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Implementing quantum algorithms on realistic devices requires translating high-level global operations into sequences of hardware-native logic gates, a process known as quantum compiling. Physical limitations, such as constraints in connectivity and gate alphabets, often result in unacceptable implementation costs. To enable successful near-term applications, it is crucial to optimize compilation by exploiting the capabilities of existing hardware. Here we implement a resource-efficient construction for a quantum version of AND logic that can reduce the compilation overhead, enabling the execution of key quantum circuits. On a high-scalability superconducting quantum processor, we demonstrate low-depth synthesis of high-fidelity generalized Toffoli gates with up to 8 qubits and Grover’s search algorithm in a search space of up to 64 entries. Our experimental demonstration illustrates a scalable and widely applicable approach to implementing quantum algorithms, bringing more meaningful quantum applications on noisy devices within reach.

Background Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), a newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been shown to play an important role in the pathophysiological processes and TME remodelling of various tumours. Methods CircRNA sequencing analysis was performed to explore circRNA expression profiles in normal and glioma tissues. The biological function of a novel circRNA, namely, circNEIL3, in glioma development was confirmed both in vitro and in vivo. Mechanistically, RNA pull-down, mass spectrum, RNA immunoprecipitation (RIP), luciferase reporter, and co-immunoprecipitation assays were conducted. Results We identified circNEIL3, which could be cyclized by EWS RNA-binding protein 1(EWSR1), to be upregulated in glioma tissues and to correlate positively with glioma malignant progression. Functionally, we confirmed that circNEIL3 promotes tumorigenesis and carcinogenic progression of glioma in vitro and in vivo. Mechanistically, circNEIL3 stabilizes IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) protein, a known oncogenic protein, by preventing HECTD4-mediated ubiquitination. Moreover, circNEIL3 overexpression glioma cells drives macrophage infiltration into the tumour microenvironment (TME). Finally, circNEIL3 is packaged into exosomes by hnRNPA2B1 and transmitted to infiltrated tumour associated macrophages (TAMs), enabling them to acquire immunosuppressive properties by stabilizing IGF2BP3 and in turn promoting glioma progression. Conclusions This work reveals that circNEIL3 plays a nonnegligible multifaceted role in promoting gliomagenesis, malignant progression and macrophage tumour-promoting phenotypes polarization, highlighting that circNEIL3 is a potential prognostic biomarker and therapeutic target in glioma.

Abstract Glioma is the most common malignant tumor of the central nervous system in adults. The tumor microenvironment (TME) is related to poor prognosis in glioma patients. Glioma cells could sort miRNA into exosomes to modify TME. And hypoxia played an important role in this sorting process, but the mechanism is not clear yet. Our study was to find miRNAs sorted into glioma exosomes and reveal the sorting process. Sequencing analysis of glioma patients cerebrospinal fluid (CSF) and tissue showed that miR-204-3p tends to be sorted into exosomes. miR-204-3p suppressed glioma proliferation through the CACNA1C/MAPK pathway. hnRNP A2/B1 can accelerate exosome sorting of miR-204-3p by binding a specific sequence. Hypoxia plays an important role in exosome sorting of miR-204-3p. Hypoxia can upregulate miR-204-3p by upregulating the translation factor SOX9. Hypoxia promotes the transfer of hnRNP A2/B1 to the cytoplasm by upregulating SUMOylation of hnRNP A2/B1 to eliminate miR-204-3p. Exosomal miR-204-3p promoted tube formation of vascular endothelial cells through the ATXN1/STAT3 pathway. The SUMOylation inhibitor TAK-981 can inhibit the exosome-sorting process of miR-204-3p to inhibit tumor growth and angiogenesis. This study revealed that glioma cells can eliminate the suppressor miR-204-3p to accelerate angiogenesis under hypoxia by upregulating SUMOylation. The SUMOylation inhibitor TAK-981 could be a potential drug for glioma. This study revealed that glioma cells can eliminate the suppressor miR-204-3p to accelerate angiogenesis under hypoxia by upregulating SUMOylation. The SUMOylation inhibitor TAK-981 could be a potential drug for glioma.

Background During the eleven years from 2010 to 2021, preliminary statistics have shown that Fuwai Hospital completed 23,571 mechanical valve replacements for various types of valves, and 1139 mechanical valve replacements were performed in Guangyuan First People's Hospital. Only two patients developed valve leaflet escape, so valve leaflet escape is a rare postoperative complication. Case presentation In 2010 and 2021, two patients were selected after they had unilateral leaflet escape after having mechanical valve replacements in Fuwai Hospital of Chinese Academy of Medical Sciences and Guangyuan First People's Hospital. Both patients underwent reoperations with the classic operation and the new bileaflet mechanical prosthetic heart valve was sutured. The treatment of detached single lobe and distal vessel was comprehensively determined, and the condition was treated according to the patient's symptoms, CT results, ultrasound results and other test results, as well as whether this detached lobe caused any abnormal hemodynamics of the distal vessel. The patient with mechanical aortic valve escape completed the 10-year follow-up, and patient with mechanical mitral valve escape completed the 3-month follow-up. there was no thrombosis or hematoma at the embolic site; the patient had no lower limb symptoms. Conclusions The reason for the leaflet escape may be related to the valve design and the leaflet material. If the detached leaflets are damaged and if the distal blood vessels are affected, simultaneous surgical treatment is required. Those patients whose vessels were not damaged by the valve lobe should be carefully monitored.

