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A survey of health care providers reveals significant adverse effects on the ability to serve patients and sustain the practice. Without policy solutions and financial support, practice sales and closures may be imminent., Summary A survey developed through a partnership of clinicians, researchers, and public and private entities in Massachusetts was hosted by Harvard Medical School. Between May 20 and July 9, 2020, respondents from 398 practices shared details on the revenue and expense implications of the novel coronavirus, as well as insights into the personal impact Covid-19 is having. More than 60% of practices reported they would cut salaries of providers or employees, cut services or other operating expenses, and furlough or lay off more employees without additional financial assistance, with a roughly 40% likelihood of following through. Consolidation, selling, or closing the practice were reported by 20%–40% of practices, driven by independent practices such as primary care (60% noted closure at 21% likelihood). The authors include policy actions that may mitigate the harm to access to care.