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The organophosphorus pesticide profenofos (PFF) is widely used as an environmental contaminant, and it can remain in water bodies causing serious harm to aquatic organisms. Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. However, the mechanism of PFF induced genotoxicity in fish hepatocytes and the role Albicanol can play in this process are unknown. In this study, the model was established by treating grass carp hepatocytes with PFF (150 μM) and/or Albicanol (5 × 10

Profenofos (PFF) as an environmental pollutant seriously harms the health of aquatic animals, and even endangers human safety through the food chain. Albicanol, a sesquiterpenoid extraction from the Dryopteris fragrans, has previously been shown to effectively exhibit anti-aging, anti-oxidant, and antagonize the toxicity of heavy metals. However, the mechanism of hepatocyte toxicity caused by PFF and the role that Albicanol plays in this process are still unclear. In this study, a PFF poisoning model was established by treating grass carp hepatocytes cells with PFF (150μM) for 24 h The results of AO/EB staining, Tunel staining and flow cytometry showed that the proportion of apoptotic liver cells increased significantly after exposure. The results of ROS staining show that compared with the control group, ROS levels and PTEN/PI3K/AKT-related gene expression were up-regulated after PFF exposure. RT-qPCR and Western blotting results showed that the expression of PTEN/PI3K/AKT related genes was up-regulated. These results indicate that PFF can induce oxidative stress in hepatocytes and inhibit the phosphorylation of AKT. We further found that the expressions of Bax, CytC, Caspase-3, Caspase-9, Caspase-8 and TNFR1 after PFF exposure were significantly higher than those of the control group, and Bcl-2/Bax was significantly lower than that of the control group. These results indicate that PFF can induce oxidative stress in hepatocytes and inhibit the phosphorylation of AKT and activate mitochondrial apoptosis. Using Albicanol (5×10−5μg mL−1) can significantly reduce the above-mentioned effects of PFF exposure on grass carp hepatocytes cells. In summary, Albicanol inhibits PFF-induced apoptosis by regulating the ROS/PTEN/PI3K/AKT pathway.

Oxygen isotope compositions of fossil foraminifera tests are commonly used proxies for ocean paleotemperatures, with reconstructions spanning the last 112 million years. However, the isotopic composition of these calcitic tests can be substantially altered during diagenesis without discernible textural changes. Here, we investigate fluid-mediated isotopic exchange in pristine tests of three modern benthic foraminifera species (Ammonia sp., Haynesina germanica, and Amphistegina lessonii) following immersion into an 18O-enriched artificial seawater at 90 °C for hours to days. Reacted tests remain texturally pristine but their bulk oxygen isotope compositions reveal rapid and species-dependent isotopic exchange with the water. NanoSIMS imaging reveals the 3-dimensional intra-test distributions of 18O-enrichment that correlates with test ultra-structure and associated organic matter. Image analysis is used to quantify species level differences in test ultrastructure, which explains the observed species-dependent rates of isotopic exchange. Consequently, even tests considered texturally pristine for paleo-climatic reconstruction purposes may have experienced substantial isotopic exchange; critical paleo-temperature record re-examination is warranted., Paleoclimate reconstructions commonly use oxygen isotope compositions from fossil foraminifera tests as proxies. Here, the authors show that these tests exchange O-isotopes with surrounding fluids, with implications for paleotemperature records.

The integration of excellent traditional culture into the classroom of ideological and political education in colleges and universities can promote students’ ideological awareness, enhance college students’ sense of identity with traditional culture and nation, and further strengthen the cultural confidence of the Chinese nation. This paper analyzes the significance of the integration of excellent traditional culture and ideological and political education in colleges and universities, discusses the current problems faced by the integration of the two, and puts forward targeted suggestions.

Formamidinium lead iodide perovskites are promising light-harvesting materials, yet stabilizing them under operating conditions without compromising optimal optoelectronic properties remains challenging. We report a multimodal host-guest complexation strategy to overcome this challenge using a crown ether, dibenzo-21-crown-7, which acts as a vehicle that assembles at the interface and delivers Cs+ ions into the interior while modulating the material. This provides a local gradient of doping at the nanoscale that assists in photoinduced charge separation while passivating surface and bulk defects, stabilizing the perovskite phase through a synergistic effect of the host, guest, and host-guest complex. The resulting solar cells show power conversion efficiencies exceeding 24% and enhanced operational stability, maintaining over 95% of their performance without encapsulation for 500h under continuous operation. Moreover, the host contributes to binding lead ions, reducing their environmental impact. This supramolecular strategy illustrates the broad implications of host-guest chemistry in photovoltaics. It remains a challenge to achieve a balance between performance and stability, as well as addressing the environmental impact of perovskite solar cells. Here, the authors propose a multimodal host-guest complexation strategy enabling these shortcomings to be addressed simultaneously.

