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Communication can impressively improve cooperation in multi-agent reinforcement learning (MARL), especially for partially-observed tasks. However, existing works either broadcast the messages leading to information redundancy, or learn targeted communication by modeling all the other agents as targets, which is not scalable when the number of agents varies. In this work, to tackle the scalability problem of MARL communication for partially-observed tasks, we propose a novel framework Transformer-based Email Mechanism (TEM). The agents adopt local communication to send messages only to the ones that can be observed without modeling all the agents. Inspired by human cooperation with email forwarding, we design message chains to forward information to cooperate with the agents outside the observation range. We introduce Transformer to encode and decode the message chain to choose the next receiver selectively. Empirically, TEM outperforms the baselines on multiple cooperative MARL benchmarks. When the number of agents varies, TEM maintains superior performance without further training., Accepted by IJCAI 2023

Paleomagnetic data constrain paleogeographic motion of rocks relative to the Earth's spin axis, which is a sum of plate motion relative to the mantle and true polar wander. Discerning between these effects is challenging for studies aiming to reconstruct paleo-plate motions from deformed orogenic terranes. Here, we study the paleolatitudinal drift history of the Lhasa terrane of southern Tibet that migrated from the northern Gondwana to the southern Eurasian margin between late Triassic and early Cretaceous time. Previous work identified a 180 Ma near-equatorial Lhasa latitude and assumed near-constant paleolatitudinal drift. Large-scale true polar wander at this time, however, which has been argued for in previous work, requires highly variable Lhasa plate motion rates relative to Gondwana. Here, we test whether the alternative interpretation of constant plate motion rates provides a better prediction of paleomagnetic data. To this end, we present a new paleomagnetic pole from ∼155 Ma volcanics (here dated by U/Pb zircon) of the Lhasa terrane. Our pole comprises site mean directions from 46 lavas, passes a fold test, and is supported by an extensive rock magnetic and microscopic analysis that reveals no evidence of remagnetization. Our results give an average direction of D±ΔDx=337.1°±2.6°, I±ΔIx=−13.8°±4.9°, and a corresponding paleopole position at λp=45.3°N, φp=295.3°E with K=69.8 and A95=2.5°, predicting a similar near-equatorial, paleolatitude as at 180 Ma. This paleolatitudinal standstill is consistent with predicted paleolatitudes from global APWPs that account for Jurassic TPW and assume a constant Lhasa-Gondwana (India) oceanic spreading rate of ∼8 cm/a during the 215-130 Ma opening of the Neotethys and closure of the Mesotethys oceans. Contemporaneous arc magmatism on the Lhasa terrane was previously interpreted to indicate that the Lhasa terrane was located above a subduction zone during its northward journey to Tibet: our results show that if our reconstruction is accurate, then trench migration rates also must have been ∼8 cm/a. Our results are consistent with the range of rates of global long-lived trench migration that have been reconstructed in other studies, but they are much higher than measured in most modern systems. Our results more completely document the Lhasa terrane's separation from Gondwana and provide a straightforward methodology of using paleomagnetic data to test plate kinematic scenarios, overcoming the problem of the unknown effect of true polar wander on paleomagnetic data from deformed terranes.

To investigate the feasibility of using absorbable Mg alloy pedicle screws for atlantoaxial dislocation fixation, four types of Mg alloy pedicle screws of different thread forms were designed, and simulation analysis of the pull-out force was performed using the finite element method. Stress and displacement distributions of the atlantoaxial fixation model were obtained. Subsequently, screw samples were prepared using the WE43 Mg alloy for extraction, torsion, and immersion corrosion tests. Finite element analysis results showed that the pull-out forces of triangular, rectangular, trapezoidal, and zigzag thread screws were 552.61, 540.91, 546.4, and 542.74 N, respectively, and the stresses on the screws were 146, 185, 195, and 265 MPa, respectively, when they were pulled out. In other words, the triangular thread screw had the largest pull-out resistance and smallest stress peak. The average corrosion rate of Mg alloy screws in vitro was 0.46 mg·cm−2·day−1. Compared with that before corrosion, the extraction resistance of the corroded screws did not change significantly; however, the torsional strength decreased, but it was still greater than the torque required for screw implantation. It can be concluded that triangular thread Mg alloy pedicle screws have good extraction resistance and mechanical stability and can meet the load-bearing requirements for atlantoaxial dislocation fixation. The degradation of the Mg alloy reduced the mechanical strength of the screws, but the triangularly threaded screws can still maintain their effectiveness.

