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The purpose of this study was to evaluate the effects of a high intensity ankle stability exercise of ankle isokinetic muscle function and posture balance in college students with chronic ankle sprain. The high intensity ankle stability exercise group participated in the exercise program for short-term (12 times) and the effects on isokinetic muscle function(peak torque, total work) and posture balance(weight distribution index, stability index) were evaluated. The high intensity ankle stability exercise group in analyses of ankle muscle functions, as for changes in Peak Torque, significant improvements were shown in right and left Plantar Flexion. With regard to changes in total work, although significant improvements were shown in all variables. Posture balance was improved but no significant difference was seen. To conclude, applying the high intensity ankle stability exercise of short-term period appeared to effectively improve the fundamental ankle muscle function and posture balance in college students of chronic ankle sprain. This research can provide a guideline of the effective verification model of a high intensity ankle stability exercise of short-term period exercise program to college students of chronic ankle sprain.