak, Renata S. Cumbee, Megan E. Eckart, Fred M. Finkbeiner, Sam V. Hull, Richard L. Kelley, Caroline A. Kilbourne, Maurice A. Leutenegger, Frederick S. Porter, Kazuhiro Sakai, Nicholas A. Wakeham, and Edward J. Wassell
Subjects: Electrical and Electronic Engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Published: 2023
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6. Multivariate continuous-time autoregressive moving-average processes on cones

Author: Fred Espen Benth and Sven Karbach
Subjects: Statistics and Probability, primary: 60G10, 60G12 secondary: 60G51, Applied Mathematics, Modeling and Simulation, Probability (math.PR), FOS: Mathematics, Mathematics - Probability
Abstract: In this article we study multivariate continuous-time autoregressive moving-average (MCARMA) processes with values in convex cones. More specifically, we introduce matrix-valued MCARMA processes with L\'evy noise and present necessary and sufficient conditions for processes from this class to be cone valued. We derive specific hands-on conditions in the following two cases: First, for classical MCARMA on $\mathbb{R}_{d}$ with values in the positive orthant $\mathbb{R}_{d}^{+}$. Second, for MCARMA processes on real square matrices taking values in the cone of symmetric and positive semi-definite matrices. Both cases are relevant for applications and we give several examples of positivity ensuring parameter specifications. In addition to the above, we discuss the capability of positive semi-definite MCARMA processes to model the spot covariance process in multivariate stochastic volatility models. We justify the relevance of MCARMA based stochastic volatility models by an exemplary analysis of the second order structure of positive semi-definite well-balanced Ornstein-Uhlenbeck based models., Comment: 37 pages
Published: 2023
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7. Tabu search exploiting local optimality in binary optimization

Author: Saïd Hanafi, Yang Wang, Fred Glover, Wei Yang, and Rick Hennig
Subjects: Information Systems and Management, General Computer Science, Modeling and Simulation, Management Science and Operations Research, Industrial and Manufacturing Engineering
Published: 2023
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8. Design of a multi-institutional neurocognitive discovery study in adult congenital heart disease (MINDS-ACHD)

Author: Scott Cohen, Michelle Gurvitz, Kristin M. Burns, Olivia Wheaton, Ashok Panigrahy, Laura Umfleet, Michelle Loman, Nicole Brown, Tim Cotts, Peter Ermis, Susan Fernandes, Stephanie Gaydos, Arvind Hoskoppal, Ian Lindsay, Larry W. Markham, Annique Nyman, Fred H. Rodriguez, Cynthia C. Smith, Mario Stylianou, Felicia Trachtenberg, and Ali N. Zaidi
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023
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9. Benefits of a Laser Chorioretinal Anastomosis Plus Ranibizumab vs Ranibizumab Alone for Central Retinal Vein Occlusion: 4-Year Results

Author: Ian L. McAllister, Lynne A. Smithies, Fred K. Chen, David A. Mackey, and Paul G. Sanfilippo
Subjects: Ophthalmology
Published: 2023
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10. Holding Back or Letting Go?

Author: Stela Ivanova, Theresa Treffers, Fred Langerak, and Markus Groth
Subjects: Economics and Econometrics, emotion regulation, authenticity, relationship viability, new venture teams, Business and International Management, appropriateness, emotion suppression
Abstract: Drawing on emotion regulation theory, this study investigates if and how emotion suppression informs relationship viability within new venture teams (NVTs) when such teams face obstacles. In particular, we use a dyadic approach to examine the suppressor’s authenticity and team members’ perceptions of appropriateness as mediators in the link between emotion suppression and relationship viability. A round-robin study with 93 respondents nested in 37 NVTs, which generated 167 observations, provides empirical support for the theoretically derived model by showing that both authenticity and appropriateness fully mediate the relationship between emotion suppression and relationship viability. In particular, the findings show that the negative indirect effect of emotion suppression on relationship viability via authenticity is larger than the positive indirect effect via appropriateness. A follow-up study after two years indicates that relationship viability and emotion suppression significantly predict venture survival. Together, these findings make ample contributions to the literature and provide interesting opportunities for further research.
Published: 2023

11. Circadian desynchrony and health

Author: Keith C. Summa and Fred W. Turek
Published: 2024
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12. Contributors

Author: Sabra M. Abbott, Takashi Abe, Imran I. Ali, J. Todd Arnedt, Alon Y. Avidan, Ronny P. Bartsch, Ruth M. Benca, Orfeu M. Buxton, Anne-Marie Chang, Ronald D. Chervin, Nancy Collop, Jennifer Corrigan, David F. Dinges, Emmanuel H. During, Mohan Dutt, Danny J. Eckert, Jack D. Edinger, E. Devon Eldridge-Smith, Chiara Formentin, Patrick M. Fuller, Jacqueline Geer, Cathy Goldstein, Patrick J. Hanly, Ronald M. Harper, Max Hirshkowitz, Michael J. Howell, Mary S.M. Ip, Muna Irfan, Plamen Ch. Ivanov, Shahrokh Javaheri, Sogol Javaheri, Christopher W. Jones, Yo-El S. Ju, Marc Kaizi-Lutu, Levente Kapas, Meir H. Kryger, Scott J. Kutscher, Won Y. Lee, Peter Y. Liu, Macy M.S. Lui, Bethany L. Lussier, Atul Malhotra, Raman K. Malhotra, Catherine A. McCall, William V. McCall, Wallace Mendelson, Sara Montagnese, Pier Luigi Parmeggiani, Aric A. Prather, Kathryn J. Reid, Thomas Roth, Logan Douglas Schneider, Colin M. Shapiro, Amir Sharafkhaneh, Ajaz A. Sheikh, Stephen H. Sheldon, Deena Sherman, Jerome M. Siegel, Andrea M. Spaeth, Robert Stickgold, Keith C. Summa, Leslie Swanson, Éva Szentirmai, Lauren Tobias, Fred W. Turek, Christopher D. Turnbull, Bradley V. Vaughn, Richard L. Verrier, Erin J. Wamsley, Sophie D. West, Daniel Whibley, John W. Winkelman, Brian S. Wojeck, Christine H.J. Won, Steven Yao, Kin M. Yuen, and Phyllis C. Zee
Published: 2024
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13. Deficiencia de vitamina D en pacientes con preeclampsia severa y embarazo único a término

Author: Alan Rigoberto Carvajal-Sepúlveda, Fred Morgan-Ortiz, Everardo Quevedo-Castro, Guadalupe López-Manjarrez, Fred Valentín Morgan-Ruiz, and Perla Yareli Gutiérrez-Arzapalo
Subjects: General Medicine
Abstract: La preeclampsia es una de las principales causas de morbimortalidad materna, es una enfermedad específica del embarazo caracterizado por trastornos hipertensivos que pueden estar asociados a diferentes grados de proteinuria, con posibilidad de evolucionar a diferentes espectros clínicos de severidad. En presencia de alguna de las características marcadas como “severas”, los pacientes pueden clasificarse automáticamente. La forma activa de la vitamina D juega un papel regulador en el proceso de placentación, la cual se une a su receptor de vitamina D (VDR), que se expresa en altas cantidades en el trofoblasto y tejido decidual en función de la carga genética y la síntesis de vitamina D endógena. Cuando hay una disminución en la carga de VDR, el trofoblasto comienza a crecer e invadir de manera desorganizada, la invasión no llega a ser funcional, porque la desorganización hace que los espacios lagunares no sean alcanzados correctamente, comprometiendo el suministro de oxígeno de la unidad fetoplacentaria. Debido a estos eventos ocurre una disminución del factor de crecimiento tipo 3 (TGFB3), encargado de inducir el crecimiento placentario, neovascularización y aporte nutrimental al trofoblasto invasor, contribuyendo a la patogenia de la preeclampsia. En general, resultados de distintos estudios sugieren que los niveles disminuidos de 25(OH) D en el embarazo pueden estar asociados con la preeclampsia en subgrupos específicos de la población. Palabras Clave: Preeclampsia, vitamina D, hipovitaminosis D, embarazo
Published: 2022
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14. The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Author: Victor, P.D Victor, Ajie, P.C Ajie, Reuben, E Reuben, Okpara, P. E Okpara, George, B.O George, Fred, B.B Fred, and Otto, B. Otto
Abstract: Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003). Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days. Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups. Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.
Published: 2022
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15. Sintering mechanics of binder jet 3D printed ceramics treated with a reactive binder

Author: Lynnora O. Grant, C. Fred Higgs, and Zachary C. Cordero
Subjects: Materials Chemistry, Ceramics and Composites
Published: 2023
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16. Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation

Author: Matthew J. Lewis, Leigh C. Reardon, Jamil Aboulhosn, Christiane Haeffele, Sharon Chen, Yuli Kim, Stephanie Fuller, Lisa Forbess, Laith Alshawabkeh, Marcus A. Urey, Wendy M. Book, Fred Rodriguez, Jonathan N. Menachem, Daniel E. Clark, Anne Marie Valente, Matthew Carazo, Alexander Egbe, Heidi M. Connolly, Eric V. Krieger, Jilian Angiulo, Ari Cedars, Jong Ko, Roni M. Jacobsen, Michael G. Earing, Jonathan W. Cramer, Peter Ermis, Christopher Broda, Natalia Nugaeva, Heather Ross, Jordan D. Awerbach, Richard A. Krasuski, and Marlon Rosenbaum
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023
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17. Distributed Absolute and Relative Estimation of Spacecraft Formations

