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OBJECTIVE: To assess appetite and gut hormone levels in patients following partial (PR) or total resection (TR) of the large bowel. METHODS: A comparative cross sectional study was carried out with healthy controls (n = 99) and patients who had undergone PR (n = 64) or TR (n = 12) of the large bowel. Participants consumed a standard (720 kcal) breakfast meal at 0830 (t = 0) h followed by lactulose (15 g) and a buffet lunch (t = 210 min). Participants rated the subjective feelings of hunger at t = -30, 0, 30, 60, 120, and 180 min. Breath hydrogen (BH) concentrations were also evaluated. In a matched subset (11 controls, 11 PR and 9 TR patients) PYY and GLP-1 concentrations were measured following breakfast. The primary outcome measure was appetite, as measured using visual analogue scales and the buffet lunch. The secondary outcome was BH concentrations following a test meal. RESULTS: PR and TR participants had lower hunger and energy intake at the buffet lunch meal compared to controls. PR subjects had higher BH concentrations compared to controls and TR subjects. BH levels correlated with circulating GLP-1 levels at specific time points. CONCLUSIONS: PR or TR of the large bowel reduced feelings of hunger and energy intake, and PR increased gastrointestinal fermentation.

Background: Epidemiology of acute poisoning has been extensively studied in agricultural areas of Sri Lanka. It has not been well documented in the other parts of the country. The objective of this study was to describe the pattern of acute poisoning in a Tertiary Care Teaching Hospital in urban Sri Lanka to describe the difference of poisoning patterns in different areas of a country. Methods: This study was performed as a retrospective study in Colombo South Teaching Hospital (CSTH), Sri Lanka. The bed head tickets (BHTs) of the patients admitted to the medical units of CSTH from 1st January 2009 to 31st December 2009 were retrieved. Patients admitted to pediatric units and with snake bites and food poisoning were excluded. Results: From 1st of January 2009 to 31st of December 2009, 92668 patients were admitted to CSTH and 1.27% (1178) was admitted following acutehttps://www.omicsonline.org/open-access/current-trends-of-poisoning-an-experience-at-a-tertiary-care-hospitalhadoti-region-rajasthan-india-2161-0495-1000298.php?aid=74588www.omicsonline.org/open-access/current-trends-of-poisoning-an-experience-at-a-tertiary-care-hospitalhadoti-region-rajasthan-india-2161-0495-1000298.php. Of those patients we were able to collect data on 70.46% (828). Male to female ratio was 37:63. The commonest cause of poisoning was due to medicinal drug overdose 63.52% (526) of which paracetamol overdose accounted for 37.6% (311). Organoposphate (OP) accounted for 11.11% (92) of the admissions. Mean duration of hospital stay was 3.49 (SD4.97) days. Discussion: The pattern of poisoning observed in CSTH is significantly different to the pattern seen in agricultural areas of the country.