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The 100 MeV high intensity proton cyclotron (CYCIAE-100) developed by China Institute of Atomic Energy is a multi-purpose variable energy AVF cyclotron. Its design specifications are: energy from 75 to 100 MeV continuously adjustable, beam intensity 200uA, beam current can be extracted in both directions. CYCIAE-100 was commissioned to extract 100 MeV proton beam for the first time in July 2014. The first physics experiment was carried out in November 2016. By June 2019, the design specifications of CYCIAE-100 was commissioned and the maximum beam power was 52 kW. The beam intensity range from 1 pA to 520 µA is achieved, and the beam stability is about 1% for 8 hours. Several typical physics experiments have been carried out. Such as: The physics experiment of CYCIAE-100 driving ISOL device to generate radioactive nuclear beam, SiC and SRAM proton irradiation experiments, calibration experiment of high-energy proton electron total dose detector probe, etc. At present, the beam time for CYCIAE-100 is about 5,000 hours, providing effective beam time for more than 3,000 hours for many users at home and abroad, and the other beam time for beam development., Proceedings of the 22nd International Conference on Cyclotrons and their Applications, Cyclotrons2019, Cape Town, South Africa

The cross-regional water diversion project has been widely applied as an important way to relieve water pressure. Study about the tradeoff between multiple regions and multiple water use sectors has caused widespread concern. In this study, an inexact two-stage water resources management model for multi-region water resources planning with a large-scale water diversion project has been developed. The water sources in 11 districts, including independent water sources and public water sources diverted from the project, are considered in the optimization model. Water supply cost and recourse cost are analyzed in the objective function. Based on interval-parameter programming and two-stage stochastic programming, uncertainties in the water resources system are described by both interval values and probability distributions. The result indicates that the water diversion project would greatly change the composition of the water resource system and settle the uneven distribution of regional water resources to achieve district-optimal allocation of water resources. In general, the proposed method can help decision-makers to formulate water management strategies for rational utilization of all kinds of water resources in different regions.

One possible reason for the less than satisfactory long-term outcomes for schizophrenia is the lack of coordination between inpatient and community-based services.Assess the effectiveness of a rehabilitation model for schizophrenia that integrates hospital and community services.Ninety patients with schizophrenia participating in an integrated rehabilitation program at 10 community centers in Changning, Shanghai (intervention group) and 52 community-based patients with schizophrenia randomly selected from all patients in Changning participating in routine outpatient care (control group) were assessed at enrollment using the Positive and Negative Syndrome Scale (PANSS) and the Morningside Rehabilitation Status Scale (MRSS) and then re-assessed 1 year later by clinicians who were blind to the group assignment of the patients. The patients' registered guardians (the vast majority were co-resident family members) were assessed at the same times using the Family Burden Scale (FBS), the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS) and the Social Support Rating Scale (SSRS).At enrollment the clinical status of patients in the two groups (assessed with PANSS) was similar but the social functioning measures assessed by MRSS were significantly worse in the intervention group than in the control group. After one year the improvement of both clinical symptoms and social functioning measures were significantly greater in the intervention group than in the control group. In the year of follow-up, 3 individuals (3.3%) in the intervention group and 6 individuals (11.5%) in the control group were re-hospitalized (Fisher Exact Test, p=0.074). The feelings of burden, depression, anxiety and reported social support among guardians of patients in the intervention group were not significantly different from those for guardians of patients in the control group either at the time of enrollment or after the 1-year intervention. However, guardians in the intervention group showed a significant decrease in depressive and anxiety symptoms over the one-year follow-up.Rehabilitative approaches that integrate hospital and community services can improve clinical and social outcomes for patients with schizophrenia. Further development of these programs is needed to increase the proportion of patients who achieve regular employment (i.e., 'community re-integration') and to provide family members with better psychosocial support.精神分裂症患者远期疗效不理想的可能因素之一是住院治疗与社区精神卫生服务间缺乏连贯性。评估医院-社区一体化康复模式对精神分裂症患者康复的疗效。从上海市长宁区10家社区卫生服务中心参与医院-社区一体化康复计划的90例精神分裂症患者作为干预组，在长宁区社区普通管理的门诊精神分裂症患者中随机抽取52例患者作为对照组。由不了解患者分组情况的医生在入组（基线）和12个月后采用阳性与阴性症状量表（Positive and Negative Syndrome Scale, PANSS）、Morningside康复状态量表（Morningside Rehabilitation Status Scale，MRSS）评估患者情况。同时在上述两个时点采用家庭负担会谈量表（Family Burden Scale，FBS）、抑郁自评量表（Self-rating Depression Scale，SDS）、焦虑自评量表（Self-rating Anxiety Scale，SAS）和社会支持评定量表（Social Support Rating Scale，SSRS）评估患者法定监护人（绝大部分是与患者同住的家属）的情况。入组时，PANSS评估结果显示两组的临床状况相仿，但是MRSS评估结果表明干预组的社会功能明显不如对照组。 干预1年后研究组的临床症状和社会功能的改善程度均比对照组显著。1年中，研究组有3 例（3.3%）住院，而对照组有6例（11.5%）（Fisher确切概率法， p=0.074）。无论是入组时还是1年后，两组监护人之间在感到的负担、抑郁、焦虑以及自我报告的社会支持等的差异均无显著性，但是干预组患者监护人的抑郁和焦虑症状在1年后得到改善。医院-社区一体化康复模式能促进精神分裂症患者临床症状和社会功能的改善。今后需要进一步开展这一项目，来提高参与一体化康复模式的患者比例，并为患者家属提供更好的心理社会支持服务。