Author: Kaushik Prabhu, Kyle T. Alfriend, Amir Rahmani, and Fred Y. Hadaegh
Subjects: Space and Planetary Science, Control and Systems Engineering, Applied Mathematics, Aerospace Engineering, Electrical and Electronic Engineering
Abstract: For optimal decision making and collaborative task performance in multispacecraft missions, it is essential for each spacecraft to maintain a state estimate of all the spacecraft in the formation. However, especially in the case of large formation sizes, each spacecraft may not be able to track or communicate with all other spacecraft. Further, for formations deployed in deep space, the unavailability of the Global Navigation Satellite System makes inertial state estimation challenging. We propose the Distributed Absolute and Relative Estimation (DARE) algorithm for autonomous inertial estimation of spacecraft formations. The algorithm enables each spacecraft to maintain an accurate inertial estimate of the entire formation even in the presence of observability and communication constraints. Each spacecraft utilizes measurements of feature points (landmarks) for inertial localization and measurements of neighboring spacecraft for relative localization. The algorithm is distributed and scalable to any number of spacecraft in the formation. A modified version of the algorithm called the Sparse Distributed Absolute and Relative Estimation (SDARE) algorithm is also derived. This algorithm is computationally more efficient at the expense of estimation accuracy, making it suitable for implementation on nanosatellites where resources are limited. Numerical simulation results demonstrating the effectiveness and comparing the performance of both algorithms are provided.
Published: 2023
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18. Effects of consolidants and their removal by polar solvents on the stable isotope compositions of bone

Author: Diana K. Moreiras Reynaga, Jordon S. Munizzi, Rhy McMillan, Jean-François Millaire, and Fred J. Longstaffe
Subjects: Earth-Surface Processes
Published: 2023
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19. New cultivars

Author: Julien Müller, Evan Wang, Emmy Wang, Mark Rubnitz, Arlen Weng, Emanuele Melani, Lukas Mondoux, Michael Richard Sprouse, Fred Vosse, Mentaz Philippe, Guilherme Baião, and Bruno Garcia
Abstract: Thirteen new carnivorous plant cultivars are named and described: Dionaea 'Angioma', Dionaea 'EEC Thresher Shark', Pinguicula 'Urchin', Pinguicula 'Damon's Choice', Sarracenia 'Camisole', Sarracenia 'GraceY', Sarracenia 'Spanish Dancer', Sarracenia 'Yellow Hornet', Sarracenia 'White Cobra', Sarracenia 'Wilkerson White Knight', Sarracenia 'Flamenco', Sarracenia 'Asmoderolle', Utricularia 'Garcia's Treasure'
Published: 2023
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20. Effect of Prior Local Therapy on Response to First-line Androgen Receptor Axis Targeted Therapy in Metastatic Castrate-resistant Prostate Cancer: A Secondary Analysis of the COU-AA-302 Trial

Author: Soumyajit Roy, Yilun Sun, Scott C. Morgan, Christopher J.D. Wallis, Kevin King, Yu M. Zhou, Leah A. D'souza, Omar Azem, Adrianna E. Cueto-Marquez, Nathaniel B. Camden, Daniel E. Spratt, Amar U. Kishan, Fred Saad, and Shawn Malone
Subjects: Urology
Published: 2023
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21. Mind-mindedness in a high-risk sample: Differential benefits for developmental outcomes based on child maltreatment

Author: Michelle P. Brown, Rowena Ng, Joe Lisle, Melissa Koenig, Dane Sannes, Fred Rogosch, and Dante Cicchetti
Subjects: Developmental and Educational Psychology, Life-span and Life-course Studies, Demography
Abstract: Mind-mindedness is associated with positive developmental outcomes. However, much of the literature uses mostly White, middle to high socioeconomic status (SES) samples despite evidence that the benefits of mind-mindedness may vary based on degree of social risk. Additionally, few studies have examined relations between mind-mindedness and language development. The current study investigates whether mind-mindedness predicts children's language development and behavioral functioning and if family history of childhood maltreatment moderates the relation of mind-mindedness to these outcomes. Participants were 98 mothers (49.0% Black, 24.5% White, 13.3% Latina, 7.2% multiracial; 81.6% low SES per Hollingshead classifications) and their children (49 boys, 49 girls) from the Rochester, New York area recruited at Time 1 (
Published: 2023
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22. Morbidity and Mortality in Adult Fontan Patients After Heart or Combined Heart-Liver Transplantation

Author: Matthew J. Lewis, Leigh C. Reardon, Jamil Aboulhosn, Christiane Haeffele, Sharon Chen, Yuli Kim, Stephanie Fuller, Lisa Forbess, Laith Alshawabkeh, Marcus A. Urey, Wendy M. Book, Fred Rodriguez, Jonathan N. Menachem, Daniel E. Clark, Anne Marie Valente, Matthew Carazo, Alexander Egbe, Heidi M. Connolly, Eric V. Krieger, Jilian Angiulo, Ari Cedars, Jong Ko, Roni M. Jacobsen, Michael G. Earing, Jonathan W. Cramer, Peter Ermis, Christopher Broda, Natalia Nugaeva, Heather Ross, Jordan D. Awerbach, Richard A. Krasuski, and Marlon Rosenbaum
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023
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23. Measuring Brain Temperature in Youth Bipolar Disorder Using a Novel Magnetic Resonance Imaging Approach: A Proof-of-concept Study

Author: Benjamin I. Goldstein, Yi Zou, Chinthaka Heyn, Anahit Grigorian, Fred Tam, Ana Cristina Andreazza, Simon J. Graham, and Bradley J. Maclntosh
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), General Medicine
Abstract: Background: There is evidence of alterations in mitochondrial energy metabolism and cerebral blood flow (CBF) in adults and youth with bipolar disorder (BD). Brain thermoregulation is based on the balance of heat-producing metabolism and heat-dissipating mechanisms, including CBF. Objective: To examine brain temperature, and its relation to CBF, in relation to BD and mood symptom severity in youth. Methods: This study included 25 youth participants (age 17.4 ± 1.7 years; 13 BD, 12 control group (CG)). Magnetic resonance spectroscopy data were acquired to obtain brain temperature in the left anterior cingulate cortex (ACC) and the left precuneus. Regional estimates of CBF were provided by arterial spin labeling imaging. Analyses used general linear regression models, covarying for age, sex, and psychiatric medications. Results: Brain temperature was significantly higher in BD compared to CG in the precuneus. A higher ratio of brain temperature to CBF was significantly associated with greater depression symptom severity in both the ACC and precuneus within BD. Analyses examining the relationship of brain temperature or CBF with depression severity score did not reveal any significant finding in the ACC or the precuneus. Conclusion: The current study provides preliminary evidence of increased brain temperature in youth with BD, in whom reduced thermoregulatory capacity is putatively associated with depression symptom severity. Evaluation of brain temperature and CBF in conjunction may provide valuable insight beyond what can be gleaned by either metric alone. Larger prospective studies are warranted to further evaluate brain temperature and its association with CBF concerning BD.
Published: 2023
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24. Effect of an Educational Intervention for Primary Stroke Risk Reduction in Ghana and Nigeria: Pilot Randomized Controlled Trial

Author: Fred Stephen Sarfo, Joshua Odunayo Akinyemi, Reginald Obiako, Michelle Nichols, Adekunle Gregory Fakunle, Nathaniel Adusei, Michael Ampofo, Oyedunni Arulogun, Carolyn Jenkins, Onoja M. Akpa, Benjamin Aribisala, Saheed Abdulrasaq, Rufus Akinyemi, Bruce Ovbiagele, and Mayowa O. Owolabi
Subjects: Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Background: Using tailored mobile health interventions to improve global vascular risk awareness and control is yet to be investigated for primary stroke prevention in Africa. Methods: This 2-arm pilot randomized controlled trial involved 100 stroke-free adults with at least 2 vascular risk factors for stroke. Eligible participants were assigned randomly to a control arm offering 1-time counseling (n=50) or a 2-month educational intervention arm (n=50) comprising a stroke video and riskometer app aimed at improving stroke risk factor awareness and health-seeking behavioral modification to control total vascular risk. Reduction in total stroke risk score was the primary outcome while feasibility and process measures were secondary outcomes. Results: All enrolled participants completed the 2-month follow-up (retention rate=100%). The mean (SD) age of participants was 59.5 (±12.5) years, 38% were males. The mean change in stroke risk score at 2 months was −11.9% (±14.2) in the intervention arm versus −1.2% (±9.1) in the control arm, P =0.0001. Stroke risk awareness improved by 16.1% (±24.7) in the intervention arm versus 8.9% (±24.7) in the control arm, P =0.08. The intervention arm had 11.1 mm Hg reduction in systolic blood pressure compared with 4.8 mm Hg reduction in the control arm. Conclusions: The intervention demonstrated a positive signal of effect over a 2-month period. A definitive clinical trial with a longer duration of follow-up is warranted on the premise of these promising findings from this pilot randomized clinical trial. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT05619406.
Published: 2023
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25. Deep Learning Forecast Uncertainty for Precipitation over the Western United States

Author: Weiming Hu, Mohammadvaghef Ghazvinian, William E. Chapman, Agniv Sengupta, Fred Martin Ralph, and Luca Delle Monache
Subjects: Atmospheric Science
Abstract: Reliably quantifying uncertainty in precipitation forecasts remains a critical challenge. This work examines the application of a deep learning (DL) architecture, Unet, for postprocessing deterministic numerical weather predictions of precipitation to improve their skills and for deriving forecast uncertainty. Daily accumulated 0–4-day precipitation forecasts are generated from a 34-yr reforecast based on the West Weather Research and Forecasting (West-WRF) mesoscale model, developed by the Center for Western Weather and Water Extremes. The Unet learns the distributional parameters associated with a censored, shifted gamma distribution. In addition, the DL framework is tested against state-of-the-art benchmark methods, including an analog ensemble, nonhomogeneous regression, and mixed-type meta-Gaussian distribution. These methods are evaluated over four years of data and the western United States. The Unet outperforms the benchmark methods at all lead times as measured by continuous ranked probability and Brier skill scores. The Unet also produces a reliable estimation of forecast uncertainty, as measured by binned spread–skill relationship diagrams. Additionally, the Unet has the best performance for extreme events (i.e., the 95th and 99th percentiles of the distribution) and for these cases, its performance improves as more training data are available. Significance Statement Accurate precipitation forecasts are critical for social and economic sectors. They also play an important role in our daily activity planning. The objective of this research is to investigate how to use a deep learning architecture to postprocess high-resolution (4 km) precipitation forecasts and generate accurate and reliable forecasts with quantified uncertainty. The proposed approach performs well with extreme cases and its performance improves as more data are available in training.
Published: 2023
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26. A new species of Lepidodactylus (Squamata: Gekkonidae) from Umboi Island, Papua New Guinea

