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Recently, observational hints for supermassive black holes have been accumulating, which has inspired ones to wonder: Can primordial black holes (PBHs) be supermassive, in particular with the mass $M\gtrsim 10^{9}M_\odot$? A supercritical bubble (with an inflating baby universe inside it) that nucleated during inflation can develop into a PBH in our observable Universe. Here, we find that when the inflaton slowly passes by a neighboring vacuum, the nucleating rate of supercritical bubbles would inevitably attain a peak, so the mass distribution of multiverse PBHs, and the mass of peak can be up to $M\gtrsim 10^{11}M_\odot$. Thus our mechanism naturally provides a primordial origin of supermassive BHs., Comment: 15 pages, 4 figures

The upper part of a pier wharf on the sea is usually made up of the horizontal panels with both longitudinal and transverse beams above the still water level. To estimate the wave force on the structures, many scholars have conducted theoretical and experimental researches, and proposed a lot of empirical equations concerning the wave force and corresponding pressure distribution. Nevertheless, due to the complex factors and changeable girder systems, the generation mechanism of wave uplifting forces has not been fully understood so far, and the discreteness and limitations of experimental data lead to vastly difference between various empirical formulas, which causes that the calculated wave forces using different formulas differ by ten times. Therefore, it is necessary to determine wave the uplifting force and horizontal force on girder structures by conducting physical model experiments. In the present study, the physical model experiments with a scale of 1:40 are used to measure the wave forces on the wharf platform, abutment and pile foundations under different combinations of water level and waves at Petrochemical Wharf, Haicang Harbor, Xiamen. The experiment results have already been adopted in practice by some design institutes.

Sarcomatoid carcinoma (SC) is a rare primary malignant tumor in which both carcinomatous and sarcomatous elements occur. It can occur in many different organs and anatomical locations, such as the skin, thyroid gland, bone, urinary tract, breast, pancreas, liver and other areas. Of them, pulmonary sarcomatoid carcinoma (PSC) is a rare malignant cancer composed of sarcoma and sarcoma-like tumors with spindle or giant cell features. Here a case of a 75-year-old Chinese man with a six-month history of cough and hemoptysis is reported. Chest X-ray showed a tumor shadow in the left lung field. Chest computed tomography (CT) scan showed a lobulated mass in his left hilum and even the left pulmonary artery. Pleomorphic interstitial cells were found by bronchoscopic brushing. To establish a definitive diagnosis for PSC, a left pneumonectomy was performed. The pathological stage was IIB (pT2N1M0) based on the tumor node metastasis (TNM) staging system. The tumor's pathology, histology, immunohistochemistry and treatment methods are discussed.

To build a scientific and efficient Distribution Management System (DMS), it is necessary to achieve sharing of data and avoid information silos. The IEC61968-based information exchange platform, which adopts IEC61968 Information Exchange Model (IEM) and interface specification, is an effective means to resolve the above problem, realizing seamless data exchange and sharing of data between various subsystems. It is shown by applications that, the adapters for multi-system interfaces are simple and practical, ensuring efficient communication for data exchange, and meeting requirements for data exchange and sharing of data between various subsystems. This platform effectively solves the problem of information silos, laying a solid foundation for development of smart grid information technology.

Concept lattice is an effective tool for data analysis and rule extraction, a bottleneck factor on impacting the applications of concept lattice is how to generate lattice efficiently. In this paper, an algorithm LCLG on generating lattice in batch processing based on layered concept lattice is developed, this algorithm is based on layered concept lattice, the lattice is generated downward layer by layer through concept nodes and provisional nodes in current layer; the concept nodes are found parent-child relationships upward layer by layer, then the Hasse diagram of inter-layer connection is generated; in the generated process of the lattice nodes in each layer, we do the pruning operations dynamically according to relevant properties, and delete some unnecessary nodes, such that the generating speed is improved greatly; the experimental results demonstrate that the proposed algorithm has good performance. DOI: http://dx.doi.org/10.11591/telkomnika.v11i8.3063

In this paper, a frequent itemsets mining algorithm of data stream based on concept lattice and sliding window is presented. This algorithm mines frequent concepts for new inflowing basic window in batches in a sliding window and generates concept lattice Hasse diagram. With introduction into small support degreeand error factorto do the pruning operations for non-frequent concept node, each connection point in the Hasse diagram contains the information of frequent itemsets and support degree. As the generation of Hasse diagram in the new basic windows, we integrate concept lattice vertically with the generated Hasse diagram and sliding window, and ultimately output all frequent itemsets through scanning all the graph nodes of Hasse diagram graph. The experimental results show that the proposed algorithm has a good performance. DOI: http://dx.doi.org/10.11591/telkomnika.v11i8.3140

A Manufacturing Execution System for Mass Customization (MESMC) is a rather important system to perform Mass Customization Manufacturing efficiently. In this paper, the characteristics of MESMC are analyzed, and “four aspects” of the characteristics are summed up, which are the diversity of Customization tasks, the changeability of manufacturing process, the feedback of information and the customer participation in manufacturing process. In order to meet the requirements of the “four aspects”, a new MES mode, Manufacturing Execution System based on Equipment Networked Operation (MES-ENO), is proposed, and an applicable architecture is constructed. A successful case study shows the MES-ENO is practical.

Aim of the study Hepatocellular carcinoma suppressor 1 (HCCS1) has been identified as a tumor suppressor gene in the high-frequency loss of heterozygosity (LOH) region on chromosome 17p13.3 in hepatocellular carcinoma (HCC). There was also a high frequency of LOH on chromosome 17p13.3 in non-small cell lung cancer (NSCLC). Therefore, the aim of this study was to explore the expression of HCCS1 in NSCLC as well as its clinical significance. Material and methods Real-time PCR and immunohistochemistry were performed to detect the expression level of HCCS1 mRNA and protein in NSCLC and noncancerous tissues, respectively. Further, we explored the relationship between HCCS1 expression and various clinical features in NSCLC. Results The mRNA and protein expression of HCCS1 were both significantly lower in NSCLC samples than those in noncancerous tissues. That is, the mRNA level of HCCS1 was 0.0044 ±0.0036 and 0.0067 ±0.0054 in NSCLC samples and noncancerous tissues, respectively. The protein level of HCCS1 was 4.67 ±1.15 and 6.13 ±1.24 in NSCLC samples and noncancerous tissues, respectively. Importantly, this difference in expression was significantly correlated with tumor lymph node metastasis (TNM) in NSCLC (p < 0.05), but not with gender and age of the patients, pathological types, TNM stages, or grades of cancers (p > 0.05). Conclusion Our results suggest that HCCS1 may be involved in NSCLC carcinogenesis.

In this paper, a Agile Model of General report system by using MDA technology is studied according to the characterstics of general report system. A architecture of agile general report system based on MDA is constructed, and report basic model by using MDA is designed for general report system. Based on MDA methodology, the basic elements and styles of report are designed into configurable model, and a PIM was built with UML for the agile general report system. The agile general report system based on MDA improves efficiency and the capability and scalbility of the whole system. The system can be applied to different system with good performance through an applied test.