Scaling is now a key challenge in superconducting quantum computing. One solution is to build modular systems in which smaller-scale quantum modules are individually constructed and calibrated, and then assembled into a larger architecture. This, however, requires the development of suitable interconnects. Here, we report low-loss interconnects based on pure aluminium coaxial cables and on-chip impedance transformers featuring quality factors up to $8.1 \times 10^5$, which is comparable to the performance of our transmon qubits fabricated on single-crystal sapphire substrate. We use these interconnects to link five quantum modules with inter-module quantum state transfer and Bell state fidelities up to 99\%. To benchmark the overall performance of the processor, we create maximally-entangled, multi-qubit Greenberger-Horne-Zeilinger (GHZ) states. The generated inter-module four-qubit GHZ state exhibits 92.0\% fidelity. We also entangle up to 12 qubits in a GHZ state with $55.8 \pm 1.8\%$ fidelity, which is above the genuine multipartite entanglement threshold of 1/2. These results represent a viable modular approach for large-scale superconducting quantum processors.

Zuogui Pill is a kidney-yin-tonifying formula in traditional Chinese medicine that is widely used to manage osteoporosis with kidney-yin-deficiency in China. Herein, an efficient and accurate high-performance liquid chromatography-tandem mass spectrometry method was developed to determine the concentrations of 5 bioactive compounds in rat plasma following oral administration of Zuogui Pill. Because drug absorption and distribution differ under physiological and pathological conditions, the established method was used to quantify blood components and dynamic change in osteoporotic rats with different syndrome types. Moreover, integrated pharmacokinetic study was conducted to describe the overall pharmacokinetic characteristics of traditional Chinese medicine. The results showed that the absorption, distribution, and metabolism of Zuogui Pill varied widely under different states. The bioavailability of most active components showed significant advantages in osteoporotic rats with kidney-yin-deficiency, which corresponds to the opinion that Zuogui Pill has the effect of nourishing kidney-yin. It is hoped that this finding could interpret the pharmacodynamic substances and mechanism of Zuogui Pill in the treatment of osteoporosis with kidney-yin-deficiency.

Objective: Unilateral leaflet shedding is a rare complication. This paper discusses the causes and treatment strategies of unilateral leaflet shedding of bileaflet mechanical prosthetic heart valves after surgery. Methods: This study was a retrospective study that included 1 case of unilateral leaflet shedding after mechanical valve replacement of the aortic valve in Fuwai Hospital in 2010 and 1 case of unilateral leaflet shedding after mechanical valve replacement of the mitral valve in the First People’s Hospital of Guangyuan in 2021. The new mechanical valves were replaced during subsequent surgeries. data were collected, and the patients were followed up for 10 years and 3 months after the operations, respectively. Results: The patient with an aortic valve replacement was a male; the patient with a mitral valve replacement was a female; and they had an average STS risk score of 3.9%. Both patients had severe regurgitation, and the results of the reoperations were satisfactory. After the operations, the echocardiograms showed that there was no regurgitation in either of the valve replacements. There were no changes in the ankle-brachial index (ABI) before and after the operation in either of the two patients, and no complications or deaths occurred during follow-up. Conclusion: The reason for the leaflet sheddings may be related to the valve design and the leaflet materia. If the detached leaflets are damaged and if the distal blood vessels are affected, simultaneous surgical treatment is required. Those patients whose vessels were not damaged by the valve lobe should be carefully monitored.

We have developed a one-iridium-catalyst system that transforms N-allyl-N-sulfonyl-2-(silylalkynyl)aniline derivatives, which are 1,7-enynes in which both multiple bonds have a heteroatom, to the corresponding substituted indole derivatives via isomerization/cycloisomerization/aromatization. This strategy provides an atom-economical and straightforward synthetic approach to a series of valuable indoles having vinyl and silylmethyl groups at the 2- and 3-positions.

Doppler wind lidar (DWL) uses the optical Doppler effect to measure atmospheric wind speed with high spatial-temporal resolution and long detection range and has been widely applied in scientific research and engineering applications. With the development of related technology, especially laser and detector technology, the performance of the DWL has significantly improved for the past few decades. DWL utilizes different principles and different tracers to sense the wind speed from the ground to the mesosphere, which leads to the difference in choosing the laser working wavelength. This article will review the working wavelength consideration of DWL, and typical DWLs will present from ultraviolet to near-infrared, after which three typical applications will be shown.

