Author: "Inst Hosp del Mar Invest Med" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

6 results on '"Inst Hosp del Mar Invest Med"'

1. Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study

Author: Lopez Montesinos, Inmaculada, Gomez-Zorrilla, Silvia, Palacios-Baena, Zaira Raquel, Prim, Nuria, Echeverria-Esnal, Daniel, Gracia, Maria Pilar, Montero, Maria Milagro, Duran-Jorda, Xavier, Sendra, Elena, Sorli, Luisa, Guerri-Fernandez, Roberto, Padilla, Eduardo, Grau, Santiago, Horcajada, Juan Pablo, PROA PSMAR grp, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, [Lopez Montesinos, Inmaculada] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Gomez-Zorrilla, Silvia] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Montero, Maria Milagro] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Sendra, Elena] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Sorli, Luisa] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Guerri-Fernandez, Roberto] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Horcajada, Juan Pablo] Univ Pompeu Fabra, Spanish Network Res Infect Dis REIPI, Inst Hosp del Mar Invest Med IMIM, Infect Dis Serv,Hosp del Mar,Infect Pathol & Anti, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Palacios-Baena, Zaira Raquel] Univ Hosp Virgen Macarena, Inst Biomed Seville IBIS, Unit Infect Dis & Clin Microbiol, Ave Dr Fedriani 3, Seville 41009, Spain, [Prim, Nuria] Lab Referencia Catalunya, Microbiol Serv, Carrer Selva 10, El El Prat De Llobregat 08820, Barcelona, Spain, [Padilla, Eduardo] Lab Referencia Catalunya, Microbiol Serv, Carrer Selva 10, El El Prat De Llobregat 08820, Barcelona, Spain, [Echeverria-Esnal, Daniel] Univ Pompeu Fabra, Inst Hosp del Mar Invest Med IMIM, Hosp del Mar, Pharm Serv,Infect Pathol & Antimicrobials Res Grp, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Grau, Santiago] Univ Pompeu Fabra, Inst Hosp del Mar Invest Med IMIM, Hosp del Mar, Pharm Serv,Infect Pathol & Antimicrobials Res Grp, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Gracia, Maria Pilar] Univ Pompeu Fabra, Inst Hosp del Mar Invest Med IMIM, Hosp del Mar, Intens Care Unit Serv, Passeig Maritim Barceloneta 25,29, Barcelona 08003, Spain, [Duran-Jorda, Xavier] Inst Hosp del Mar Invest Med IMIM, Methodol & Biostat Support Unit, Carrer Dr Aiguader 88, Barcelona 08003, Spain, Ministerio de Economia y competitividad of Spain, Instituto de Salud Carlos III, European Development Regional Fund 'A way to achieve Europe' (ERDF), Operative program Intelligent Growth 2014-2020, and Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)
Subjects: Microbiology (medical), medicine.medical_specialty, medicine.drug_class, Cefepime, Antibiotics, Ceftazidime, Aztreonam, Antimicrobial stewardship, chemistry.chemical_compound, Sepsis, Internal medicine, Medicine, Extensively drug-resistant Pseudomonas aeruginosa, Mortality, Amikacin, business.industry, Colistin, medicine.disease, Urinary tract infections, Infectious Diseases, chemistry, Bacteremia, SOFA score, business, medicine.drug
Abstract: [Introduction] Extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or polymyxin monotherapy versus other antibiotic regimens (carbapenems, aztreonam, ceftazidime, cefepime, ceftolozane-tazobactam, or ceftazidime-avibactam) in complicated urinary tract infections (cUTI) caused by XDR-PA., [Methods] Study performed at a tertiary-care hospital from 2010 to 2019. All consecutive adult patients with XDR-PA urine cultures and diagnosed with cUTI were retrospectively reviewed. XDR phenotype was defined according to Magiorakos et al. A propensity score was used as a covariate in multivariate analyses and for matching. Primary outcome was early clinical failure and at end of treatment (EOT). Main secondary outcomes were 30- and 90-day mortality, microbiological clearance, and antibiotic-related side effects., [Results] Of the 465 episodes screened, 101 were included, 48% were treated with aminoglycoside or colistin monotherapy. Most XDR-PA were susceptible to colistin (100%) and amikacin (43%). Patients treated with antibiotic regimens other than aminoglycosides or polymyxin monotherapy were more likely to have hematologic malignancy (p, [Conclusions] Aminoglycosides or polymyxin monotherapy showed good efficacy and safety profile in treating cUTI caused by XDR-PA. These results may be useful for antibiotic stewardship activities., This work was supported by the Ministerio de Economia y competitividad of Spain, Instituto de Salud Carlos III [grant number PI17/00251 to J.P.H.], co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (ERDF), Operative program Intelligent Growth 2014–2020. Silvia Gómez-Zorrilla has received a research grant from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) to support her research. The journal’s Rapid Service Fee was funded by the authors.
Published: 2022

