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8 results on '"Gou, K."'

1. The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Author

Wang H, Zhou C, Su Y, Gou K, Geng X, and Qiu X

Subjects
beagle dog, voriconazole, ripretinib, Therapeutics. Pharmacology, RM1-950, pharmacokinetics, uplc-ms/ms, itraconazole
Abstract

Hui-jun Wang,1 Chun-yan Zhou,1 Yan-ding Su,1 Kai-feng Gou,1 Xiao-nan Geng,1 Xiang-jun Qiu1,2 1Department of Pharmacy, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, 471023, People’s Republic of China; 2Functional Experiment Teaching Center, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, 471023, People’s Republic of ChinaCorrespondence: Xiang-jun QiuFunctional Experiment Teaching Center, School of Basic Medical Sciences, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang, 471023, People’s Republic of ChinaTel +8613698882699Fax +86379-64830346Email lyxiangjun@126.comBackground: A new UPLC-MS/MS technique for the determination of ripretinib in beagle dog plasma was developed, and the pharmacokinetic effects of voriconazole and itraconazole on ripretinib in beagle dogs were studied.Methods: After extraction with ethyl acetate under alkaline conditions, ripretinib was detected using avapritinib as the internal standard (IS). The mobile phases were 0.1% formic acid-acetonitrile. The scanning method was multi-reaction monitoring using ESI+ source, and the ion pairs for ripretinib and IS were m/z 509.93→ 416.85 and 499.1→ 482.09, respectively. This animal experiment adopted a three period self-control experimental design. In the first period, ripretinib was orally administered to six beagle dogs at a dose of 5 mg/kg. In the second period, the same six beagle dogs were orally given itraconazole at a dose of 7 mg/kg, after 30 min, ripretinib was orally given. In the third period, voriconazole at a dose of 7 mg/kg was given orally, and then ripretinib was orally given. At different time points, the blood samples were collected. The concentration of ripretinib was detected, and the pharmacokinetic parameters of ripretinib were calculated.Results: Ripretinib had a good linear relationship in the range of 1– 1000 ng/mL. The precision, accuracy, recovery, matrix effect and stability met the requirements of the guiding principles. After erdafitinib combined with itraconazole, the Cmax and AUC0→t of ripretinib increased by 38.35% and 36.36%, respectively, and the t1/2 was prolonged to 7.53 h. After ripretinib combined with voriconazole, the Cmax and AUC0→t of ripretinib increased by 37.44% and 25.52%, respectively, and the t1/2 was prolonged to 7.33 h.Conclusion: A new and reliable UPLC-MS/MS technique was fully optimized and developed to detect the concentration of ripretinib in beagle dog plasma. Itraconazole and voriconazole could inhibit the metabolism of ripretinib in beagle dogs and increase the plasma exposure of ripretinib.Keywords: itraconazole, voriconazole, ripretinib, UPLC-MS/MS, pharmacokinetics, beagle dog

Published
2021

2. Longitudinal plasma proteomics analysis reveals novel candidate biomarkers in acute COVID-19

Author

Mohammed, Y., Goodlett, D.R., Cheng, M.P., Vinh, D.C., Lee, T.C., Mcgeer, A., Sweet, D., Tran, K., Lee, T., Murthy, S., Boyd, J.H., Singer, J., Walley, K.R., Patrick, D.M., Quan, C., Ismail, S., Amar, L., Pal, A., Bassawon, R., Fesdekjian, L., Gou, K., Lamontagne, F., Marshall, J., Haljan, G., Fowler, R., Winston, B.W., Russell, J.A., and ARBs CORONA I

Subjects
Proteomics, COVID-19, amyloid, longitudinal analysis, General Chemistry, ARB, Biochemistry, Plasma, targeted quantitative proteomics, Humans, complement, Biomarkers, Retrospective Studies, ACEi
Abstract

The host response to COVID-19 pathophysiology over the first few days of infection remains largely unclear, especially the mechanisms in the blood compartment. We report on a longitudinal proteomic analysis of acute-phase COVID-19 patients, for which we used blood plasma, multiple reaction monitoring with internal standards, and data-independent acquisition. We measured samples on admission for 49 patients, of which 21 had additional samples on days 2, 4, 7, and 14 after admission. We also measured 30 externally obtained samples from healthy individuals for comparison at baseline. The 31 proteins differentiated in abundance between acute COVID-19 patients and healthy controls belonged to acute inflammatory response, complement activation, regulation of inflammatory response, and regulation of protein activation cascade. The longitudinal analysis showed distinct profiles revealing increased levels of multiple lipid-associated functions, a rapid decrease followed by recovery for complement activation, humoral immune response, and acute inflammatory response-related proteins, and level fluctuation in the regulation of smooth muscle cell proliferation, secretory mechanisms, and platelet degranulation. Three proteins were differentiated between survivors and nonsurvivors. Finally, increased levels of fructose-bisphosphate aldolase B were determined in patients with exposure to angiotensin receptor blockers versus decreased levels in those exposed to angiotensin-converting enzyme inhibitors. Data are available via ProteomeXchange PXD029437.