BackgroundGlioblastoma (GBM) is a fatal brain tumor with no effective treatment. The specific GBM tumor immune microenvironment (TIME) may contribute to resistance to immunotherapy, a tumor therapy with great potential. Thus, an in-depth understanding of the characteristics of tumor-infiltrating immune cells is essential for exploring biomarkers in GBM pathogenesis and immunotherapy.MethodsWe estimated the relative abundances of 25 immune cell types in 796 GBM samples using single sample gene set enrichment analysis (ssGSEA). Unsupervised clustering was used to identify different GBM-associated TIME immune cell infiltration (GTMEI) patterns. The GTMEIscore system was constructed with principal component analysis (PCA) to determine the immune infiltration pattern of individual tumors.ResultsWe revealed three distinct GTMEI patterns with different clinical outcomes and modulated biological pathways. We developed a scoring system (GTMEIscore) to determine the immune infiltration pattern of individual tumors. We comprehensively analyzed the genomic characteristics, molecular subtypes and clinicopathological features as well as proteomic, phosphoproteomic, acetylomic, lipidomic and metabolomic properties associated with the GTMEIscore and revealed many novel dysregulated pathways and precise targets in GBM. Moreover, the GTMEIscore accurately quantified the immune status of many other cancer types. Clinically, the GTMEIscore was found to have significant potential therapeutic value for chemotherapy/radiotherapy, immune checkpoint inhibitor (ICI) therapy and targeted therapy.ConclusionsFor the first time, we employed a multilevel and multiplatform strategy to construct a multidimensional molecular map of tumors with different immune infiltration patterns. These results may provide theoretical basises for identifying more effective predictive biomarkers and developing more effective drug combination strategies or novel immunotherapeutic agents for GBM.

Weyl semimetals have drawn considerable attention for their exotic topological properties in many research fields. When in combination with s-wave superconductors, the supercurrent can be carried by their topological surface channels, forming junctions mimicking the behavior of Majorana bound states. Here, we present a transmon-like superconducting quantum intereference device (SQUID) consisting of lateral junctions made of Weyl semimetal Td-MoTe2 and superconducting leads of niobium nitride (NbN). The SQUID is coupled to a readout cavity made of molybdenum rhenium (MoRe), whose response at high power reveals the existence of the constituting Josephson junctions (JJs). The loop geometry of the circuit allows the resonant frequency of the readout cavity to be tuned by the magnetic flux. We demonstrate a JJ made of MoTe2 and a flux-tunable transmon-like circuit based on Weyl semimetals. Our study provides a platform to utilize topological materials in SQUID-based quantum circuits for potential applications in quantum information processing.

BACKGROUND: To evaluate whether the heated humidified ventilation can effectively maintain core temperature and improve prognosis in normothermic thoraco-abdominal aortic aneurysm repair surgery. METHODS: Patients who were scheduled for normothermic thoraco-abdominal aortic aneurysm repair surgery were randomized into the group using heated humidified ventilation combined with water blanket and the group using water blanket only. During the operation, the core temperature will be measured every 30 minutes. We analyzed intraoperative core-temperature, coagulation function and in-hospital mortality. RESULTS: HHV&WB group showed lesser decrease in core temperature than WB groups in the first two hours, while WB group had a higher body temperature at the third to fifth hour (2-hour: 35.45±0.47 vs. 35.24±0.59 °C, P=0.284; 5-hour: 35.38±0.70 vs. 35.51±0.88 °C, P=0.664). There was less blood loss, dosage of coagulation drugs and in-hospital mortality (13.33% vs. 20.00%, P=1) in the HHV&WB group. CONCLUSIONS: Heated humidified ventilation can improve the prognosis of normothermic thoraco-abdominal aortic aneurysm repair surgery to some extent, but it can only maintain the core temperature during the first 2 hours.

