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Tumor is a metabolic disease. The effect of oncogene expression on the metabolism of cancer cells is one of the hotspots in cancer research. In this study, 1H NMR-based metabonomics analysis was used to explore the metabolic characteristics of glioma cell lines with low expression of SIRT7, and to identify the characteristic metabolites and metabolic pathways related to the expression of SIRT7. The results showed that there were significant differences in metabolic profiles between the SIRT7 low expression group and the control group, and 22 aqueous metabolites were found to vary significantly. Compared with the control group, the concentration of 12 metabolites including lactate, glycine, and glutamate, and so on, increased in SIRT7 low expression glioma cell lines, while the concentration of 10 metabolites such as valine, leucine, lysine, et al. decreased. Pathway enrichment analysis indicated that the metabolic pathways of aminoacyl-tRNA biosynthesis, tyrosine metabolism, and so on, were closely related to the low expression of SIRT7. The results provide a theoretical basis for further mechanism elucidation of SIRT7 regulating glioma cell metabolism.

The directional characteristic of the parallel coupled printed dipole is analyzed in this paper. The balun structure is used as the feed structure. The far-field pattern of this antenna is formulated, and an example is simulated by using HFSS. The center frequency of this example operates at 5.5 GHz and it has about bandwidth of 20%. The simulated results demonstrate its directional characteristic.