2. Genomics And Susceptibility Profiles Of Extensively Drug-resistant Pseudomonas Aeruginosa Isolates From Spain

Author: Ester del Barrio-Tofiño, Luisa Sorlí, José Antonio Martínez, Concepción Segura, Fe Tubau, Antonio Oliver, Luis Martínez-Martínez, Natividad Benito, Alba Rivera, Gabriel Cabot, Elena Resino-Foz, Juan Pablo Horcajada, Raquel Durá-Navarro, Laura Zamorano, María Milagro Montero, Cristina Labayru-Echverria, Silvia Gómez-Zorrilla, Marta Fernández-Martínez, Ignacio Ayestarán, Esther Viedma, Carlos Dueñas, Izaskun Alejo-Cancho, Carla López-Causapé, Claudia González-Rico, Nuria Tormo, [del Barrio-Tofino, Ester] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [Lopez-Causape, Carla] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [Cabot, Gabriel] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [Ayestaran, Ignacio] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [Zamorano, Laura] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [Oliver, Antonio] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Dept Microbiol, Intens Care Unit, Palma De Mallorca, Spain, [del Barrio-Tofino, Ester] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Lopez-Causape, Carla] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Cabot, Gabriel] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Ayestaran, Ignacio] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Zamorano, Laura] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Oliver, Antonio] Hosp Univ Son Espases, Inst Invest Illes Balears IdISBa, Unidad Invest, Palma De Mallorca, Spain, [Rivera, Alba] Hosp Santa Creu & Sant Pau, Dept Microbiol & Infect Dis, Barcelona, Spain, [Benito, Natividad] Hosp Santa Creu & Sant Pau, Dept Microbiol & Infect Dis, Barcelona, Spain, [Segura, Concepcion] Hosp del Mar, Lab Referencia Catalunya, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Milagro Montero, Maria] Hosp del Mar, Lab Referencia Catalunya, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Sorli, Luisa] Hosp del Mar, Lab Referencia Catalunya, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Pablo Horcajada, Juan] Hosp del Mar, Lab Referencia Catalunya, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Segura, Concepcion] Hosp del Mar, Dept Infect Dis, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Milagro Montero, Maria] Hosp del Mar, Dept Infect Dis, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Sorli, Luisa] Hosp del Mar, Dept Infect Dis, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Pablo Horcajada, Juan] Hosp del Mar, Dept Infect Dis, Infect Pathol & Antimicrobial Res Grp IPAR, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Tubau, Fe] Hosp Univ Bellvitge, Dept Microbiol & Infect Dis, Barcelona, Spain, [Gomez-Zorrilla, Silvia] Hosp Univ Bellvitge, Dept Microbiol & Infect Dis, Barcelona, Spain, [Tormo, Nuria] Consorcio Hosp Gen Univ Valencia, Dept Microbiol & Infect Dis, Valencia, Spain, [Dura-Navarro, Raquel] Consorcio Hosp Gen Univ Valencia, Dept Microbiol & Infect Dis, Valencia, Spain, [Viedma, Esther] Hosp Univ 12 Octubre, Dept Microbiol & Infect Dis, Madrid, Spain, [Resino-Foz, Elena] Hosp Univ 12 Octubre, Dept Microbiol & Infect Dis, Madrid, Spain, [Fernandez-Martinez, Marta] Hosp Univ Marques de Valdecilla, Inst Invest Valdecilla IDIVAL, Dept Microbiol & Infect Dis, Santander, Spain, [Gonzalez-Rico, Claudia] Hosp Univ Marques de Valdecilla, Inst Invest Valdecilla IDIVAL, Dept Microbiol & Infect Dis, Santander, Spain, [Alejo-Cancho, Izaskun] Hosp Univ Clin, Dept Microbiol & Infect Dis, Barcelona, Spain, [Antonio Martinez, Jose] Hosp Univ Clin, Dept Microbiol & Infect Dis, Barcelona, Spain, [Labayru-Echverria, Cristina] Hosp Univ Burgos, Dept Microbiol & Infect Dis, Burgos, Spain, [Duenas, Carlos] Hosp Univ Burgos, Dept Microbiol & Infect Dis, Burgos, Spain, [Martinez-Martinez, Luis] Univ Cordoba, Hosp Univ Reina Sofia, Dept Microbiol, Unit Microbiol, Cordoba, Spain, [Martinez-Martinez, Luis] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, Plan Nacional de I+D+i, Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Spanish Network for Research in Infectious Diseases, and European Development Regional Fund (ERDF)
Subjects: 0301 basic medicine, Imipenem, Ceftazidime, Penicillanic Acid, Aztreonam, Drug resistance, medicine.disease_cause, Antimicrobial resistance, chemistry.chemical_compound, polycyclic compounds, Pharmacology (medical), Aminoglycoside resistance, Molecular Epidemiology, extensively drug resistant, Beta-lactam resistance, Ceftolozane-tazobactam, Broth microdilution, 3. Good health, Anti-Bacterial Agents, Infectious Diseases, high-risk clones, Amikacin, whole-genome sequencing, Molecular epidemiology, Pseudomonas aeruginosa, Erratum, Convergent evolution, Mutations, medicine.drug, Fluoroquinolones, Field gel-electrophoresis, Tazobactam, Carbapenem resistance, Cxa-101 fr264205, Epidemiologia molecular, 030106 microbiology, Microbial Sensitivity Tests, Biology, beta-Lactam Resistance, beta-Lactamases, Microbiology, 03 medical and health sciences, Polymyxin resistance, Bacterial Proteins, Pseudomonas, Drug Resistance, Bacterial, medicine, Humans, Pseudomonas Infections, Polymyxins, Pharmacology, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Cephalosporins, Aminoglycosides, chemistry, Spain
Abstract: This study assessed the molecular epidemiology, resistance mechanisms, and susceptibility profiles of a collection of 150 extensively drug-resistant (XDR) Pseudomonas aeruginosa clinical isolates obtained from a 2015 Spanish multicenter study, with a particular focus on resistome analysis in relation to ceftolozane-tazobactam susceptibility. Broth microdilution MICs revealed that nearly all (>95%) of the isolates were nonsusceptible to piperacillin-tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem, and ciprofloxacin. Most of them were also resistant to tobramycin (77%), whereas nonsusceptibility rates were lower for ceftolozane-tazobactam (31%), amikacin (7%), and colistin (2%). Pulsed-field gel electrophoresis–multilocus sequence typing (PFGE-MLST) analysis revealed that nearly all of the isolates belonged to previously described high-risk clones. Sequence type 175 (ST175) was detected in all 9 participating hospitals and accounted for 68% ( n = 101) of the XDR isolates, distantly followed by ST244 ( n = 16), ST253 ( n = 12), ST235 ( n = 8), and ST111 ( n = 2), which were detected only in 1 to 2 hospitals. Through phenotypic and molecular methods, the presence of horizontally acquired carbapenemases was detected in 21% of the isolates, mostly VIM (17%) and GES enzymes (4%). At least two representative isolates from each clone and hospital ( n = 44) were fully sequenced on an Illumina MiSeq. Classical mutational mechanisms, such as those leading to the overexpression of the β-lactamase AmpC or efflux pumps, OprD inactivation, and/or quinolone resistance-determining regions (QRDR) mutations, were confirmed in most isolates and correlated well with the resistance phenotypes in the absence of horizontally acquired determinants. Ceftolozane-tazobactam resistance was not detected in carbapenemase-negative isolates, in agreement with sequencing data showing the absence of ampC mutations. The unique set of mutations responsible for the XDR phenotype of ST175 clone documented 7 years earlier were found to be conserved, denoting the long-term persistence of this specific XDR lineage in Spanish hospitals. Finally, other potentially relevant mutations were evidenced, including those in penicillin-binding protein 3 (PBP3), which is involved in β-lactam (including ceftolozane-tazobactam) resistance, and FusA1, which is linked to aminoglycoside resistance.
Published: 2017

3. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

Author: Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Clary B. Clish, Marta Guasch-Ferré, Jesús F. García-Gavilán, Clemens Wittenbecher, Angel Alonso-Gómez, Montse Fitó, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramon Estruch, Miquel Fiol, Jose M. Santos-Lozano, Luis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González, [Razquin, Cristina] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA Inst Invest Sanitaria Navarra, Pamplona 31008, Spain, [Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA Inst Invest Sanitaria Navarra, Pamplona 31008, Spain, [Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA Inst Invest Sanitaria Navarra, Pamplona 31008, Spain, [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA Inst Invest Sanitaria Navarra, Pamplona 31008, Spain, [Razquin, Cristina] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Ruiz-Canela, Miguel] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Toledo, Estefania] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Garcia-Gavilan, Jesus F.] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Alonso-Gomez, Angel] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Fito, Montse] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Estruch, Ramon] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Fiol, Miquel] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Santos-Lozano, Jose M.] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Serra-Majem, Luis] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Ros, Emilio] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Aros, Fernando] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Martinez-Gonzalez, Miguel A.] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain, [Clish, Clary B.] Harvard Univ, Broad Inst MIT, Cambridge, MA 02142 USA, [Guasch-Ferre, Marta] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA, [Wittenbecher, Clemens] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA, [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA, [Martinez-Gonzalez, Miguel A.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA, [Guasch-Ferre, Marta] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, DK-1165 Copenhagen, Denmark, [Guasch-Ferre, Marta] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, DK-1353 Copenhagen, Denmark, [Garcia-Gavilan, Jesus F.] Univ Rovira i Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus 43201, Spain, [Salas-Salvado, Jordi] Univ Rovira i Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus 43201, Spain, [Garcia-Gavilan, Jesus F.] Hosp Univ San Joan Reus, Inst Invest Sanitaria Pere Virgili IISPV, Reus 43204, Spain, [Salas-Salvado, Jordi] Hosp Univ San Joan Reus, Inst Invest Sanitaria Pere Virgili IISPV, Reus 43204, Spain, [Wittenbecher, Clemens] Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci Div, SciLifeLab, SE-41296 Gothenburg, Sweden, [Alonso-Gomez, Angel] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria 01009, Spain, [Aros, Fernando] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria 01009, Spain, [Fito, Montse] Inst Hosp del Mar Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona 08003, Spain, [Liang, Liming] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA 02115 USA, [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia 46100, Spain, [Gomez-Gracia, Enrique] Univ Malaga, Dept Prevent Med, Malaga 29071, Spain, [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona 08036, Spain, [Fiol, Miquel] Hosp Univ Son Espases, Plataforma Ensayos Clin, Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca 07120, Spain, [Santos-Lozano, Jose M.] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville 41013, Spain, [Serra-Majem, Luis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Nutr Res Grp, Las Palmas Gran Canaria 35016, Spain, [Ros, Emilio] Univ Barcelona, Hosp Clin, Agust Pi Sunyer Biomed Res Inst IDIBAPS i, Dept Endocrinol & Nutr,Lipid Clin, Barcelona 08036, Spain, and [Hu, Frank B.] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Subjects: PREDIMED, amino acids, Predictors, Organic Chemistry, General Medicine, case-cohort, peripheral artery disease, metabolomics, Catalysis, Computer Science Applications, Association, Inorganic Chemistry, Life, Health, Physical and Theoretical Chemistry, Ratio, Molecular Biology, Spectroscopy
Abstract: Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61–0.99); 0.67 (0.51–0.86) and 0.75 (0.59–0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14–1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.
Published: 2022
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4. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

