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19 results on '"Horan M"'

1. Extracorporeal membrane oxygenation in children with COVID-19

Author

Nardo, M. di, Hoskote, A., Thiruchelvam, T., Lillie, J., Horan, M., Hofheinz, S.B., Dupic, L., Gimeno, R., Piero, M.E. de, Coco, V. lo, Roeleveld, P., Davidson, M., Jones, T., Broman, L.M., Lorusso, R., Belohlavek, J., and EuroELSO Neonatal Pediat

Published
2020

2. Extracorporeal membrane oxygenation in children with COVID-19: Preliminary report from the collaborative EuroELSO prospective survey

Author

Di Nardo M, Hoskote A, Thiruchelvam T, Lillie J, Horan M, Belda Hofheinz S, Dupic L, Gimeno R, De Piero ME, Lo Coco V, Roeleveld P, Davidson M, Jones T, Broman LM, Lorusso R, Belohlavek J, and EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19

Subjects
pediatrics, inflammation, extracorporeal membrane oxygenation, severe acute respiratory syndrome coronavirus 2
Published
2020

3. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium (vol 22, pg 336, 2017)

Author

Trampush, JW, Yang, MLZ, Yu, J, Knowles, E, Davies, G, Liewald, DC, Starr, JM, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, AJ, Steen, VM, Espeseth, T, Raikkonen, K, Widen, E, Palotie, A, Eriksson, JG, Giegling, I, Konte, B, Roussos, P, Giakoumaki, S, Burdick, KE, Payton, A, Ollier, W, Horan, M, Chiba-Falek, O, Attix, DK, Need, AC, Cirulli, ET, Voineskos, AN, Stefanis, NC, Avramopoulos, D, Hatzimanolis, A, Arking, DE, Smyrnis, N, Bilder, RM, Freimer, NA, Cannon, TD, London, E, Poldrack, RA, Sabb, FW, Congdon, E, Conley, ED, Scult, MA, Dickinson, D, Straub, RE, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, AR, Weinberger, DR, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, MC, Andreassen, OA, Deary, IJ, Glahn, DC, Malhotra, AK, and Lencz, T

Subjects
Psychiatry, 17 Psychology And Cognitive Sciences, Biochemistry & Molecular Biology, Science & Technology, Neurosciences, Neurosciences & Neurology, 11 Medical And Health Sciences, 06 Biological Sciences, Life Sciences & Biomedicine
Published
2017

4. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Author

Trampush, J. W. Yang, M. L. Z. Yu, J. Knowles, E. and Davies, G. Liewald, D. C. Starr, J. M. Djurovic, S. and Melle, I. Sundet, K. Christoforou, A. Reinvang, I. and DeRosse, P. Lundervold, A. J. Steen, V. M. Espeseth, T. and Raikkonen, K. Widen, E. Palotie, A. Eriksson, J. G. and Giegling, I. Konte, B. Roussos, P. Giakoumaki, S. and Burdick, K. E. Payton, A. Ollier, W. Horan, M. and Chiba-Falek, O. Attix, D. K. Need, A. C. Cirulli, E. T. and Voineskos, A. N. Stefanis, N. C. Avramopoulos, D. and Hatzimanolis, A. Arking, D. E. Smyrnis, N. Bilder, R. M. and Freimer, N. A. Cannon, T. D. London, E. Poldrack, R. A. and Sabb, F. W. Congdon, E. Conley, E. D. Scult, M. A. and Dickinson, D. Straub, R. E. Donohoe, G. Morris, D. and Corvin, A. Gill, M. Hariri, A. R. Weinberger, D. R. and Pendleton, N. Bitsios, P. Rujescu, D. Lahti, J. Le Hellard, S. Keller, M. C. Andreassen, O. A. Deary, I. J. and Glahn, D. C. Malhotra, A. K. Lencz, T.

Abstract

The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P

Published
2017

5. A Genome-wide association study of non-pathological cognitive ageing

Author

Davies, G, Harris, S, Reynolds, C, Payton, A, Liewald, D, Lopez, L, Luciano, M, Gow, A, Corley, J, Henderson, R, Murray, C, Pattie, A, Fox, H, Redmond, P, Lutz, M, Chiba-Falek, O, Linnertz, C, Saith, S, Knight, H, Haggarty, P, McNeill, G, Ollier, W, Horan, M, Roses, A, and Ponting, C

Published
2016

6. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Author

Peters, M, Broer, L, Willemen, H, Eiriksdottir, G, Hocking, L, Holliday, K, Horan, M, Meulenbelt, I, Neogi, T, Popham, M, Schmidt, C, Soni, A, Valdes, A, Amin, N, Dennison, E, Eijkelkamp, N, Harris, T, Hart, D, Hofman, A, Huygen, F, Jameson, K, Jones, G, Launer, L, Kerkhof, H, and de Kruijf, M

Abstract

BACKGROUND AND OBJECTIVES: Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP. METHODS: We conducted a GWAS meta-analysis in 1308 female CWP cases and 5791 controls of European descent, and replicated the effects of the genetic variants with suggestive evidence for association in 1480 CWP cases and 7989 controls. Subsequently, we studied gene expression levels of the nearest genes in two chronic inflammatory pain mouse models, and examined 92 genetic variants previously described associated with pain. RESULTS: The minor C-allele of rs13361160 on chromosome 5p15.2, located upstream of chaperonin-containing-TCP1-complex-5 gene (CCT5) and downstream of FAM173B, was found to be associated with a 30% higher risk of CWP (minor allele frequency=43%; OR=1.30, 95% CI 1.19 to 1.42, p=1.2×10(-8)). Combined with the replication, we observed a slightly attenuated OR of 1.17 (95% CI 1.10 to 1.24, p=4.7×10(-7)) with moderate heterogeneity (I2=28.4%). However, in a sensitivity analysis that only allowed studies with joint-specific pain, the combined association was genome-wide significant (OR=1.23, 95% CI 1.14 to 1.32, p=3.4×10(-8), I2=0%). Expression levels of Cct5 and Fam173b in mice with inflammatory pain were higher in the lumbar spinal cord, not in the lumbar dorsal root ganglions, compared to mice without pain. None of the 92 genetic variants previously described were significantly associated with pain (p>7.7×10(-4)). CONCLUSIONS: We identified a common genetic variant on chromosome 5p15.2 associated with joint-specific CWP in humans. This work suggests that CCT5 and FAM173B are promising targets in the regulation of pain.

Published
2016

7. Besteht ein Zusammenhang zwischen subcoracoidalem Impingement und Läsionen des Rotatorenintervalls?

Author

Braun, S., Elser, F., Horan, M. P., and Millett, P. J.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Pathologien des Rotatorenintervalls (RI) können eine häufig leicht übersehene Ursache von Schulterbeschwerden sein. Ein verringerter coracohumeraler Intervall (CHI) kann der Auslöser eines subcoracoidalen Impingements und resultierender Schulterschmerzen sein. Der [for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2009

8. Impacts, vulnerability and adaptation in key South African sectors: an input into the Long Term Mitigation Scenarios process

Author

Midgley, G, Chapman, R, Mukheibir, P, Tadross, M, Hewitson, B, Wand, S, Schulze, R, Lumsden, T, Horan, M, Warburton, M, Kgope, B, Mantlana, B, Knowles, A, Abayomi, A, Ziervogel, G, Cullis, R, Theron, A, Energy Research Centre, and Faculty of Engineering and the Built Environment

Subjects
Long Term Mitigation Scenarios, Energy policy
Abstract

Ten free-standing chapters make up this report, and this Executive Summary and supporting Synthesis Report serve to draw together the main findings in both an abbreviated and an extended and illustrated format that focuses on main findings, but also adds a level of detail for the purpose of communicating the key results, and the uncertainties associated with them, for the benefit of a policy maker. The chapters that make up this report are compiled as separate documents as follows. These are generally reviews of the literature available, but in some cases comprise new work that has been carried out to provide information in an area that is lacking an assessment.

Published
2007

14. Fertility Preservation in Adolescent Males

Author

Horan M, Hartigan L, Groarke H, Louise Glover, Owens C, and Wingfield M

Subjects
Cryopreservation, Male, Semen Analysis, Adolescent, Semen, Neoplasms, Fertility Preservation, Humans, Child, Semen Preservation
Abstract

Aim Survival rates of childhood cancer are now above 80%, so there is increasing emphasis on survivorship. A major late effect of cancer treatment is fertility loss. International best practice indicates that post-pubertal boys with cancer should be offered sperm cryopreservation prior to treatment. The aim of this study was to demonstrate the feasibility of a national sperm cryopreservation program for adolescent males and to examine outcomes for a pilot. Methods Patient demographics and semen parameters of adolescent male oncology patients referred to our service were analysed. Sperm analyses were performed in accordance with WHO guidelines. Results Fifteen patients were referred, 12 of whom (80%) attempted sperm production. Of these 12 samples, 25% (3/12) were unsuitable for freezing. One patient was too unwell to produce a sample. Eight patients (age range 12-17 years) had sperm successfully cryopreserved. Of these 8 samples, 25% were within WHO 'normal' limits, 50% had reduced sperm concentration. The number of cryopreserved samples (straws) ranged from 4-8 per patient. Conclusion We have established a successful, structured fertility preservation service for adolescent males in Ireland. Sperm cryopreservation is an accessible method of safeguarding fertility in male patients facing cancer treatment and should be offered to all.

19. Performance of the pediatric logistic organ dysfunction-2 score in critically ill children requiring plasma transfusions

Author

Alvin Yiu, Suzan Cochius-den Otter, David Inwald, Rica Morzov, Stephen McKeever, Laura Campbell, Marie E. Steiner, Tracey Bushell, Aurélie Portefaix, Manuel Nieto Faza, Dan Nerheim, Marisa Tucci, Simon Erickson, Maria Teresa Alonso, Melissa Thomas, Amanda Johnson, Marc Andre Dugas, Miriam Rea, Petr Jirasek, David McKinley, Melania M. Bembea, Jennifer Sankey, Isobel MacLeod, Pierre Louis Leger, Elizabeth Scarlett, Marisa Vieira, Joan Balcells, Anna Deho, Erin Felkel, Amina Abdulla, Shancy Rooze, Maria José Solana, Davinia E. Withington, Scot T. Bateman, Arash Afshari, Olivier Brissaud, Peter Davis, Etienne Javouhey, Marcy Singleton, Pierre Tissieres, Stéphan Clénent de Cléty, Barry P. Markovitz, Lee Ann M. Christie, Carmel Delzoppo, Kelly Michelson, Lois Sanders, Anne Mette Baek Jensen, Tavey Dorofaeff, Nicola Kelly, Fleur Cour-Andlauer, John Beca, Maria Pisarcikova, Matthieu Maria, Miriam Santschi, Claire Sherring, Pierre Demaret, Simon J. Stanworth, Lasse Hoegh Andersen, Michael C. McCrory, Antonio Morales Martinez, Ariane Willems, Debbie Spear, Debbie Long, Douglas F. Willson, Sophie Raghunanan, Marc Trippaerts, Marianne E. Nellis, Caroline P. Ozment, Bettina Von Dessauer, Jennifer A. Muszynski, Nicolas Roullet-Renoleau, Saleh Alshehri, Bob Taylor, Annick De Jaeger, Sheila J. Hanson, Julie Guichoux, Nathan Smalley, Jesús López-Herce, Aimée Dorkenoo, Barney Scholefield, Sholeen Nett, Gavin Morrison, Marie-Hélène Perez, Christopher Babbitt, Dean Jarvis, Alice Bordessoule, Gunnar Bentsen, Kevin O’Brien, Katherine Woods, Marta Vazquez Moyano, Carsten Doell, Jens Christian Nilsson, Santiago Campos Mino, Vivianne Amiet, Samuel J. Ajizian, Karen Choong, Audrey Breining, Oliver Karam, Anna Camporesi, Kym Bain, Guillaume Mortamet, Richard Levin, Antonio Perez-Ferrer, Alain Duhamel, Janice Tijssen, Caroline Berghe, Marie Horan, Kathy Murkowski, Margaret M. Parker, Michelle Hoot, Tatsuya Kawasaki, Liz Rourke, Hannah Sparkes, Gordon Krahn, Lisa Steele, Andrew Michael, David Triscari, Jay Rilinger, David Wensley, Iolanda Jordan, Minal Parikh, Stéphane Leteurtre, Manal Alasnag, Jozef De Dooy, Alison Shefler, Nadia Ordenes, Nicolas Joram, Katie McCall, Daniel Martin, Jill M. Cholette, Renee A. Higgerson, Shira Gertz, Asumthia Jeyapalan, Marta Moniz, S. Faustino, Jose Carlos Flores González, Machelle Zink, Valerie Payen, Satnam Virdee, Edward J. Truemper, Julia Hickey, Elaine Gilfoyle, Federica Mario, Mariana Dumitrascu, Vanessa Rea, Joe Brierley, Gabriela Pereira, Lynette Wohlgemuth, Victoria Brown, Berber Kapitein, E. Vincent, Vicki L. Montgomery, Harry Steinherr, Kay C. Hawkins, Greg Wiseman, Mathias Johansen, Glenn Levine, Louise Gosselin, Warwick Butt, Jesús de Vicente Sánchez, Susan George, Amanda Galster, Alexandra Dinis, Filippia Nikolaou, Jeff Terry, Michelle Grunauer, Philip C. Spinella, Martin C. J. Kneyber, Shinya Miura, Mickael Afanetti, Andrea Kelleher, Neal J. Thomas, Kim Sykes, Anke Top, CHU Lille, Université de Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, University of Oxford, University of Washington [Seattle], John Radcliffe Hospital [Oxford University Hospital], CHU Sainte Justine [Montréal], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of Oxford [Oxford], PlasmaTV investigators, Butt, W., Delzoppo, C., Bain, K., Erickson, S., Smalley, N., Dorofaeff, T., Long, D., Wiseman, G., Clénent de Cléty, S., Berghe, C., de Jaeger, A., Demaret, P., Trippaerts, M., Willems, A., Rooze, S., De Dooy, J., Gilfoyle, E., Wohlgemuth, L., Tucci, M., Dumitrascu, M., Withington, D., Hickey, J., Choong, K., Sanders, L., Morrison, G., Tijssen, J., Wensley, D., Krahn, G., Dugas, M.A., Gosselin, L., Santschi, M., Von Dessauer, B., Ordenes, N., Afshari, A., Andersen, L.H., Nilsson, J.C., Johansen, M., Baek Jensen, A.M., Campos Mino, S., Grunauer, M., Joram, N., Roullet-Renoleau, N., Javouhey, E., Cour-Andlauer, F., Portefaix, A., Brissaud, O., Guichoux, J., Payen, V., Léger, P.L., Afanetti, M., Mortamet, G., Maria, M., Breining, A., Tissieres, P., Dorkenoo, A., Deho, A., Steinherr, H., Nikolaou, F., Camporesi, A., Mario, F., Kawasaki, T., Miura, S., Beca, J., Rea, M., Sherring, C., Bushell, T., Bentsen, G., Dinis, A., Pereira, G., Vieira, M., Moniz, M., Alshehri, S., Alasnag, M., Pisarcikova, M., Jordan, I., Balcells, J., Perez-Ferrer, A., de Vicente Sánchez, J., Vazquez Moyano, M., Morales Martinez, A., Lopez-Herce, J., Solana, M.J., Flores González, J.C., Alonso, M.T., Nieto Faza, M., Perez, M.H., Amiet, V., Doell, C., Bordessoule, A., Cochius-den Otter, S., Kapitein, B., Kneyber, M., Brierley, J., Rea, V., McKeever, S., Kelleher, A., Scholefield, B., Top, A., Kelly, N., Virdee, S., Davis, P., George, S., Hawkins, K.C., McCall, K., Brown, V., Sykes, K., Levin, R., MacLeod, I., Horan, M., Jirasek, P., Inwald, D., Abdulla, A., Raghunanan, S., Taylor, B., Shefler, A., Sparkes, H., Hanson, S., Woods, K., Triscari, D., Murkowski, K., Ozment, C., Steiner, M., Nerheim, D., Galster, A., Higgerson, R., Christie, L., Spinella, P.C., Martin, D., Rourke, L., Muszynski, J., Steele, L., Ajizian, S., McCrory, M.C., O'Brien, K., Babbitt, C., Felkel, E., Levine, G., Truemper, E.J., Zink, M., Nellis, M., Thomas, N.J., Spear, D., Markovitz, B., Terry, J., Morzov, R., Montgomery, V., Michael, A., Thomas, M., Singleton, M., Jarvis, D., Nett, S., Willson, D., Hoot, M., Bembea, M., Yiu, A., McKinley, D., Scarlett, E., Sankey, J., Parikh, M., Faustino, EVS, Michelson, K., Rilinger, J., Campbell, L., Gertz, S., Cholette, J.M., Jeyapalan, A., Parker, M., Bateman, S., Johnson, A., UCL - (SLuc) Service de soins intensifs, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
medicine.medical_specialty, Population, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology, Organ Dysfunction Scores, Internal medicine, medicine, 030212 general & internal medicine, 10. No inequality, Intensive care medicine, education, Children, Outcome, Pediatric intensive care unit, education.field_of_study, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, ddc:618, business.industry, Mortality rate, Research, Organ dysfunction, Score, Critical care, Multiple organ failure, Plasma transfusion, 030208 emergency & critical care medicine, Clinical trial, PlasmaTV investigators, Observational study, medicine.symptom, business
Abstract

BACKGROUND: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions.METHODS: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).RESULTS: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.CONCLUSIONS: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.

Published
2016

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