1. Diterpenoids from the Hainan Soft Coral Sinularia parva
- Author
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Li, Yan, Gao, An-Hui, Huang, Hui, Li, Jia, Mollo, Ernesto, Gavagnin, Margherita, Cimino, Guido, Gu, Yu-Cheng, and Guo, Yue-Wei
- Abstract
Two new cembrane diterpenes, sinulaparvalides A and B (1 and 2, resp.), which contain an intriguing seven-membered lactone moiety, along with the four known related cembranoids 3-6, were isolated from the Hainan soft coral Sinularia parva. The structures of compounds I and 2 were established by spectroscopic methods, mainly on the basis of 2D-NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxic activities of these compounds were tested on human colon carcinoma (HCT-116), human promyelocytic leukemia (HL-60), and human lung carcinoma (A-549) tumor cell lines.
- Published
- 2009