Author: Iurilli, Maria L. C., Zhou, Bin, Bennett, James E., Carrillo-Larco, Rodrigo M., Sophiea, Marisa K., Rodriguez-Martinez, Andrea, Bixby, Honor, Solomon, Bethlehem D., Taddei, Cristina, Danaei, Goodarz, Di Cesare, Mariachiara, Stevens, Gretchen A., Riley, Leanne M., Savin, Stefan, Cowan, Melanie J., Bovet, Pascal, Damasceno, Albertino, Chirita-Emandi, Adela, Hayes, Alison J., Ikeda, Nayu, Jackson, Rod T., Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Miranda, J. Jaime, Saidi, Olfa, Sebert, Sylvain, Soric, Maroje, Starc, Gregor, Gregg, Edward W., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F. Abdul, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Avi, Shina, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha, Jorgensen, Maja Boksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Baran, Joanna, Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio Jd, Gomes Barros, Mauro Virgilio, Basit, Abdul, Bastos, Joao Luiz D., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhutta, Zulfiqar A., Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M., Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Bloch, Katia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Bogova, Elena, Boissonnet, Carlos P., Bojesen, Stig E., Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H. 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Univ Nove Julho, Publ Hlth Agcy Canada, Canarian Hlth Serv, Univ Ind Santander, Assoc Calabrese Epatol, Univ Minho, Fiji Natl Univ, Spanish Nutr Fdn, Publ Hlth Agcy Sweden, Inst Food Sci Natl Res Council, Sitaram Bhartia Inst Sci & Res, Kindergarten Avlonari, Natl Inst Hlth, Catalan Dept Hlth, Biodonostia Hlth Res Inst, Inst Saude Ambiental, South Karelia Social & Hlth Care Dist, McMaster Univ, Hosp Italiano Buenos Aires, Rigshosp, Acad Med Ctr Univ Amsterdam, Ctr Oral Hlth Serv & Res Midnorway, Lagos State Univ, Univ Las Palmas Gran Canaria, Comenius Univ, Natl Ctr Dis Control & Publ Hlth, Nippon Med Sch, Sungkyunkwan Univ, Finnish Inst Occupat Hlth, Publ Hlth Promot & Dev Org, St Vincents Hosp, Nes Municipal, Hlth Polytech Jakarta II Inst, Diponegoro Univ, Univ Bari, Inst Reg Sante Publ, Univ Bordeaux, Oslo Metropolitan Univ, Univ Leuven, Lamprecht & Stamm Sozialforsch & Beratung AG, Univ Bonn, Kalina Malina Kindergarten, Jikei Univ, Fu Jen Catholic Univ, Natl Stat Off, Natl Inst Publ Hlth Natl Inst Hyg, Sci Res Inst Maternal & Child Hlth, Univ Lincoln, Cent Univ Kerala, Amsterdam Publ Hlth Res Inst, Hlth Serv Murcia, Inst Invest Sanitaria Illes Balears, Univ Bologna, Hellen Hlth Fdn, Govt Med Coll, Sefako Makgatho Hlth Sci Univ, Addis Ababa Univ, Univ Ctr Occidental Lisandro Alvarado, Meharry Med Coll, Dokuz Eylul Univ, Univ Tampere, Sabiha Gokcen Ilkokulu, Polytech Inst Porto, Icahn Sch Med Mt Sinai, Univ CEU San Pablo, Univ Miguel Hernandez, Vrije Univ Amsterdam, Sunflower Nursery Sch, North Karelia Ctr Publ Hlth, Univ Witwatersrand, Med Univ Vienna, Cork Inst Technol, Inst Med Res, Xinjiang Med Univ, Shanghai Educ Dev Co Ltd, Rebro Univ, St Georges Univ London, Univ Indonesia, Minist Agr & Rural Affairs, Fudan Univ, Univ Cyprus, Niigata Univ, Int Med Univ, Iran Univ Med Sci, Ctr Diabet & Endocrine Care, Peking Univ First Hosp, Jiangsu Prov Ctr Dis Control & Prevent, Sun Yat Sen Univ, West Kazakhstan Med Univ, Inner Mongolia Med Univ, and Przedszkole 81
Subjects: Life Sciences & Biomedicine - Other Topics, Science & Technology, AUSTRALIAN ADULTS, CHINESE ADULTS, nutritional and metabolic diseases, MALNUTRITION, TRENDS, DOUBLE BURDEN, PREVALENCE, POOLED ANALYSIS, US ADULTS, SYSTEMATIC ANALYSIS, HEALTH, sense organs, skin and connective tissue diseases, Life Sciences & Biomedicine, Biology
Abstract: Made available in DSpace on 2021-06-25T15:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09 Wellcome Trust From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. 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State Of Palest, Israel Usmanu Danfodiyo Univ Teaching Hosp, Sokoto, Nigeria Inst Mexicano Seguro Social, Mexico City, DF, Mexico Flinders Univ S Australia, Adelaide, SA, Australia Mahidol Univ, Salaya, Nakhon Pathom, Thailand BRAC James P Grant Sch Publ Hlth, Dhaka, Bangladesh Univ Copenhagen, Copenhagen, Denmark Copenhagen Univ Hosp, Copenhagen, Denmark Food & Nutr Res Inst, Taguig, Philippines Urmia Univ Med Sci, Orumiyeh, Iran Inst Nacl Ciencias Med & Nut, Mexico City, DF, Mexico Univ Amsterdam, Amsterdam, Netherlands Shahrekord Univ Med Sci, Shahrekord, Iran Noncommunicable Dis Res Ctr, Tehran, Iran Univ Oslo, Oslo, Norway Univ Bremen, Bremen, Germany Republican Ctr Hlth Promot, Bishkek, Kyrgyzstan Natl Ctr Diabet Endocrinol & Genet, Amman, Jordan Princess Nourah Bint Abdulrahman Univ, Riyadh, Saudi Arabia Kuwait Inst Sci Res, Kuwait, Kuwait King Abdulaziz Univ, Jeddah, Saudi Arabia Dasman Diabet Inst, Kuwait, Kuwait Luxembourg Inst Hlth, Strassen, Luxembourg Aldara Hosp & Med Ctr, Riyadh, Saudi Arabia King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark Barcelona Inst Global Hlth CIBERESP, Barcelona, Spain World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt Bombay Hosp & Med Res Ctr, Mumbai, Maharashtra, India Res Ctr Social Determinants Hlth, Tehran, Iran UMR CNRS MNHN 7206 Ecoanthropologie, Paris, France Univ Lille, Lille, France Lille Univ Hosp, Lille, France Western Norway Univ Appl Sci, Sogndal, Norway Norwegian Sch Sport Sci, Oslo, Norway Madras Diabet Res Fdn, Chennai, Tamil Nadu, India Zahedan Univ Med Sci, Zahedan, Iran Natl Inst Publ Hlth, Tunis, Tunisia Univ Porto, Inst Publ Hlth, Porto, Portugal Norwegian Inst Publ Hlth, Oslo, Norway Univ Massachusetts, Amherst, MA 01003 