AimsVarious kinds of surgical strategies and prostheses have been advocated to improve short-term and long-term outcomes in type A aortic dissection (TAAD). Large-scale repair of the pathological aorta is hard to generalize due to complex procedures. We aimed to investigate the performance, effectiveness and safety of a novel Sutureless Integrated Stented (SIS) graft prosthesis in TAAD patients undergoing total arch replacement (TAR) and frozen elephant trunk (FET) implantation surgery.MethodsAll patients admitted to Fuwai Hospital were prospectively screened. Urgent or scheduled surgery was arranged for eligible patients. The primary endpoint was operative mortality. Key secondary endpoints included stroke, spinal cord injury, unexpected aortic reoperation, and 1-year survival. Discharged patients were followed up with computed tomography angiography and transthoracic echocardiography at 3 months, 6 months, and 1 year after surgery. Performance, effectiveness and safety analyses were performed in those patients.ResultsBetween August 1 and September 3, 2020, ten TAAD patients were enrolled in this study and successfully implanted with the SIS graft prosthesis. The median (IQR) age was 56.50 (43.75, 66.75) years (range from 31 to 75), and seven patients were male (70.0%). All patients underwent ascending aorta replacement + TAR + FET and additional procedures when necessary. The median (IQR) operation time, cardiopulmonary bypass time and cross clamp time were 270.50 (218.50, 312.50), 110.00 (88.00, 125.75), 69.50 (51.25, 82.75) min, respectively. Of note, the median (IQR) circulatory arrest time was 9.00 (8.00, 9.00) min (range from 4 to 12). The median (IQR) lowest nasopharyngeal temperature was 26.75 (25.98, 27.67) °C. Follow-up was 100% completed. During the 1-year follow-up, no patients died, no severe adverse events occurred, and rate of freedom from aortic reintervention was 100%.ConclusionsThe SIS graft prosthesis was implanted in a novel sutureless way, which simplified the surgical procedure, shortened the circulatory arrest time and avoided deep hypothermia. The preliminary clinical outcomes and follow-up outcomes demonstrated the effectiveness and safety of this prosthesis. A large-scale trial is being conducted to further assess these findings.

Circular RNAs (circRNAs) play important roles in the malignant progression of tumours. Herein, we identified an unreported circRNA (hsa-circ-0072688, also named circADAMTS6) that is specifically upregulated in the hypoxic microenvironment of glioblastoma and closely correlated with poor prognosis of gliblastoma patients. We found that circADAMTS6 promotes the malignant progression of glioblastoma by promoting cell proliferation and inhibiting apoptosis. Mechanistically, the hypoxic tumour microenvironment upregulates circADAMTS6 expression through transcription factor activator protein 1 (AP-1) and RNA-binding protein TAR DNA-binding protein 43 (TDP43). Moreover, circADAMTS6 accelerates glioblastoma progression by recruiting and stabilising annexin A2 (ANXA2) in a proteasomes-dependent manner. Furthermore, we found T-5224 (AP-1 inhibitor) treatment induces downregulation of circADAMTS6 and then inhibits tumour growth. In conclusion, our findings highlight the important role of the circADAMTS6/ANXA2 axis based on hypoxic microenvironment in glioblastoma progression, as well as its regulation in NF-κB pathway. Targeting circADAMTS6 is thus expected to become a novel therapeutic strategy for glioblastoma.

The angiography image enhancement technology has the potential to enhance the vascular structure in the image while suppressing the background and nonvascular structures simultaneously. This technology has the ability to enhance the result as close to the real structure of blood vessels as possible. Angiographic image processing is one of the essential contents in the field of medical image processing and analysis. However, the existing cardiovascular angiography schemes suffer from various issues. In this paper, the detection process of cardiovascular angiography is studied by combining the Internet of Things and rough set technology. Firstly, this paper designs the architecture design of the cardiovascular angiography process combined with the Internet of Things technology. Secondly, this paper uses a rough set algorithm to optimize the background noise and boundary shrinkage because of the sensitivity of the contrast background noise and boundary shrinkage. Simulation results verified the applicability and efficiency of the proposed model in the cardiovascular angiography scheme. The model has been optimized during implementation. Compared with the traditional algorithm, the same image data processing speed is significantly improved to ensure the enhancement effect.

This study sought to identify the midterm outcomes of one-stage hybrid aortic arch repair (HAAR) in patients with Stanford type A aortic dissection (TAAD). Between January 2010 and December 2015, 75 consecutive patients with TAAD involving the aortic arch who underwent one-stage type Ⅱ HAAR at our institution were identified. During this period, 496 consecutive patients with TAAD underwent traditional total aortic arch replacement (TAR) with frozen elephant trunk. The preoperative, perioperative, and postoperative data of all patients were compared. A propensity score-matching analysis was applied to adjust for baseline risk factors. Five hundred and seventy-one patients were included for analysis (428 men; mean age, 48.9 ± 11.1 years). For all patients, the mean follow-up time was 41.1 ± 22.1 months, in-hospital mortality was 4.7%, and the 5-year survival rate was 89.5%. Midterm outcomes between the propensity-matched groups were compared (59 HAAR vs TAR pairs). HAAR group showed shorter cardiopulmonary bypass time (105-159 minutes vs 158-230 minutes, P0.001), aortic cross-clamping time, postoperative ventilation time, and intensive care unit stays (33-108 hours vs 45-131 hours, P = 0.010) than the TAR group. There were no significant differences in in-hospital mortality, rate of stroke and rate of paraplegia between the 2 groups, however, better 5-year survival rate was found in HAAR group (94.9% vs 75.8%, Log-rank P = 0.005). As compared to propensity matched cohort of TAR patients, HAAR shows good midterm outcomes for patients with TAAD. Further randomized study was needed to clarify the optimal management strategy of TAAD.

