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We carried out a high time-resolution, multicolour optical observing campaign for eight $\gamma$-ray detected blazars during 2010-2020. We analyze flux variations, correlations between magnitudes and colours on different timescales. Intraday variability (IDV) is detected in all eight sources of our sample. A bluer-when-brighter (BWB) chromatic trend is dominant on intraday timescales. On the short timescales, the BWB trend only shows up in ON 231, 3C 279, BL Lacertae and 1E 1458.8+2249. There is a BWB trend in 3C 279 on the long timescale. We estimate the upper limits of black hole mass for three blazars (i.e. ON 321, 1ES 1426+42.8, PKS 1510-089) using variability timescales. On April 13, 2010 a potential quasi-periodic oscillation (QPO) with the period of $P=48.67\pm13.90$ minutes is found in 1ES 1426+42.8. The light curve on March 16, 2021 further shows the existence of the QPO phenomenon. The QPO in this target deserves further observation and confirmation., Comment: 18 pages, 8 figures, accepted in MNRAS

In order to investigate developmental coordination disorder (DCD) of kindergarten children in Zhejiang province, 200 ordinary kindergartens were randomly selected by stratified random sampling in 11 prefecture-level cities of Zhejiang Province, and 38 900 children from 1 000 classes in each grade were then randomly selected into the study from June 2019 to December 2019. The Little DCD Questionnaire and a self-designed questionnaire were used to screen the DCD of those children. There were 36 807 valid questionnaires, and 6.50% (2 391/36 807) of them were positive results. The results showed that boy, age ≤5 years, overweight or obesity, left handedness, comorbidity with motor or developmental disorders and premature infants were risk factors of DCD in children. As for parents and families, maternal gestational age20 years, maternal overweight or obesity before pregnancy, low-middle level education of parents, direct family and low income of family were also associated with DCD in children. Therefore, it is necessary to conduct early prevention and intervention strategies targeting on identified risk factors among relevant population.为了解浙江省幼儿园儿童发育性协调障碍（DCD）的情况，于2019年6至12月在浙江省11个地级市采取分层随机抽样法抽取200个普通幼儿园，并在其各年级中分层整群抽取1 000个班级，共38 900名儿童作为研究对象。应用中文版小龄儿童发育性协调障碍问卷及自行设计调查问卷对研究对象进行DCD筛查，回收有效问卷36 807份，6.50%（2 391/36 807）儿童DCD筛查呈阳性。分析结果显示，儿童方面：男性、年龄≤5岁、超重或肥胖、左利手、共患运动或发育障碍性疾病、早产儿是儿童DCD的危险因素；父母家庭方面：母亲孕龄20岁、母亲孕前超重或肥胖、父母中低文化水平、直系家庭、家庭收入低是儿童DCD的危险因素，建议针对相关危险因素及早开展预防与干预。.

门静脉积气（portal venous gas）在临床中是一种较为少见的影像学表现，过去这种表现预示着极高的病死率，随着影像学发展进步，现在门静脉积气可被及早地发现并引导医师通过各类检查手段寻找病因，然而在这些病因中克罗恩病并不常见，以下报道1例小肠克罗恩病并发产气荚膜梭菌入血引起的门静脉系统积气病例。.

The visible world is founded on the proton, the only composite building block of matter that is stable in nature. Consequently, understanding the formation of matter relies on explaining the dynamics and the properties of the proton's bound state. A fundamental property of the proton involves the response of the system to an external electromagnetic field. It is characterized by the electromagnetic polarizabilitiessup1/supthat describe how easily the charge and magnetization distributions inside the system are distorted by the electromagnetic field. Moreover, the generalized polarizabilitiessup2/supmap out the resulting deformation of the densities in a proton subject to an electromagnetic field. They disclose essential information about the underlying system dynamics and provide a key for decoding the proton structure in terms of the theory of the strong interaction that binds its elementary quark and gluon constituents. Of particular interest is a puzzle in the electric generalized polarizability of the proton that remains unresolved for two decadessup2/sup. Here we report measurements of the proton's electromagnetic generalized polarizabilities at low four-momentum transfer squared. We show evidence of an anomaly to the behaviour of the proton's electric generalized polarizability that contradicts the predictions of nuclear theory and derive its signature in the spatial distribution of the induced polarization in the proton. The reported measurements suggest the presence of a new, not-yet-understood dynamical mechanism in the proton and present notable challenges to the nuclear theory.

Water is one of essential resources of modern society. Employing cost-effective technologies to treat water and wastewater is of vital importance for household uses, industries and the environment. Water-stable metal-organic frameworks (MOFs) have emerged as promising innovative materials for water treatment, due to their versatility and properties such as large internal surface area, designable pore sizes, and chemical functionalities. In highly porous MOFs, metal center(s)/cluster(s) and organic ligands are linked with coordination bonds. This review paper presents the most recent developments in the industrial-scale synthesis of MOFs and applications in water purification. MOFs can be fabricated by several approaches; the microwave assisted continuous flow synthesis technologies can lead to higher production yields. The fabricated MOFs are then purified by the organic solvent and/or the solid separation, and activated by a few technologies (e.g., supercritical CO2). Process safety in production, reactors design, and process optimization are important in production. The shaping techniques for MOFs on supporting materials via surface grafting/coating or embedment can be used to fabricate the MOFs-based materials with the better stability suitable for industrial applications. MOFs demonstrate much better performances than the commercially available materials in adsorption, filtration, sensing, and catalysis. Toxicity from MOFs is mainly due to the chemicals involved in the production and nano-size effects on human cells. Mitigation strategies like environmental-friendly processes for fabrication of MOFs and shaping using polymer are suggested. Various advantages from MOFs make them suitable for water treatment in the near future.