USA Abt Associates Inc, Kathmandu, Nepal Univ Iceland, Reykjavik, Iceland Univ Yaounde I, Yaounde, Cameroon Univ Fed Pelotas, Pelotas, RS, Brazil Univ Med 1, Yangon, Myanmar Banska Bystrica Reg Author Publ Hlth, Banska Bystrica, Slovakia Tel Aviv Univ, Tel Aviv, Israel Hebrew Univ Jerusalem, Jerusalem, Israel Univ Porto, Med Sch, Porto, Portugal Neyshabur Univ Med Sci, Neyshabur, Iran Res Inst Endocrine Sci, Tehran, Iran Indian Council Med Res, New Delhi, India Natl Inst Publ Hlth, Copenhagen, Denmark Univ Sci & Technol, Sanaa, Yemen Med Univ Lodz, Lodz, Poland Med Univ Gdansk, Gdansk, Poland Univ Autonoma Madrid CIBERESP, Madrid, Spain Univ Rzeszow, Rzeszow, Poland Univ Palermo, Palermo, Italy Pan Amer Hlth Org, Washington, DC USA Mohammed V Univ Rabat, Rabat, Morocco Univ Pernambuco, Recife, PE, Brazil Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan Univ Fed Santa Catarina, Florianopolis, SC, Brazil Dalhousie Univ, Halifax, NS, Canada Jordan Univ Sci & Technol, Irbid, Jordan Univ Fed Maranhao, Sao Luis, Brazil Farabi Kazakh Natl Univ, Alma Ata, Kazakhstan Univ Coll Dublin, Dublin, Ireland Christian Med Coll & Hosp, Vellore, Tamil Nadu, India Fed Minist Social Affairs Hlth Care & Consumer Pr, 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Potsdam, Germany Endocrinol Res Ctr, Moscow, Russia Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina IRCCS Neuromed, Pozzilli, Italy Toulouse Univ, Sch Med, Toulouse, France Univ Zurich, Zurich, Switzerland Univ Hosp KU Leuven, Leuven, Belgium Flemish Agcy Care & Hlth, Brussels, Belgium Univ Ghent, Ghent, Belgium FrieslandCampina, Amersfoort, Netherlands Univ Cent Venezuela, Caracas, Venezuela Bielefeld Univ, Bielefeld, Germany World Hlth Org Reg Off Europe, Moscow, Russia German Canc Res Ctr, Heidelberg, Germany Fred Hollows Fdn, Auckland, New Zealand Univ Med & Pharm Bucharest, Bucharest, Romania Swansea Univ, Swansea, W Glam, Wales Univ Coll Copenhagen, Copenhagen, Denmark Inst Publ Hlth, Tirana, Albania Munster Technol Univ, Cork, Ireland Univ La Laguna, Tenerife, Spain Univ Malta, Msida, Malta Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA Minist Hlth, Tongatapu, Tonga Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada Hosp Santa Maria, Lisbon, Portugal Istanbul Univ Cerrahpasa, Istanbul, Turkey Univ Fed Juiz de Fora, Juiz De Fora, Brazil Minist Publ Hlth, Asuncion, Paraguay Natl Inst Publ Hlth, Prague, Czech Republic Gaetano Fucito Hosp, Mercato San Severino, Italy Univ Groningen, Groningen, Netherlands Karolinska Inst, Huddinge, Sweden Ctr Estudios Nutr Infantil, Buenos Aires, DF, Argentina Univ Porto, Porto, Portugal Univ Zaragoza, Zaragoza, Spain Santiago de Compostela Univ, Santiago De Compostela, Spain Minist Hlth, Ankara, Turkey Council Agr Res & Econ, Rome, Italy Fed Univ Rio Grande, Rio Grande, Brazil India Diabet Res Fdn, Chennai, Tamil Nadu, India Duke NUS Med Sch, Singapore, Singapore ICMR Natl Inst Med Stat, New Delhi, India Singapore Eye Res Inst, Singapore, Singapore Acad Sinica, Taipei, Taiwan Capital Inst Pediat, Beijing, Peoples R China Duke Univ, Durham, NH USA Kailuan Gen Hosp, Tangshan, Peoples R China Univ Oxford, Oxford, England Ahvaz Jundishapur Univ Med Sci, Ahvaz, Iran Gertner Inst Epidemiol & Hlth Policy 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Madrid, Spain Indian Stat Inst, Kolkata, India Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran Geneva Univ Hosp, Geneva, Switzerland Sciensano, Brussels, Belgium Univ Med Ctr Groningen, Groningen, Netherlands Natl Res Ctr Prevent Med, Moscow, Russia Innovating Hlth Int, Port Au Prince, Haiti Univ Montreal, Montreal, PQ, Canada French Natl Res Inst Sustainable Dev, Montpellier, France French Publ Hlth Agcy, St Maurice, France Mediterranea Cardioctr, Naples, Italy Univ Vale Rio dos Sinos, Sao Leopoldo, Brazil Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina Minist Hlth & Med Educ, Tehran, Iran Univ Novi Sad, Novi Sad, Serbia Natl Inst Nutr, Hanoi, Vietnam Univ Queensland, Brisbane, Qld, Australia Ist Super Sanita, Rome, Italy Univ Cuenca, Cuenca, Ecuador Helmholtz Zentrum Munchen, Munich, Germany Univ Tehran Med Sci, Tehran, Iran Minist Sante & Hyg Publ, Abidjan, Cote Ivoire Univ Hosp Dusseldorf, Dusseldorf, Germany Natl Inst Cardiol, Warsaw, Poland Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China UMI 3189 ESS, Marseille, France Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Scuola Super Sant Anna, Pisa, Italy Univ Latvia, Riga, Latvia Minist Hlth & Med Serv, Gizo, Solomon Islands Hormozgan Univ Med Sci, Bandar Abbas, Iran Univ Benin, Benin, Nigeria Univ Skovde, Skovde, Sweden Natl Inst Nutr & Food Technol, Tunis, Tunisia Univ West Indies, Kingston, Jamaica Univ Calif Davis, Davis, CA 95616 USA Univ Stellenbosch, Cape Town, South Africa Univ Duisburg Essen, Duisburg, Germany Karadeniz Tech Univ, Trabzon, Turkey Univ Helsinki, Helsinki, Finland Mashhad Univ Med Sci, Mashhad, Razavi Khorasan, Iran Rafsanjan Univ Med Sci, Rafsanjan, Iran Queens Univ Belfast, Belfast, Antrim, North Ireland Tabriz Univ Med Sci, Tabriz, Iran Fasa Univ Med Sci, Fasa, Iran Shiraz Univ Med Sci, Shiraz, Iran Baqai Med Univ, Karachi, Pakistan Ctr Salud Villanueva Norte, Badajoz, Spain Hosp Don Benito Villanueva Serena, Badajoz, Spain Minist Hlth, Buenos Aires, DF, Argentina Univ Insubria, Varese, Italy Pontificia Univ Catolica Chile, Santiago, Chile Inst Mother & Child Hlth, Warsaw, Poland Swiss Trop & Publ Hlth Inst, Basel, Switzerland Univ Tartu, Tartu, Estonia Univ Sains Malaysia, Kota Baharu, Kelantan, Malaysia Umea Univ, Umea, Sweden Univ Fed Sao Paulo, Sao Paulo, Brazil Hosp Univ Son Espases, Palma De