In the paper, a model capable of grading any country’s higher education system with high efficiency is built. Our research team then simplify the model and combine it with Markov Chains to make it able to predict the score of any country’s higher education system in the future. On this process Multiple Linear Regression is used and the value inside Markov Chains’s matrix is fixed. After parameterization, our research team test the model and get several interesting findings of its character and use it on China and make a possible policy for it.

Background This study is to establish prediction tools for in-hospital rupture of type A aortic dissection (TAAD) patients, to better guide emergency surgical triage and patient counselling. Methods We retrospectively evaluated 1,133 consecutive patients with TAAD from January 2010 to December 2016. The study population was divided into training and testing datasets in a 70:30 ratio for further analysis using Random Forest. Results The Random Forest classification model was developed with the training dataset and 16 variables were confirmed as 'important': age, BMI, gender, syncope, lower limb numbness/pain, acute phase of the TAAD, BP >160 mmHg at admission; acute liver dysfunction, WBC >15×109/L, aortic size, aortic height index (AHI), periaortic hematoma, pleural effusion, brachiocephalic artery involvement, renal artery involvement, and hemopericardium. Validation of the model showed good discrimination with an AUC, sensitivity, specificity, positive predictive value and negative predictive value of 0.994, 1.000, 0.987, 0.998 and 1.000, respectively, in the training dataset, and 0.752, 0.990, 0.514, 0.945 and 0.857, respectively, in the testing dataset. Conclusions An easy-to-use tool to predict in-hospital rupture for TAAD patients was developed and validated (http://47.107.228.109/). Periaortic hematoma is the strongest predictor. Simple clinical information such as syncope can be very useful in in-hospital rupture risk stratification.

Reactions based on transition-metal-catalyzed C-O bond cleavage have attracted much attention as a new synthetic method. Until now, several intermolecular reactions via C-O bond cleavage of aryl ethers, alkenyl ethers, esters, and others have been reported. Here we report an unprecedented C-O bond cleavage of 3-phenoxy acrylic acid derivatives, followed by intramolecular C-O bond formation with alkynes. This reaction gave 2,3-disubstituted benzofurans having useful functional groups-silyl substituents and acrylic acid derivatives-at the 2- and 3-positions, respectively. This report also described theoretical (DFT) insights into the mechanism.

The study aims to build and validate a nomogram for estimating the probability of patients developing type A aortic dissection at a diameter less than 55 mm.A primary cohort of 896 patients diagnosed with acute type A aortic dissection by computed tomography angiography (CTA) were used for model development, with data collected between January 2005 and March 2012. The subjects were assigned to two groups based on ascending aorta diameter (group A55 mm, Group B ≥ 60 mm). Univariate and multivariate logistic regression analyses were employed for the development of the prediction model. Demographic factors, as well as clinical and imaging characteristics were taken into account. The resulting nomogram was evaluated for performance traits, e.g. calibration, discrimination and clinical usefulness. After internal validation, the nomogram was further assessed in a different cohort containing 385 consecutive subjects examined between January 2013 and December 2015.The individualized prediction nomogram included 9 predictors derived from univariate and multivariable analyses, including gender, age, weight, hypertension, liver cyst, renal cyst, bicuspid aortic valve, and bovine arch. Those predictors were double confirmed with Lasso regression. Internal validation showed good discrimination of the model with area under the curve (AUC) of 0.854 and good calibration (Hosmer-Lemeshow test, P = 0.876). Application of the nomogram in the validation cohort still revealed good discrimination (AUC = 0.802) and good calibration (Hosmer-Lemeshow test, P = 0.398). Decision curve analysis demonstrated that the prediction nomogram was clinically useful.The current work presents a prediction nomogram incorporating demographical data as well as clinical and imaging characteristics that could help identify patients who might develop type A aortic dissection at a diameter less than 55 mm with convenience.