The ratio of the nucleon F_{2} structure functions, F_{2}^{n}/F_{2}^{p}, is determined by the MARATHON experiment from measurements of deep inelastic scattering of electrons from ^{3}H and ^{3}He nuclei. The experiment was performed in the Hall A Facility of Jefferson Lab using two high-resolution spectrometers for electron detection, and a cryogenic target system which included a low-activity tritium cell. The data analysis used a novel technique exploiting the mirror symmetry of the two nuclei, which essentially eliminates many theoretical uncertainties in the extraction of the ratio. The results, which cover the Bjorken scaling variable range 0.19x0.83, represent a significant improvement compared to previous SLAC and Jefferson Lab measurements for the ratio. They are compared to recent theoretical calculations and empirical determinations of the F_{2}^{n}/F_{2}^{p} ratio.

When protons and neutrons (nucleons) are bound into atomic nuclei, they are close enough to feel significant attraction, or repulsion, from the strong, short-distance part of the nucleon-nucleon interaction. These strong interactions lead to hard collisions between nucleons, generating pairs of highly energetic nucleons referred to as short-range correlations (SRCs). SRCs are an important but relatively poorly understood part of nuclear structure

Fluorine is one of the most interesting elements in nuclear astrophysics, where the ^{19}F(p,α)^{16}O reaction is of crucial importance for Galactic ^{19}F abundances and CNO cycle loss in first generation Population III stars. As a day-one campaign at the Jinping Underground Nuclear Astrophysics experimental facility, we report direct measurements of the essential ^{19}F(p,αγ)^{16}O reaction channel. The γ-ray yields were measured over E_{c.m.}=72.4-344 keV, covering the Gamow window; our energy of 72.4 keV is unprecedentedly low, reported here for the first time. The experiment was performed under the extremely low cosmic-ray-induced background environment of the China JinPing Underground Laboratory, one of the deepest underground laboratories in the world. The present low-energy S factors deviate significantly from previous theoretical predictions, and the uncertainties are significantly reduced. The thermonuclear ^{19}F(p,αγ)^{16}O reaction rate has been determined directly at the relevant astrophysical energies.

We report measurements of the exclusive neutral pion electroproduction cross section off protons at large values of $x_B$ (0.36, 0.48 and 0.60) and $Q^2$ (3.1 to 8.4 GeV$^2$) obtained from Jefferson Lab Hall A experiment E12-06-014. The corresponding structure functions $d\sigma_L/dt+\epsilon d\sigma_T/dt$, $d\sigma_{TT}/dt$, $d\sigma_{LT}/dt$ and $d\sigma_{LT'}/dt$ are extracted as a function of the proton momentum transfer $t-t_{min}$. The results suggest the amplitude for transversely polarized virtual photons continues to dominate the cross-section throughout this kinematic range. The data are well described by calculations based on transversity Generalized Parton Distributions coupled to a helicity flip Distribution Amplitude of the pion, thus providing a unique way to probe the structure of the nucleon.

Fluorine is one of the most interesting elements in nuclear astrophysics, where the ^{19}F(p,α)^{16}O reaction is of crucial importance for Galactic ^{19}F abundances and CNO cycle loss in first generation Population III stars. As a day-one campaign at the Jinping Underground Nuclear Astrophysics experimental facility, we report direct measurements of the essential ^{19}F(p,αγ)^{16}O reaction channel. The γ-ray yields were measured over E_{c.m.}=72.4-344 keV, covering the Gamow window; our energy of 72.4 keV is unprecedentedly low, reported here for the first time. The experiment was performed under the extremely low cosmic-ray-induced background environment of the China JinPing Underground Laboratory, one of the deepest underground laboratories in the world. The present low-energy S factors deviate significantly from previous theoretical predictions, and the uncertainties are significantly reduced. The thermonuclear ^{19}F(p,αγ)^{16}O reaction rate has been determined directly at the relevant astrophysical energies.

In conventional atmospheric models, isotope exchange between liquid, gas, and solid phases is usually assumed to be in equilibrium, and the highly kinetic phase transformation processes inferred in clouds are yet to be fully investigated. In this study, a two-moment microphysical scheme in the National Center for Atmospheric Research (NCAR) Weather Research and Forecasting (WRF) model was modified to allow kinetic calculation of isotope fractionation due to various cloud microphysical phase-change processes. A case of a moving cold front is selected for quantifying the effect of different factors controlling isotopic composition, including water vapor sources, atmospheric transport, phase transition pathways of water in clouds, and kinetic-versus-equilibrium mass transfer. A base-run simulation was able to reproduce the ∼ 50 ‰ decrease in δD that was observed during the frontal passage. Sensitivity tests suggest that all the above factors contributed significantly to the variations in isotope composition. The thermal equilibrium assumption commonly used in earlier studies may cause an overestimate of mean vapor-phase δD by 11 ‰, and the maximum difference can be more than 20 ‰. Using initial vertical distribution and lower boundary conditions of water stable isotopes from satellite data is critical to obtain successful isotope simulations, without which the δD in water vapor can be off by about 34 ‰ and 28 ‰, respectively. Without microphysical fractionation, the δD in water vapor can be off by about 25 ‰.