Mallorca, Spain Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil Univ Sumatera Utara, Medan, Indonesia Kindai Univ, Osaka, Japan Kyoto Univ, Kyoto, Japan Med Univ Warsaw, Warsaw, Poland Jagiellonian Univ, Med Coll, Krakow, Poland Minist Salute DG Prevenz Sanit, Rome, Italy Univ Catania, Catania, Italy CIBER Epidemiol & Salud Publ, Alicante, Spain Africa Hlth Res Inst, Mtubatuba, South Africa Univ Geneva, Med Sch, Geneva, Switzerland CIBER Epidemiol & Salud Publ, Barcelona, Spain Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil Univ Utrecht, Utrecht, Netherlands Wageningen Univ, Wageningen, Netherlands Univ Adelaide, Adelaide, SA, Australia Lund Univ, Lund, Sweden Aristotle Univ Thessaloniki, Thessaloniki, Greece Inst Natl Sante & Rech Med, Villejuif, France Minist Hlth, Jerusalem, Israel McGill Univ, Montreal, PQ, Canada Gasol Fdn, Barcelona, Spain PASs Hirszfeld Inst Immunol & Expt Therapy, Wroclaw, Poland Univ Politecn Madrid, Madrid, Spain St Annes Univ Hosp, Brno, Czech Republic Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico Ctr Estudios Diabet AC, Mexico City, DF, Mexico Univ Autonoma Santo Domingo, Santo Domingo, Dominican Rep Minist Hlth, Lisbon, Portugal Inst Clin & Expt Med, Prague, Czech Republic Childrens Mem Hlth Inst, Warsaw, Poland Natl Ctr Cardiovasc Dis, Beijing, Peoples R China Univ Ferrara, Ferrara, Italy Author Sanitaria San Marino, San Marino, CA USA Iceland Heart Assoc, Kopavogur, Iceland Univ Icesi, Cali, Colombia Univ Estadual Montes Claros, Montes Claros, MG, Brazil Kings Coll London, London, England Int Agcy Res Canc, Lyon, France Capital Med Univ, Beijing, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India Univ Ibadan, Ibadan, Nigeria Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina Natl Hlth Insurance Serv, Wonju, South Korea Prevent Metab Disorders Res Ctr, Tehran, Iran Res & Educ Inst Child Hlth, Nicosia, Cyprus Danish Canc Soc Res Ctr, Copenhagen, Denmark Univ West Indies, Cave Hill, Barbados Kermanshah Univ Med Sci, Kermanshah, Iran Univ Eastern Finland, Kuopio, Finland Beijing Inst Ophthalmol, Beijing, Peoples R China Int Hellen Univ, Thessaloniki, Greece Kyushu Univ, Fukuoka, Japan Univ Bergen, Bergen, Norway Tulane Univ, New Orleans, LA USA Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China Univ Pecs, Pecs, Hungary Danish Hlth Author, Copenhagen, Denmark Joep Lange Inst, Amsterdam, Netherlands Univ Fed Pernambuco, Recife, PE, Brazil Oulu Univ Hosp, Oulu, Finland Univ Autonoma Bucaramanga, Bucaramanga, Colombia Swiss Fed Inst Technol, Zurich, Switzerland Chron Dis Res Ctr, Tehran, Iran Univ Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong, Hong Kong, Peoples R China Univ Western Australia, Perth, WA, Australia Kingston Hlth Sci Ctr, Kingston, ON, Canada Fdn Oftalmol Santander, Bucaramanga, Colombia Univ Oran 1, Oran, Algeria Nay Pyi Taw, Independent Publ Hlth Specialist, Nay Pyi Taw, Myanmar Minist Hlth & Sports, Nay Pyi Taw, Myanmar Peking Univ, Beijing, Peoples R China Natl Inst Publ Hlth, Bucharest, Romania Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands Amer Univ Beirut, Beirut, Lebanon CIBER Epidemiol & Salud Publ, San Sebastian, Spain Cairo Univ, Cairo, Egypt Erasmus MC, Rotterdam, Netherlands Med Univ Varna, Varna, Bulgaria Univ Tokyo, Tokyo, Japan Deakin Univ, Geelong, Vic, Australia Tokyo Metropolitan Inst Gerontol, Tokyo, Japan Hadassah 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Estonia Kansai Med Univ, Hirakata, Osaka, Japan Hungarian Sch Sport Federat, Budapest, Hungary Minist Hlth & Qual Life, Port Louis, Mauritius Univ Hosp Ulm, Ulm, Germany North West Univ, Potchefstroom, South Africa Univ Jyvaskyla, Jyvaskyla, Finland Inst Publ Hlth, Podgorica, Montenegro Amrita Inst Med Sci, Cochin, Kerala, India Inst Endocrinol, Prague, Czech Republic All India Inst Med Sci, New Delhi, India African Populat & Hlth Res Ctr, Nairobi, Kenya Hanoi Univ Publ Hlth, Hanoi, Vietnam Hassan First Univ Settat, Settat, Morocco Minist Hlth, Algiers, Algeria Harokopio Univ, Athens, Greece Sahlgrens Acad, Gothenburg, Sweden Endocrinol & Metab Res Ctr, Tehran, Iran Univ Publ Hlth, Yangon, Myanmar Int Food Policy Res Inst, Dakar, Senegal Natl Univ Singapore, Singapore, Singapore Hong Kong Polytech Univ, Hong Kong, Peoples R China Tampere Univ Hosp, Tampere, Finland Univ Douala, Douala, Cameroon Univ Cape Town, Cape Town, South Africa Natl Inst Hlth Dev, Tallinn, Estonia West Virginia 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Stockholm, Sweden Natl Inst Hyg & Epidemiol, Hanoi, Vietnam Univ Med & Pharm Ho Chi Minh City, Ho Chi Minh City, Vietnam Hanoi Med Univ, Hanoi, Vietnam LifeDoc Hlth, Memphis, TN USA Heartfile, Islamabad, Pakistan Eastern Mediterranean Publ Hlth Network, Amman, Jordan Univ Manchester, Manchester, Lancs, England State Univ Med & Pharm, Kishinev, Moldova Tachikawa Gen Hosp, Nagaoka, Niigata, Japan Korea Ctr Dis Control & Prevent, Cheongju, South Korea Japan Wildlife Res Ctr, Tokyo, Japan Istanbul Univ, Istanbul, Turkey Minist Hlth, Bandar Seri Begawan, Brunei Univ Fed Parana, Curitiba, Parana, Brazil Univ Madeira, Funchal, Portugal Univ Puerto Rico, San Juan, PR 00936 USA Ctr Clin Res & Prevent, Glostrup, Denmark MRC Lifecourse Epidemiol Unit, Southampton, Hants, England Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana UniSante, Lausanne, Switzerland Inst Canc Res, Prevent & Clin Network, Florence, Italy Univ Wisconsin, Madison, WI USA Heidelberg Univ, Heidelberg, Germany IRCCS Ente Osped Specializzato Gastroenterol S de, Bari, Italy Zayed Univ, Abu Dhabi, U Arab Emirates Catholic Univ Daegu, Daegu, South Korea Univ Med Pharm Sci & Technol Targu Mures, Targu