5 results on '"Holly Paden"'
Search Results
2. Dietary Impacts on Changes in Diversity and Abundance of the Murine Microbiome during Progression and Treatment of Cancer
- Author
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Holly Paden, Nikola Kurbatfinski, Jelmer W. Poelstra, Kate Ormiston, Tonya Orchard, and Sanja Ilic
- Subjects
disease progression ,Nutrition and Dietetics ,cancer ,murine microbiome ,sucrose ,alpha diversity ,omega-3 ,dietary composition ,chemotherapy ,Food Science - Abstract
The intestinal microbial population is recognized for its impact on cancer treatment outcomes. Little research has reported microbiome changes during cancer progression or the interplay of disease progression, dietary sugar/fat intake, and the microbiome through surgery and chemotherapy. In this study, the murine gut microbiome was used as a model system, and changes in microbiome diversity, richness, and evenness over the progression of the cancer and treatment were analyzed. Mice were categorized into four diet cohorts, combinations of either high or low sucrose and high or low omega-3 fatty acids, and two treatment cohorts, saline vehicle or chemotherapy, for a total of eight groups. Fecal samples were collected at specific timepoints to assess changes due to diet implementation, onset of cancer, lumpectomy, and chemotherapy. Akkermansia muciniphila abundance was very high in some samples and negatively correlated with overall Amplicon Sequence Variant (ASV) richness (r(64) = −0.55, p = 3 × 10−8). Throughout the disease progression, ASV richness significantly decreased and was impacted by diet and treatment. Alpha-diversity and differential microbial abundance were significantly affected by disease progression, diet, treatment, and their interactions. These findings help establish a baseline for understanding how cancer progression, dietary macronutrients, and specific treatments impact the murine microbiome, which may influence outcomes.
- Published
- 2023
3. Sucrose and Fat Dietary Consumption Impact on the Murine Microbiome During Progression and Treatment of Cancer
- Author
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Holly Paden, Nikola Kurbatfinski, Jelmer Poelstra, and Sanja Ilic
- Subjects
Nutrition and Dietetics ,Medicine (miscellaneous) ,Food Science - Published
- 2022
4. Assessment of Food Safety Knowledge and Behaviors of Cancer Patients Receiving Treatment
- Author
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Aashish D. Bhatt, Maryam B. Lustberg, Cassandra Grenade, D. Diaz Pardo, Anna Beery, Irene Hatsu, Holly Paden, Sanja Ilic, and Kathleen Kane
- Subjects
Male ,Health Knowledge, Attitudes, Practice ,Social Determinants of Health ,Disease ,Food Supply ,Foodborne Diseases ,0302 clinical medicine ,Risk Factors ,food insecurity ,Neoplasms ,Surveys and Questionnaires ,Medicine ,030212 general & internal medicine ,education.field_of_study ,Nutrition and Dietetics ,Food security ,Incidence (epidemiology) ,digestive, oral, and skin physiology ,General Medicine ,Middle Aged ,foodborne disease ,food safety ,030220 oncology & carcinogenesis ,Female ,lcsh:Nutrition. Foods and food supply ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,Food storage ,lcsh:TX341-641 ,Food Contamination ,Risk Assessment ,Article ,Young Adult ,03 medical and health sciences ,Environmental health ,cancer ,Humans ,Intensive care medicine ,education ,Aged ,business.industry ,Cancer ,Food safety ,medicine.disease ,Diet ,Cross-Sectional Studies ,Increased risk ,Socioeconomic Factors ,food safety knowledge ,business ,Food Science - Abstract
Cancer patients receiving treatment are at a higher risk for the acquisition of foodborne illness than the general population. Despite this, few studies have assessed the food safety behaviors, attitudes, risk perceptions, and food acquisition behaviors of this population. Further, no studies have, yet, quantified the food safety knowledge of these patients. This study aims to fill these gaps in the literature by administering a thorough questionnaire to cancer patients seeking treatment in three hospitals in a Midwest, metropolitan area. Demographic, treatment, food security, and food safety knowledge, behaviors, attitudes, risk perceptions, and acquisition information was assessed for 288 patients. Specific unsafe attitudes, behaviors, and acquisition practices were identified. Most notable is that 49.4% (n = 139) of participants were not aware that they were at increased risk of foodborne infection, due to their disease and treatment. Additionally, though patients exhibited a general understanding of food safety, the participant average for correctly answering the food safety questions was 74.77% ±, 12.24%. The section concerning food storage showed lowest participant knowledge, with an average score of 69.53% ±, 17.47%. Finally, patients reporting low food security also reported a higher incidence of unsafe food acquisition practices (P <, 0.05). These findings will help healthcare providers to better educate patients in the food safety practices necessary to decrease risk of foodborne infection, and to provide targeted food safety education to low-food-security patients.
- Published
- 2019
5. An Evaluation of Factors Predicting Diet Quality among Cancer Patients
- Author
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Sanja Ilic, Holly Paden, Cassandra Grenade, Kathleen Kane, Maryam B. Lustberg, Irene Hatsu, Dayssy Alexandra Diaz, Anna Beery, and Aashish D. Bhatt
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Psychological intervention ,Nutritional Status ,lcsh:TX341-641 ,Recommended Dietary Allowances ,Lower risk ,Affect (psychology) ,Diet Surveys ,Article ,03 medical and health sciences ,Risk Factors ,Neoplasms ,Internal medicine ,Humans ,cancer ,Medicine ,Healthcare Disparities ,Aged ,Ohio ,Aged, 80 and over ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Cancer ,Regression analysis ,diet quality ,Middle Aged ,Protective Factors ,Prognosis ,healthy eating index ,medicine.disease ,Socioeconomic Factors ,Diet quality ,Tukey's range test ,Female ,Analysis of variance ,Diet, Healthy ,business ,lcsh:Nutrition. Foods and food supply ,Nutritive Value ,Food Science - Abstract
A high diet quality is associated with a lower risk of cancer mortality. However, the predictive factors of diet quality among cancer patients are not well understood. This study determines the socio-demographic and disease-related factors that affect diet quality among cancer patients. Two hundred and forty-two cancer patients completed questionnaires assessing sociodemographic and disease-related characteristics. Diet quality was measured using the Healthy Eating Index 2010 (HEI). Independent sample t-tests and one-way ANOVA with post-hoc analysis using the Tukey HSD test were used to compare mean HEI scores across these characteristics. A regression model was used to determine factors that predicted diet quality. The overall HEI score among cancer patients was 61.59 (SD = 11.67). Patients with a high school degree or General Education Diploma (GED) or less had lower HEI scores (&beta, = &minus, 4.03, p = 0.04, &beta, 7.77, p = 0.001, respectively) compared to those with college degrees. Additionally, homemakers had significantly higher HEI scores (&beta, = 7.95, p = 0.008) compared to those who worked at least 40 hours per week. Also, individuals with some types of cancers (e.g., endometrial or uterine) had significantly higher HEI scores (&beta, = 12.56, p = 0.002) than those with other cancers (e.g., head and neck). Our findings will help oncology healthcare providers identify and target cancer patients with specific demographic characteristics who are at increased risk for consuming poor-quality diets with much needed food resource interventions.
- Published
- 2018
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