The E12-14-012 experiment, performed in Jefferson Lab Hall A, has collected exclusive electron-scattering data (e,e$^\prime$p) in parallel kinematics using natural argon and natural titanium targets. Here, we report the first results of the analysis of the data set corresponding to beam energy of 2,222 MeV, electron scattering angle 21.5 deg, and proton emission angle -50 deg. The differential cross sections, measured with $\sim$4% uncertainty, have been studied as a function of missing energy and missing momentum, and compared to the results of Monte Carlo simulations, obtained from a model based on the Distorted Wave Impulse Approximation.

Quasielastic C12(e,e′p) scattering was measured at spacelike 4-momentum transfer squared Q2=8, 9.4, 11.4, and 14.2 (GeV/c)2, the highest ever achieved to date. Nuclear transparency for this reaction was extracted by comparing the measured yield to that expected from a plane-wave impulse approximation calculation without any final state interactions. The measured transparency was consistent with no Q2 dependence, up to proton momenta of 8.5 GeV/c, ruling out the quantum chromodynamics effect of color transparency at the measured Q2 scales in exclusive (e,e′p) reactions. These results impose strict constraints on models of color transparency for protons.

Positron beams, both polarized and unpolarized, are identified as essential ingredients for the experimental programs at the next generation of lepton accelerators. In the context of the hadronic physics program at Jefferson Lab (JLab), positron beams are complementary, even essential, tools for a precise understanding of the electromagnetic structure of nucleons and nuclei, in both the elastic and deep-inelastic regimes. For instance, elastic scattering of polarized and unpolarized electrons and positrons from the nucleon enables a model independent determination of its electromagnetic form factors. Also, the deeply-virtual scattering of polarized and unpolarized electrons and positrons allows unambiguous separation of the different contributions to the cross section of the lepto-production of photons and of lepton-pairs, enabling an accurate determination of the nucleons and nuclei generalized parton distributions, and providing an access to the gravitational form factors. Furthermore, positron beams offer the possibility of alternative tests of the Standard Model of particle physics through the search of a dark photon, the precise measurement of electroweak couplings, and the investigation of charged lepton flavor violation. This document discusses the perspectives of an experimental program with high duty-cycle positron beams at JLab., Comment: 18 pages, 7 figures This version superseeds the previous version which scientific content was decomposed into several more elaborated articles. All of these articles will be collected in the EPJ A Topical Issue about "Positron beam and physics at Jefferson Lab (e+@Jlab)"

Measuring the spin structure of protons and neutrons tests our understanding of how they arise from quarks and gluons, the fundamental building blocks of nuclear matter. At long distances the coupling constant of the strong interaction becomes large, requiring non-perturbative methods to calculate quantum chromodynamics processes, such as lattice gauge theory or effective field theories. Here we report proton spin structure measurements from scattering a polarized electron beam off polarized protons. The spin-dependent cross-sections were measured at large distances, corresponding to the region of low momentum transfer squared between 0.012 and 1.0 GeV$^2$. This kinematic range provides unique tests of chiral effective field theory predictions. Our results show that a complete description of the nucleon spin remains elusive, and call for further theoretical works, e.g. in lattice quantum chromodynamics. Finally, our data extrapolated to the photon point agree with the Gerasimov-Drell-Hearn sum rule, a fundamental prediction of quantum field theory that relates the anomalous magnetic moment of the proton to its integrated spin-dependent cross-sections., Published version. 10 pages, 5 figures. 20 pages of supplementary material (data tables and a figure)

Spectroscopic factors to low-lying negative-parity states in $^{11}$Be extracted from the $^{12}$B($d$,$^3$He)$^{11}$Be proton-removal reaction are interpreted within the rotational model. Earlier predictions of the $p$-wave proton removal strengths in the strong coupling limit of the Nilsson model underestimated the spectroscopic factors to the $3/2^-_1$ and $5/2^-_1$ states and suggested that deviations in the $1^+$ ground state of the odd-odd $^{12}$B due to Coriolis coupling should be further explored. In this work we use the Particle Rotor Model to take into account these effects and obtain a good description of the level scheme in $^{11}$B, with a moderate $K$-mixing of the proton Nilsson levels [110]1/2 and [101]3/2. This mixing, present in the $1^+$ bandhead of $^{12}$B, is key to explaining the proton pickup data., 5 Pages, 2 Figures, to be submitted to Phys. Rev. C