Reconstructing the Paleogene topography and climate of central Tibet informs understanding of collisional tectonic mechanisms and their links to climate and biodiversity. Radiometric dates of volcanic/sedimentary rocks and paleotemperatures based on clumped isotopes within ancient soil carbonate nodules from the Lunpola Basin, part of an east-west trending band of basins in central Tibet and now at 4.7 km, suggest that the basin rose from 4.0 km by 29 Ma. The height change is quantified using the rates at which wet-bulb temperatures ( T w ) decline at land surfaces as those surface rise. In this case, T w fell from ~8°C at ~38 Ma to ~1°C at 29 Ma, suggesting at least ~2.0 km of surface uplift in ~10 Ma under warm Eocene to Oligocene conditions. These results confirm that a Paleogene Central Tibetan Valley transformed to a plateau before the Neogene.

Supplemental material, sj-pdf-1-mdm-10.1177_0272989X221107902 for PaCAR: COVID-19 Pandemic Control Decision Making via Large-Scale Agent-Based Modeling and Deep Reinforcement Learning by Xudong Guo, Peiyu Chen, Shihao Liang, Zengtao Jiao, Linfeng Li, Jun Yan, Yadong Huang, Yi Liu and Wenhui Fan in Medical Decision Making

Rare earth elements (REE) are important raw materials for electronic products and green-energy technology and deep-sea sediment as an important potential source of REE mineral. It is of great scientific significance to understand the influence of REE in deep-sea sediments. In this paper, thirty sediments samples and eleven sediments samples were collected at the site SH3 and SH1 of Shenhu area, respectively. The trace elements, major elements, and different Fe-Mn minerals were analyzed to investigate the role of anaerobic oxidation of methane (AOM) in the enrichment of rare earth elements in the marine sediments. The result showed that the content of ∑REE/Ti increased at the top of sulfate and methane transition zone (SMTZ) at site SH1 and SH3. Combined with the analysis of different forms of ferromanganese minerals and the REE patterns, it is inferred that there is little influence of terrigenous input to the REE content. In contrary, the REE-rich carbonate phase and REE-rich Fe-Mn oxides (hydroxides) phase have important contribution of REE enrichment at the top of SMTZ. Meanwhile, the calculations of the quantitative relationship between the REE-rich carbonate phase and REE-rich Fe-Mn oxides (hydroxides) phase also confirm this conclusion. And the AOM caused the decrease of the REE-rich Fe-Mn oxides (hydroxides) phase and increase of the REE-rich carbonate phase. This is the potential explanation of ∑REE/Ti enrichment at the top of SMTZ. This study is of great scientific significance for the study of REE enrichment mechanism in the methane seeps and provided a new sight of REE enrichment mechanism in deep-sea sediments.

Supplemental material, sj-pdf-1-mdm-10.1177_0272989X221107902 for PaCAR: COVID-19 Pandemic Control Decision Making via Large-Scale Agent-Based Modeling and Deep Reinforcement Learning by Xudong Guo, Peiyu Chen, Shihao Liang, Zengtao Jiao, Linfeng Li, Jun Yan, Yadong Huang, Yi Liu and Wenhui Fan in Medical Decision Making

Additional file 1. Supplemental Figures S1���S10 and Tables S1���S4.

COVID-19 is the most severe pandemic globally since the 1918 influenza pandemic. Effectively responding to this once-in-a-century global pandemic is a worldwide challenge that the international community needs to jointly face and solve. This study reviews and discusses the key measures taken by major countries in 2020 to fight against COVID-19, such as lockdowns, social distancing, wearing masks, hand hygiene, using Fangcang shelter hospitals, large-scale nucleic acid testing, close-contacts tracking, and pandemic information monitoring, as well as their prevention and control effects. We hope it can help improve the efficiency and effectiveness of pandemic prevention and control in future.