Author: FRED KRAUS, VARPU VAHTERA, and VALTER WEIJOLA
Subjects: Reptilia, Squamata, Animalia, Animal Science and Zoology, Biodiversity, Chordata, Gekkonidae, Ecology, Evolution, Behavior and Systematics, Taxonomy
Abstract: We describe a new species of Lepidodactylus from Umboi Island, just to the west of New Britain. It is a member of the Lepidodactylus guppyi Group and can be distinguished from all other Melanesian Lepidodactylus by aspects of digital scalation, digital webbing, enlarged femoral/precloacal scales, and color pattern. It is genetically distinct from its closest congeners, and genetic and morphological data indicate that the new species is most similar among named species to Lepidodactylus guppyi from the Solomon Islands, but it diverged from this species and other close relatives approximately 8 MYA or longer at a time prior to the existence of the island that it now occupies. The new species is known from only three individuals collected on a single tree, and efforts to find more animals in what seemed good habitat nearby were unsuccessful. This duplicates the pattern of apparent rarity seen for many Lepidodactylus species. Sufficient habitat exists on Umboi Island for arboreal geckos, suggesting that the species is not actually endangered but is ecologically cryptic. However, lack of needed information leads us to assess this species’ conservation status as Data Deficient.
Published: 2023
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27. Importancia de un programa propedéutico en educación física psicomotriz para docentes y estudiantes en Básica Primaria en Colombia

Author: Wilmar Fred Copete Perea
Subjects: General Medicine
Abstract: El presente artículo de investigación da cuenta de cómo la elaboración de un programa propedéutico en educación física psicomotriz para docentes puede dar solución a una problemática que se presenta en el sistema educativo colombiano, se trata de la falta de docentes licenciados en educación física para impartir la catedra en básica primaria en Colombia y como posiblemente la falta de preparación específica de los docentes que aplican la asignatura influye en el desarrollo psicomotriz de los educandos.
Published: 2023
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28. Prospecção Tecnológica Voltada para o Agronegócio

Author: Fernando Lucas and Fred Leite Siqueira Campos
Subjects: General Medicine
Abstract: Este trabalho é o resultado de uma prospecção tecnológica em banco de dados de patentes, por meio da plataforma de pesquisa PatSeer Pro. O tema envolve o agronegócio, nos aspectos tecnológicos que estão sendo desenvolvidos e aplicados dentro do contexto do Agro 4.0, sendo as tecnologias de interesse da pesquisa aquelas relacionadas com a Internet das Coisas, Inteligência Artificial, big data e aprendizado de máquina. A pesquisa compreendeu uma busca por documentos patentários de ambas as naturezas, a saber: patentes de invenção e modelos de utilidade, sendo a busca definida por palavras-chave e filtro temporal, que, ao final, retornou 591 documentos, os quais compõem um portfólio único e que foi analisado graficamente, trazendo os principais aspectos tecnológicos dentro do campo pesquisado. Do resultado da prospecção tecnológica, é possível identificar que a Índia (IN) vem se destacando no desenvolvimento das tecnologias que se relacionam às palavras-chave utilizadas, obtendo atualmente elevada taxa de crescimento nos depósitos de patentes, inclusive superando a China (CN), maior depositante dentro do campo tecnológico pesquisado. Ademais, dentro do escopo do Agro 4.0, a principal tecnologia em que os depositantes mais buscam por proteção patentária relaciona-se com o Big Data Agrícola.
Published: 2023
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29. Deindustrialization, Gender, and Working-Class Militancy in Saint-Henri, Montréal

Author: Fred Burrill
Subjects: Organizational Behavior and Human Resource Management, History, Industrial relations
Abstract: Tracing the history of gendered working-class responses to deindustrialization in the Montréal neighbourhood of Saint-Henri reveals that many of the local political initiatives of the 1960s and 1970s were connected to longer-term working-class efforts to navigate shifting patterns of capital accumulation extending back to the 1940s. The gendered tradition of territory-based organizing in this community encouraged women workers’ shop-floor militancy and was foundational for new forms of local political advocacy around issues like health care and housing. In deindustrialization’s moment, the concerns of a precariously employed, feminized working-class population spurred a crossover of industrial struggle with survival-focused reproductive labour issues, centred around a grassroots organization called the popir (Projet d’organisation populaire, d’information, et de regroupement). This pattern of gendered working-class militancy and solidarity persisted throughout the 1980s and shaped resistance to Saint-Henri’s subsequent gentrification at the turn of the new millennium.
Published: 2023
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30. Exploratory study of the efficacy of the Culturo-Techno-Contextual Approach (CTCA) in student’s understanding of biology

Author: Fred Awaah, Peter Okebukola, Juma Shabani, Hussein Abdul Azeez Taiwo, Olansunkanmi Gbeleyi, Andrew Tetteh, Jessie Foli, and Dorcas Adomaa Addo
Subjects: Education
Published: 2023
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31. Change in Drug Use Disorders Identification Test – Consumption (DUDIT-C) with Telehealth Treatment Compared to in-Person Treatment

Author: Jonathan Neufeld, Fred Ullrich, Kimberly A. S. Merchant, Divya Bhagianadh, Knute D. Carter, James P. Marcin, Eve-Lynn Nelson, Carly McCord, Kari Beth Law, and Marcia M. Ward
Subjects: Psychiatry and Mental health, Health (social science), Public Health, Environmental and Occupational Health, Medicine (miscellaneous)
Published: 2023
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32. Of missions and marshes: Stable isotope analysis of Mission-Era Guale oyster harvesting on St. Catherines Island, Georgia

Author: Cayla B. Colclasure, C. Fred T. Andrus, and Elliot H. Blair
Subjects: Archeology, History, Ecology, Oceanography
Published: 2023
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33. ‘From a guy’s perspective’? Male students, masculinity and autobiographical loneliness narratives

Author: Richard Vytniorgu, Fred Cooper, and Manuela Barreto
Subjects: Gender Studies, Education
Published: 2023
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34. External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer

Author: Susan Halabi, Qian Yang, Akash Roy, Bin Luo, John C. Araujo, Christopher Logothetis, Cora N. Sternberg, Andrew J. Armstrong, Michael A. Carducci, Kim N. Chi, Johann S. de Bono, Daniel P. Petrylak, Karim Fizazi, Celestia S. Higano, Michael J. Morris, Dana E. Rathkopf, Fred Saad, Charles J. Ryan, Eric J. Small, and William Kevin Kelly
Subjects: Cancer Research, Oncology
Abstract: PURPOSE We have previously developed and externally validated a prognostic model of overall survival (OS) in men with metastatic, castration-resistant prostate cancer (mCRPC) treated with docetaxel. We sought to externally validate this model in a broader group of men with docetaxel-naïve mCRPC and in specific subgroups (White, Black, Asian patients, different age groups, and specific treatments) and to classify patients into validated two and three prognostic risk groupings on the basis of the model. METHODS Data from 8,083 docetaxel-naïve mCRPC men randomly assigned on seven phase III trials were used to validate the prognostic model of OS. We assessed the predictive performance of the model by computing the time-dependent area under the receiver operating characteristic curve (tAUC) and validated the two-risk (low and high) and three-risk prognostic groups (low, intermediate, and high). RESULTS The tAUC was 0.74 (95% CI, 0.73 to 0.75), and when adjusting for the first-line androgen receptor (AR) inhibitor trial status, the tAUC was 0.75 (95% CI, 0.74 to 0.76). Similar results were observed by the different racial, age, and treatment subgroups. In patients enrolled on first-line AR inhibitor trials, the median OS (months) in the low-, intermediate-, and high-prognostic risk groups were 43.3 (95% CI, 40.7 to 45.8), 27.7 (95% CI, 25.8 to 31.3), and 15.4 (95% CI, 14.0 to 17.9), respectively. Compared with the low-risk prognostic group, the hazard ratios for the high- and intermediate-risk groups were 4.3 (95% CI, 3.6 to 5.1; P < .0001) and 1.9 (95% CI, 1.7 to 2.1; P < .0001). CONCLUSION This prognostic model for OS in docetaxel-naïve men with mCRPC has been validated using data from seven trials and yields similar results overall and across race, age, and different treatment classes. The prognostic risk groups are robust and can be used to identify groups of patients for enrichment designs and for stratification in randomized clinical trials.
Published: 2023
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35. Sexual Coercion and Harassment of Students with Disabilities in a Public University in Ghana

Author: Fred Yao Gbagbo, Gifty Nana Yaa Rockson, Frank Quansah, and Edward Kwabena Ameyaw
Subjects: Clinical Psychology
Published: 2023
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36. Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody–Drug Conjugate

