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3 results on '"Garcia-Hernando V"'

1. Electrocardiographic Distinction of Left Circumflex and Right Coronary Artery Occlusion in Patients With Inferior Acute Myocardial Infarction

Author

Vives-Borras, M, Maestro, A, Garcia-Hernando, V, Jorgensen, D, Ferrero-Gregori, A, Moustafa, AH, Sole-Gonzalez, E, Noriega, FJ, Alvarez-Garcia, J, and Cinca, J

Subjects
cardiovascular diseases
Abstract

Previously reported electrocardiographic (ECG) criteria to distinguish left circumflex (LCCA) and right coronary artery (RCA) occlusion in patients with acute inferior ST-segment elevation myocardial infarction (STEMI) afford a modest diagnostic accuracy. We aimed to develop a new algorithm overcoming limitations of previous studies. Clinical, ECG, and coronary angiographic data were analyzed in 230 nonselected patients with acute inferior STEMI who underwent primary percutaneous coronary intervention. A decision-tree analysis was used to develop a new ECG algorithm. The diagnostic accuracy of reported ECG criteria was reviewed. LCCA occlusion occurred in 111 cases and RCA in 119. We developed a 3-step algorithm that identified LCCA and RCA occlusion with a sensitivity of 77%, specificity of 86%, accuracy of 82%, and Youden index of 0.63. The area under the ROC curve was 0.85 and resulted 0.82 after a 10-fold cross validation. The key leads for LCCA occlusion were V3 (ST depression in V3/ST elevation in III >1.2) and V6 (ST elevation >= 0.1 mV or greater than III). The key leads for RCA occlusion were I and aVL (ST depression >= 0.1 mV). Fifteen of 21 reviewed studies had less than 20 cases of LCCA occlusion, only 48% performed primary percutaneous coronary intervention, and previous infarction or multivessel disease were often excluded. The diagnostic accuracy of reported ECG criteria decreased when applied to our study population. In conclusion, we report a simple and highly discriminative 3-step ECG algorithm to differentiate LCCA and RCA occlusion in an "all comers" population of patients with acute inferior STEMI. The diagnostic key ECG leads were V3 and V6 for LCCA and I and aVL for RCA occlusion. (C) 2019 The Authors. Published by Elsevier Inc.

Published
2019

2. Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction

Author

Emeline M. Van Craenenbroeck, Maria Frigerio, Sean Pinney, Victor Garcia-Hernando, Akihiro Isotani, Akinori Sawamura, Jessica Artico, Barry H. Greenberg, Luciano Potena, Piero Gentile, Sherin Hashem, Fabrizio Oliva, Claudia Raineri, Paolo G. Camici, Santiago Montero, Giacomo Veronese, Yoh Arita, Manlio Cipriani, Florent Huang, Enrico Fabris, Alessandro Sionis, Palak Shah, Alberto Foà, Oscar Ö. Braun, Hiroaki Shimokawa, Matthieu Schmidt, Ornella Leone, Marco Merlo, Toyoaki Murohara, Anuradha Lala, Paola Sormani, Caroline M. Van De Heyning, Michela Brambatti, Enrico Ammirati, Takahiro Okumura, Andrea Garascia, Koichiro Sugimura, Marisa Varrenti, Eric Adler, Rajiv Patel, Kaoru Hirose, Kimberly N. Hong, Tatsuo Aoki, Gianfranco Sinagra, Duccio Petrella, Valentina Agostini, Ammirati, E., Veronese, G., Brambatti, M., Merlo, M., Cipriani, M., Potena, L., Sormani, P., Aoki, T., Sugimura, K., Sawamura, A., Okumura, T., Pinney, S., Hong, K., Shah, P., Braun, O., Van de Heyning, C. M., Montero, S., Petrella, D., Huang, F., Schmidt, M., Raineri, C., Lala, A., Varrenti, M., Foa, A., Leone, O., Gentile, P., Artico, J., Agostini, V., Patel, R., Garascia, A., Van Craenenbroeck, E. M., Hirose, K., Isotani, A., Murohara, T., Arita, Y., Sionis, A., Fabris, E., Hashem, S., Garcia-Hernando, V., Oliva, F., Greenberg, B., Shimokawa, H., Sinagra, G., Adler, E. D., Frigerio, M., Camici, P. G., Ammirati E., Veronese G., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O., Van de Heyning C.M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foà Alberto., Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E.M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E.D., Frigerio M., Camici P.G., Ammirati, E, Veronese, G, Brambatti, M, Merlo, M, Cipriani, M, Potena, L, Sormani, P, Aoki, T, Sugimura, K, Sawamura, A, Okumura, T, Pinney, S, Hong, K, Shah, P, Braun, O, Van de Heyning, C, Montero, S, Petrella, D, Huang, F, Schmidt, M, Raineri, C, Lala, A, Varrenti, M, Foa, A, Leone, O, Gentile, P, Artico, J, Agostini, V, Patel, R, Garascia, A, Van Craenenbroeck, E, Hirose, K, Isotani, A, Murohara, T, Arita, Y, Sionis, A, Fabris, E, Hashem, S, Garcia-Hernando, V, Oliva, F, Greenberg, B, Shimokawa, H, Sinagra, G, Adler, E, Frigerio, M, and Camici, P