BackgroundSeveral studies have demonstrated immunogenicity after COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD) [1], but the differences between mRNA-based and vector vaccines and the cellular responses to COVID-19 vaccines according to distinct immunogenicity in AIRD patients are still unclear.ObjectivesTo investigate the differences in efficacy and safety between the vector vaccine ChAdOx1 nCoV-19/AZD1222 (Oxford-AstraZeneca) and mRNA-based vaccine mRNA-1273 (Moderna) in patients with AIRD, and to explore the cell-cell interactions between high and low anti-SARS-CoV-2 IgG levels in patients with rheumatic arthritis (RA) by single-cell RNA sequencing (scRNA-seq).MethodsFrom September 16 to November 15, 2021, we consecutively enrolled 243 participants aged ≥20 years with AIRD who received COVID-19 vaccination, of whom 113 were immunized with AZD1222 and 130 with mRNA-1273. The level of serum IgG antibodies to the SARS-CoV-2 receptor-binding domain on the spike protein S1 subunit was quantified by electrochemiluminescence immunoassay at 4-6 weeks after vaccination. Moreover, peripheral blood mononuclear cells were isolated from two RA patient with high anti-SARS-CoV-2 IgG level and four RA patients with low level for scRNA-seq and cell-cell communication signal was analyzed by CellChat.ResultsThe anti-SARS-CoV-2 IgG seropositivity rate was 78.8% (89/113) for AZD1222 and 83.1% (108/130) for mRNA-1273. The level of anti-SARS-CoV-2 IgG was higher in patients who received mRNA-1273 than in those who received AZD1222 (β: 30.15, 95% CI: 11.67-48.63, p=0.002) (Table 1). Prednisolone-equivalent dose >5 mg/day and methotrexate (MTX) use in AIRD patients, and non-anti-tumor necrosis factor (TNF)-α biologics and Janus kinase (JAK) inhibitor use in RA patients were associated with inferior immunogenicity. ScRNA-seq revealed CD16-monocytes were predominant in RA patients with high anti-SARS-CoV2-IgG antibody level, and enriched pathways related to antigen presentation via major histocompatibility complex class II (MHC class II) were found (Figure 1). HLA-DRA and CD4 interaction was vigorous among all identified MHC-II pathway and was enhanced in high anti-SARS-CoV2-IgG antibody group.Table 1.Multivariate analysis of anti-SARS-CoV-2 IgG level in patients with rheumatic diseases following COVID-19 vaccinesMultivariate analysisβ95% CIp valueMedicationsGlucocorticoidsNot usedReference≤5 mg/day−22.48(−56.33,11.37)0.192>5 mg/day−23.45(−43.54,-3.36)0.022Methotrexate−24.89(−45.70,-4.08)0.019Targeted therapiesTargeted therapies group Not usedReference TNF inhibitor−15.78(−41.33,9.76)0.224 Non-TNF bDMARD−25.27(−55.47,4.93)0.100 JAK inhibitor−17.08(−47.23,13.07)0.265VaccineChAdOx1 nCoV-19/AZD1222ReferencemRNA-127330.15(11.67,48.63)0.002TNF: tumor necrosis factor, bDMARDs: biologic disease-modifying antirheumatic drugs, JAK: Janus kinase.Figure 1.The comprehensive cell atlas of PBMC of RA patients with high and low anti-SARS-CoV2-IgG antibodies. A) UMAP visualization of PBMC cells from RA patients. B) The proportion of cell types between high and low antibody groups. C) Volcano plot of CD16-monocyte showed differential expressed genes. D) Pathway analysis between high and low antibody groups; PRBC: peripheral blood mononuclear cell, RA: rheumatoid arthritis, NK cell: natural killer cell, pDC: plasmacytoid dendritic cell, CLP: common lymphoid progenitor.ConclusionmRNA-1273 and AZD1222 vaccines exhibited differential immunogenicity in patients with AIRD. Enriched pathways related to antigen presentation via MHC class II in CD16-monocytes might be associated with higher anti-SARS-CoV2-IgG level in RA patients and further study is warranted.References[1]Geisen UM, Berner DK, Tran F, et al. Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort. Ann Rheum Dis. 2021;80:1306-1311.AcknowledgementsThe authors thank the Biostatistics Task Force of Taichung Veterans General Hospital for their assistance with the statistical analysis in this study.Disclosure of InterestsNone declared

Author(s): Morse, C; MacChiavelli, AO; Crawford, HL; Zhu, S; Wu, CY; Wang, YY; Meng, J; Back, BB; Bucher, B; Campbell, CM; Carpenter, MP; Chen, J; Clark, RM; Cromaz, M; Fallon, P; Henderson, J; Janssens, RVF; Jones, MD; Khoo, TL; Kondev, FG; Lauritsen, T; Lee, IY; Li, J; Potterveld, D; Santamaria, C; Savard, G; Seweryniak, D; Stolze, S; Weisshaar, D | Abstract: The neutron-rich barium nuclei have been the subject of intense interest due to the enhanced octupole correlations they are predicted to exhibit. The observation of enhanced octupole collectivity in Ba144,146 as measured in sub-barrier Coulomb excitation, consistent with static octupole deformation, has further heightened this interest. In the present work, these studies are extended to the neighboring odd-mass Ba143 to investigate the interplay between single-particle and collective octupole degrees of freedom. A new measurement of the first 92 - state lifetime is also presented. Reflection-Asymmetric Triaxial Particle Rotor Model calculations indicate that the negative-parity bands in Ba143 can be understood as a decoupled structure of νh9/2 parentage, while the positive-parity bands are built on a decoupled octupole phonon. No evidence for E3 excitation is observed in this work, but an upper limit is placed on the E3 matrix element to the lowest octupole band.