Author: Patrick G. Groothuis, Daniëlle C.H. Jacobs, Inge A.T. Hermens, Désirée Damming, Kim Berentsen, Ellen Mattaar-Hepp, Marloes E.M. Stokman, Tinie van Boekel, Myrthe Rouwette, Monique A.J. van der Vleuten, Aloys Sesink, Fred A. Dijcks, Ruud G.E. Coumans, Jan Schouten, Dirk H. Glaudemans, Daniëlle van Wijk, Marion Blomenröhr, Wendela A. Kappers, Ruud Ubink, Miranda M.C. van der Lee, and Wim H.A. Dokter
Subjects: Cancer Research, Oncology
Abstract: MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specifically conjugated duocarmycin-based antibody–drug conjugate (ADC), comprising a humanized cysteine-engineered IgG1 monoclonal antibody with low pmol/L binding affinity towards both human and cynomolgus MET. In vitro studies showed that BYON3521 internalizes efficiently upon MET binding and induces both target- and bystander-mediated cell killing. BYON3521 showed good potency and full efficacy in MET-amplified and high MET–expressing cancer cell lines; in moderate and low MET–expressing cancer cell lines good potencies and partial efficacy were observed. In mouse xenograft models, BYON3521 showed significant antitumor activity upon single-dose administration in multiple non-MET–amplified tumor types with low, moderate, and high MET expression, including complete tumor remissions in models with moderate MET expression. In the repeat-dose Good Laboratory Practice (GLP) safety assessment in cynomolgus monkeys, BYON3521 was well tolerated and based on the observed toxicities and their reversibility, the highest non-severely toxic dose was set at 15 mg/kg. A human pharmacokinetics (PK) model was derived from the PK data from the cynomolgus safety assessments, and the minimal efficacious dose in humans is estimated to be in the range of 3 to 4 mg/kg. In all, our nonclinical data suggests that BYON3521 is a safe ADC with potential for clinical benefit in patients. A first-in-human dose-escalation study is currently ongoing to determine the maximum tolerated dose and recommended dose for expansion (NCT05323045).
Published: 2023
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37. Extraction, purification and characterization of an arabinogalactan from frost (riverbank) grape (Vitis riparia Michx.) stems

Author: Fred J. Eller, Steven F. Vaughn, Neil P. J. Price, James A. Kenar, Michael A. Jackson, Mark A. Berhow, Korey J. Brownstein, and Gordon W. Selling
Subjects: Environmental Engineering, Bioengineering, Waste Management and Disposal
Abstract: This study investigated the extraction and properties of an arabinogalactan polysaccharide from frost grape (FGP) as a potential alternative to gum arabic (GA). Collection date, solvent:feed ratio (S:F), chip size, C-18 filtration, ultrafiltration, freeze drying versus spray drying, methanol pre-extraction, and water absorption were examined. Sugar composition, elemental analysis, dietary fiber content, emulsification activity index (EAI), emulsification stability index (ESI), and viscosity were used to evaluate the extracts. Exudates collected in March from live stems were viscous with high percentage solids and FGP, while May collections were watery with low percentage solids and FGP. Frost grape stems were collected, chipped, and classified by size. The extraction system utilized pressure or vacuum to increase contact between the chips and extraction water. A S:F ratio of ca. 24% gave an excellent yield of FGP. Chips between 1.8 and 3.8 mm gave the highest mass yields. Pre-extracting the chips with methanol and C-18 filtration of the water extract both yielded a lighter product. The EAI for the FGP was higher than that for GA; however, its ESI was lower. Ultrafiltration of the crude extract separated glucose, fructose, and sucrose from the FGP. FGP with glucose, fructose, and sucrose adsorbed water and became darker.
Published: 2023
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38. 'Marketing Ecosófico': uma reflexão sobre o Marketing Ambiental à luz dos conceitos de ecosofia, rizoma e agenciamento de enunciação

Author: Fred Tavares and Eliane Almeida
Subjects: Earth-Surface Processes
Abstract: Este ensaio teórico propõe uma reflexão psicossocial, pelo olhar da Ecosofia, baseado nas três ecologias (mental, social e ambiental) de Félix Guattari, e busca refletir sobre os problemas socioambientais do mundo pós-moderno. À luz dos conceitos de ecosofia, rizoma e agenciamento de enunciação, o estudo tem como objetivo central pensar como o marketing formula as “subjetividades verdes”, utilizando-se de discursos estratégicos empresariais que exploram temas como recursos naturais, e agenciando uma “rede rizomática verde” para a captura de modos de ser ecológico ou “ecopsicossocial”. A pesquisa é bibliográfica, fundamentada nas pistas teóricas trilhadas por Félix Guattari e Gilles Deleuze; associada a Teoria Ator-Rede (TAR)/Cartografia de Controvérsias de Latour, à qual é utilizada como método de mapeamento dos processos de agenciamento de enunciação do “rizoma verde”. O resultado é uma discussão psicossocial, que revela novas pistas para o marketing ambiental, apontando para a necessidade de se pensar um novo olhar para o marketing, do qual denominamos de “marketing ecosófico”.
Published: 2023
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39. Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients

Author: Yi-Hui Zhou, Paul J. Gallins, Rhonda G. Pace, Hong Dang, Melis A. Aksit, Elizabeth E. Blue, Kati J. Buckingham, Joseph M. Collaco, Anna V. Faino, William W. Gordon, Kurt N. Hetrick, Hua Ling, Weifang Liu, Frankline M. Onchiri, Kymberleigh Pagel, Elizabeth W. Pugh, Karen S. Raraigh, Margaret Rosenfeld, Quan Sun, Jia Wen, Yun Li, Harriet Corvol, Lisa J. Strug, Michael J. Bamshad, Scott M. Blackman, Garry R. Cutting, Ronald L. Gibson, Wanda K. O’Neal, Fred A. Wright, and Michael R. Knowles
Subjects: Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published: 2023
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40. In the era of universal test and treat in Uganda, recent intimate partner violence is not associated with subsequent ART use or viral suppression

Author: Amanda P. Miller, Eileen V. Pitpitan, Susan M. Kiene, Anita Raj, Sonia Jain, María Luisa Zúñiga, Dorean Nabulaku, Fred Nalugoda, Robert Ssekubugu, Betty Nantume, Godfrey Kigozi, Nelson K. Sewankambo, Joseph Kagaayi, Steven J. Reynolds, Maria Wawer, and Jennifer A. Wagman
Subjects: Health (social science), Social Psychology, Public Health, Environmental and Occupational Health
Published: 2023
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41. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY)