Published
2022

3. Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen

Author

Xin W, Wang Y, Guo X, Gou K, Li J, Li S, Zhao L, and Li H

Subjects
Medicine (General), msf, R5-920, bimodal mesostructured, biomimetic synthesis, bioavailability, ibuprofen
Abstract

Wei Xin,1,2 Yumei Wang,3 Xianmou Guo,3 Kaijun Gou,3 Jing Li,3 Sanming Li,3 Lin Zhao,1 Heran Li1 1School of Pharmacy, China Medical University, Shenyang 110122, People’s Republic of China; 2The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 3School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaCorrespondence: Heran Li; Lin ZhaoSchool of Pharmacy, China Medical University, 77 Puhe Road, Shenyang North New Area, Shenyang 110122, People’s Republic of ChinaTel +8613897945866; +8618900911856Email liheranmm@163.com; zl_cmu@163.comPurpose: The aim of this study was to improve the oral bioavailability and anti-inflammatory activity of the poorly soluble drug ibuprofen (IBU) by employing a new kind of poly(ethyleneimine)s (PEIs)-based mesocellular siliceous foam (MSF) called B-BMSF@PEI as drug carrier.Methods: B-BMSF@PEI was biomimetically synthesized by using PEIs as templates, catalysts and scaffolds under ambient conditions, and the structural characteristics, including size, morphology, mesoscopic structure and pore properties, were estimated by TEM, SEM, FTIR and N2 desorption/adsorption measurement. Then, IBU was incorporated into B-BMSF@PEI at the drug:carrier weight ratio of 1:1. The structural features of IBU before and after drug loading were systemically characterized. IBU and B-BMSF@PEI were then subject to in vitro drug release study and wettability analysis. Finally, in vivo pharmacokinetics and anti-inflammatory pharmacodynamics studies were carried out to evaluate the efficacy of B-BMSF@PEI on improving the oral adsorption of IBU.Results: The results demonstrated that B-BMSF@PEI was a meso–meso porous silica material with foam appearance. It consisted of uniform spherical cells (40 nm) with interconnected pore networks. IBU can be successfully loaded into B-BMSF@PEI with high efficiency (as high as 39.53%), and crystal IBU was effectively converted to an amorphous state during this process. Benefiting from the great architectures of B-BMSF@PEI, IBU/B-BMSF@PEI performed good wetting property and significantly improved the dissolution rate in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Notably, IBU exhibited very satisfactory relative bioavailability (681.4%) and anti-inflammatory effects (the inhibition rates were between the ranges of 113.5% to 1504.3%).Conclusion: B-BMSF@PEI with bimodal mesoporous system and interconnected nanopores was obtained owing to the dynamic self-assembly functions of PEIs. It had superiority in drug loading and could improve the oral adsorption of ibuprofen to a satisfactory level.Keywords: biomimetic synthesis, MSF, bimodal mesostructured, bioavailability, ibuprofen

Published
2020

4. Design and expected performances of the large acceptance calorimeter for the HERD space mission

Author

Pacini, L., Adriani, O., Bai, Y. -L., Bao, T. -W., Berti, E., Bottai, S., Cao, W. -W., Casaus, J., Cui, X. -Z., D’Alessandro, R., Formato, V., Gao, J. -R., Li, R., Liu, X., Lorusso, L., Lyu, L. -W., Marin, J., Martinez, G., Pizzolotto, C., Qin, J. -J., Quan, Z., Shi, D. -L., Starodubtsev, O., Tang, Z. -C., Tiberio, A., Vagelli, V., Velasco, M. A., Wang, B., Wang, Hongmei, R. -J., Z. -G., Xu, M., Yang, Y., Zhang, L., Zheng, J. -K., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Space experiments, Energy, Scintillating fiber, Performance, Monte Carlo methods, Measurements of, Space stations, Space missions, Cosmology, Cosmic rays, Intelligent systems, Scintillation counters, Silicon detectors, Charge detectors, Fiber trackers, Radiation detection, Read out systems, Calorimeters
Published
2022