Phenolic acid grafed oligochitosan (PA- g -OCS and GA- g -OCS) have been synthesized through the reaction of protocatechuic acid and gallic acid with oligochitosan, which was catalyzed by laccase. Subsequently, the two modified waterborne polyurethanes (POCS-WPU and GOCS-WPU) were obtained using PA- g -OCS and GA- g -OCS as biobased crossing agents to react with polyurethane prepolymer, respectively. The structure of POCS-WPU and GOCS-WPU was characterized by Fourier transform infrared (FTIR) and Ultraviolet-Visible absorption (UV–vis) spectroscopy, and the properties of POCS-WPU and GOCS-WPU coatings were examined. The results elaborated that both of the films present fine water contact angle, pronounced mechanical properties (tensile strength, 23.26 and 29.39 MPa; elongation at break, 504 and 491%, respectively) and significant thermal stability. Moreover, the polymers exhibited favorable antioxidant activity measured from the DPPH and ABTS radical scavenging assays.

As a newly discovered mechanosensitive ion channel protein, the piezo1 protein participates in the transmission of mechanical signals on the cell membrane and plays a vital role in mammalian biomechanics. Piezo1 has attracted widespread attention since it was discovered in 2010. In recent years, studies on piezo1 have gradually increased and deepened. In addition to the discovery that piezo1 is expressed in the respiratory, cardiovascular, gastrointestinal, and urinary systems, it is also stably expressed in cells such as mesenchymal stem cells (MSCs), osteoblasts, osteoclasts, chondrocytes, and nucleus pulposus cells that constitute vertebral bodies and intervertebral discs. They can all receive external mechanical stimulation through the piezo1 protein channel to affect cell proliferation, differentiation, migration, and apoptosis to promote the occurrence and development of lumbar degenerative diseases. Through reviewing the relevant literature of piezo1 in the abovementioned cells, this paper discusses the effect of piezo1 protein expression under mechanical stress stimuli on spinal degenerative disease, providing the molecular basis for the pathological mechanism of spinal degenerative disease and also a new basis, ideas, and methods for the prevention and treatment of this degenerative disease.

Respiratory viruses are major threats causing development of acute respiratory tract infections, which are common causes of illness and death throughout the world. Here, an integrated microsystem based on real-time colorimetry was developed for diagnosing multiple respiratory viruses. The microsystem employed magnetic beads for nucleic acid extraction and an eight-channel microfluidic array chip integrated with a loop-mediated isothermal amplification system for point-of-care screening of respiratory viruses. The overall detection process (including sample collection, nucleic acid extraction, sample loading, real-time detection, and signal output) could be completed within 1 h. Our results show that the developed method could specifically recognize influenza A virus subtypes (H1N1, H3N2, H5N1, and H7N9), influenza B virus, and human adenoviruses. The results obtained with 109 clinical samples indicate that the developed method has high specificity (100%, confidence interval 94.9-100.0) and sensitivity (96%, confidence interval 78.1-99.9). The integration of magnetic bead-based pre-treatment techniques and microfluidic isothermal amplification provides an effective solution for rapidly detecting etiological agents of respiratory diseases. The strategy of using a closed chip system and real-time colorimetry reduced aerosol contamination and ensured the accuracy of the results. The developed method provides an effective alternative for rapid point-of-care screening for viruses that cause respiratory disease syndromes and further aids in accurate and timely detection to control and prevent the spread of respiratory diseases caused by such pathogens.

Rhododendron possesses valuable horticultural and medicinal properties. However, the genetic studies have been hindered due to the lack of genetic markers. Based on RNA-seq, large-scale molecular markers were developed from four Rhododendron species endemic to Dabie Mountains (central China): R. fortunei (5.25 Gb; SSRs, 12,756, one/2.37 kb, 147 types; SNPs, 38,313; InDels, 3,174), R. simsii (5.80 Gb; SSRs, 13,294, one/2.58 kb, 167 types; SNPs, 136,590; InDels, 6,258), R. mariesii (6.53 Gb; SSRs, 15,724, one/2.51 kb, 170 types; SNPs, 44,942; InDels, 4,126), and R. molle (4.35 Gb; SSRs, 10,214, one/2.49 kb, 110 types; SNPs, 77,829; InDels, 3,416). Di-nucleotide repeats were the main type (59.126%-64.314%), and AG/CT repeat (55.18%-61.22%) was the most. In particular, 89 species-specific types had been found. Furthermore, C:G→T:A mutation was the main SNP type (30.475%-34.99%). However, C:G→G:C mutation was the least type in R. fortunei, while T:A→G:C mutation was the least in the other three species. InDels with length of 3 nt was most in R. fortunei, but 1 nt InDels were the main type in the other three species. Twelve microsatellite markers developed from R. simsii reveled high genetic diversity in the four populations, and heterozygote excess was observed. This research would benefit the genetic study, molecular marker-assisted selection, and breeding studies in Rhododendron species.