Author: Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Abdelaziz, Mohamed Abdelfattah, Bushra Abdelqader, Audrey Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Ajibode Abdulakeem, Rezan Abdul-Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andres Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Laura Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana G Ahmed, Syed Ahmed, Syed H Ahmed, Roa Ahmed Ali, Bilal Ahmed Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, Christine Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al-Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John Alexander, Peter D G Alexander, Julyan Al-fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al-Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed Ali, Mohammad Ali, Muhammad S Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ali, Emilio Aliberti, Jade Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Abdullah Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal F T Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al-Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al-Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Amel Amelia Ganefianty, Katharine Ames, Maria R Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, James Amoah-Dankwa, Victoria Amosun, Muhammad Amsal, Khaled Amsha, John Amuasi, Noelia Amutio Martin, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, Laura Anderson, Marina Anderson, Michelle Anderson, Nicola Anderson, Rachel Anderson, Rebecca Anderson, Rory Anderson, Samantha Anderson, Wendy Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Joyann Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Louise Anning, Maldwyn Ansah, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Varghese Anu, Muhammad Anwar, Elena Apetri, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia F Aquino, Bianca Araba, Samuel Aransiola, Mariana Araujo, Ann Archer, Denise Archer, Samuel Archer, Simon Archer, Daniele Arcoria, Christian Ardley, Ana-Maria Arias, Oluwatoyin Aribike, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Jennifer Armistead, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Wendy Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Andrew Arnott, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Armena Arumaithurai, Ayush Arya, Rita Arya, Diptesh Aryal, Denisa Asandei, Adeeba Asghar, Malik Asghar, Arif Ashab, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Georgia Asher, Zakariya Ashfak, Ayesha Ashfaq, Abdul Ashish, Dawn Ashley, Sally Ashman-Flavell, Sundar Ashok, Abd-El-Aziz Ashour, Muhammad Z Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Fiona J Ashworth, Rebecca Ashworth, Arshia Aslam, I Aslam, Suhail Aslam, Laura Aslett, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne, Billie Atkins, Christopher Atkins, Stacey Atkins, John Atkinson, Vicki Atkinson, Abolaji Atomode, Brygitta Atraskiewicz, Abdul A Attia, Eva Attubato, Marie Attwood, Paula Aubrey, Zoltan Auer, Avinash Aujayeb, Aye Chan Thar Aung, Hnin Aung, Hnin Wint Wint Aung, Ko Ko Aung, Kyaw Thu Aung, Nwe Aung, Yin Aung, Zaw Myo Aung, Emily Austin, Karen Austin, Abdusshakur Auwal, Malcolm Avari, Miriam Avery, Nicholas Aveyard, Joanne Avis, Georgina Aviss, Cristina Avram, Paula Avram, Abuzar Awadelkareem, Gabriel Awadzi, Mahmoud Awaly, Atia Awan, Aszad Aya, Eman Ayaz, John Maximilian Ayerh, Amanda Ayers, Jawwad Azam, Ahmed Azeem, Mohammed Azharuddin, Ammar Aziz, Ghazala Aziz, Imran Aziz, N Aziz, Ali Azkoul, Ashaari Azman Shah, Giada Azzopardi, Hocine Azzoug, Fiyinfoluwa Babatunde, Melvin Babi, Babiker Babiker, Gayna Babington, Matthew Babirecki, Marta Babores, Adetona O Babs-Osibodu, Sammy Bacciarelli, Roudi Bachar, Michel-Elie Bachour, Alisjahbana Bachti, Gina Bacon, Jenny Bacon, Bibi Badal, Aysha Badat, Maryuma Bader, Gurpreet R Badhan, Shreya Badhrinarayanan, Joseph P Bae, Alice Baggaley, Amy Baggott, Graham Bagley, Dinesh Bagmane, Lynsey Bagshaw, Kasra Bahadori, Angela Bailey, James Bailey, Katie Bailey, Lindsey Bailey, Liz Bailey, Lucy Bailey, Maria A Bailey, Morgan Bailey, Pippa Bailey, Sarah Bailey, Hamish Baillie, J Kenneth Baillie, Jennifer Bain, Vikram Bains, David Baird, Eilidh Baird, Kevin Baird, Susan Baird, Tracy Baird, Yolanda Baird, Aiysha Bajandouh, Danielle C Baker, Evelyn Baker, Johanne Baker, Josephine Baker, Kenneth Baker, Mark Baker, Rebecca Baker, Terri-Anne Baker, Victoria Baker, Hugh Bakere, Nawar Bakerly, Michelle Baker-Moffatt, Ameet Bakhai, Nauman Bakhtiar, Panos Bakoulas, Dhanalakshmi Bakthavatsalam, Niranjan Balachandran, Andrea Balan, Prasath Balasingam, Theodosios Balaskas, Madhu Balasubramaniam, Nicola Balatoni, Alison Balcombe, Alexander Baldwin, Ashley Baldwin, Caron Baldwin, Danielle Baldwin, Fiona Baldwin, Rebekah Baldwin-Jones, Nichola Bale, James Balfour, Matthew Ball, Robert Ball, K Ballard, Ismael Balluz, Craig Balmforth, Emese Balogh, Abeir Baltmr, Amir Baluwala, Gabby Bambridge, Alasdair Bamford, Amy Bamford, Peter Bamford, Adefunke Bamgboye, Elizabeth Bancroft, Hollie Bancroft, Joyce Banda, Krishna Bandaru, Srini Bandi, Nageswar Bandla, Somaditya Bandyopadhyam, Amit Banerjee, Ritwik Banerjee, Santosh Baniya, Omar Bani-Saad, Harrison Banks, Luke Banks, Paul Banks, Claudia Bann, Helen Bannister, Oliver Bannister, Laura Banton, Tran Bao, Mariamma Baptist, Tanya Baqai, Ananya M Baral, Sharad Chandra Baral, Desislava Baramova, Russel Barber, Emma Barbon, Monica Barbosa, Jamie Barbour, Alexander Barclay, Amanda Barclay, Claire Barclay, George Bardsley, Stephanie Bareford, Shahedal Bari, Morris Barimbing, Amy Barker, Debbie Barker, Erandi Barker, Helen Barker, Joseph Barker, Leon Barker, Lesley Barker, Oliver Barker, Kerry Barker-Williams, Sinha Barkha, Juliana Barla, Gavin Barlow, Richard Barlow, Valerie Barlow, James Barnacle, Alex Barnard, Debi Barnes, Nicky Barnes, Rory Barnes, Theresa Barnes, Calum Barnetson, Amy Barnett, Ashton Barnett-Vanes, Prince Gyenti Barning, William Barnsley, Andrew Barr, David Barr, James Barr, Charlotte Barr, Nina Barratt, Shaney Barratt, Manuella Barrera, Amy Barrett, Fiona Barrett, Jessica Barrett, Sue Barrett, Esther Barrow, Jazz Bartholomew, Claire Bartlett, Georgina Bartlett, James Bartlett, Louise Bartlett, Shauna Bartley, Sandra Bartolmeu-Pires, Anna Barton, Greg Barton, Jill Barton, Lorna Barton, Rachael Barton, Rosaleen Baruah, Sonia Baryschpolec, Hannah Bashir, Archana Bashyal, Betsy Basker, Sudha Basnet, Buddha Basnyat, Ayten Basoglu, Alexander Basran, John Bassett, G Bassett, Chris Bassford, Bengisu Bassoy, Victoria Bastion, Anup Bastola, Anupam Basumatary, Precious Basvi, Jireh A Batac, Vipula R Bataduwaarachchi, Tristan Bate, Harry J Bateman, Kathryn Bateman, Vhairi Bateman, Eleanor Bates, Hayley Bates, Michelle Bates, Simon Bates, Sally Batham, Ana Batista, Amit Batla, Dushyant Batra, Harry Batty, Thomas Batty, Alice Batty, Miranda Baum, Rachel Baumber, Carina Bautista, Fareha Bawa, Tanveer Bawa, Fatima S Bawani, Simon Bax, Matt Baxter, Nicola Baxter, Zachary Baxter, Hannah Bayes, Lee-Ann Bayo, Farid Bazari, Rohit Bazaz, Ahmad Bazli, Laura Beacham, Wendy Beadles, Kirsten Beadon, Philip Beak, Andy Beale, Kathy Beard, Jack Bearpark, Alanna Beasley, Sandee Beattie, Karen Beaumont, Dawn Beaumont-Jewell, Theresa Beaver, Sarah Beavis, Christy Beazley, Sarah Beck, Virginia Beckett, Rosie Beckitt, Sarah Beckley, Heidi Beddall, Seonaid Beddows, Deborah Beeby, Sophia Beeby, Gail Beech, Michelle Beecroft, Nigel Beer, Sally Beer, Jane Beety, Gabriela Bega, Alison Begg, Susan Begg, Sara Beghini, Ayesha Begum, Salman Begum, Selina Begum, Teresa Behan, Roya Behrouzi, Jon Beishon, Claire Beith, James Belcher, Holly Belfield, Katherine Belfield, Ajay Belgaumkar, Dina Bell, Gareth Bell, Gillian Bell, Jessica Bell, Lauren Bell, Louise Bell, Nicholas Bell, Pippa Bell, Stephanie Bell, Jennifer Bellamu, Mary Bellamy, Tammy Bellamy, Arianna Bellini, Amanda Bellis, Fionn Bellis, Lesley Bendall, Naveena Benesh, Nicola Benetti, Leonie Benham, Guy Benison-Horner, Sarah Benkenstein, Tracey Benn, Ann Bennett, Caroline Bennett, Denise Bennett, Gillian Bennett, Kaytie Bennett, Kristopher Bennett, Lorraine Bennett, Miriam R Bennett, Sara Bennett, Karen Bennion, Gautham Benoy, Vivienne Benson, Andrew Bentley, James Bentley, Ian Benton, Eva Beranova, Matthew Beresford, Colin Bergin, Malin Bergstrom, Jolanta Bernatoniene, Thomas Berriman, Zoe Berry, Frida Best, Kimberley Best, Ans-Mari Bester, Yvonne Beuvink, Emily Bevan, Sarah Bevins, Tom Bewick, Andrew Bexley, Sonay Beyatli, Fenella Beynon, Arjun Bhadi, Sanjay Bhagani, Shiv Bhakta, Rekha Bhalla, Khushpreet Bhandal, Kulbinder Bhandal, Ashwin Bhandari, Lila Nath Bhandari, Sangam Bhandari, Jennifer Bhanich Supapol, Aashutosh Bhanot, Ravina Bhanot, Swati Bhasin, Abdul Bhat, Prashanth Bhat, Rahul Bhatnagar, Karan Bhatt, Janki Bhayani, Deepika Bhojwani, Parminder Bhuie, M S Bhuiyan, Salimuzzaman Bhuiyan, Anna Bibby, Fatima Bibi, Naheeda Bibi, Salma Bibi, Tihana Bicanic, Sarah Bidgood, Julie Bigg, Sarah Biggs, Alphonsa Biju, Andras Bikov, Sophie Billingham, Jessica Billings, Prof Binh, Alice Binns, Muhammad BinRofaie, Oliver Bintcliffe, Catherine Birch, Janine Birch, Jenny Birch, Katherine Birchall, Sam Bird, Sumedha Bird, Sarah Bird, Mark Birt, Claire Bishop, Kilanalei Bishop, Linda Bishop, Lisa Bishop, Karen Bisnauthsing, Nibedan Biswas, Mustapha Bittaye, Sahar Biuk, Karen Blachford, Ethel Black, Helen Black, Karen Black, Mairead Black, Polly Black, Virginia Black, Hayley Blackgrove, Bethan Blackledge, Joanne Blackler, Samantha Blackley, Helen Blackman, Caroline Blackstock, Cameron Blair, Francesca Blakemore, Helen Blamey, Alison Bland, Sujata Blane, Simon Blankley, Parry Blaxill, Katie Blaylock, Jane Blazeby, Natalie Blencowe, Ben Bloom, Jack Bloomfield, Angela Bloss, Alex Blowers, Samuel Blows, Hannah Bloxham, Susan Blrd, Louise Blundell, Andrew Blunsum, Mark Blunt, Tadhg Blunt, Ian Blyth, Kevin Blyth, Andrew Blythe, Karen Blythe, Kwabena Appiah Boahen, Marilyn Boampoaa, Sarah Board, Boniface Bobie, Karen Bobruk, 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Sarah Haysom, James Hayward, Patrick Haywood, Hazel Haywood Hasford, Tracy Hazelton, Phoebe Hazenberg, Zhengmai He, Elizabeth Headon, Carrie Heal, Brendan Healy, Jessica L Healy, Amy Hearn, David Heasman, Angela Heath, Debbie Heath, Rowan Heath, Diane Heaton, Adam Heavens, Kerry Hebbron, Catherine Heckman, Gemma Hector, Sadie Heddon, Andy Hedges, Katrine Hedges, Cheryl Heeley, Elaine Heeney, Richard Heinink, Rajdeep Heire, Ingvild Helgesen, Joanne Hemingway, Ulla Hemmila, Beth Hemmings, Scott Hemphill, Deborah Hemsley, Abigail Henderson, Eilidh Henderson, Jennifer Henderson, Steven Henderson, Joanne Henry, Karol Henry, Lavinia Henry, Margo Henry, Natalie Henry, David Henshall, Gillian Herdman, Rosaleen Herdman-Grant, Morag Herkes, Lucas E Hermans, Fe Marie Hernandez, Emma Heron, Lisa Heron, William Herrington, Emilia Heselden, Peta Heslop, Tracey Heslop, Simon Hester, Emily Hetherington, Joseph Hetherington, Chamila Hettiarachchi, Pramodh Hettiarachchi, Hayley Hewer, John Hewertson, 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Elizabeth Horsley, Sarah Horton, Jane Hosea, Toby Hoskins, Muhammad S Hossain, Rashed Hossain, Maxine Hough, Sarah Hough, Catherine Houghton, Kathryn Houghton, Rebecca Houlihan, Kay Housely, Hamish Houston, Roseanna Hovvels, Lee How, Laura Howaniec, Joanne Howard, Kate Howard, Laura Howard, Linda Howard, Lucy Howard, Megan Howard, Sarah Howard, Stuart Howard, Richard Howard-Griffin, Louise Howard-Sandy, Serena Howe, Alice Howell, Mark Howells, Lyn Howie, Kerry Howlett, Sophie Howlett, Ruth Howman, Josh Hrycaiczuk, Hein Htet, Naing Z Htoon, Su Htwe, Ying Hu, Chiang O H Huah, Sylvia Huang, Kelly Hubbard, Abby Huckle, Shahzya Huda, Alison Hudak, Lisa Hudig, Heather Hudson, Suzanne Hudson, Oli Hudson, Alison Hufton, Connor Huggins, Alistair Hughes, Caitlin Hughes, Emma Hughes, Gareth Hughes, Heather Hughes, Luke Hughes, Martin Hughes, Rachel Hughes, Rebecca Hughes, Samantha Hughes, Stephen Hughes, Vikki Hughes, Wesley Hughes, Lukas