1. Importing genetically altered animals: ensuring quality
- Author
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Guillaume Pavlovic, Edward Ryder, R. Matteoni, Marie-Christine Birling, Jan Rozman, Lydia Teboul, Ferdinando Scavizzi, Martin Fray, Lauryl M J Nutter, Marcello Raspa, Sara Wells, Petr Kasparek, J. Kopkanova, M. Massimi, V. Voikar, Lluis Montoliu, Biosciences, Neuroscience Center, French National Infrastructure for Mouse Phenogenomics (PHENOMIN), Institut Clinique de la Souris (ICS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MRC Harwell, Institute of Molecular Genetics of the Czech Academy of Sciences (IMG / CAS), Czech Academy of Sciences [Prague] (CAS), CNR - Italian National Research Council (CNR), Centro Nacional de Biotecnología [Madrid] (CNB-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), The Hospital for sick children [Toronto] (SickKids), The Wellcome Trust Sanger Institute [Cambridge], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, and univOAK, Archive ouverte
- Subjects
EXPRESSION ,media_common.quotation_subject ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,Biology ,MOUSE ,mouse mutant ,03 medical and health sciences ,0302 clinical medicine ,Documentation ,REPRODUCIBILITY ,Genetics ,Animals ,Humans ,Quality (business) ,030304 developmental biology ,media_common ,0303 health sciences ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,disease model ,1184 Genetics, developmental biology, physiology ,Reproducibility of Results ,MICROBIOTA ,GENE ,Biological materials ,Research Personnel ,CRE RECOMBINASE ,RODENT ,MICE ,Risk analysis (engineering) ,CELLS ,RAT ,030217 neurology & neurosurgery - Abstract
The reproducibility of research using laboratory animals requires reliable management of their quality, in particular of their genetics, health and environment, all of which contribute to their phenotypes. The point at which these biological materials are transferred between researchers is particularly sensitive, as it may result in a loss of integrity of the animals and/or their documentation. Here, we describe the various aspects of laboratory animal quality that should be confirmed when sharing rodent research models. We also discuss how repositories of biological materials support the scientific community to ensure the continuity of the quality of laboratory animals. Both the concept of quality and the role of repositories themselves extend to all exchanges of biological materials and all networks that support the sharing of these reagents.
- Published
- 2021
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