Quasielastic ^{12}C(e,e^{'}p) scattering was measured at spacelike 4-momentum transfer squared Q^{2}=8, 9.4, 11.4, and 14.2 (GeV/c)^{2}, the highest ever achieved to date. Nuclear transparency for this reaction was extracted by comparing the measured yield to that expected from a plane-wave impulse approximation calculation without any final state interactions. The measured transparency was consistent with no Q^{2} dependence, up to proton momenta of 8.5 GeV/c, ruling out the quantum chromodynamics effect of color transparency at the measured Q^{2} scales in exclusive (e,e^{'}p) reactions. These results impose strict constraints on models of color transparency for protons.

In the original PDF online version of this article, the references 22–26 were missing.These are the missing references.

$^{2}\mathrm{H}(e,e'p)n$ cross sections have been measured at 4-momentum transfers of $Q^{2} = 4.5 \pm 0.5$ (GeV/c)$^{2}$ over a range of neutron recoil momenta, $p_{\mathrm{r}}$, reaching up to $\sim1.0$ GeV/c. The data were obtained at fixed neutron recoil angles $\theta_{nq} = 35^\circ$, $45^\circ$ and $75^{\circ}$ with respect to the 3-momentum transfer $\vec q$. The new data agree well with previous data which reached $p_{\mathrm{r}}\sim500$ MeV/c. At $\theta_{nq} = 35^\circ$ and $45^\circ$, final state interactions (FSI), meson exchange currents (MEC) and isobar currents (IC) are suppressed and the plane wave impulse approximation (PWIA) provides the dominant cross section contribution. The new data are compared to recent theoretical calculations, where we observe a significant discrepancy for missing momenta $p_{\mathrm{r}}>700$ MeV/c., Comment: main article: 6 pages, 2 figures | supplemental material: 7 pages, 13 figures | numerical tables of cross sections for data and theory are provided as ancillary material | This version has minor additions in the concluding paragraph to address the light-cone / EFT formalisms in the context of this experiment. The supplemental materials have new Fig. 10, and modified Fig. 9

The aim of this study is to explore the regulatory mechanism of circRNA UBAP2 (circUBAP2) in colorectal cancer (CRC).The expression levels of circUBAP2, miR-199a, and VEGFA in tissues and cell lines were detected by RT-qPCR. The cell proliferation was examined by CCK-8 and colony formation assays. The migration and invasion abilities were evaluated by wound healing and transwell assays, respectively. Bioinformatics analysis and Luciferase activity assay were applied to determine the interaction between genes.The expression of circUBAP2 was upregulated in CRC tissues and cell lines, and depletion of circUBAP2 suppressed the cell proliferation, migration, and invasion of CRC. Furthermore, miR-199a inhibitor abrogated the suppressive effect of circUBAP2 knockdown on CRC progression. Vascular endothelial growth factor A (VEGFA) was identified as a downstream target gene of miR-199a, and overexpression of VEGFA rescued the tumor phenotypes attenuated by circUBAP2 knockdown or miR-199a overexpression.Our findings demonstrated that circUBAP2 facilitated CRC progression by sponging miR-199a to upregulate VEGFA. These findings implied that circUBAP2 may be a potential therapeutic biomarker for CRC.

The aim of the study was to explore the effect of lipoxin A4 (LXA4) on lung injury in sepsis rats through the p38/mitogen-activated protein kinase (MAPK) signaling pathway. Sprague-Dawley rats were used for the study. The rat model of sepsis-induced acute lung injury was established via cecal ligation (Sepsis group, n=20). LXA4 (0.1 mg/kg) was injected at 6 h after modeling (Treatment group, n=20), and a The Control group (n=20) was also set up. The 7-day survival rate was 100% in The Control group, and LXA4 raised the survival rate of rats in the Sepsis group from 40% to 60% (P0.01). Alveolar fluid clearance (AFC) significantly declined and the wet/dry weight (W/D) ratio of lung tissues rose remarkably in the Sepsis group compared with those in the Control group, while LXA4 restored AFC and reduced the W/D ratio of lung tissues (P0.05), suggesting that LXA4 treatment reduces lung fluids and partially enhances AFC, thus lowering the W/D ratio of lung. The total cell count, polymorphonuclear neutrophils (PMN) percentage and concentration of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in bronchoalveolar lavage fluid (BALF) were obviously increased in the Sepsis group compared with those in the Control group, while they were markedly decreased in the Treatment group (P0.05). The activity of myeloperoxidase (MPO) in lung tissue homogenate was evidently higher in the Sepsis group than that in The Control group, while it was notably lower in the Treatment group than that in the Sepsis group after LXA4 treatment (P0.05). Moreover, it was observed microscopically that the morphology of lung tissues was intact in the Control group. Finally, the results of Western blotting manifested that the p-p38/ MAPK protein expression was remarkably increased in the Sepsis group, indicating the activation of the p38/MAPK pathway, while it was remarkably decreased in the Treatment group, indicating the inhibited activity of the pathway (P0.05). LXA4 has an anti-inflammatory effect on sepsis rats with lung injury, and such effect is related to the p38/MAPK signaling pathway.

The spin-structure functions $g_1$ and $g_2$, and the spin-dependent partial cross-section $\sigma_\mathrm{TT}$ have been extracted from the polarized cross-sections differences, $\Delta \sigma_{\parallel}\hspace{-0.06cm}\left(\nu,Q^{2}\right)$ and $\Delta \sigma_{\perp}\hspace{-0.06cm}\left(\nu,Q^{2}\right)$ measured for the $\vec{^\textrm{3}\textrm{He}}(\vec{\textrm{e}},\textrm{e}')\textrm{X}$ reaction, in the E97-110 experiment at Jefferson Lab. Polarized electrons with energies from 1.147 to 4.404 GeV were scattered at angles of 6$^{\circ}$ and 9$^{\circ}$ from a longitudinally or transversely polarized $^{3}$He target. The data cover the kinematic regions of the quasi-elastic, resonance production and beyond. From the extracted spin-structure functions, the first moments $\overline{\Gamma_1}\hspace{-0.06cm}\left(Q^{2}\right)$, $\Gamma_2\hspace{-0.06cm}\left(Q^{2}\right)$ and $I_{\mathrm{TT}}\hspace{-0.06cm}\left(Q^{2}\right)$ are evaluated with high precision for the neutron in the $Q^2$ range from 0.035 to 0.24~GeV$^{2}$. The comparison of the data and the chiral effective field theory predictions reveals the importance of proper treatment of the $\Delta$ degree of freedom for spin observables., Comment: 7 pages, 5 figures, 3 tables. Version published in Phys. Lett. B

We report the first measurement of the (e,e^{'}p) three-body breakup reaction cross sections in helium-3 (^{3}He) and tritium (^{3}H) at large momentum transfer [⟨Q^{2}⟩≈1.9 (GeV/c)^{2}] and x_{B}>1 kinematics, where the cross section should be sensitive to quasielastic (QE) scattering from single nucleons. The data cover missing momenta 40≤p_{miss}≤500 MeV/c that, in the QE limit with no rescattering, equals the initial momentum of the probed nucleon. The measured cross sections are compared with state-of-the-art ab initio calculations. Overall good agreement, within ±20%, is observed between data and calculations for the full p_{miss} range for ^{3}H and for 100≤p_{miss}≤350 MeV/c for ^{3}He. Including the effects of rescattering of the outgoing nucleon improves agreement with the data at p_{miss}>250 MeV/c and suggests contributions from charge-exchange (SCX) rescattering. The isoscalar sum of ^{3}He plus ^{3}H, which is largely insensitive to SCX, is described by calculations to within the accuracy of the data over the entire p_{miss} range. This validates current models of the ground state of the three-nucleon system up to very high initial nucleon momenta of 500 MeV/c.

The ratio of the electric and magnetic form factor of the proton, $\mu_p G_E^p/G_M^p$, has been measured for elastic electron-proton scattering with polarized beam and target up to four-momentum transfer squared, $Q^2=5.66$ (GeV/c)$^2$ using the double spin asymmetry for target spin orientation aligned nearly perpendicular to the beam momentum direction. This measurement of $\mu_p G_E^p/G_M^p$ agrees with the $Q^2$ dependence of previous recoil polarization data and reconfirms the discrepancy at high $Q^2$ between the Rosenbluth and the polarization-transfer method with a different measurement technique and systematic uncertainties uncorrelated to those of the recoil-polarization measurements. The form factor ratio at $Q^2$=2.06 (GeV/c)$^2$ has been measured as $\mu_p G_E^p/G_M^p = 0.720 \pm 0.176_{stat} \pm 0.039_{sys}$, which is in agreement with an earlier measurement with the polarized target technique at similar kinematics. The form factor ratio at $Q^2$=5.66 (GeV/c)$^2$ has been determined as $\mu_p G_E^p/G_M^p=0.244\pm0.353_{stat}\pm0.013_{sys}$, which represents the highest $Q^2$ reach with the double spin asymmetry with polarized target to date.

As an emerging means of energy supply, small modular reactors (SMRs) are considered as a promising option for relieving environmental pressure caused by increasing fossil fuel consumption. Since SMRs are at an early stage of development, in-depth analysis on the necessity and feasibility of their deployment is essential. The site selection of SMRs, which is a multifaceted process and should be guided by a clearly established set of criteria, is a crucial step. To propose comprehensive recommendations for SMR site selection, a review is provided in this study. The review involves development process, technical characteristics and potential applications of SMRs, research status of SMR site selection, and criteria for site selection of nuclear power plants (NPPs). Different considerations of siting criteria between SMRs and NPPs are analyzed. Based on the review and analyses, perspectives and targeted suggestions on SMR site selection are provided.

We report the first measurement of the (e,e^{'}p) three-body breakup reaction cross sections in helium-3 (^{3}He) and tritium (^{3}H) at large momentum transfer [⟨Q^{2}⟩≈1.9 (GeV/c)^{2}] and x_{B}1 kinematics, where the cross section should be sensitive to quasielastic (QE) scattering from single nucleons. The data cover missing momenta 40≤p_{miss}≤500 MeV/c that, in the QE limit with no rescattering, equals the initial momentum of the probed nucleon. The measured cross sections are compared with state-of-the-art ab initio calculations. Overall good agreement, within ±20%, is observed between data and calculations for the full p_{miss} range for ^{3}H and for 100≤p_{miss}≤350 MeV/c for ^{3}He. Including the effects of rescattering of the outgoing nucleon improves agreement with the data at p_{miss}250 MeV/c and suggests contributions from charge-exchange (SCX) rescattering. The isoscalar sum of ^{3}He plus ^{3}H, which is largely insensitive to SCX, is described by calculations to within the accuracy of the data over the entire p_{miss} range. This validates current models of the ground state of the three-nucleon system up to very high initial nucleon momenta of 500 MeV/c.