Huhn, Ching Hui, Ruth Hulbert, Diana Hull, Grace Hull, 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Julie Jones, Kate E Jones, Kimberly Jones, Laura Jones, Laura M Jones, Louise Jones, Mathew Jones, Nancy Jones, Nicola Jones, Olivia Jones, Paul Jones, Philip H Jones, Rhianna Jones, Ruth E Jones, Samantha Jones, Sophie Jones, Stefanie Jones, Steve Jones, Susan Jones, Taya Jones, Thomas Jones, Tim Jones, Tracey Jones, Ramya Jonnalagadda, Rebecca Jordache, Michele Jordan, Sarah Jordan, Abi Jose, Litty Jose, Louise Jose, Sanal Jose, Anna Joseph, Gigee Joseph, P Aiden Joseph, Rosane Joseph, Sibet Joseph, Dhaara Joshi, Mehul Joshi, Pratichi Joshi, Tushar Joshi, Benz Josiah, Lijo Joy, Tiffany Joyce, Hong Ju, Adriel Ju Wen Kwek, Andrew Judd, Edward Jude, Parminder Judge, Jessica Juhl, Sirisha Jujjavarapu, Mark Juniper, Edmund Juszczak, Deepthi Jyothish, Kasamu Kabiru Dawa, Mark Kacar, Nikhil Kadam, Nicole Kader, Ajai Kailey, Matthew Kain, Gail Kakoullis, Azad Kala Bhushan, Richard J K Kalayi, Roobala Kaliannan Periyasami, Efthymia Kallistrou, Thomas Kalmus Eliasz, Seika Kalsoom, Elisa Kam, 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Robert Laing, Inez Laing-Faiers, Emily Laity, Katharine Lake, Nicki Lakeman, David Lalloo, Fiona Lalloo, Alison Lam, Classy Lam, Fiona Lamb, Lucy Lamb, Thomas Lamb, Oscar Lambert, Pauline Lambert, Claudia Lameirinhas, Mohammed K G Lami, Holly Lamont, Michal Lamparski, Djillali Lamrani, Christine Lanaghan, Ivone Lancona-Malcolm, Geraldine Landers, Martin J Landray, Matthew Lane, Nicholas Lane, Alidih Lang, Stephen Lang, Daniel Langer, Margaret Langley, Charles Langoya, Emma Langridge, Emily Langthorne, Helen Langton, Beatriz Lara, Taiya Large, Lawrencia Naadu Lartey, Samuel Lassa, Anna Last, Scott Latham, Victoria Latham, Afzal Latheef, Larissa Latif, Nang Latt, Carmen Lau, Dawn Lau, Eva Lau, Gonzalez G Laura, Myra Laurenson, Eloise Lavington, Hou Law, Jessica Law, June Law, Kar Y Law, Penny Law, Richard Law, Laura Lawless, Chris Lawrence, Emma Lawrence, Geoffrey Lawrence, Holly M Lawrence, Neil Lawrence, Ryan Lawrie, Louise Lawson, Natalie Lawson, Rod Lawson, Michael Lay, Stephen Laybourne, Christine Laycock, Reina Layug, Maria Lazo, Thi Thao Le, Vietland Le, Amelia Lea, William Lea, Louisa E Leach, Ian Leadbitter, Thomas Leahy, Richard Lean, Lorna Leandro, Darren Leaning, Ruth Leary, Sandra Leason, Marie A Ledingham, Caroline Lee, Emma Lee, Hannah Lee, Irish Lee, Joshua Lee, Judith Lee, Sam Lee, Shannon Lee, Shi Han Lee, Simon Lee, Sindy Lee, Stephanie Lee, Tracey Lee, Xiang Lee, Robyn Lee, Diana Lees, Jennifer Lees, Helen Legge, Julian Leggett, Katie Leigh-Ellis, David Leitch, Nicky Leitch, Eleni Lekoudis, Petula Lemessy, Nicholas Lemoine, Rebecca Lenagh, Katy Leng, Katrina Lennon, Liz Lennon, Beth Leonard, Kelly Leonard, Wen Leong, Nicky Leopold, Oskar Lepiarczyk, Isla Leslie, Eva Noviani Lestari, Eleni Lester, Emma Levell, Chris Levett, Anastasia Levynska, Alice Lewin, Alison Lewis, Christopher Lewis, David Lewis, Dee Lewis, Heather Lewis, Joanne Lewis, Joseph Lewis, Kathryn Lewis, Keir Lewis, Leon Lewis, Mandy Lewis, Marissa Lewis, Nicolas Lewis, Robert Lewis, Catherine Lewis-Clarke, Adam Lewszuk, Penny Lewthwaite, Samantha Ley, Angela Liao, Victoria Licence, David Lieberman, Susan Liebeschuetz, Teresa Light, Nicky Lightfoot, Patrick Lillie, Ashling Lillis, Ben Lim, Carys Lim, Ee T Lim, Ivy Lim, Terence Lim, Wei Shen Lim, Wilson Lim, James Limb, Dipraj Limbu, Usha Limbu, Christian Linares, Dermot Linden, Gabriella Lindergard, Kate Lindley, Charlotte Lindsay, Emily Lindsay, Max Lindsay, Helen Lindsay- Clarke, Mirella Ling, Claire Lingam, Linette Linkson, Thinzar Linn, Mike Linney, Conrad Lippold, George Lipscomb, Karen Lipscomb, Laura Lipskis, Ana Lisboa, Evangeline Lister, Jeff Little, Sam Little, Lucy Littlejohn, Sky Liu, Xuedi Liu, Daniel K Llanera, Rhiannon Llewellyn, Martin Llewelyn, Adam Lloyd, Aimee Lloyd, Arwel Lloyd, Oliver Lloyd, Richard Lloyd, Su Lo, David Loader, Caroline Loan, Livia Lobosco, Lydianne Lock, Sara Lock, Stephen Lock, Angela Locke, Jacqueline Locke, Thomas Locke, Teresa Lockett, Jeorghino Lodge, Krishan 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Wallbutton, Jessica Wallen, Karl Wallendszus, Arabella Waller, Rosemary Waller, Gabiel Wallis, Gabriel Wallis, Louise Wallis, Matthew Wallis, Emma Walmsley, Donna Walsh, Elizabeth Walsh, Livia Walsh, Deborah Walstow, Daniel Walter, Alex Walters, Holt Walters, James Walters, Jocelyn Walters, Eileen Walton, Lucy Walton, Maisie Walton, Michael Walton, Olivia Walton, Sharon Walton, Susan Walton, Mandy Wan, Junita Wanda, Mary Wands, Rachel Wane, Frank Wang, Nick Wang, Ran Wang, Shentong Wang, Deborah Warbrick, Samantha Warburton, Christopher Ward, Deborah Ward, Emma Ward, Hannah Ward, Janice Ward, Joanna Ward, Luke Ward, Nicola Ward, Rachael Ward, Thomas Ward, Tom Ward, Scott A Warden, Gibril Wardere, Steve Wardle, Hassan Wardy, Gareth Waring, Scott Waring, Jenny Warmington, Ben Warner, Christian Warner, Lewis Warnock, Sarah Warran, Jade Warren, Lisa Warren, Rebecca Warren, Yolanda Warren, Davina Warrender, Hannah Warren-Miell, Adilia Warris, Gill Warwick, Helen Wassall, Sean Wasserman, Elizabeth Wasson, Hazel J Watchorn, Holly Waterfall, Abby Waters, Donald Waters, Mark Waterstone, Abigail Watkin, Catherine Watkins, Catrin Watkins, Eleanor Watkins, Karen Watkins, Lynn Watkins, Abigail Watson, Adam J R Watson, Ekaterina Watson, Eleanor Watson, Felicity Watson, J G R Watson, Louisa Watson, Paul Watson, Rebecca Watson, Robert Watson, Kathleen Watson, Malcolm Watters, Donna Watterson, Khairiah Wattimena, Daniel Watts, John Watts, Merlin Watts, Victoria Waugh, Emma Wayman, Matthew Wayman, Akhlaq Wazir, Mark Weatherhead, Nick Weatherly, Chloe Webb, Claire Webb, Hayley Webb, Kathryn Webb, Kylie Webb, Stephen Webb, Cheryl Websdale, Deborah Webster, Ian Webster, Jemma Webster, Tim Webster, Jordan Wedlin, Ling Wee, Rebecca Weerakoon, Thanuja Weerasinghe, Janaka Weeratunga, Maria Weetman, Shuying Wei, Immo Weichert, Emma Welch, Hugh Welch, James Welch, Leanne Welch, Steven Welch, Benjamin Welham, Samantha Weller, Lucy Wellings, Brian Wells, Susan Wellstead, Berni Welsh, Richard Welsh, Ingeborg Welters, Rachael Welton, Victoria Wenn, Lauren Wentworth, Joan Wesonga, Kate Wesseldine, Joe West, Magdelena West, Raha West, Ruth West, Sophie West, Luke Western, Ruth Westhead, Heather Weston, Alice Westwood, Kelly Westwood, Sharon Westwood, Bill Wetherill, Sharon Wheaver, Helen Wheeler, Ben Whelan, Matthew Whelband, Amanda Whileman, Alison Whitcher, Andrew White, Ayesha White, Benjamin White, Catherine White, Christopher White, Duncan White, James White, Jonathan White, Katie White, Marie White, Nick White, Nikki White, Sarah White, Sonia White, Tracey White, Catherine Whitehead, Kelly Whitehorn, Anne Whitehouse, Claire Whitehouse, Tony Whitehouse, Julia Whiteley, Louiza Whiteley, Sophie Whiteley, Rachael Whitham, Gabriel Whitlingum, David Whitmore, Elizabeth Whittaker, Lindsay Whittam, Ashley Whittington, Helen Whittle, Robert Whittle, Eunice Wiafe, Lou Wiblin, Olivia Wickens, John Widdrington, Jason Wieboldt, Hannah Wieringa, Cornelia Wiesender, Laura Wiffen, Andrew Wight, Ashleigh Wignall, Christopher Wignall, Annamaria Wilce, Danielle Wilcock, Emma Wilcock, Louise Wilcox, Ben Wild, Laura Wild, Stephen Wild, Michael Wilde, Laura Wilding, Peter Wilding, Tracey Wildsmith, Joe Wileman, Joy Wiles, Kate Wiles, Elva Wilhelmsen, Thomas Wiliams, Janet Wilkie, David Wilkin, Hannah Wilkins, Joy Wilkins, Suzanne Wilkins, Iain Wilkinson, Lesley Wilkinson, Nicola Wilkinson, Sophia Wilkinson, Susan Wilkinson, Tim Wilkinson, Sylvia Willetts, Aimee Williams, Alexandra Williams, Alison Williams, Angharad Williams, Anna Williams, Ava Williams, Carl Williams, Caroline V Williams, Claire Williams, Dewi Williams, Eleri Williams, Gail Williams, Gemma Williams, Gina Williams, Hannah Williams, Heledd Williams, James Williams, Jennie Williams, Jill Williams, John Williams, Joseph Williams, Karen Williams, Kathryn Williams, Mandy Williams, Marie Williams, Mark Williams, Matthew Williams, Patricia Williams, Penny Williams, Rachel Williams, Robin Williams, Rupert Williams, Samson Williams, Sarah Williams, Sophie Williams, Steffan Williams, Tamanna Williams, Tania Williams, Annie Williamson, Cath Williamson, Catherine Williamson, Dawn Williamson, James D Williamson, Jodie Williamson, Rachel Williamson, Helen Williamson, Elaine Willis, Elizabeth Willis, Emily Willis, Heather Willis, Herika Willis, Joanna Willis, Louise Wills, Lucy Willsher, Catherine Willshire, Francesca Willson, Jayne Willson, Alison Wilson, Andrea Wilson, Anna Wilson, Antoinette Wilson, Billy Wilson, David Wilson, Imogen Wilson, James Wilson, Karen Wilson, Kate Wilson, Kristy-Ann Wilson, Lucinda Wilson, Mark Wilson, Stephen Wilson, Toni Wilson, John Wilson, Khin Lei Yee Win, Marlar Win, Than Win, Tin Tin Win, Wut Yee Win Win, Lucinda Winckworth, Laura Winder, Piers Winder, Stuart Winearl, Helen Winmill, Simon Winn, Carmen Winpenny, Helen Winslow, Helen Winter, Jonathan Winter, Barbara Winter-Goodwin, Joseph Winterton, Hannah Winwood, Jack Wischhusen, Stephen Wisdom, Matthew Wise, Martin Wiselka, Rebecca Wiseman, Sophie Wiseman, Steven Wishart, Tabitha WIshlade, Eric Witele, Nicholas Withers, Janet Wittes, Donna Wixted, Therese Wodehouse, Will Wolf, Nicola Wolff, Kirsten Wolffsohn, Rebecca Wolf-Roberts, Elena Wolodimeroff, Adam Wolstencroft, Alan Wong, Charlotte Wong, Chi-Hung Wong, Chi-Man Wong, Edwin Wong, Jessica S Y Wong, Kit Y Wong, Mei Yin Wong, Nick Wong, Sam Wong, Ting Wong, Aaron B Wongkyezeng, Amanda Wood, Caroline Wood, Dianne Wood, Fiona Wood, Gordon Wood, Hannah Wood, Jennifer Wood, Joe Wood, Lisa Wood, Louise Wood, Madeleine Wood, Stephen Wood, Tracy Wood, Katharine Woodall, Rebecca Woodfield, Christopher Woodford, Elizabeth Woodford, Jill Woodford, Louise Woodhead, Timothy Woodhead, Philip Woodland, Marc Woodman, Myles Woodman, Stephen Woodmansey, Charlotte Woods, Jane Woods, Katherine Woods, Sarah Woods, Zoe Woodward, Megan Woolcock, Gemma Wooldridge, Rebecca Woolf, Chris Woollard, Christopher Woollard, Louisa Woollen, Emma Woolley, Jade 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Younes Ibrahim, Eoin Young, Gail Young, Louise Young, Asfand Yousafzar, Sajeda Youssouf, Ahmed Yousuf, Hartantri Yovita, Chrissie Yu, Jack S J Yuan, Nindya Yufaniaputri, Bernard Yung, Daniel Yusef, Said Yusef, Intekhab Yusuf, Anna-Sophia Zafar, Silvia Zagalo, Su Zaher, Aqsa Zahoor, Mahrukh Zainab, Thornton Zak, Kareem Zaki, Nabhan Zakir, Kasia Zalewska, Ane Zamalloa, Mohsin Zaman, Shakir Zaman, Julie Zamikula, Louise Zammit, Marie Zammit-Mangion, Marcelina Zawadzka, Mohammed Zayed, Esther Zebracki, Daniel Zehnder, Lisa Zeidan, Darius Zeinali, Jing Zhang, Xiaobei Zhao, Dongling Zheng, Doreen Zhu, Madiha Zia, Omar Zibdeh, Rabia Zill-E-Huma, Ei Thankt Zin, Eva Zincone, Garikai Zindoga, Eleanor Zinkin, Vivian Zinyemba, Christos Zipitis, Letizia Zitter, Arkadiusz Zmierczak, Garazi Zubikarai, Azam Zubir, Naz Zuhra, Rasha Zulaikha, Sabrina Zulfikar, Carol Zullo, Ana Zuriaga-Alvaro, University of St Andrews. Infection and Global Health Division, University of St Andrews. School of Medicine, and Group, RECOVERY Collaborative
Subjects: Adult, Male, Hypoxia/etiology, SARS-CoV-2, COVID-19, 3rd-DAS, General Medicine, Adrenal Cortex Hormones/therapeutic use, AC, Dexamethasone/therapeutic use, Hospitals, Oxygen, Treatment Outcome, SDG 3 - Good Health and Well-being, MCP, Humans, Female
Abstract: Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group. Methods This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation Findings Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]). Interpretation In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation. Funding UK Research and Innovation (Medical Research Council), National Institute of Health and Care Research, and Wellcome Trust.
Published: 2023
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42. Just Transitions’ Meanings: A Systematic Review