Although much work has been reported on superhydrophobic surfaces at this stage, most materials will face a wide variety of harsh environments in practical applications, and there will be serious challenges in the mechanical strength and corrosion resistance of coatings in such extreme environments. In this study, hydrophobic anti-corrosion coatings were prepared by combining hydrophobic coatings with conventional anti-corrosion coatings. Polyphenylene sulfide was firstly modified by carboxylation, and chitosan-polyphenylene sulfide nanocomposites were prepared by melt blending with chitosan as nano-filler. Chitosan as a natural biopolymer, not only has good corrosion resistance, but also can form an amide bond with carboxyl polyphenylene sulfide, thus achieving a mechanical interlocking structure and forming a tight crack-free surface. Then it was used as a coating and the surface of the coating was modified with polyvinylidene fluoride to obtain a double-layer composite coating with a water contact angle of 156±1.5° and sliding angle of 9 ± 1°. The corrosion performance of the coating was evaluated by a combination of laboratory tests (i.e., electrochemical polarization, neutral salt spray) and post-salt spray performance tests. The mechanical properties of the coating were evaluated by a scratch tester and pencil hardness method. The antifouling properties of the coating were also tested in liquids with different surface tensions. The results show that the composite coating exhibits good corrosion resistance, mechanical properties and antifouling properties and can be used as antifouling coating for different equipment and appliances and can provide long-term anti-corrosion protection for metals.

Surface plasmon resonance and quartz crystal microbalance are workhorses of protein-DNA interaction research for over 20 years, providing ways to quantitatively determine the protein-DNA binding. However, the cost, necessary technical expertise, and severe nonspecific adsorption poses barriers to their use. Convenient and effective techniques for the measurement of protein-DNA binding affinity and the epitope binning between DNA and proteins for developing highly sensitive detection platform remain challenging. Here, we develop a binding-induced alteration in electron transfer kinetics of the redox reporter labeled (methylene blue) on DNA aptamer to measure the binding affinity between prostate-specific antigen (PSA) and aptamer. We demonstrate that the binding of PSA to aptamer decreases the electron transfer rate of methylene blue for ∼45%. Further, we identify the best pairwise selection of aptamers for developing sandwich assay by sorting from 10 pairwise modes with the PSA detection limit of 500 ng/mL. Our study provides promising ways to analyze the binding affinity between ligand and receptor and to sort pairwise between aptamers or antibodies for the development of highly sensitive sandwich immunoassays.

Chromium (Cr (VI)) is one of the heavy metals that seriously endanger human health and the environment. It is a huge challenge to develop high-efficiency adsorbents with low cost, simple preparation method and green production technique and zero pollution to the environment. In this work, electrospinning technology was used to prepare polyacrylonitrile/polyethyleneimine (PAN/PEI) electrospinning nanofiber membranes (ENM), and then polyacrylonitrile/polyethyleneimine/polypyrrole (PAN/PEI/Ppy) composite nanofiber membrane (CNM) was successfully synthesized by chemical depositing polypyrrole (Ppy) on the surface of PAN/PEI ENM. PAN/PEI ENM provided a larger specific surface area, which facilitated better and more uniform deposition of Ppy on the surface of nanofiber membranes. Scanning electron microscope (SEM) and transmission electron microscope (TEM) images showed that the prepared PAN/PEI/Ppy CNM looked like "balsam pear", and had high adsorption capacity of Cr (VI), with a maximum adsorption capacity of 368 mg g-1. After five times of adsorption-desorption, the removal of Cr (VI) reached more than 95%. More importantly, compared to the current complex chemical synthesis of Cr (VI) ion adsorbents and secondary pollution to the environment, electrospinning fully demonstrates the huge technical advantages of industrial applications, including high efficiency, simple preparation, and green (no harmful chemical by-products), low cost, no secondary pollution. PAN/PEI/Ppy CNM will be promising solid adsorbent candidates for the removal of Cr (VI) ions in wastewater.

