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An 11-year-old male Cocker Spaniel was presented with acute onset of apathy, polyuria and polydipsia. Blood examination showed hypoalbuminemia and hyperglobulinemia, while electrophoresis revealed monoclonal gammopathy. Subsequent tests showed glycosuria, proteinuria, a positive serology test for Anaplasma spp. and ultrasonographical changes of the liver and spleen. Urine electrophoresis confirmed the presence of Bence-Jones protein. The dog’s condition deteriorated, and the dog had developed skin lesions on the neck and body. The owner decided to euthanize the dog and agreed to bone marrow and skin biopsy. Bone marrow cytology revealed an increased number of plasma cells and several cellular atypia. Histopathology of the skin lesions showed a round cell tumor of lymphoid or plasmacytoid origin. Subsequent immunohistology supported the diagnosis of multiple myeloma cutaneous involvement. This case report describes unusual features observed in a dog with multiple myeloma.

Babesia canis infection occurs in many locations throughout Europe. However, various studies report different clinicopathological findings in affected dogs. This study was focused on changes in clinical and hematologic parameters in dogs with B. canis infection from eastern Slovakia.The study was prospective and included 45 dogs with suspected babesiosis. Babesia canis infection was confirmed by PCR in 34 cases and by blood smear microscopy in 24 (70.6%) of them. Hematology results, clinical examination from these dogs, and possible co-infection with other tick-borne pathogens by PCR were subsequently evaluated.The major clinical signs found included lethargy (91%), fever (59%), anorexia (59%), pigmenturia (47%) and icterus (18%). Mortality rate was 6%. Thrombocytopenia was the most common hematologic change, observed in 100% of the dogs with B. canis infection. Other frequent findings were lymphopenia (82%) and anemia (68%). No co-infections were detected. Anaplasma phagocytophilum infection was diagnosed by PCR only in one dog, which was not infected with B. canis.This study showed that B. canis infection in eastern Slovakia should be diagnosed by PCR when there is clinical suspicion of the disease, as almost 30% of the infected sick dogs did not have demonstrable parasites in their blood smear by microscopy. Lymphopenia is a frequent hematologic finding in B. canis infection and observed even more often than anemia. However, in agreement with previous studies, thrombocytopenia remains the most common hematologic finding associated with B. canis infection.