5. Gamma-ray performance study of the HERD payload

Author

Adriani, O., Alemanno, F., Aloisio, R., Altomare, C., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, P., Berti, E., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bonvicini, V., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Casaus, J., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, Y., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetano, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Nicola, Mazziotta, Oliva, M., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantaleo, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Performance, Cosmology, Gamma rays, Optical transfer function, Space stations, Dark matter searches, Detector geometry, Full simulations, Gamma-rays, Knee energy, Performance study, Radiation detection, Space astronomy, Cosmic rays
Published
2022

6. The High Energy cosmic-Radiation Detector (HERD) Trigger System

Author

Velasco, M. A., Bao, T., Berti, E., Bonvicini, V., Casaus, J., Giovacchini, F., Liu, X., Marco, R., Marín, J., Martínez, G., Mori, N., Oliva, A., Pacini, L., Quan, Z., Tang, Z., Xu, M., Zampa, G., Zampa, N., Adriani, O., Alemanno, F., Aloisio, R., Altomare, G., Ambrosi, G., An, Q., Antonelli, M., Azzarello, P., Bai, L., Bai, Y. L., Bao, T. W., Barbanera, M., Barbato, F. C. T., Bernardini, B., Bertucci, B., X. J., Bi, Bigongiari, G., Bongi, M., Bordas, P., Bosch-Ramon, V., Bottai, S., Brogi, P., Cadoux, F., Campana, D., Cao, W. W., Cao, Z., Catanzani, E., Cattaneo, P. W., Chang, J., Chang, Y. H., Chen, G. M., Chen, F., Cianetti, F., Comerma, A., Cortis, D., Cui, X. H., Cui, X. Z., Dai, C., Dai, Z. G., D'Alessandro, R., Gaetanoe, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Gomez, N., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marrocchesi, R., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mussolin, L., Nicola, Mazziotta, Orlandi, M., Osteria, D., Panico, G., Pantalei, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Rappoldi, L., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zha, Q., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Cosmology, Gamma rays, Intelligent systems, Monte Carlo methods, Space stations, Tellurium compounds, Topology, Dark matter, Electron spectrum, Energy, Fundamental physics, Measurements of, Plastic scintillator detector, Precise measurements, Radiation detection, Space-borne, Trigger systems, Cosmic rays
Published
2022

7. The Plastic Scintillator Detector of the HERD space mission

Author

Kyratzis, D., Alemanno, F., Altomare, C., Barbato, F. C. T., Bernardini, P., Cattaneo, P. W., Mitri, De, Palma, De, Venere, Di, Santo, Di, Fusco, M., Gargano, P., Loparco, F., Loporchio, F., Marsella, S., Mazziotta, G., Pantaleo, M. N., Parenti, F. R., Pillera, A., Rappoldi, R., Raselli, A., Rossella, G., Serini, M., Silveri, D., Surdo, L., Wu, A., Adriani, L., Aloisio, O., Ambrosi, G., An, G., Antonelli, Q., Azzarello, M., Bai, P., Bai, L., Bao, Y. L., Barbanera, T. W., Berti, M., Bertucci, B., Bi, B., Bigongiari, X. J., Bongi, G., Bonvicini, M., Bordas, V., Bosch-Ramon, P., Bottai, V., Brogi, S., Cadoux, P., Campana, F., Cao, D., Cao, W. W., Casaus, Z., Catanzani, J., Chang, E., Chang, J., Chen, Y. H., Chen, G. M., Cianetti, F., Comerma, F., Cortis, A., Cui, D., Cui, X. H., Dai, X. Z., Dai, C., D'Alessandro, Z. G., Gaetano, De, Felice, Di, Giovanni, Di, Dong, A., Dong, J. N., Donvito, Y. W., Duranti, G., D'Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Gao, J. M., Gascon-Fora, J. R., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Marra, La, Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Y. Q., Lu, Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Martinez, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, L., Oliva, L., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Papa, B., Papini, S., Paredes, P., Pauluzzi, J. M., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pizzolotto, G., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Ren, Z., Renno, X. X., Ribo, F., Rico, M., Ryde, J., Sanmukh, F., Scotti, A., Shi, V., Shi, D. L., Starodubtsev, Q. Q., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Tang, Z. T., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Gamma-ray astronomy, Charged particles, Gamma rays, High energy gamma rays, Measurements of, Space-borne instruments, Space stations, Mass composition, Space missions, Cosmology, Cosmic ray energy spectrum, Plastic scintillator detector, Precise measurements, Scintillation counters, Cosmic rays
Published
2022