Measurements of elastic electron scattering data within the past decade have highlighted two-photon exchange contributions as a necessary ingredient in theoretical calculations to precisely evaluate hydrogen elastic scattering cross sections. This correction can modify the cross section at the few percent level. In contrast, dispersive effects can cause significantly larger changes from the Born approximation. The purpose of this experiment is to extract the carbon-12 elastic cross section around the first diffraction minimum, where the Born term contributions to the cross section are small to maximize the sensitivity to dispersive effects. The analysis uses the LEDEX data from the high resolution Jefferson Lab Hall A spectrometers to extract the cross sections near the first diffraction minimum of $$^{12}$$ C at beam energies of 362 MeV and 685 MeV. The results are in very good agreement with previous world data, although with less precision. The average deviation from a static nuclear charge distribution expected from linear and quadratic fits indicate a 30.6% contribution of dispersive effects to the cross section at 1 GeV. The magnitude of the dispersive effects near the first diffraction minimum of $$^{12}$$ C has been confirmed to be large with a strong energy dependence and could account for a large fraction of the magnitude for the observed quenching of the longitudinal nuclear response. These effects could also be important for nuclei radii extracted from parity-violating asymmetries measured near a diffraction minimum.

The three-dimensional structure of nucleons (protons and neutrons) is embedded in so-called generalized parton distributions, which are accessible from deeply virtual Compton scattering. In this process, a high energy electron is scattered off a nucleon by exchanging a virtual photon. Then, a highly-energetic real photon is emitted from one of the quarks inside the nucleon, which carries information on the quark's transverse position and longitudinal momentum. By measuring the cross-section of deeply virtual Compton scattering, Compton form factors related to the generalized parton distributions can be extracted. Here, we report the observation of unpolarized deeply virtual Compton scattering off a deuterium target. From the measured photon-electroproduction cross-sections, we have extracted the cross-section of a quasi-free neutron and a coherent deuteron. Due to the approximate isospin symmetry of quantum chromodynamics, we can determine the contributions from the different quark flavours to the helicity-conserved Compton form factors by combining our measurements with previous ones probing the proton's internal structure. These results advance our understanding of the description of the nucleon structure, which is important to solve the proton spin puzzle.

Short Range Correlations (SRCs) have been identified as being responsible for the high momentum tail of the nucleon momentum distribution, n(k). Hard, short-range interactions of nucleon pairs generate the high momentum tail and imprint a universal character on n(k) for all nuclei at large momentum. Triple coincidence experiments have shown a strong dominance of np pairs, but these measurements involve large final state interactions. This paper presents the results from Jefferson Lab experiment E08014 which measured inclusive electron scattering cross-section from Ca isotopes. By comparing the inclusive cross section from 48Ca to 40Ca in a kinematic region dominated by SRCs we provide a new way to study the isospin structure of SRCs., Comment: 7 pages, 3 figures

Missing-mass spectroscopy with the 3H(e, e′K+) reaction was carried out at Jefferson Lab’s (JLab) Hall A in Oct–Nov, 2018. The differential cross section for the 3H(γ∗, K+)Λnn was deduced at ω = Ee − Ee′ = 2.102 GeV and at the forward K+-scattering angle (0° ≤ θγ∗K ≤ 5°) in the laboratory frame. Given typical predicted energies and decay widths, which are (BΛ, Γ) = (−0.25, 0.8) and (−0.55, 4.7) MeV, the cross sections were found to be 11.2 ± 4.8(stat.)+4.1−2.1(sys.) and 18.1 ± 6.8(stat.)+4.2−2.9(sys.) nb/sr, respectively. The obtained result would impose a constraint for interaction models particularly between Λ and neutron by comparing to theoretical calculations.

An nnΛ is a neutral baryon system with no charge. The study of the pure Λ-neutron system such as nnΛ gives us information on the Λn interaction. The nnΛ search experiment (E12-17-003) was performed at JLab Hall A in 2018. In this article, the Λn FSI was investigated by a shape analysis of the 3H(e, e′K+)X missing mass spectrum, and a preliminary result for the Λn FSI study is given.

We performed an experiment using tritium and hydrogen cryogenic gas targets at Thomas Jefferson National Accelerator Facility (JLab) in 2018 (E12-17-003)[1, 2]. In this article, we discuss the Λ/Σ0 hyperon electroproduction from hydrogen target. Elementary Λ/Σ0 hyperon production processes are important not only for an absolute mass scale calibration in our experiment, but also for the study of the electroproduction mechanisms themselves. In this article, we reported the results of the differential cross section for the p(e, e’K+)Λ/Σ0 reaction at Q2 ∼ 0.5 (GeV/c)2.

