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O presente estudo teve por objetivo compreender e documentar o conhecimento acerca do uso plantas medicinais dos responsáveis dos educandos do Centro de Responsabilidade Socioambiental do Jardim Botânico do Rio de Janeiro que residem em áreas urbanas e incentivar a interação entre responsável-aluno no ambiente de aprendizagem. Foram realizadas reuniões mensais com atividades participativas em cinco etapas diferentes para atingir os objetivos propostos. O grupo foi composto por 68 responsáveis, sendo 75% representado pelo sexo feminino e 25% pelo sexo masculino com uma variação de faixa etária entre 25 a 75 anos. Os responsáveis mencionaram a utilização de 65 espécies distribuídas em 35 famílias. Conclui-se que o presente estudo evidencia uma metodologia de educação em saúde exitosa, que aproxima a comunidade científica da população, gerando conhecimento, saúde e autonomia para o indivíduo.

We present an asymptomatic pregnant patient with congenitally corrected transposition of the great arteries and severe atrioventricular bioprosthesis regurgitation – with increased maternal and fetal risk due to volume overload. She was considered high risk for reintervention and was submitted to an off-label post-partum transcatheter valve-in-valve implantation with a Sapiens 3 valve. The procedure was successful, and she remains asymptomatic 30 months after – and even went through another successful pregnancy.

No presente artigo busca-se apresentar os principais resultados de uma pesquisa de mestrado que analisouas propostas de Disciplinas Eletivas vivenciadas em uma escola da rede do Serviço Social da Indústria do Estado de São Paulo (SESI-SP) e Eixos Integradores em uma escola da Secretaria de Educação do Estado de São Paulo (SEDUC-SP). Ambas propostas curriculares partem da premissa de que o estudante do Ensino Médio, ao escolher disciplinas e conteúdos de seu interesse, tem uma aprendizagem significativa. Assim, o objetivo deste trabalho foi analisar como a Pedagogia de Projetos contribui, ou não, para os processos formativos vivenciados por professores e estudantes. Além disso, a pesquisa foi desenvolvida a partir de uma abordagem qualitativa, mediante a aplicação de entrevistas reflexivas. Os eixos temáticos de análise dão indicadores doestudante como protagonista e o professor como mediador. Dessa maneira, a Pedagogia de Projetos mostrou-se importante estratégia para os processos formativos.

Este trabalho apresenta resultados de uma ação formativa que articula extensão e pesquisa no ensino superior, tomando como objeto de intervenção o futsal feminino. A extensão ocorre por meio da atividade “Futsal feminino na UNIFAP”. A pesquisa tem se materializado por meio dos projetos “Trajetória de mulheres no futebol: um estudo com estudantes da UNIFAP” e da investigação da Iniciação Científica, denominada de “Análise sobre a formação do time de futsal feminino da Universidade Federal do Amapá: estudo documental descritivo”. Quanto à extensão, atendemos a 85 mulheres, entre alunas da UNIFAP e comunidade externa. Ressaltamos que, a partir deste projeto, foi possível institucionalizar um time que representa a instituição em competições esportivas universitárias. Em relação à pesquisa, identificamos que, entre 2016 e 2021, houve diminuição da participação das alunas em competições esportivas envolvendo o futsal, indicando a necessidade de fortalecer a modalidade no contexto analisado.

O momento em que vivemos evidencia que já estamos na Era da desinformação e a pandemia do coronavírus é um ambiente consentâneo para propagação de notícias falsas. No Brasil, os bons serviços voltados à imunização (PNI/SUS) mostraram pontos positivos, porém a ideia do movimento antivacina continua viva. O objetivo deste artigo foi investigar e descrever o processo do negacionismo científico no contexto pandêmico da Covid-19 utilizando o método de pesquisa exploratório, descritivo e explicativo. Observou-se que o negacionismo gerou um levante de profissionais e instituições de pesquisa contra a desinformação. Foi notório o aumento da participação de pesquisadores, profissionais de saúde e acadêmicos no combate à desinformação (fake News) no decorrer da pandemia, sobretudo através das redes sociais. O bom senso, a análise crítica, a educação e a não isenção da nossa responsabilidade nesse processo de combate à desinformação e negação da ciência são a chave para reduzirmos esse desserviço à sociedade.

Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue’s self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet found a suitable long-term solution. Tissue engineering (TE) strategies aim to fabricate tissue substitutes that recreate natural tissue features to offer better alternatives to the existing inefficient treatments. Scaffold design is a key element in providing appropriate structures for tissue growth and maturation. This study presents a novel method for designing scaffolds with a mathematically defined curvature, based on the geometry of a sphere, to obtain TE constructs mimicking native OC tissue shape. The lower the designed radius, the more curved the scaffold obtained. The printability of the scaffolds using fused filament fabrication (FFF) was evaluated. For the case-study scaffold size (20.1 mm × 20.1 mm projected dimensions), a limit sphere radius of 17.064 mm was determined to ensure printability feasibility, as confirmed by scanning electron microscopy (SEM) and micro-computed tomography (μ-CT) analysis. The FFF method proved suitable to reproduce the curved designs, showing good shape fidelity and replicating the expected variation in porosity. Additionally, the mechanical behavior was evaluated experimentally and by numerical modelling. Experimentally, curved scaffolds showed strength comparable to conventional orthogonal scaffolds, and finite element analysis was used to identify the scaffold regions more susceptible to higher loads.

Analisando-se as atribuições do Bombeiro Militar, observa-se que dentre os requisitos necessários para um bom desempenho profissional existe um altamente relevante, que é a manutenção do bom nível de aptidão física de cada integrante da Corporação. Isso se deve em razão da complexidade e variedade de tipologias de ocorrências atendidas diariamente pelos profissionais bombeiros, exigindo, além do preparo técnico, um bom condicionamento físico para a prestação de serviços a população com qualidade. Dessa forma, o objetivo deste trabalho é analisar a efetividade e continuidade do Treinamento Físico Militar (TFM) no desenvolvimento e manutenção de um condicionamento físico e vida saudável, visto que a falta de um TFM específico para as atividades operacionais pode colaborar para o absenteísmo nas escalas de serviços ou lesões nos Bombeiros militares. Espera-se, também, contribuir para ampliar o acervo literário a respeito do tema em questão e futuras pesquisas. Para tanto foi empregado o método indutivo e as técnicas de pesquisa descritiva, possibilitando perceber que as tarefas e esforços impostos aos Bombeiros Militares são necessários, pois quando estes realizam exercícios físicos regularmente, preocupam-se com seu condicionamento físico, refletindo em uma melhor capacidade no exercício da profissão quando na atuação da linha de frente. É importante, então, motivar a prática de exercícios pelos Bombeiros Militares, aperfeiçoando suas aptidões físicas e estabelecendo prioridades para obter uma evolução profissional no Corpo de Bombeiros Militar. Dessa forma, a presente pesquisa se justifica pela necessidade de se atender ao previsto na Constituição Federal de 1988 e na Constituição do Estado do Amazonas de 1989, que determinam quais as tarefas específicas do Corpo de Bombeiros Militar no âmbito da Segurança Pública.

Background: Molecular therapy with sorafenib remains the mainstay for advancedstage hepatocellular carcinoma. Notwithstanding, treatment efficacy is low, with few patients obtaining long-lasting benefits due to the high chemoresistance rate. Objective: To perform, for the first time, an overview of the literature concerning the role of adenosine triphosphate-binding cassette (ABC) transporters in sorafenib therapy for hepatocellular carcinoma. Methods: Three online databases (PubMed, Web of Science, and Scopus) were searched, from inception to October 2020. Study selection, analysis, and data collection were independently performed by two authors. Results: The search yielded 224 results; 29 were selected for inclusion. Most studies were pre-clinical, using HCC cell lines; three used human samples. Studies highlight the effect of sorafenib in decreasing ABC transporters expression. Conversely, it is described the role of ABC transporters, particularly multidrug resistance protein 1 (MDR-1), multidrug resistance-associated proteins 1 and 2 (MRP-1 and MRP-2) and ABC subfamily G member 2 (ABCG2) in sorafenib pharmacokinetics and pharmacodynamics, being key resistance factors. Combination therapy with naturally available or synthetic compounds that modulate ABC transporters may revert sorafenib resistance by increasing absorption and intracellular concentration. Conclusion: A deeper understanding of ABC transporters’ mechanisms may provide guidance for developing innovative approaches for hepatocellular carcinoma. Further studies are warranted to translate the current knowledge into practice and paving the way to individualized therapy.