Xudong Guo,1 Lei Zhao,2 Yi Shen,1 Yi Shao,1 Wenqiang Wei,3 Fen Liu11Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, People’s Republic of China; 2Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; 3National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100021, People’s Republic of ChinaBackground: Accumulating evidence has demonstrated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) (referred to as miR-SNPs) participate in the process of carcinogenesis by altering the expression and structure of mature miRNAs. However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. We, therefore, performed a comprehensive meta-analysis to systemically evaluate the correlation of genetic polymorphisms in these four miRNAs with the risk of ESCC.Methods: Relevant studies were searched in PubMed and other electronic databases up to August 2018, supplemented by a manual search of references from retrieved articles. The pooled ORswith 95% CIs were calculated using a random-effects model.Results: A total of 22 studies from 13 published articles were included in the meta-analysis. All studies have a relatively high score of quality assessment. The pooled analysis indicated that individuals with the variant TT genotype of rs11614913 in miR-196a2 gene have a significantly decreased risk of ESCC compared with CC genotype (OR =0.83, 95% CI: 0.73–0.95). The decreased risk of ESCC was also shown in the recessive model (TT vs CT/CC: OR=0.86, 95%CI: 0.77–0.96) and allele model (T vs C: OR=0.93, 95%CI: 0.87–0.99). The significantly reduced risk of ESCC was also observed in the polymorphisms of the miR-34b/c rs4938723 locus. The similar tendency was presented in the subgroup of Chinese Han population when stratified by ethnicity. However, no significant associations were observed in the miR-146a rs2910164 and miR-423 rs6505162 with the susceptibility of ESCC in any genetic model.Conclusion: Our results suggested that the polymorphisms of miR-196a and miR-34b/c genes were related to the risk of ESCC, especially among Chinese. The findings of this study, however, need to be confirmed in further researches.Keywords: microRNA, single nucleotide polymorphism, ESCC, meta-analysis

The rapid, accurate and convenient detection of heavy metal is very important to public health. Here, we developed a DNAzyme-based electrochemical sensor for Pb2+. A DNAzyme-including and Pb2+ active probe was anchored to the biosensing interface, based on the well-defined self-assembled, three-dimensional DNA nanostructure. The results indicate that the detection performance depends on the change of distances between the methylene blue and the electrode surface. The limit of detection (LOD) could reach the concentration of 0.01 μM Pb2+, and the signal change shows semi-logarithmic relationship with the concentration of Pb2+ from 0.01 μM to 100 μM. The biosensor also presents good stability and specificity to detect Pb2+ in tap or river water. This method not only provides promising approach for improving the performance of tetrahedra in detecting Pb2+, but helps deepen the understanding of tetrahedral structure design and how the position of electroactive groups affects the performance of electrochemical sensing.

The development of high-efficiency and low-cost electrocatalysts for electrolyzed splitting water to release oxygen has attracted widespread attention. In this work, the n-n heterostructure CeO2/NiFe-LDH electrocatalysts were synthesized through a simple hydrothermal reaction process. The heterostructure and morphology of feature were characterized by X-ray diffraction, X-ray photoelectron spectroscopy scanning electron microscope and transmission electron microscope and studied for OER catalyst activity. The fabricated CeO2/NiFe-LDH exhibited excellent OER activity with a low overpotential of 246 ​mV ​at the current density of 10 ​mA ​cm−2, a small Tafel slope of 65 ​mV dec−1, and good stability, due to the positively charged n-type semiconductor promoting the adsorption of OH−, and the synergy effect of CeO2 and NiFe-LDH for the OER activity. This work provided a general strategy for designing simple synthesis of heterostructure OER electrocatalysts.

Given the sustained growth of the global population, the problem of abandoned agricultural land (AAL) has gradually attracted the attention of governments and scholars. Here, four high-resolution remote sensing data sources (Sentinel-2A satellite, Resources satellite 3, Gaofen-1 satellite, and Gaofen-2 satellite) and two geographic information survey data sources (land use data and returning farmland to forest data) were used in combination. An integrated method of combined annual and interannual detection was used to monitor AAL. The integrated method produced total abandonment information and distinguished the types of AAL (completely AAL, half-AAL, and transitional AAL). By data mining the monitoring results, eight driving factors of abandonment were determined at the plot scale, including village distance, height difference, highway distance, plot area, fractal dimension index, shelter forest, irrigation condition and neighbourhood characteristics. The logistical regression results showed that seven independent variables except village distance had a significant impact on abandonment, and the prediction accuracy of the model was 95.4%. This study can be applied to monitoring AAL and analysing the driving forces of abandonment.