Due to the lack of free neutron targets, studies of the structure of the neutron are typically made by scattering electrons from either 2H or 3He targets. In order to extract useful neutron information from a 3He target, one must understand how the neutron in a 3He system differs from a free neutron by taking into account nuclear effects such as final state interactions and meson exchange currents. The target single spin asymmetry Ay0 is an ideal probe of such effects, as any deviation from zero indicates effects beyond plane wave impulse approximation. New measurements of the target single spin asymmetry Ay0 at Q2 of 0.46 and 0.96 (GeV/c)2 were made at Jefferson Lab using the quasi-elastic He↑3(e,e′n) reaction. Our measured asymmetry decreases rapidly, from >20% at Q2=0.46 (GeV/c)2 to nearly zero at Q2=0.96 (GeV/c)2, demonstrating the fall-off of the reaction mechanism effects as Q2 increases. We also observed a small ϵ-dependent increase in Ay0 compared to previous measurements, particularly at moderate Q2. This indicates that upcoming high Q2 measurements from the Jefferson Lab 12 GeV program can cleanly probe neutron structure from polarized 3He using plane wave impulse approximation. Keywords: Neutron, Quasi-elastic, Polarized, 3He, Electron scattering, Single spin asymmetry

We report the first measurement of the $(e,e'p)$ reaction cross-section ratios for Helium-3 ($^3$He), Tritium ($^3$H), and Deuterium ($d$). The measurement covered a missing momentum range of $40 \le p_{miss} \le 550$ MeV$/c$, at large momentum transfer ($\langle Q^2 \rangle \approx 1.9$ (GeV$/c$)$^2$) and $x_B>1$, which minimized contributions from non quasi-elastic (QE) reaction mechanisms. The data is compared with plane-wave impulse approximation (PWIA) calculations using realistic spectral functions and momentum distributions. The measured and PWIA-calculated cross-section ratios for $^3$He$/d$ and $^3$H$/d$ extend to just above the typical nucleon Fermi-momentum ($k_F \approx 250$ MeV$/c$) and differ from each other by $\sim 20\%$, while for $^3$He/$^3$H they agree within the measurement accuracy of about 3\%. At momenta above $k_F$, the measured $^3$He/$^3$H ratios differ from the calculation by $20\% - 50\%$. Final state interaction (FSI) calculations using the generalized Eikonal Approximation indicate that FSI should change the $^3$He/$^3$H cross-section ratio for this measurement by less than 5\%. If these calculations are correct, then the differences at large missing momenta between the $^3$He/$^3$H experimental and calculated ratios could be due to the underlying $NN$ interaction, and thus could provide new constraints on the previously loosely-constrained short-distance parts of the $NN$ interaction., 8 pages, 3 figures (4 panels)

The E12-14-012 experiment performed at Jefferson Lab Hall A has collected inclusive electron-scattering data for different targets at the kinematics corresponding to beam energy 2.222 GeV and scattering angle 15.54 deg. Here we present a comprehensive analysis of the collected data and compare the double-differential cross sections for inclusive scattering of electrons, extracted using solid targets (aluminum, carbon, and titanium) and a closed argon-gas cell. The data extend over broad range of energy transfer, where quasielastic interaction, Delta-resonance excitation, and inelastic scattering yield contributions to the cross section. The double-differential cross sections are reported with high precision (~3%) for all targets over the covered kinematic range., 11 pages, 10 figures

OBJECTIVE: To study the clinical characteristics of mandibular movement and masticatory muscle function in preoperative and postoperative patients with unilateral mandibular tumors in the region of mandibular body and ramus by combining digital mandibular movement records with electromyography, and to preliminarily explore the relationship and mechanism between movement and masticatory muscle function. METHODS: Six preoperative patients with tumor in unilateral body and ramus of mandible were included, and three postoperative patients with unilateral segmental resection and reconstruction of mandibular bone were included. The mandibular movement recording system and surface electromyography system were used to collect the movement trajectory of the patients’ mandibular marginal movement and chewing movement, and the surface electromyography of bilateral masseter and temporalis was recorded concurrently. The surface electromyography of bilateral masseter and temporalis was collected when the patients were at relaxation and at maximal voluntary clenching (MVC). The motion trajectory was observed on the digital virtual model, and the motion amplitude and direction of mandibular marginal movements were analyzed. The characteristics of masticatory electromyogram (EMG) activity in affected and unaffected sides at relaxation, MVC and bilateral mastication were analyzed, and the asymmetry indexes and activity indexes were calculated. RESULTS: The preoperative mean maximum opening of the patients was (35.20±6.87) mm. Three patients had mild mouth opening limitation, and all the patients’ mouth opening trajectory was skewed to the affected side. During lateral movements, the mean range of motion of the affected side [(10.34±1.27) mm] and that of the healthy side [(6.94±2.41) mm] were significantly different. The maximum opening of the postoperative patients was (30.65±17.32) mm, and the mandibular marginal movement characteristics were consistent with those of the patients before surgery. During MVC in the preoperative patients, the median EMG activities of the masseter muscle [44.20 (5.70, 197.90) μV] and the temporalis muscle [42.15 (22.90, 155.00) μV] on the affected side were slightly lower than those of the masseter [45.60 (7.50, 235.40) μV] and the temporalis muscle [63.30 (44.10, 126.70) μV] on the healthy side. In the postoperative patients, individualized changes occurred. Some patients suffered from weakened electromyographic activity on the affected side, while some other ones showed hyperelectromyographic activity on the affected side. CONCLUSION: Both benign and malignant tumors as well as their surgery can cause abnormal mandibular movements and change of electromyographic activity of bilateral masseter and temporalis muscles.