Author: Anthony Stark, Fred Gale, and Hannah Murphy-Gregory
Subjects: Sociology and Political Science, Environmental Science (miscellaneous), Development
Published: 2023
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43. From External to Local: Opportunities and Lessons Learned from Transitioning COMSA-Mozambique

Author: Daniela C. Rodríguez, Ivalda Macicame, Antonio Adriano, Sergio Chicumbe, Pedro Duce, Almamy Kante, Victor A. Mavie, Etelvina Mbalane, Sheila Nhachungue, Nordino Titus, Fred Van Dyk, and Agbessi Amouzou
Subjects: Infectious Diseases, Virology, Parasitology
Abstract: Donor transitions, where externally funded programs transfer to country ownership and management, are increasingly common. The Countrywide Mortality Surveillance for Action – Mozambique (COMSA) project established a nationwide surveillance system capturing vital events at the community level with funding from the Bill and Melinda Gates Foundation. COMSA was implemented in partnership between Johns Hopkins University (a U.S.-based academic institution) and the Instituto Nacional de Saúde (National Institute for Health) and Instituto Nacional de Estatística (National Institute for Statistics), two Mozambican public institutions. Midway through the project, the Gates Foundation directed COMSA’s partners to develop and implement a transition plan that ensured COMSA’s activities could be institutionalized after Gates Foundation funding ended. Here we describe the process and activities that COMSA underwent for transition planning, including stakeholder engagement and advocacy, securing financial commitments, documenting operational activities, capacity building, and supporting strategic planning. Facilitators included a project model that already embedded significant implementation and management responsibility with local agencies, high-level commitment to COMSA’s activities from local stakeholders, establishing dedicated personnel and budget to manage transition, and fortuitous timing for financing. Challenges included needing to engage multiple government agencies to ensure buy-in, navigating tensions around future roles and responsibilities, reviewing and adjusting existing implementation structures, and the reality that this transition involved shifting financing from one development partner to another. Transition implementation was also constrained by the COVID-19 pandemic because key stakeholders were engaged in response efforts. COMSA’s experience highlights lessons and threats for future programs facing donor transition in uncertain environments.
Published: 2023
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44. Completeness and Factors Affecting Community Workers’ Reporting of Births and Deaths in the Countrywide Mortality Surveillance for Action in Mozambique