We have developed a one-iridium-catalyst system that transforms

Background: This study employed three surgical techniques: total arch replacement (TAR) with frozen elephant trunk (FET), aortic balloon occlusion technique (ABO) and hybrid aortic arch repair (HAR) on patients with type I aortic dissection in Fuwai Hospital, aiming to compare the early outcomes of these surgical armamentariums.Methods: From January 2016 to December 2018, an overall 633 patients (431 of TAR+FET, 122 of HAR, and 80 of ABO) with type I aortic dissection were included in the study. Thirty-day mortality, stroke, paraplegia, re-exploration for bleeding, and renal replacement therapy were compared using the matching weight method (MWM).Results: After MWM process, the baseline characteristics were comparable among three TAR groups. It showed that ABO group had the longest cardiopulmonary bypass (p < 0.001) and aortic cross-clamp time (p < 0.001), while the operation time was longest in the HAR group (p = 0.039). There was no significant difference in 30-day mortality among groups (p = 0.783). Furthermore, the incidence of stroke (p = 0.679), paraplegia (p = 0.104), re-exploration for bleeding (p = 0.313), and CRRT (p = 0.834) demonstrated no significant difference. Of note, no significant differences were found regarding these outcomes even before using MWM.Conclusions: Based on the early outcomes, the three TAR approaches were equally applicable to type I aortic dissection. We may choose the specific procedure relatively flexibly according to patient status and surgeon's expertise. Importantly, long-term investigations are warranted to determine whether above approaches remain to be of equivalent efficacy and safety.

We describe the experimental progress and the challenges of integrating a single photon source based on quantum dots embedded in semiconductor nanowires with a cold-atom experiment in which laser-cooled caesium atoms are loaded and confined inside a hollow-core micro-structured optical fiber. We focus in particular on wavelength conversion of the photons between 895nm and wavelengths suitable for satellite links (~794nm)., Optical and Quantum Sensing and Precision Metrology, March 6-12, 2021, Online Only, United States, Series: Proceedings of SPIE

Background: Various kinds of surgical strategies and prostheses have been advocated to improve short-term and long-term outcomes in type A aortic dissection (TAAD). Large-extent repair of pathological aorta with satisfactory outcomes is hard to achieve. The aim of this study was to investigate effectiveness and safety of a novel Sutureless Integrated Stented (SIS) graft prosthesis on TAAD patients undergoing total arch replacement (TAR) combined with frozen elephant trunk (FET) surgeries. Methods: All patients admitted to Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were screened according to inclusion and exclusion criteria after signing written informed consent. Urgent or scheduled surgery was arranged for eligible patients. Before operation, candidate size of the SIS graft prosthesis was chosen comprehensively according to aortic diameter on different levels measured on aortic computed tomography angiography (CTA). During operation, final appropriate-sized SIS graft prosthesis was implanted under direct vision. The primary endpoint was operative mortality. Secondary endpoints included postoperative rate of stroke, spinal cord injury, unexpected aortic reoperation and so on. All variables related to this study were collected prospectively and classified into preoperative, intraoperative, postoperative and follow-up data. Discharged patients were contacted by telephone 1 month after surgery and were asked to return to hospital 3 months, 6 months and 12 months after surgery. Inquiry, physical examination, aortic computed tomography angiography (CTA) examinations and transthoracic echocardiography (TTE) were performed on the occasion of the return visit. Effectiveness and safety analyses were done in these patients. Findings: Between Aug 1 and Sep 3, 2020, 10 TAAD patients were enrolled in this study. The SIS graft prostheses were successfully implanted in all patients. The median (IQR) age was 56.50 (43.75, 66.75) years (range from 31 to 75), and 7 patients were male (70.0%). All patients were performed with ascending aorta replacement + TAR + FET. Concomitant procedure included Bentall procedure, David procedure, adventitial inversion technique and ascending aorta-femoral artery bypass. The median (IQR) operation time, CPB time and cross clamp time were 270.50 (218.50, 312.50), 110.00 (88.00, 125.75), 69.50 (51.25, 82.75) min, respectively. Of note, the median (IQR) CA time was 9.00 (8.00, 9.00) min (range from 4 to 12). The median (IQR) lowest nasopharynx temperature was 26.75 (25.98, 27.67) °C. The median (IQR) platelets transfusion was 1.00 (1.00, 1.00) U. The median (IQR) platelets transfusion was 0.00 (0.00, 0.00) U. The median (IQR) platelets transfusion was 0.00 (0.00, 0.00) mL. No patients died after surgery and no severe postoperative complications occurred. Follow-up was 100% completed. Survival rate at 1-year follow-up was 100%. No patients have ever experienced any major organ complication. Freedom from prosthesis related adverse events and aortic reintervention was both 100%. Interpretation: The SIS graft prosthesis could be implanted in a novel sutureless way, which simplified surgery procedure, reduced CA time and avoided DHCA. The preliminary clinical outcomes and follow-up outcomes were satisfactory and with 0 death, 0 severe complication and 0 reintervention until 1 year postoperatively, which demonstrated effectiveness and safety of this prosthesis. Large-sample size trial has been conducted to further identify our findings. Trial Registration: This study was registered with Chinese Clinical Trial Registry, ChiCTR2000032264. Funding: Beijing Science and Technology Program (Z191100007619042), Capital Health Development and Scientific Research Foundation (2018-2-4035), CAMS Initiative for Innovative Medicine (2016-I2M-1-016), Special Subject Development Foundation of Fuwai Hospital (2015-FWTS01). Declaration of Interest: We declare no competing interests. Ethical Approval: This study was approved by Ethic Committee of Fuwai Hospital, Chinese Academy of Medical Sciences.

