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Supplemental material, sj-docx-1-tpx-10.1177_01926233221099273 for Scientific and Regulatory Policy Committee Points to Consider: Primary Digital Histopathology Evaluation and Peer Review for Good Laboratory Practice (GLP) Nonclinical Toxicology Studies by Thomas Forest, Famke Aeffner, Dinesh S. Bangari, Bhupinder Bawa, Jonathan Carter, James Fikes, Wanda High, Shim-mo Hayashi, Matthew Jacobsen, LuAnn McKinney, Daniel Rudmann, Thomas Steinbach, Vanessa Schumacher, Oliver Turner, Jerrold M. Ward and Cynthia J. Willson in Toxicologic Pathology

Bioengineered spider silk block copolymers were studied to understand the effect of protein chain length and sequence chemistry on the formation of secondary structure and materials assembly. Using a combination of in vitro protein design and assembly studies, we demonstrate that silk block copolymers possessing multiple repetitive units self-assemble into lamellar microstructures. Additionally, the study provides insights into the assembly behavior of spider silk block copolymers in concentrated salt solutions., National Institutes of Health (U.S.) (NIH U01 EB014976)

Real-time computer vision applications have difficult runtime constraints within which to execute. Implementing on a CPU provides a baseline for performance. But using custom parallel hardware such as graphics processing units (GPUs) and field programmable gate arrays (FPGAs) represents a cost effective method to achieve greater performance. Greater performance can move an algorithm from non-real-time into the realm of real-time. This opens numerous possibilities for interaction that did not exist before. Tasks such as face detection can be used to set focus points in cameras if performed in real-time. Similarly, body part tracking can be used as input for consumer televisions or video game systems when run in real-time. Acceleration using heterogeneous hardware is attractive because algorithms exhibit different models of computation at different stages of execution. Each platform can be exploited to execute when most efficient. However, it can be difficult to combine these platforms into a single application. This is due to the lack of reusable components and communication abstractions for these devices. This work describes a framework to lower the barrier for computer vision application acceleration called the Smart Frame Grabber Framework. This framework is a collection of reusable hardware acceleration components that are commonly used for accelerating computer vision applications using CPUs and FPGAs. It allows applications to be easily partitioned across multiple heterogenous compute devices. At the heart of this framework is a communication and synchronization platform called RIFFA: A Reusable Integration Framework for FPGA Accelerators. Using the Smart Frame Grabber Framework, researchers can design and build a hardware accelerated computer vision application in considerably less time and with less upfront effort than it would take using existing vendor provided tools alone

Thermoelectric materials have long been investigated for possible use as power sources. This application was recently put to use in the Voyager space program, powering the deep space probes. Despite the usefulness of these materials, the use of pressure to investigate the material properties has only recently become interesting. As such, the work in this document was to developing a system for concurrently measuring the necessary properties. This system is capable of measuring the electrical resistivity, thermal conductivity, and Seebeck coefficient in the pressure range from 0 - 10 GPa. The results for zinc, almandine garnet, and nickel are presented and demonstrate the capabilities of the system. In addition, results are presented for selected established (Bi2Te3, Sb2Te3, BiSbTe3) and potential (GaTe, InTe, and InGaTe2) thermoelectric materials. The measurements have been made with pressure up to 10 GPa (transport properties, except heat capacity) or 20 GPa (structure). From these measured properties, it is possible to evaluate how pressure effects the interactions.