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Additional file 1: Table S1. Education, comorbidities, laboratory results, brain imaging, and Hoehn and Yahr stagging of PD patients at baseline. Table S2. Percentage change of motor and physical activity over 6 months and 1-year follow-up. Table S3. Comparison between mild PD vs advanced-moderate PD regarding baseline characteristics and motor progression. Table S4. Gender comparison regarding baseline characteristics and motor progression. Table S5. Comparison between Tremor Dominant and non-TD patients regarding baseline characteristics and motor progression. Table S6. Comparison between late onset vs early onset PD regarding baseline characteristics and motor progression. Table S7. Correlations between progression of motor subscores with baseline demographic, clinical, Lab and imaging characteristics.

Background: Identifying the clinical phenotypes of non-motor symptoms (NMSs) of essential tremor (ET) among different populations is necessary due to their impact on the quality of life (QoL). This study aimed to investigate the clinical phenotype and impact of NMSs on QoL in Egyptian patients with ET. Methods: Thirty ET patients were compared to 30 matched controls. Subjects were evaluated by the Fahn-Tolosa-Marin Tremor Rating Scale, Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment, Hamilton Anxiety Rating Scale, Beck Depression Inventory, Pittsburgh Sleep quality Index, and the Short Form 36 Health Survey Questionnaire. Both groups were divided into two subgroups of younger (45 years, 16 patients) groups, to investigate age-related differences. Results: ET patients showed significantly worse cognition, depression, anxiety, sleep and NMSS domains (p, Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements