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Two new phenolic glycosides (1 and 2), one known analogue (3), along with a new diterpene glucoside (4) were obtained from ethanolic extract of the stems of Eurya chinensis R. Br. The structures of these isolated compounds were identified by extensive analysis of HRESIMS and NMR spectroscopic data. The cytotoxicities of these compounds were evaluated on MCF-7, A549, HepG2, CaCo2 and 5-8 F cell lines by MTT method, but no obvious activities were observed.

Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC50 value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect.

Jiao Zhu,1 Bo Li,1 Juan Juan Hu,1 Weiping Liu,2 Dan Lu,1 Jun Liu1 1Department of Otorhinolaryngology Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Pathology, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Dan Lu; Jun LiuDepartment of Otorhinolaryngology Head & Neck Surgery, West China Hospital, Sichuan University, Wuhou Distrcit, Chengdu, People’s Republic of ChinaEmail dashijie001@163.com; hxheadneckjunl@163.comAbstract: Undifferentiated small round cell sarcoma (USRCS) is a rare malignant tumor. No reports about USRCS of the postcricoid region of the hypopharynx are available, and its clinical features and treatment guidelines remain undefined. We report a case of USRCS of the postcricoid region of the hypopharynx with treatment of surgery and radiotherapy. A 50-year-old man presented with a 4.9 cm x 3.7 cm tumor in the postcricoid region of the hypopharynx. It was diagnosed as USRCS. The tumor showed small round cells and positive immunoexpression of CD56, Cyclin D1, TLE1 and CD99, but no rearrangement or fusion of EWSR1, SS18, CIC, and BCOR. The patient underwent radiotherapy after surgery, without signs of tumor progression and metastasis at the 9-month follow-up. In conclusion, USRCS of postcricoid region of hypopharyngeal is ultra-rare. To make diagnosis, pathological examination is necessary. Surgery followed by radiotherapy might offer an optional treatment for USCRS.Keywords: hypopharynx, sarcoma, immunohistochemistry, case report