Scalable quantum information processing requires the ability to tune multi-qubit interactions. This makes the precise manipulation of quantum states particularly difficult for multi-qubit interactions because tunability unavoidably introduces sensitivity to fluctuations in the tuned parameters, leading to erroneous multi-qubit gate operations. The performance of quantum algorithms may be severely compromised by coherent multi-qubit errors. It is therefore imperative to understand how these fluctuations affect multi-qubit interactions and, more importantly, to mitigate their influence. In this study, we demonstrate how to implement dynamical-decoupling techniques to suppress the two-qubit analogue of the dephasing on a superconducting quantum device featuring a compact tunable coupler, a trending technology that enables the fast manipulation of qubit--qubit interactions. The pure-dephasing time shows an up to ~14 times enhancement on average when using robust sequences. The results are in good agreement with the noise generated from room-temperature circuits. Our study further reveals the decohering processes associated with tunable couplers and establishes a framework to develop gates and sequences robust against two-qubit errors., Comment: 19 pages, 14 figures

We report the generation of single-photon pulses from an InAsP quantum dot utilizing a CW diode laser and a fiber electro-optic modulator as a pump in lieu of a pulsed picosecond Ti;Sapphire laser.

Weyl semimetals have drawn considerable attention for their exotic topological properties in many research fields. When in combination with s-wave superconductors, the supercurrent can be carried by their topological surface channels, forming junctions mimicking the behavior of Majorana bound states. Here, we present a transmon-like superconducting quantum intereference device (SQUID) consisting of lateral junctions made of Weyl semimetal Td-MoTe

Objective: Cardiac magnetic resonance (CMR) imaging is a well-established technique for diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) and evaluation of cardiac function, but the process is complicated and time consuming. Therefore, this paper proposes a cardiomyopathy recognition algorithm using a multi-task learning mechanism and a double-branch deep learning neural network. Method: We implemented a double-branch neural network CMR-based HOCM recognition algorithm. Compared with the traditional classification algorithms such as the ResNet, DenseNet network, contrast the accuracy of network classification of cardiomyopathy is higher by 10.11%. Result: The loss curve of the algorithm basically converges in 100 rounds, and the convergence speed of the algorithm is twice that of the traditional algorithm. The accuracy of this algorithm to classify cardiomyopathy is 96.79%, and the sensitivity is 95.24%, which is 10.11% higher than the conventional algorithm. Conclusion: The CMR imaging automatic recognition algorithm for HOCM capture static morphological and motion characteristics of the heart, and comprehensively enhances recognition accuracy when the sample size is limited.

We have developed cycloisomerization between an aryl vinyl ether and a functionalized alkyne, such as silylalkyne, to give 2,3-disubstituted benzofuran derivatives using [IrCl(cod)]2, PCy3, and NaBArF4. This catalyst system not only catalyzes the above cycloisomerization but also isomerize a terminal olefin to give an aryl vinyl ether.

High-quality two-qubit gate operations are crucial for scalable quantum information processing. Often, the gate fidelity is compromised when the system becomes more integrated. Therefore, a low-error-rate, easy-to-scale two-qubit gate scheme is highly desirable. Here, we experimentally demonstrate a new two-qubit gate scheme that exploits fixed-frequency qubits and a tunable coupler in a superconducting quantum circuit. The scheme requires less control lines, reduces cross talk effect, and simplifies calibration procedures, yet produces a controlled-$Z$ gate in 30 ns with a high fidelity of 99.5%, derived from the interleaved randomized benchmarking method. Error analysis shows that gate errors are mostly coherence limited. Our demonstration paves the way for large-scale implementation of high-fidelity quantum operations.

We present spectroscopy measurements of individual InAsP quantum dots in photonic nanowires [1] using (i) a home-build Czerny Turner spectrometer with an astronomy camera and (ii) an economical sub-picometre laser wavemeter from MOGLabs®.

We integrate a semiconductor nanowire embedded quantum dot with a single-mode fiber. To maximize photon collection, we optimize the nanowire geometry and align the lens-tipped fiber with the nanowire using lithographically defined structure., CLEO: Applications and Technology, 10–15 May 2020, Washington, DC

Pulmonary artery aneurysm (PAA) is a relatively rare disease. The symptoms are usually nonspecific and often identified due to coughing or dyspnea. Pericardial tamponade caused by the PAA dissection or rupture is the most common cause of death, so active surgical treatment is recommended. The surgical reports in the literature are handful. Here we report three cases, all of whom were admitted due to exertional dyspnea. PAAs were observed from the main to the left and/or the right pulmonary artery. All three cases received PAA resection and artificial graft replacement with good outcomes.