Rationale: Both inflammatory myofibroblastic tumor (IMT) and retroperitoneal fibrosis are rare lesions, but kidney involvement is more rare. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis and we hold that fibroblast proliferation may be an intermediate status in oncogenesis of IMT. But further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT. Patient concerns: A 54-year-old female presented no positive signs except dull back pain after overwork. Diagnoses: On the basis of the urinary ultrasonography and computed tomography (CT) scan, we strongly suspected a renal cell carcinoma. Interventions: Considering the little remaining function of the right kidney and the possibility of malignancy, we performed a laparoscopic right radical nephrectomy. Outcomes: According to the analysis of the postoperative paraffin section and immunohistochemistry assay, a final diagnosis of IMT and retroperitoneal fibrosis nodules was made. Lessons: Both IMTs are rare lesions and its etiology and pathogeny are unclear. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis. This report suggested that fibroblast proliferation may be an intermediate status in oncogenesis of IMT, but further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT. The preoperative diagnosis of renal IMT remains difficult. Preoperative fine-needle aspiration or percutaneous biopsy and intraoperative frozen section were applied to confirm the diagnosis to avoid unnecessary nephrectomy, especially in patients with renal insufficiency, bilateral masses, or a solitary kidney.

CdSe/ZnS core/shell quantum dots (QDs) were synthesized and adsorbed onto nanocrystalline TiO 2 films for application in quantum dot sensitized solar cells(QDSSCs). Femtosecond transient absorption spectra was measured to investigate the effect of the ZnS shell coating on electron injection from CdSe QDs to nanocrystalline TiO 2 films. The results showed a decrease in electron injection rate from 7.14×10 11 to 2.38×10 11 s -1 after ZnS shell coating, which means the electron injection rate only remained 1/3. The fill factor(FF) and stability of QDSSCs were improved by ZnS coating, but the photocurrent decreased, resulting in an overall decrease in efficiency. The slower electron injection rate is found to be the main cause for this decrease in photocurrent and efficiency, which matches well with the photovoltaic property test. These results provide information for optimizing the current and efficiency of QDSSCs employing core/shell QDs.

Owing to increasingly severe environmental pollution, food safety and other problems, higher and higher requirements for the detecting technique of poisonous and harmful biochemical molecules have been put forward. The conventional biochemical detector has the disadvantages of large size, high cost and inability to realize far-end and in-situ detection functions. Based on the requirements of the biochemical molecular detection technology for high sensitivity, miniaturization, far-end detection, insitu detection, real-time analysis and the like, a detection method using a fiber surface-enhanced Raman scattering (SERS) probe to carry out Raman signal detection has been put forward in recent years. The detection method not only realizes far-end and insitu detection functions, but also has a relatively high sensitivity. In this paper, a taper and cylinder combination type fiber probe is made by adopting a simple tube corrosion method, Under the situation of fixed temperature, cone-cylinder combined fiber probes with different diameters are obtained by controlling the corrosion time, and silver nanoparticles are bound to the surface of a silanized silicon dioxide fiber probe through electrostatic forces. Then, the sizes and morphologies of silver nanoparticles on the surface of the fiber probe are observed under a scanning electron microscope. Besides, the detection limit of a rhodamine 6G (R6G) solution is used to manifest both the activity and the sensitivity of the fiber probe, and the self-assembly time of the silver nanoparticles are further optimized to be 30 min and the diameter of the fiber probe to be 62 upm. When the concentration of a silver sol solution is constant, a high-sensitivity fiber SERS probe can be prepared. Through far-end detection, the detection limit of the R6G can reach 10-14 mol/L, and the enhancement factor is 1.36104. This work can serve as an experimental basis for a novel fiber surface-enhanced Raman scattering sensor in such aspects as high sensitivity and low cost. The studies of this paper are expected to provide an appropriate detection technique for rapid quantitative detection of biochemical molecules, and further provide a reference for various application fields of environmental monitoring and food safety analysis in future in terms of realizing rapid and accurate in-situ detection. Therefore, the fiber SERS probe has large application foreground in molecular detection.