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7 results on '"Ingunn Þorsteinsdóttir"'

1. Prevalence of smoldering multiple myeloma based on nationwide screening

Author

Sigrún Thorsteinsdóttir, Gauti K. Gíslason, Thor Aspelund, Sæmundur Rögnvaldsson, Jón Þórir Óskarsson, Guðrún Á Sigurðardóttir, Ásdís R. Þórðardóttir, Brynjar Viðarsson, Páll T. Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Elías Eyþórsson, Ásbjörn Jónsson, Oscar Berlanga, Malin Hultcrantz, Brian G. M. Durie, Thorvardur J. Löve, Stephen Harding, Ola Landgren, and Sigurður Y. Kristinsson

Subjects
General Medicine, General Biochemistry, Genetics and Molecular Biology
Published
2023
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2. Correction: Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies

Author

Sæmundur Rögnvaldsson, Thorvardur Jon Love, Sigrun Thorsteinsdottir, Elín Ruth Reed, Jón Þórir Óskarsson, Íris Pétursdóttir, Guðrún Ásta Sigurðardóttir, Brynjar Viðarsson, Páll Torfi Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Ásdís Rósa Þórðardóttir, Elías Eyþórsson, Ásbjörn Jónsson, Andri S. Björnsson, Gunnar Þór Gunnarsson, Runólfur Pálsson, Ólafur Skúli Indriðason, Gauti Kjartan Gíslason, Andri Ólafsson, Guðlaug Katrín Hákonardóttir, Manje Brinkhuis, Sara Lovísa Halldórsdóttir, Tinna Laufey Ásgeirsdóttir, Hlíf Steingrímsdóttir, Ragnar Danielsen, Inga Dröfn Wessman, Petros Kampanis, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, and Sigurður Yngvi Kristinsson

Subjects
Oncology, Hematology
Published
2023
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3. Author Correction: Prevalence of smoldering multiple myeloma based on nationwide screening

Author

Sigrún Thorsteinsdóttir, Gauti K. Gíslason, Thor Aspelund, Sæmundur Rögnvaldsson, Jón Þórir Óskarsson, Guðrún Á Sigurðardóttir, Ásdís R. Þórðardóttir, Brynjar Viðarsson, Páll T. Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Elías Eyþórsson, Ásbjörn Jónsson, Oscar Berlanga, Malin Hultcrantz, Brian G. M. Durie, Thorvardur J. Löve, Stephen Harding, Ola Landgren, and Sigurður Y. Kristinsson

Subjects
General Medicine, General Biochemistry, Genetics and Molecular Biology
Published
2023
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4. Predicting the Need for Upfront Bone Marrow Sampling in Individuals with MGUS: Derivation of a Multivariable Prediction Model Using the Prospective Population-Based Istopmm Cohort

Author

Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Elin Ruth Reed, Gudrún Ásta Sigurdardóttir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ísleifur Ólafsson, Ingunn Þorsteinsdóttir, Signy Vala Sveinsdottir, Fridbjorn Sigurdsson, Ásdis Rósa Thórdardottir, Runolfur Palsson, Olafur Indridason, Thorir Einarsson Long, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Hlif Steingrimsdottir, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Thor Aspelund, Thorvardur Jon Love, and Sigurdur Y Kristinsson

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
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5. OAB-037: Detection of abnormal plasma cells by multiparameter flow cytometry in a screened cohort of patients with monoclonal gammopathy of undetermined significance

Author

Jón Þórir Óskarsson, Sæmundur Rögnvaldsson, Sigrún Þorsteinsdóttir, Íris Pétursdóttir, Hrafnhildur Una Þórðardóttir, Steinar Bragi Gunnarsson, Guðlaug Katrín Hákonardóttir, Guðrún Ásta Sigurðardóttir, Ásdís Rósa Þórðardóttir, Gauti Kjartan Gíslason, Andri Ólafsson, Jón Kristinn Sigurðsson, Brynjar Viðarsson, Páll Torfi Önundarson, Bjarni A. Agnarsson, Róbert Pálmason, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Brian Durie, Þorvarður Jón Löve, and Sigurður Yngvi Kristinsson

Subjects
Cancer Research, Oncology, Hematology
Published
2022
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7. Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies

Author

Ola Landgren, Andri Olafsson, Margrét Sigurðardóttir, Asbjorn Jonsson, Manje Brinkhuis, Ásdís Rósa Þórðardóttir, Hlif Steingrimsdottir, Gunnar Þór Gunnarsson, Stephen E. Harding, Runolfur Palsson, Gauti Kjartan Gislason, Pall T. Onundarson, Guðlaug Katrín Hákonardóttir, Andri S. Bjornsson, Malin Hulcrantz, Ólafur Skúli Indriðason, Elin Ruth Reed, Ingunn Þorsteinsdóttir, Elías Sæbjörn Eyþórsson, Brian G.M. Durie, Sigurður Yngvi Kristinsson, Sara Lovísa Halldórsdóttir, Petros Kampanis, Tinna Laufey Ásgeirsdóttir, Thorvardur Jon Love, Jón Þórir Óskarsson, Inga Wessman, Brynjar Viðarsson, Bjarni A. Agnarsson, Iris Petursdottir, Sigrun Thorsteinsdottir, Ragnar Danielsen, Sæmundur Rögnvaldsson, Isleifur Olafsson, and Guðrún Ásta Sigurðardóttir

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Population, Iceland, Myeloma, Early Therapy, Monoclonal Gammopathy of Undetermined Significance, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Randomized controlled trial, Risk Factors, law, Informed consent, Humans, Medicine, education, RC254-282, Aged, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, education.field_of_study, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Hematology, Middle Aged, medicine.disease, Biobank, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Randomized controlled trials, Disease Progression, Female, Multiple Myeloma, business, Monoclonal gammopathy of undetermined significance, Follow-Up Studies, Blood sampling
Abstract

Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma study (iStopMM), the first population-based screening study for MGUS including a randomized trial of follow-up strategies. Icelandic residents born before 1976 were offered participation. Blood samples are collected alongside blood sampling in the Icelandic healthcare system. Participants with MGUS are randomized to three study arms. Arm 1 is not contacted, arm 2 follows current guidelines, and arm 3 follows a more intensive strategy. Participants who progress are offered early treatment. Samples are collected longitudinally from arms 2 and 3 for the study biobank. All participants repeatedly answer questionnaires on various exposures and outcomes including quality of life and psychiatric health. National registries on health are cross-linked to all participants. Of the 148,704 individuals in the target population, 80 759 (54.3%) provided informed consent for participation. With a very high participation rate, the data from the iStopMM study will answer important questions on MGUS, including potentials harms and benefits of screening. The study can lead to a paradigm shift in MM therapy towards screening and early therapy.

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