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1. Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Author

Guang-Xing Yu, Jing Wu, Bao-Bao Shi, Mei-Fen Bao, and Xiang-Hai Cai

Subjects
Pharmacology, Organic Chemistry, Plant Science, Toxicology, Biochemistry, Food Science, Analytical Chemistry
Abstract

Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.

Published
2022

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