Mures, Romania Jivandeep Hosp, Anand, Gujarat, India South African Med Res Council, Durban, South Africa Natl Dent Care Ctr Singapore, Singapore, Singapore Univ Malaga, Malaga, Spain Univ Hosp Varese, Varese, Italy Vietnam Natl Heart Inst, Hanoi, Vietnam Clin Med Avanzada Dr Abel Gonzalez, Santo Domingo, Dominican Rep Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany Univ Sarajevo, Sarajevo, Bosnia & Herceg Cardiovasc Prevent Ctr Udine, Udine, Italy Pisa Univ Hosp, Pisa, Italy Minist Hlth & Med Serv, Honiara, Solomon Islands Publ Hlth Agcy Catalonia, Barcelona, Spain Inst Hosp del Mar Invest Med, Barcelona, Spain Ardabil Univ Med Sci, Ardebil, Iran Ctr Dis Prevent & Control, Riga, Latvia Alborz Univ Med Sci, Karaj, Iran Minist Hlth, Hanoi, Vietnam Pure Earth, Dhaka, Bangladesh Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh Univ Turku, Turku, Finland Inst Univ Invest Atenc Primaria Jordi Gol, Girona, Spain Univ Putra Malaysia, Serdang, Malaysia Univ Malaya, Kuala Lumpur, Malaysia Sotiria Hosp, Athens, Greece Univ Valencia, Valencia, Spain Univ Philippines, Manila, Philippines Slovak Acad Sci, Bratislava, Slovakia Nutr Res Fdn, Barcelona, Spain Minas Gerais State Secretariat Hlth, Belo Horizonte, MG, Brazil CS S Agustin Ibsalut, Palma De Mallorca, Spain Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands Natl Inst Hlth Doutor Ricardo Jorge, Lisbon, Portugal Univ Nove Julho, Sao Paulo, Brazil Publ Hlth Agcy Canada, Ottawa, ON, Canada Canarian Hlth Serv, Tenerife, Spain Univ Ind Santander, Bucaramanga, Colombia Assoc Calabrese Epatol, Reggio Di Calabria, Italy Univ Minho, Braga, Portugal Fiji Natl Univ, Suva, Fiji Spanish Nutr Fdn, Madrid, Spain Publ Hlth Agcy Sweden, Stockholm, Sweden Inst Food Sci Natl Res Council, Avellino, Italy Sitaram Bhartia Inst Sci & Res, New Delhi, India Kindergarten Avlonari, Evia, Greece Natl Inst Hlth, Lima, Peru Minist Hlth, Jakarta, Indonesia Catalan Dept Hlth, Barcelona, Spain Biodonostia Hlth Res Inst, San Sebastian, Spain Inst Saude Ambiental, Lisbon, Portugal South Karelia Social & Hlth Care Dist, Lappeenranta, Finland McMaster Univ, Hamilton, ON, Canada Natl Canc Ctr, Tokyo, Japan Univ Sao Paulo Clin Hosp, Sao Paulo, Brazil Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina Rigshosp, Copenhagen, Denmark Acad Med Ctr Univ Amsterdam, Amsterdam, Netherlands Ctr Oral Hlth Serv & Res Midnorway, Trondheim, Norway Lagos State Univ, Coll Med, Lagos, Nigeria Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain Comenius Univ, Bratislava, Slovakia Natl Ctr Dis Control & Publ Hlth, Tbilisi, Georgia Nippon Med Sch, Tokyo, Japan Sungkyunkwan Univ, Seoul, South Korea Finnish Inst Occupat Hlth, Helsinki, Finland Publ Hlth Promot & Dev Org, Kathmandu, Nepal St Vincents Hosp, Sydney, NSW, Australia Nes Municipal, Aarnes, Norway Hlth Polytech Jakarta II Inst, Jakarta, Indonesia Diponegoro Univ, Semarang, Indonesia Univ Bari, Bari, Italy Inst Reg Sante Publ, Ouidah, Benin Univ Bordeaux, Bordeaux, France Oslo Metropolitan Univ, Oslo, Norway Inst Publ Hlth, Skopje, North Macedonia Univ Leuven, Leuven, Belgium Lamprecht & Stamm Sozialforsch & Beratung AG, Zurich, Switzerland Inst Natl Sante & Rech Med, Nancy, France Univ Bonn, Bonn, Germany Sotiria Hosp, Sotiria, Greece Kalina Malina Kindergarten, Pazardjik, Bulgaria Jikei Univ, Sch Med, Tokyo, Japan Fu Jen Catholic Univ, Taipei, Taiwan Natl Stat Off, Praia, Cape Verde Natl Inst Publ Hlth Natl Inst Hyg, Warsaw, Poland Deakin Univ, Sydney, NSW, Australia Sci Res Inst Maternal & Child Hlth, Ashkhabad, Turkmenistan Univ Lincoln, Lincoln, England Minist Hlth, Amman, Jordan UNICEF, Niamey, Niger Cent Univ Kerala, Kasaragod, India Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands Hlth Serv Murcia, Murcia, Spain Inst Invest Sanitaria Illes Balears, Menorca, Spain Univ Bologna, Bologna, Italy Hellen Hlth Fdn, Athens, Greece Govt Med Coll, Bhavnagar, Gujarat, India Sefako Makgatho Hlth Sci Univ, Ga Rankuwa, South Africa Addis Ababa Univ, Addis Ababa, Ethiopia Minist Hlth, Wellington, New Zealand Univ Ctr Occidental Lisandro Alvarado, Barquisimeto, Venezuela Meharry Med Coll, Nashville, TN 37208 USA Dokuz Eylul Univ, Izmir, Turkey Univ Tampere, Tays Eye Ctr, Tampere, Finland Sabiha Gokcen Ilkokulu, Ankara, Turkey Polytech Inst Porto, Porto, Portugal Icahn Sch Med Mt Sinai, New York, NY 10029 USA Univ CEU San Pablo, Madrid, Spain CNR, Pisa, Italy Univ Miguel Hernandez, Alicante, Spain Vrije Univ Amsterdam, Amsterdam, Netherlands Sunflower Nursery Sch, Craiova, Romania North Karelia Ctr Publ Hlth, Joensuu, Finland Univ Witwatersrand, Johannesburg, South Africa Med Univ Vienna, Vienna, Austria Cork Inst Technol, Cork, Ireland Inst Med Res, Kuala Lumpur, Malaysia Xinjiang Med Univ, Urumqi, Peoples R China Shanghai Educ Dev Co Ltd, Shanghai, Peoples R China Minist Hlth, Auckland, New Zealand Rebro Univ, Rebro, Sweden St Georges Univ London, London, England Univ Indonesia, Jakarta, Indonesia Minist Agr & Rural Affairs, Inst Food & Nutr Dev, Beijing, Peoples R China Fudan Univ, Childrens Hosp, Shanghai, Peoples R China Univ Cyprus, Nicosia, Cyprus Niigata Univ, Niigata, Japan Int Med Univ, Shah Alam, Selangor, Malaysia Hellen Mediterranean Univ, Iraklion, Greece Iran Univ Med Sci, Tehran, Iran Ctr Diabet & Endocrine Care, Srinagar, India Peking Univ First Hosp, Beijing, Peoples R China Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Peoples R China Sun Yat Sen Univ, Guangzhou, Peoples R China West Kazakhstan Med Univ, Aktobe, Kazakhstan Inner Mongolia Med Univ, Hohhot, Peoples R China Przedszkole 81, Warsaw, Poland Univ Estadual Paulista, Presidente Prudente, Brazil
Published: 2021

5. Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

Author: Antonia Serrano, Julie A. Chowen, Laura Sánchez-Marín, Marta Torrens, Juan Decara, María Pedraz, Vicente Barrios, Francisco Javier Pavón, Ana Luisa Gavito, Fernando Rodríguez de Fonseca, Nuria García-Marchena, Pablo Romero-Sanchiz, Pedro Araos, Estela Castilla-Ortega, Guillermo Ponce, Jesús Argente, Daniel Silva, Gabriel Rubio, [Garcia-Marchena, Nuria] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Fernando Araos, Pedro] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Sanchez-Marin, Laura] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Pedraz, Maria] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Castilla-Ortega, Estela] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Romero-Sanchiz, Pablo] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Gavito, Ana L.] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Decara, Juan] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Serrano, Antonia] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Rodriguez de Fonseca, Fernando] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Javier Pavon, Francisco] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain, [Garcia-Marchena, Nuria] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Silva, Daniel] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Rodriguez de Fonseca, Fernando] Univ Complutense Madrid, Fac Psicol, Madrid, Spain, [Barrios, Vicente] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Chowen, Julie A.] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Argente, Jesus] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Madrid, Spain, [Barrios, Vicente] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Chowen, Julie A.] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Argente, Jesus] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain, [Barrios, Vicente] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Chowen, Julie A.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Argente, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Ponce, Guillermo] Hosp Univ 12 Octubre, Serv Psiquiatria, Madrid, Spain, [Rubio, Gabriel] Hosp Univ 12 Octubre, Serv Psiquiatria, Madrid, Spain, [Torrens, Marta] Inst Neuropsiquiatria & Addicc INAD, Barcelona, Spain, [Torrens, Marta] Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain, [Torrens, Marta] Univ Autonoma Barcelona, Dept Psychiat, Barcelona, Spain, RETICS Red de Trastornos Adictivos - Instituto de Salud Carlos III (ISC-III), European Regional Development Funds-European Union (ERDF-EU), Ministerio de Economia y Competitividad, ISC-III, Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas, Consejeria de Economia, Innovacion y Ciencia, Junta de Andalucia, ERDF-EU, Consejeria de Salud y Bienestar Social, Junta de Andalucia, [García-Marchena,N, Araos,PF, Sánchez-Marín,L, Pedraz,M, Castilla-Ortega,E, Romero-Sanchiz,P, Gavito,AL, Decara,J, Serano,A, Rodríguez de Fonseca,F, Pavón,FJ] Unidad Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. [García-Marchena,N, Silva,D, Rodríguez de Fonseca,F] Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Barrios,V, Chowen,JA, Argente,J] Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain. CIBER Fisiopatología de la obesidad y nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. [Ponce,G] Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Madrid, Spain, [Torrens,M] Institut de Neuropsiquiatria i Addiccions (INAD), Barcelona, Spain. Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain,. Department of Psychiatry, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., The present study has been supported by RETICS Red deTrastornos Adictivos (RD12/0028/0021) funded by Instituto de Salud Carlos III (ISC-III) and European Regional Development Funds-European Union (ERDF-EU), research projects funded by Ministerio de Economía y Competitividad and ISC-III (PI13/02261 and PI16/01953), Ministerio de Sanidad, Servicios Sociales e Igualdad and Plan Nacional sobre Drogas (049/2009 and 049/2013), Consejería de Economía, Innovación y Ciencia, Junta de Andalucía and ERDF-EU (CTS-433), and and Consejería de Salud y Bienestar Social, Junta de Andalucía (PI0228-2013 and PI0823-2012). AS and FP hold Miguel Servet research contracts funded by ISC-III and ERDF-EU (CP14/00173 and CP14/00212, respectively). PR-S holds a 'Río Hortega' research contract funded by ISC-III and ERDF-EU (CM13/0115). EC-O holds a 'Sara Borrell' research contract funded by ISC-III and ERDF-EU (CD12/00455).
Subjects: 0301 basic medicine, Eotaxin, Aspartato aminotransferasas, Chemokine, Pathology, Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Anatomy::Digestive System::Liver [Medical Subject Headings], PRISM, Etanol, Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders [Medical Subject Headings], Trastornos del humor, Quimiocina CXCL12, Co-morbidity, Cocaine users, Anxiety, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Aminoacyltransferases::gamma-Glutamyltransferase [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders [Medical Subject Headings], Alcohol use disorder, 0302 clinical medicine, Psychiatry and Psychology::Behavioral Disciplines and Activities::Behavioral Sciences::Psychiatry [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity [Medical Subject Headings], Medicine, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar [Medical Subject Headings], Quimiocina CX3CL1, Masculino, Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CC::Chemokine CCL11 [Medical Subject Headings], Voluntarios sanos, Health Care::Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], CCL11, Original Research, Persons::Persons::Patients::Outpatients [Medical Subject Headings], Psychiatry, Hígado, biology, Pacientes ambulatorios, Femenino, Alcoholisme -- Tractament, Brain, Comorbilidad, Humanos, Psychiatry and Mental health, psychiatric comorbidity, Trastornos relacionados con sustancias, Cytokines, Sex, Microglia, outpatient setting, medicine.symptom, Fenotipo, medicine.medical_specialty, Cells, Psychiatric comorbidity, Check Tags::Male [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CX3C::Chemokine CX3CL1 [Medical Subject Headings], Conducta adictiva, alcohol use disorder, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive [Medical Subject Headings], Increased serum-levels, 03 medical and health sciences, Células del estroma, Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CXC::Chemokine CXCL12 [Medical Subject Headings], Internal medicine, Persons::Persons::Volunteers::Healthy Volunteers [Medical Subject Headings], mental disorders, sex, Interleukin 8, eotaxin, CX3CL1, Psiquiatría, Anatomy::Cells::Connective Tissue Cells::Stromal Cells [Medical Subject Headings], Outpatient setting, Ethanol, business.industry, Ratas wistar, chemokine, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Aspartate Aminotransferases [Medical Subject Headings], medicine.disease, Psychiatry and Psychology::Mental Disorders::Mood Disorders [Medical Subject Headings], Comorbidity, Quimiocina CCL11, Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol [Medical Subject Headings], 030104 developmental biology, Endocrinology, Check Tags::Female [Medical Subject Headings], Mood disorders, biology.protein, Trastornos relacionados con alcohol, gamma-glutamiltransferasa, Prevalencia, business, 030217 neurology & neurosurgery, Liver-disease
Abstract: Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X3-C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p
Published: 2017

6. RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

Author: Elisabeth Figuerola, Carlos Pardo-Pastor, Jaume Mora, Enrique de Álava, Lourdes Hontecillas-Prieto, Carmen de Torres, Angel M. Carcaboso, Eva Rodríguez, Inmaculada Hernández-Muñoz, Oscar M. Tirado, Sara Sanchez-Molina, Ana I. Fernández-Mariño, José M. Fernández-Fernández, Daniel J. García-Domínguez, Maria I. Bahamonde, Cinzia Lavarino, Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission, Ministerio de Economía y Competitividad (España), Asociación Española Contra el Cáncer, Asociación Pablo Ugarte, [Hernandez-Munoz, Inmaculada] Fdn Inst Hosp del Mar Invest Med FIMIM, E-08003 Barcelona, Spain, [Figuerola, Elisabeth] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Sanchez-Molina, Sara] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Rodriguez, Eva] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Lavarino, Cinzia] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Carcaboso, Angel M.] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [de Torres, Carmen] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Mora, Jaume] Hosp St Joan de Deu, Dept Pediat Hematol & Oncol, Dev Tumor Biol Lab, Barcelona 08950, Spain, [Isabel Fernandez-Marino, Ana] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Lab Fisiol Mol, E-08003 Barcelona, Spain, [Pardo-Pastor, Carlos] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Lab Fisiol Mol, E-08003 Barcelona, Spain, [Isabel Bahamonde, Maria] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Lab Fisiol Mol, E-08003 Barcelona, Spain, [Fernandez-Fernandez, Jose M.] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Lab Fisiol Mol, E-08003 Barcelona, Spain, [Garcia-Dominguez, Daniel J.] Univ Seville, Hosp Univ Virgen del Rocio, CSIC, Inst Biomed Sevilla IBiS,Dept Pediat Hematol & On, E-41013 Seville, Spain, [Hontecillas-Prieto, Lourdes] Univ Seville, Hosp Univ Virgen del Rocio, CSIC, Inst Biomed Sevilla IBiS,Dept Pediat Hematol & On, E-41013 Seville, Spain, [de Alava, Enrique] Univ Seville, Hosp Univ Virgen del Rocio, CSIC, Inst Biomed Sevilla IBiS,Dept Pediat Hematol & On, E-41013 Seville, Spain, [Tirado, Oscar M.] Inst Invest Biomed Bellvitge IDIBELL, Lab Oncol Mol, Sarcoma Res Grp, Barcelona 08908, Spain, [Isabel Fernandez-Marino, Ana] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurosci & Biomol Chem, Madison, WI 53705 USA, Xarxa de Bancs de Tumors de Catalunya, Pla Director d'Oncologia de Catalunya, ISCIII-FEDER, Ministerio de Economia y Competitividad (MEC), FEDER Funds, Asociacion Espanola Contra el Cancer (AECC), AECC, MEC-FEDER, European FP7 Projects EuroSARC (FP7HEALTH-two-stage), Euroewing, Fundacion Memoria de DM Solorzano Barruso, Fundacion Cris contra el Cancer, Pablo Ugarte Foundation, Fundacion M. Garcia Estrada, and European FP7 projects (FP7) under a Marie Curie International Reintegration Grant
Subjects: 0301 basic medicine, P50, Cellular differentiation, Neuroectodermal tumors, RING1B, Bone Neoplasms, Sarcoma, Ewing, Genomic landscape, NF-κB, 03 medical and health sciences, chemistry.chemical_compound, Sarcoma -- Aspectes genètics, Fibroblast-growth-factor, In-vivo, voltage-gated sodium channel, Voltage-gated sodium channel, Tumor Cells, Cultured, Medicine, Humans, Family, FGFR/SHP2/STAT3, STAT3, Polycomb Repressive Complex 1, biology, Oncogene, business.industry, Histone h2a, Tyrosine-phosphatase, NF-kappa B, NFKB1, Stem-cells, 3. Good health, 030104 developmental biology, Oncology, chemistry, Apoptosis, NAV1.6 Voltage-Gated Sodium Channel, Cancer research, biology.protein, Marrow stromal cells, Signal transduction, Neural differentiation, business, Ewing sarcoma, Research Paper, Signal Transduction
Abstract: Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES cells display an expression profile enriched in genes functionally involved in hematological development but RING1B depletion does not induce cellular differentiation. In ES cells, RING1B directly binds the SCN8A sodium channel promoter and its depletion results in enhanced Nav1.6 expression and function. The signaling pathway most significantly modulated by RING1B is NF-κB. RING1B depletion results in enhanced p105/p50 expression, which sensitizes ES cells to apoptosis by FGFR/SHP2/STAT3 blockade. Reduced NaV1.6 function protects ES cells from apoptotic cell death by maintaining low NF-κB levels. Our findings identify RING1B as a trait of the cell-of-origin and provide a potential targetable vulnerability., IHM is a Miguel Servet investigator (Instituto de Salud Carlos III, ISCIII). This work was supported by the Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncologia de Catalunya and by grants from ISCIII-FEDER (PS09/00973; RIC RD12/0042/0014, Red HERACLES), Ministerio de Economía y Competitividad (MEC) (SAF2012-31089 and SAF2015-69762-R), FEDER Funds and by the Asociación Española Contra el Cáncer (AECC). E.Á.’s lab is supported by the AECC, MEC-FEDER (RD12/0036/0017, PT13/0010/0056, RTC-2014-2102-1, ISCIII Sara Borrell CD06/00001, PI12/03102, PI14/01466), the European FP7 Projects EuroSARC (FP7-HEALTH-2011-two-stage, Project 278742 EUROSARC), Euroewing (FP7-HEALTH.2013.2.4.1-1, Project 602856), Fundación Memoria de DM Solorzano Barruso, Fundación Cris contra el Cáncer, Pablo Ugarte Foundation, and Fundación M. García Estrada. O.M.T. is funded by ISCIII-FEDER (CES12/021) and the AECC. AMC is funded by the European FP7 projects (FP7/2007-2013) under a Marie Curie International Reintegration Grant (PIRG-08- GA-2010-276998) and ISCIII-FEDER (CP13/00189). The Ewing group at the Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, is supported by the AECC and the generous donations from Pablo Ugarte Foundation.

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1. Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study

2. Genomics And Susceptibility Profiles Of Extensively Drug-resistant Pseudomonas Aeruginosa Isolates From Spain

3. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

4. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

5. Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

6. RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

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