Author: Almamy M. Kante, Azarias Mulungo, Mussagy Ibraimo, Aveika Akum, Nordino Titus, Antonio Adriano, Fred Van Dyk, Ivalda Macicame, Robert E. Black, and Agbessi Amouzou
Subjects: Infectious Diseases, Virology, Parasitology
Abstract: Since March 2018, the Countrywide Mortality Surveillance for Action project, implemented as a national sample registration system by the Mozambique Instituto Nacional de Saude and the Instituto Nacional de Estatistica in 700 geographic clusters randomly distributed across the 11 provinces, has trained and deployed community surveillance agents (CSAs) to report births and deaths in each cluster prospectively. An independent, retrospective data collection was conducted to assess the completeness of surveillance data. Record linkage procedures were used to match households and vital events reported in the two data sources. We calculated birth and death reporting rates and used a regression model to determine factors associated with the likelihood of vital events being reported by the CSAs. Between March 2018 and December 2019, CSAs reported 54% of births (8,787/16,421) and 45% of deaths (1,726/3,867). Births of smaller cluster sizes (< 1,000 people) were more likely to be reported (adjusted odds ratio [aOR] = 1.45; 95% CI = 1.15–1.83) compared with those of larger cluster sizes (> 1,500 people). Deaths of rural clusters were more likely to be reported (aOR = 1.41; 95% CI = 1.07–1.85) than those of urban clusters. Adult deaths were more likely to be reported (aOR = 1.49; 95% CI = 1.10–2.02) than child deaths. Our findings suggest that a fully functioning sample vital registration system must adopt a dual system with high-quality surveys or other ways to estimate underregistration periodically, consider a smaller cluster size manageable by a community worker, and pay special attention to urban clusters as underreporting is larger.
Published: 2023
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45. Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author: Jeffrey Perl, Edwina A. Brown, Christopher T. Chan, Cécile Couchoud, Simon J. Davies, Rümeyza Kazancioğlu, Scott Klarenbach, Adrian Liew, Daniel E. Weiner, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Martin E. Wilkie, Alferso C. Abrahams, Samaya J. Anumudu, Joanne M. Bargman, Geraldine Biddle Moore, Peter G. Blake, Natalie Borman, Elaine Bowes, James O. Burton, Agnes Caillette-Beaudoin, Yeoungjee Cho, Brett Cullis, Yael Einbinder, Osama el Shamy, Kevin F. Erickson, Ana E. Figueiredo, Fred Finkelstein, Richard Fluck, Jennifer E. Flythe, James Fotheringham, Masafumi Fukagawa, Eric Goffin, Thomas A. Golper, Rafael Gómez, Vivekanand Jha, David W. Johnson, Talerngsak Kanjanabuch, Yong-Lim Kim, Mark Lambie, Edgar V. Lerma, Robert S. Lockridge, Fiona Loud, Ikuto Masakane, Nicola Matthews, Will McKane, David C. Mendelssohn, Thomas Mettang, Sandip Mitra, Thyago Proença de Moraes, Rachael Morton, Lily Mushahar, Annie-Claire Nadeau-Fredette, K.S. Nayak, Joanna L. Neumann, Grace Ngaruiya, Ikechi Okpechi, Robert R. Quinn, Janani Rangaswami, Yuvaram N.V. Reddy, Brigitte Schiller, Jenny I. Shen, Rukshana Shroff, Maria Fernanda Slon Roblero, Laura Solá, Henning Søndergaard, Isaac Teitelbaum, Karthik Tennankore, Floris Van Ommeslaeghe, Rachael C. Walker, Robert J. Walker, Angela Yee-Moon Wang, Bradley A. Warady, Suzanne Watnick, Eric D. Weinhandl, Caroline M. Wilkie, Jennifer Williams, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, and KAZANCIOĞLU, RÜMEYZA
Subjects: Internal Diseases, Hemodialysis, Home, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), home dialysis, Renal Dialysis, UROLOGY & NEPHROLOGY, Health Sciences, Humans, Klinik Tıp (MED), Renal Insufficiency, healthcare policy, ÜROLOJİ VE NEFROLOJİ, Internal Medicine Sciences, hemodialysis, Klinik Tıp, Dahili Tıp Bilimleri, CLINICAL MEDICINE, dialysis modality, Tıp, Nefroloji, peritoneal dialysis, quality of life, Nephrology, Medicine, Kidney Failure, Chronic
Abstract: Home dialysis modalities (home hemodialysis [HD] and peritoneal dialysis [PD]) are associated with greater patient autonomy and treatment satisfaction compared with in-center modalities, yet the level of home-dialysis use worldwide is low. Reasons for limited utilization are context-dependent, informed by local resources, dialysis costs, access to healthcare, health system policies, provider bias or preferences, cultural beliefs, individual lifestyle concerns, potential care-partner time, and financial burdens. In May 2021, KDIGO (Kidney Disease: Improving Global Outcomes) convened a controversies conference on home dialysis, focusing on how modality choice and distribution are determined and strategies to expand home-dialysis use. Participants recognized that expanding use of home dialysis within a given health system requires alignment of policy, fiscal resources, organizational structure, provider incentives, and accountability. Clinical outcomes across all dialysis modalities are largely similar, but for specific clinical measures, one modality may have advantages over another. Therefore, choice among available modalities is preference-sensitive, with consideration of quality of life, life goals, clinical characteristics, family or care-partner support, and living environment. Ideally, individuals, their care-partners, and their healthcare teams will employ shared decision-making in assessing initial and subsequent kidney failure treatment options. To meet this goal, iterative, high-quality education and support for healthcare professionals, patients, and care-partners are priorities. Everyone who faces dialysis should have access to home therapy. Facilitating universal access to home dialysis and expanding utilization requires alignment of policy considerations and resources at the dialysis-center level, with clear leadership from informed and motivated clinical teams.
Published: 2023
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46. Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting

Author: Ineke Brouwer, Emma Kerklingh, Fred van Leeuwen, Tineke Laura Lenstra, Medical Biology, AII - Cancer immunology, and CCA - Cancer biology and immunology
Subjects: Structural Biology, Molecular Biology
Abstract: SummaryTranscriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated by remodeling of promoter nucleosomes is unknown. Here, we use single-molecule live-cell imaging of GAL10 transcription in budding yeast to measure how transcriptional bursting changes upon single and double perturbations of chromatin remodeling factors, the transcription factor Gal4 and preinitiation complex (PIC) components. Using dynamic epistasis analysis, we reveal how remodeling of different nucleosomes regulates individual transcriptional bursting parameters. At the nucleosome covering the Gal4 binding sites, RSC acts synergistically with Gal4 binding to facilitate each burst. Conversely, nucleosome remodeling at the TATA box controls only the first burst upon galactose induction. In the absence of remodelers, nucleosomes at canonical TATA boxes are displaced by TBP binding to allow for transcription activation. Overall, our results reveal how promoter nucleosome remodeling, together with transcription factor and PIC binding regulates the kinetics of transcriptional bursting.
Published: 2023

47. IADC Code Upgrade: Data Collection and Workflow Required to Conduct Bit and BHA Forensics to Create Effective Changes in Practices or Design

Author: William Watson, Fred Dupriest, Ysabel Witt-Doerring, Junichi Sugiura, Paul Pastusek, Dustin Daechsel, Raafat Abbas, David Shackleton, and Mohamed Amish
Subjects: Mechanical Engineering, Energy Engineering and Power Technology
Abstract: Summary This paper introduces a forensic workflow that can be used to link drill-bit and bottomhole assembly (BHA) damage to drilling dysfunction. This paper will also discuss the data that should be collected and how it should be processed to enable operational practices and engineering design changes to address these issues. There is a vast amount of data collected in all drilling operations that can be used to improve performance if utilized within an effective forensic workflow. Several drilling forensic case studies were developed and critically reviewed by subject matter experts from across the industry. From the causal analysis for each case study, an assessment was performed on what information was (1) available, (2) required to diagnose the cause, and (3) not available but would have been preferred. The way the team communicated and acted on the data was also documented. By combining the learnings from these case studies, it was observed that a guided approach can improve data collection and lead to a more consistent, accurate, timely, and causal analysis with appropriate remedial actions. The process discussed within has been refined to support data collection for forensic analysis and provides a reference for field- and office-based drilling professionals. These practical guidelines have been developed to offer a foundation for a drilling forensic data collection methodology as well as training for the industry—they have been created such that they can grow organically and will form part of the International Association of Drilling Contactors (IADC) Bit Dull Grading Recommended Practice to support the IADC dull grade manual. In the future, these can be used for developing subsequent industry publications. The work described in this paper is part of a joint IADC/Society of Petroleum Engineers industry effort to revise the IADC dull grade manual.
Published: 2023
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48. Patterns of and Factors Associated With Mental Health Service Utilization Among School-Going Adolescent Girls in Southwestern Uganda: A Latent Class Analysis

Author: William Byansi, Fred M. Ssewamala, Torsten B. Neilands, Abel Mwebembezi, and Gertrude Nakigozi
Subjects: Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
Published: 2023
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49. Grand Theft Capital

Author: Fred Magdoff and John Bellamy Foster
Subjects: Gender Studies, Sociology and Political Science, Geography, Planning and Development, Management, Monitoring, Policy and Law
Abstract: The working class is being robbed, both through outright expropriation and the more hidden exploitation of countless workers who are struggling to make ends meet while capitalists pocket the surplus value they produce. John Bellamy Foster and Fred Magdoff dissect the neoliberal assault on the working class that is spurring a new generation of labor organizing.
Published: 2023
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50. Conservation and evolution: Inbreeding, small populations, and sex differences in life history

Author: Fred B. Bercovitch
Subjects: Animal Science and Zoology
Published: 2023
Full Text: View/download PDF

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