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Your search keyword '"Inclusion Bodies/pathology"' showing total 2 results
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2 results on '"Inclusion Bodies/pathology"'

1. Hepatocellular type II fibrinogen inclusions in a patient with severe COVID-19 and hepatitis

Author

Lorenzo Alberio, Marguerite Neerman-Arbez, Montserrat Fraga, Darius Moradpour, Alessandro Casini, Antoine G. Schneider, Haithem Chtioui, Christine Sempoux, Elodie Romailler, Florent Artru, and Jonathan Tschopp

Subjects
0301 basic medicine, Risk, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Low-Molecular-Weight/therapeutic use, ground-glass hepatocyte, Fibrinogen, Article, Venous Thromboembolism/epidemiology/prevention & control, Betacoronavirus/isolation & purification, COVID-19, Coronavirus Infections/diagnosis, Coronavirus Infections/physiopathology, Diagnosis, Differential, Fibrinogen/analysis, Glycogen Storage Disease Type IV/diagnosis, Hepatitis/etiology, Hepatitis/pathology, Hepatitis/physiopathology, Hepatitis B, Chronic/diagnosis, Humans, Inclusion Bodies/pathology, Lafora Disease/diagnosis, Liver/diagnostic imaging, Liver/pathology, Liver Function Tests/methods, Male, Middle Aged, Pandemics, Patient Care Management/methods, Pneumonia, Ventilator-Associated/therapy, Pneumonia, Viral/diagnosis, Pneumonia, Viral/physiopathology, Pulmonary Embolism/diagnosis, Pulmonary Embolism/etiology, Pulmonary Embolism/physiopathology, Respiration, Artificial/adverse effects, Respiration, Artificial/methods, SARS-CoV-2, Treatment Outcome, Pulmonary Embolism/epidemiology/prevention & control, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Internal medicine, fibrinogen storage disease, Medicine, hepatitis, ddc:576.5, cardiovascular diseases, Heparin/therapeutic use, Hepatitis, ddc:616, Hepatology, business.industry, Critically ill, Heparin, Guidance documents, Pneumonia, medicine.disease, equipment and supplies, Viral/epidemiology, 030104 developmental biology, Anticoagulants/therapeutic use, Fondaparinux/therapeutic use, Practice Guidelines as Topic, Venous Thrombosis/epidemiology/prevention & control, 030211 gastroenterology & hepatology, Coronavirus Infections/epidemiology, Differential diagnosis, business, Venous thromboembolism, medicine.drug
Abstract

Many centres have noticed a high number of venous thromboembolism (VTE) events among critically ill inpatients with COVID-19 pneumonia. The aims of this study were (1) to summarise the reported risk of VTE associated with COVID-19 infections and (2) to summarise guidance documents on thromboprophylaxis in COVID-19 patients, in a systematic review.

Published
2020

2. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length

Author

Nicole Déglon, Luís Pereira de Almeida, Patrick Aebischer, Christopher A. Ross, and Diana Zala

Subjects
Huntingtin, Mutant, Wistar, Gene Expression, Peptides/ genetics, Neural degeneration, Cell Nucleus/pathology, Corpus Striatum/drug effects/metabolism/ pathology, Inclusion Bodies/pathology, Nerve Tissue Proteins/biosynthesis/ genetics/toxicity, Tissue Distribution, Phosphoglycerate kinase 1, Promoter Regions, Genetic, Inclusion Bodies, education.field_of_study, Huntingtin Protein, Huntington Disease/genetics/ pathology, Blotting, General Neuroscience, Gene Transfer Techniques, Nuclear Proteins, Genetic Vectors/administration & dosage/genetics, Phosphoproteins/metabolism, Huntington Disease, Female, Promoter Regions (Genetics), Drug, Western, congenital, hereditary, and neonatal diseases and abnormalities, Dopamine and cAMP-Regulated Phosphoprotein 32, Microinjections, Blotting, Western, Genetic Vectors, Nerve Tissue Proteins, Biology, Animals, Cell Line, Corpus Striatum/drug effects, Corpus Striatum/metabolism, Disease Models, Animal, Dose-Response Relationship, Drug, Genetic Vectors/administration & dosage, Genetic Vectors/genetics, Humans, Huntington Disease/genetics, Huntington Disease/pathology, Lentivirus/genetics, Mutation, Nerve Tissue Proteins/biosynthesis, Nerve Tissue Proteins/genetics, Nuclear Proteins/biosynthesis, Nuclear Proteins/genetics, Peptides/genetics, Rats, Rats, Wistar, Trinucleotide Repeat Expansion, Dose-Response Relationship, Huntington's disease, Genetic model, mental disorders, medicine, ARTICLE, education, Cell Nucleus, Animal, Lentivirus, medicine.disease, Phosphoproteins, Molecular biology, Nuclear Proteins/biosynthesis/ genetics/toxicity, Corpus Striatum, nervous system diseases, nervous system, Disease Models, Trinucleotide repeat expansion, Peptides
Abstract

A new strategy based on lentiviral-mediated delivery of mutant huntingtin (htt) was used to create a genetic model of Huntington's disease (HD) in rats and to assess the relative contribution of polyglutamine (CAG) repeat size, htt expression levels, and protein length on the onset and specificity of the pathology. Lentiviral vectors coding for the first 171, 853, and 1520 amino acids of wild-type (19 CAG) or mutant htt (44, 66, and 82 CAG) driven by either the phosphoglycerate kinase 1 (PGK) or the cytomegalovirus (CMV) promoters were injected in rat striatum. A progressive pathology characterized by sequential appearance of ubiquitinated htt aggregates, loss of dopamine- and cAMP-regulated phosphoprotein of 32 kDa staining, and cell death was observed over 6 months with mutant htt. Earlier onset and more severe pathology occurred with shorter fragments, longer CAG repeats, and higher expression levels. Interestingly, the aggregates were predominantly located in the nucleus of PGK-htt171-injected rats, whereas they were present in both the nucleus and processes of CMV-htt171-injected animals expressing lower transgene levels. Finally, a selective sparing of interneurons was observed in animals injected with vectors expressing mutant htt. These data demonstrate that lentiviral-mediated expression of mutant htt provides a robust in vivo genetic model for selective neural degeneration that will facilitate future studies on the pathogenesis of cell death and experimental therapeutics for HD.

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