Subjects
Adult, Male, Inotrope, medicine.medical_specialty, Myocarditis, eosinophilic myocarditi, Prognosi, Fulminant, medicine.medical_treatment, Myocarditi, fulminant myocarditis, 030204 cardiovascular system & hematology, Severity of Illness Index, acute myocarditis, endomyocardial biopsy, eosinophilic myocarditis, giant cell myocarditis, outcome, Endomyocardial biopsy, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Internal medicine, giant cell myocarditi, Humans, Medicine, In patient, 030212 general & internal medicine, Retrospective Studies, Heart transplantation, fulminant myocarditi, business.industry, Middle Aged, Prognosis, medicine.disease, acute myocarditi, Acute myocarditis, Acute Disease, Circulatory system, Cardiology, Female, Human medicine, Cardiology and Cardiovascular Medicine, business, Human
Abstract

BACKGROUND Fulminant myocarditis (FM) is a form of acute myocarditis characterized by severe left ventricular systolic dysfunction requiring inotropes and/or mechanical circulatory support. A single-center study found that a patient with FM had better outcomes than those with acute nonfulminant myocarditis (NFM) presenting with left ventricular systolic dysfunction, but otherwise hemodynamically stable. This was recently challenged, so disagreement still exists. OBJECTIVES This study sought to provide additional evidence on the outcome of FM and to ascertain whether patient stratification based on the main histologic subtypes can provide additional prognostic information. METHODS A total of 220 patients (median age 42 years, 46.3% female) with histologically proven acute myocarditis (onset of symptoms

Published
2019

3. Viral genome search in myocardium of patients with fulminant myocarditis

Author

Alberto Foà, Victor Garcia-Hernando, Michela Brambatti, Hiroaki Shimokawa, Paola Sormani, Anuradha Lala, Sean Pinney, Duccio Petrella, Maria Frigerio, Gianfranco Sinagra, Valentina Agostini, Matthieu Schmidt, Piero Gentile, Akihiro Isotani, Enrico Ammirati, Enrico Fabris, Ornella Leone, Luciano Potena, Sherin Hashem, Barry H. Greenberg, Santiago Montero, Jessica Artico, Caroline M. Van De Heyning, Giacomo Veronese, Marco Merlo, Alessandro Sionis, Palak Shah, Emeline M. Van Craenenbroeck, Florent Huang, Claudia Raineri, Yoh Arita, Tatsuo Aoki, Fabrizio Oliva, Akinori Sawamura, Manlio Cipriani, Koichiro Sugimura, Marisa Varrenti, Oscar Ö. Braun, Eric Adler, Paolo G. Camici, Toyoaki Murohara, Andrea Garascia, Takahiro Okumura, Kimberly N. Hong, Kaoru Hirose, Rajiv Patel, Veronese, G., Ammirati, E., Brambatti, M., Merlo, M., Cipriani, M., Potena, L., Sormani, P., Aoki, T., Sugimura, K., Sawamura, A., Okumura, T., Pinney, S., Hong, K., Shah, P., Braun, O. O., Van de Heyning, C. M., Montero, S., Petrella, D., Huang, F., Schmidt, M., Raineri, C., Lala, A., Varrenti, M., Foa, A., Leone, O., Gentile, P., Artico, J., Agostini, V., Patel, R., Garascia, A., Van Craenenbroeck, E. M., Hirose, K., Isotani, A., Murohara, T., Arita, Y., Sionis, A., Fabris, E., Hashem, S., Garcia-Hernando, V., Oliva, F., Greenberg, B., Shimokawa, H., Sinagra, G., Adler, E. D., Frigerio, M., Camici, P. G., Veronese G., Ammirati E., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O.O., Van de Heyning C.M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foà Alberto, Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E.M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E.D., Frigerio M., Camici P.G., CIC Pitié BT, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), and Sorbonne Université (SU)

Subjects
Letter, Fulminant, [SDV]Life Sciences [q-bio], polymerase chain reaction, Biopsy, Cytomegalovirus, heart failure, fulminant myocarditis, 030204 cardiovascular system & hematology, medicine.disease_cause, 0302 clinical medicine, Medicine, genetics, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, virus replication, Enterovirus, genome analysis, Genome search, predictive value, Epstein Barr virus, Myocarditis, priority journal, N/A, Cardiology and Cardiovascular Medicine, left ventricular systolic dysfunction, Human, cardiac muscle, Genome, Viral, Adenoviridae, 03 medical and health sciences, Humans, human, virus identification, virus detection, Heart Failure, nonhuman, business.industry, Myocardium, medicine.disease, Epstein–Barr virus, Virology, Virus detection, virus genome, Viral replication, Human medicine, business
Abstract

[No abstract available]

Published
2020

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