Formamidinium lead iodide perovskites are promising light-harvesting materials, yet stabilizing them under operating conditions without compromising optimal optoelectronic properties remains challenging. We report a multimodal host–guest complexation strategy to overcome this challenge using a crown ether, dibenzo-21-crown-7, which acts as a vehicle that assembles at the interface and delivers Cs+ ions into the interior while modulating the material. This provides a local gradient of doping at the nanoscale that assists in photoinduced charge separation while passivating surface and bulk defects, stabilizing the perovskite phase through a synergistic effect of the host, guest, and host–guest complex. The resulting solar cells show power conversion efficiencies exceeding 24% and enhanced operational stability, maintaining over 95% of their performance without encapsulation for 500 h under continuous operation. Moreover, the host contributes to binding lead ions, reducing their environmental impact. This supramolecular strategy illustrates the broad implications of host–guest chemistry in photovoltaics., It remains a challenge to achieve a balance between performance and stability, as well as addressing the environmental impact of perovskite solar cells. Here, the authors propose a multimodal host-guest complexation strategy enabling these shortcomings to be addressed simultaneously.

Nb-Si based alloys show great promise to surpass currently advanced Ni-base superalloys due to their low densities and high melting points. Both Ti and Al are beneficial alloying elements for Nb-Si based alloys. In literatures, a small amount (≤ 3 at%) of Al can be frequently examined, while Nb aluminides are usually not formed in this case. Since Nb 3 Al and Nb 2 Al have good strength and creep properties, NbAl 3 is also a candidate hot-section material; however the study of Nb-Si alloys with these possible Nb aluminides is lacking, so we focus our efforts on whether Nb aluminide is formed or not by adding more Al in the as-cast Nb-Ti-Si alloys. The microstructures and the mechanical properties of two Nb-Ti-Si-Al alloys (A2: Nb-18Ti-14Si-9Al, A4: Nb-21Ti-14Si-9Al) with higher Al content were studied in the present work. A4 alloy was designed to examine the alloying effect of more Ti. Results show that A2 alloy consists of (Nb), Nb 5 Si 3 and Nb 3 Al, while the A4 alloy is composed of (Nb) and Nb 5 Si 3 . The room temperature fracture toughnesses of A2 alloy and A4 alloy are 11.1 and 10.9 MPa·m 1/2 , respectively. Moreover, the microindention tests were conducted to characterize the micro scale mechanical properties of these Nb-Ti-Si-Al alloys.

International journal of refractory metals & hard materials 75, 137 - 146 (2018). doi:10.1016/j.ijrmhm.2018.04.008, Cu-refractory metal composites containing Cr, Mo or W were subjected to severe plastic deformation using room temperature high-pressure torsion (HPT). A lamellar microstructure developed in each of the composites at equivalent strains of ~75. The refractory metals developed {hkl} fibre textures with a slight tilt to the tangential direction. This texture was stronger and more clearly defined in Mo and W than in Cr. By applying additional HPT deformation to these samples, perpendicular to the original shear strain, it was found that the lamellar structure of Cu30Mo70 and Cu20W80 (wt.%) composites could be retained at high equivalent strains and the refractory layer thickness could be reduced to 20-50 nm in Cu20W80 and 10-20 nm in Cu30Mo70. Although neighbouring regions of the microstucture were aligned and there was evidence of local texture in both composites, the bulk texture of Cu30Mo70 became weaker during this second step of HPT deformation. This was attributed to the refractory metal lamellae being discontinuous and imperfectly aligned. This work shows that it is possible to form ultrafine composites of Cu-group VI refractory metals via high-pressure torsion, with namolamellar structures being possible where there is a sufficient volume fraction of Mo or W., Published by Elsevier Science, Amsterdam [u.a.]