8. FIT: the scintillating fiber tracker of the HERD space mission

Author

Perrina, C., Azzarello, P., Cadoux, F., Favre, Y., Frieden, J. M., Marra, La, Sukhonos, D., Wu, D., Adriani, X., Alemanno, O., Aloisio, F., Altomare, R., Ambrosi, G., An, G., Antonelli, Q., Azzarello, M., Bai, P., Bai, L., Bao, Y. L., Barbanera, T. W., Barbato, M., Bernardini, F. C. T., Berti, P., Bertucci, B., Bi, B., Bigongiari, X. J., Bongi, G., Bonvicini, M., Bordas, V., Bosch-Ramon, P., Bottai, V., Brogi, S., Cadoux, P., Campana, F., Cao, D., Cao, W. W., Casaus, Z., Catanzani, J., Cattaneo, E., Chang, P. W., Chang, J., Chen, Y. H., Chen, G. M., Cianetti, F., Comerma, F., Cortis, A., Cui, D., Cui, X. H., Dai, X. Z., Dai, C., D’Alessandro, Z. G., Gaetano, De, Mitri, De, Palma, De, Felice, Di, Giovanni, Di, Santo, Di, Venere, Di, Dong, L., Dong, J. N., Donvito, Y. W., Duranti, G., D’Urso, M., Evoli, D., Fang, C., Fariña, K., Favre, L., Feng, Y., Feng, C. Q., Feng, H., Feng, H. B., Finetti, Z. K., Formato, N., Frieden, V., Fusco, J. M., Gao, P., Gargano, J. R., Gascon-Fora, F., Gasparrini, D., Giglietto, D., Giovacchini, N., Gomez, F., Gong, S., Gou, K., Guida, Q. B., Guo, R., Guo, D. Y., Guo, J. H., Y. Q., He, H. H., Hu, H. B., Hu, J. Y., Hu, Hu, P., Huang, Y. M., Huang, G. S., Huang, J., Huang, W. H., Huang, X. T., Huang, Y. B., Ionica, Y. F., Jouvin, M., Kotenko, L., Kyratzis, A., Li, D., M. J., Li, Q. Y., Li, Li, R., S. L., Li, Li, T., Li, X., Li, Z., Liang, Z. H., Liang, E. W., Liao, M. J., Licciulli, C. L., Lin, F., Liu, S. J., Liu, D., Liu, H. B., Liu, H., Liu, J. B., Liu, S. B., Liu, X., Liu, X. W., Loparco, Y. Q., Loporchio, F., Lu, S., Lyu, X., Lyu, J. G., Maestro, L. W., Mancini, E., Manera, E., Marin, R., Marrocchesi, J., Marsella, P. S., Martinez, G., Marzullo, M., Mauricio, D., Mocchiutti, J., Morettini, G., Mori, G., Mussolin, N., Mazziotta, L., Oliva, M. N., Orlandi, A., Osteria, D., Pacini, G., Panico, L., Pantaleo, B., Papa, F. R., Papini, S., Paredes, P., Parenti, J. M., Pauluzzi, A., Pearce, M., Peng, M., Perfetto, W. X., Perrina, F., Perrotta, C., Pillera, G., Pizzolotto, R., Qiao, C., Qin, R., Quadrani, J. J., Quan, L., Rappoldi, Z., Raselli, A., Ren, G., Renno, X. X., Ribo, F., Rico, M., Rossella, J., Ryde, M., Sanmukh, F., Scotti, A., Serini, V., Shi, D., Shi, D. L., Silveri, Q. Q., Starodubtsev, L., Su, O., D. T., Su, Sukhonos, M., Suma, D., Sun, A., Sun, X. L., Surdo, Z. T., Tang, A., Tiberio, Z. C., Tykhonov, A., Vagelli, A., Vannuccini, V., Velasco, E., Walter, M., Wang, R., Wang, A. Q., Wang, B., Wang, J. C., Wang, J. M., Wang, J. J., Wang, L., Wang, M., Wang, R. J., Wang, S., Wang, X. Y., Wang, X. L., Wei, Z. G., Wei, D. M., J. J., Wu, B. B., Wu, Wu, J., L. B., Wu, Wu, X., Xin, X. F., Y. L., Xu, Xu, M., Yan, Z. Z., Yang, H. R., Yin, Y., P. F., Yu, Yuan, Y. W., Zampa, Q., Zampa, G., Zha, N., Zhang, M., Zhang, C., Zhang, F. Z., Zhang, L., Zhang, L. F., Zhang, S. N., Zhang, Y., Zhao, Y. L., Zheng, Z. G., Zhou, J. K., Zhu, Y. L., Zhu, F. R., and K. J.

Subjects
Energy, Scintillating fiber, Gamma rays, Direct-detection, Space stations, Space missions, Cosmology, Spectra's, Scintillation, Dark matter, Fiber trackers, Gamma-rays, Indirect detection, Radiation detection, Cosmic rays

Catalog

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