This study evaluated the short- and middle-term outcomes of different aortic root managements in the setting of acute type A aortic dissection (ATAAD): aortic root repair (ARR group), untouched aortic root (UAR group), and Bentall procedure (Bentall group).The study enrolled 673 patients (512 men; age 48.8 ± 11.2 years) between 2010 and 2015. Survival, aortic growth, reintervention, and valve function were compared between the 3 groups.The ages were 50.6 ± 9.9, 49.8 ± 12.2, and 44.0 ± 12.0 years for ARR, UAR, and Bentall groups, respectively (P.01). The mean follow-up time was 3.0 years (range, 0.5-6.8 years). The aortic root diameters in the groups were 39.0 ± 5.1 mm in ARR, 38.2 ± 4.4 mm in UAR, and 50.3 ± 6.2 mm in Bentall (P.01). The overall 30-day mortality was 11.7% (79 of 673). There was no difference in 30-day mortality between the 3 groups (P = .58). The estimated aortic root growth rate was 0.60 ± 0.17 mm/y for ARR and 0.50 ± 0.14 mm/y for UAR. During follow-up, 28 patients (4.1%) died. Differences in 5-year survival between the 3 groups did not reach statistical significance (P = .82). Aortic insufficiency greater than grade 2+ developed in 15 patients (2.2%). There was no significant difference between ARR and UAR in freedom from aortic insufficiency greater than grade 2+ (P = .56). None of the patients experienced new dissection or underwent proximal reoperation during the follow-up period.Conservative techniques (ARR and UAR) and aggressive root replacement can both be performed with excellent short- and middle-term outcomes in ATAAD. Thus, an individualized approach in managing the aortic root for ATAAD is recommended based on the patient's general condition, root pathology, and the surgeon's preference.

We report loading of laser-cooled caesium atoms into a hollow-core photonic-bandgap fiber and confining the atoms in the fiber’s 7μm diameter core with a red-detuned dipole trap. In this system, the atom-photon interaction probability is in the range of 0.5% and optical depths exceeding 100 can be achieved. We discuss the outlooks for photon storage and nonlinear optics at low light levels, such as cross-phase modulation and single-photon wavelength conversion, in this system.

In this study, a dual readout biosensor is reported that combines electrochemical and surface-enhanced Raman scattering (SERS) for a multiplexed immunoassay of tumor biomarkers. A gold microelectrode array (GMA) was fabricated by electrodeposition of Au to the bottom of numerous individual silica cavities. Electrochemical studies demonstrate that the GMA possesses unique charge selectivity and an inherently high S/N ratio, which make the GMA especially suitable for differential pulse voltammetry (DPV) and square wave voltammetry (SWV) detection. Hybridization chain reaction (HCR) was designed to increase the load of labelled molecules in this super-sandwich structured biosensor. Meanwhile, the strong plasmon coupling between silver nanoparticles and the underlying gold particles enabled ultrahigh sensitivity of the GMA when using SERS readout. By combining electrochemical and SERS methods, we achieved the high-throughput preliminary screening of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA). Further quantitative analysis showed that the two proteins could be determined in a wide concentration range, and their minimum detection limits were 0.6 and 0.3 pg·mL−1 when using SERS method, respectively. The applicability of the proposed dual readout platform in clinical diagnosis was verified by the detection in human serum samples.

Background Anomalous origin of coronary artery from the pulmonary artery (ACAPA) is a rare congenital coronary malformation with a high mortality whether in infants or adult patients. This study reviews 20years of surgical treatment in a single center and aims to establish the optimal surgical strategies for this rare pathology. Methods and results From April 1994 to March 2015, 96 consecutive patients aged from 3months to 60years underwent coronary repair surgery. The surgical procedures included ligation (3 cases), ligation along with CABG (6 cases), transpulmonary baffling (Takeuchi Procedure, 14 cases) and directly implantation of the anomalous coronary artery (ACA) into the aorta (73 cases). Postoperative extracorporeal mechanical circulatory support (ECMO) was necessary in 4 cases. Mitral valve repair was performed in 40 patients with moderate or severe mitral regurgitation (MR). Mitral replacement was performed in one patient with severe MR. There were one early and two late deaths. One patient underwent a second operation because Baffle leaks. During mean 10.45±8.96year follow-up (1month–18years), both early and late improvement of left ventricular function was observed in most patients (8 patients lost of follow-up). Conclusions The establishment of a two-coronary system is the main goal of surgical therapy today. In different procedures, the direct implantation of the ACA into the ascending aorta is the best method and has good long-term results. ECMO as a bridge to recovery that will play an integral part in moderns' surgical treatment.

We present a compact and lightweight 1.5

Anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA) is a rare yet serious congenital coronary artery anomaly. The study aims to summarize the main characteristics of ARCAPA for clinical vigilance and identification. The study enrolled 16 ARCPA patients from Fuwai