Cu-refractory metal composites containing Cr, Mo or W were subjected to severe plastic deformation using room temperature high-pressure torsion (HPT). A lamellar microstructure developed in each of the composites at equivalent strains of ~75. The refractory metals developed {hkl} fibre textures with a slight tilt to the tangential direction. This texture was stronger and more clearly defined in Mo and W than in Cr. By applying additional HPT deformation to these samples, perpendicular to the original shear strain, it was found that the lamellar structure of Cu30Mo70 and Cu20W80 (wt.%) composites could be retained at high equivalent strains and the refractory layer thickness could be reduced to 20-50 nm in Cu20W80 and 10-20 nm in Cu30Mo70. Although neighbouring regions of the microstucture were aligned and there was evidence of local texture in both composites, the bulk texture of Cu30Mo70 became weaker during this second step of HPT deformation. This was attributed to the refractory metal lamellae being discontinuous and imperfectly aligned. This work shows that it is possible to form ultrafine composites of Cu-group VI refractory metals via high-pressure torsion, with namolamellar structures being possible where there is a sufficient volume fraction of Mo or W., 17 pages, 8 figures, 3 tables. Supplementary info: 1 page, 1 table, 1 figure

Nb-Ti-Si-based ultrahigh-temperature alloys concocted with boron ranging from 0 to 2 at% are prepared by arc-melting technology. The effects of adding boron on their as-melted microstructure and oxidation resistance are analyzed. The (Nb,Ti)ss, β-(Nb,Ti)5Si3 and γ-(Nb,Ti)5Si3 exist in Nb-22Ti-16Si-6Cr-3Al-4Hf alloy, while (Nb,Ti)ss, α-(Nb,Ti)5Si3 and γ-(Nb,Ti)5Si3 are present in Nb-22Ti-16Si-6Cr-3Al-4Hf-1B and Nb-22Ti-16Si-6Cr-3Al-4Hf-2B alloys. The oxidation of Nb-Ti-Si-based ultrahigh-temperature alloys is dominated by the diffusion of oxygen through (Nb,Ti)ss. Compared to boron-free alloys, the boron-containing alloys have significantly lower oxidation rate when oxidized at 1 200 °C for less than 50 h, but, for more than 50 h, their oxidation resistance deteriorates.

Oxygen isotope compositions of calcite foraminifera tests are considered to be a robust palaeotemperature proxy at earth-surface conditions, where diffusion is slow. Recrystallization of tests during diagenesis may be optically identified and is often the basis for excluding such samples from paleotemperature calculations e.g. “glassy” vs. “frosty” foraminifera. However, biogenic and abiogenic calcite can isotopically reequilibrate and recrystallize in calcite-saturated fluids, even at low temperatures (10 mol.% of a calcite’s oxygen could exchange with oxygen from the surrounding pore fluids. The calculated temperature from the resulting reequilibrated calcite could change by as much as 4 °C depending on the pore-fluid isotopic composition, compared to the original precipitation temperature. These results compel a reconsideration of the reliability of many calcitic paleoclimate proxies even in the absence of any evidence for recrystallization. Calcite precipitated at low temperatures, e.g. benthic foraminifera, are particularly vulnerable to this process, which may, in part, explain their anomalously-high apparent equilibration temperatures during the Paleocene–Eocene.

Nature Communications 12(1), 3383 (2021). doi:10.1038/s41467-021-23566-2, Formamidinium lead iodide perovskites are promising light-harvesting materials, yet stabilizing them under operating conditions without compromising optimal optoelectronic properties remains challenging. We report a multimodal host���guest complexation strategy to overcome this challenge using a crown ether, dibenzo-21-crown-7, which acts as a vehicle that assembles at the interface and delivers Cs+ ions into the interior while modulating the material. This provides a local gradient of doping at the nanoscale that assists in photoinduced charge separation while passivating surface and bulk defects, stabilizing the perovskite phase through a synergistic effect of the host, guest, and host���guest complex. The resulting solar cells show power conversion efficiencies exceeding 24% and enhanced operational stability, maintaining over 95% of their performance without encapsulation for 500 h under continuous operation. Moreover, the host contributes to binding lead ions, reducing their environmental impact. This supramolecular strategy illustrates the broad implications of host���guest chemistry in photovoltaics., Published by Nature Publishing Group UK, [London]