Search

ObjectiveThis study aimed to compare outcomes among patients who sustained major trauma from injury with and without receiving antiplatelet therapy (APT) or anticoagulant therapy (ACT) to test the hypothesis that APT does not increase the risk of mortality. However, ACT increases the mortality risk in the acute phase of trauma.MethodsPatients registered in the Japanese Observational body for Coagulation and Thrombolysis in Early Trauma 2 between April 2017 and March 2018 who had sustained a severe injury in any anatomic region of the body, as determined using an injury severity score (ISS) ≥ 16 were included in this retrospective cohort study. We analyzed the mortality within 24 h from the arrival using a multivariable linear regression analysis adjusted for several confounding variables.ResultsWe identified 1,186 eligible participants who met the inclusion criteria for this study: 105 in the APT (cases), 1,081 in the non-antiplatelet therapy (nAPT) group (controls), 65 in the ACT (cases), and 1,121 in the non-anticoagulant therapy (nACT) group (controls). The mortality within 24 h in the ACT group was significantly higher than in the nACT group (odds ratio 4.5; 95%CI: 1.2–16.79; p = 0.025); however, there was no significant difference between the two groups with or without the antiplatelet drug (odds ratio 0.32; 95%CI: 0.04–2.79; p = 0.3) administration. Other outcomes, like the 28-day mortality, mortality at discharge, and surgery for hemostasis, were not significantly different between regular users and non-users of either antiplatelet or anticoagulant drugs.ConclusionRegular antiplatelet medications did not increase mortality within 24 h, 28 days, or at discharge in patients with major trauma, suggesting that standard treatment, including surgery, is sufficient.

Background : Rhododendrol (RD) is a skin whitening ingredient that was developed in Japan. Among the 800000 users of RD-containing cosmetics, 20000 patients developed localized leukoderma (RD-induced leukoderma). Forty-two % of those users showed perilesional hyperpigmentation (leukomelanoderma), and 14% of them were associated with vitiligo vulgaris afterwards....

Additional file 3: Figure S7. Scatter diagrams showing the associations between the mfPhNR/B of mfERG in each sector and the average thickness of the GCIPL, mRNFL, and GCC of OCT in glaucoma patients. mfPhNR/B: multifocal photopic negative response to multifocal B-wave ratio, mfERG: multifocal electroretinogram, GCIPL:Ganglion cell-inner plexiform layer, mRNFL: Macular retinal nerve fiber layer, GCC: Ganglion cell complex, OCT: Optical coherence tomopraphy, Ave: Average

Additional file 1: Figure S5. Scatter diagrams showing the associations between the N/T of mfERG, the macula thickness of OCT, and the mean thresholds and the total deviation of HFA 10–2 in each sector in glaucoma patients. N/T or NT: Nasal to temporal amplitude ratio, mfERG: multifocal electroretinogram, OCT; Optical coherence tomopraphy, HFA 10–2: Humphrey Field Analyzer Program Central 10–2, GCIPL:Ganglion cell-inner plexiform layer, Ave: Average, SN: Superonasal, IN: Inferonasal, ST: Superotemporal, IT: Inferotemporal, I: Inferior, S: Superior, mRNFL: Macular retinal nerve fiber layer, GCC: Ganglion cell complex, MD: Mean deviation, MT: Mean threshold, TD: Total deviation

Supplemental_Table1_0928 for Effects of Inotropes on the Mortality in Patients With Septic Shock by Ryota Sato, Nobuhiro Ariyoshi, Daisuke Hasegawa, Erin Crossey, Natsumi Hamahata, Takuma Ishihara, Michitaka Nasu and Gehan Devendra in Journal of Intensive Care Medicine

Supplemental_Table_2 for Effects of Inotropes on the Mortality in Patients With Septic Shock by Ryota Sato, Nobuhiro Ariyoshi, Daisuke Hasegawa, Erin Crossey, Natsumi Hamahata, Takuma Ishihara, Michitaka Nasu and Gehan Devendra in Journal of Intensive Care Medicine