The current industrial and human activities scenario has accelerated the widespread use of endocrine-disrupting compounds (EDCs), which can be found in everyday products, including plastic containers, bottles, toys, cosmetics, etc., but can pose a severe risk to human health and the environment. In this regard, fungal bioremediation appears as a green and cost-effective approach to removing pollutants from water resources. Besides, immobilizing fungal cells onto nanofibrous membranes appears as an innovative strategy to improve remediation performance by allowing the adsorption and degradation to occur simultaneously. Herein, we developed a novel nanostructured bioremediation platform based on polyacrylonitrile nanofibrous membrane (PAN NFM) as supporting material for immobilizing an endophytic fungus to remove bisphenol A (BPA), a typical EDC. The endophytic strain was isolated from Handroanthus impetiginosus leaves and identified as Phanerochaete sp. H2 by molecular methods. The successful assembly of fungus onto the PAN NFM surface was confirmed by scanning electron microscopy (SEM). Compared with free fungus cells, the PAN@H2 NFM displayed a high BPA removal efficiency (above 85%) at an initial concentration of 5 ppm, suggesting synergistic removal by simultaneous adsorption and biotransformation. Moreover, the biotransformation pathway was investigated, and the chemical structures of fungal metabolites of BPA were identified by ultra-high performance liquid chromatography - high-resolution mass (UHPLC-HRMS) analysis. In general, our results suggest that by combining the advantages of enzymatic activity and nanofibrous structure, the novel platform has the potential to be applied in the bioremediation of varied EDCs or even other pollutants found in water resources.

Neurogenic bowel dysfunction (NBD) affects up to 80% of spinal cord injury (SCI) patients, triggering multiple gastrointestinal symptoms. Basic bowel management (BBM) programs provide predictable and effective fecal elimination, being recommended in this population. Implementing BBM programs can be a clinical challenge, especially in the presence of pre-/co-morbid conditions, such as inflammatory bowel disease (IBD). Clinical assessment may be complex since neurological impairment can blur abdominal signs and symptoms. As such, it is crucial to assess IBD activity through laboratory biomarkers, endoscopic and/or cross-sectional imaging. When there is evidence of IBD remission, BBM programs can be started as in any other SCI patient with NBD. In the presence of active IBD, bowel management may be hampered by active luminal disease. In this setting, therapeutic optimization is warranted before starting BBM programs. Multidisciplinary approaches, including Physical Medicine and Rehabilitation and Gastroenterology, are critically important. This article is protected by copyright. All rights reserved.

Noesis, founded in 1995, was a Portuguese business consulting firm that provided services and solutions aimed at supporting its customers to increase competitiveness, facilitate management, reduce costs and optimize processes, having as core competencies the technological background of its founding partners. Because of the company’s tenacity and strategic focus, 11 years later, in the beginning of 2016, Noesis was a leader in the Portuguese Quality Management market for the independent provision of software testing services, according to a study from International Data Corporation. In January 2016, Noesis had more than 500 employees in its different locations: Lisbon, Porto, Coimbra, Brussels, São Paulo, Dublin and Rotterdam, ensuring the adequate response to customer challenges in Portugal and international markets. The company’s outlook was positive, but the competition was increasing, and interest rates were expected to rise in the nearby future. Having a substantial amount of capital leveraging and two failed international ventures (Angola and Brazil), should Noesis continue to invest and grow at a fast pace or take some time to consolidate its operations?

A atual exigência dos consumidores e a grande competitividade no mercado, faz com que as marcas tenham de reinventar maneiras para se diferenciarem e se tornarem relevantes. Cada vez mais os consumidores procuram viver e experienciar algo marcante e único, e as marcas necessitam de pensar em diferentes formas de entrega dessas experiências, para assim poderem desenvolver emoções e ligações afetivas com estes. Torna-se assim importante atingir os sentimentos e emoções dos consumidores, através de ações e estratégias inovadoras e diferenciadas. A popularidade dos festivais de verão tem vindo a aumentar de ano para ano e são atualmente dos eventos mais aguardados de todo o ano, pelos seus participantes. Este tipo de eventos representa uma excelente oportunidade para as marcas interagirem com os seus consumidores, pois é nestes ambientes que se encontram públicos disponíveis e abertos a novas oportunidades e desafios. Desta forma, o principal objetivo deste estudo é compreender a influência da experiência dos participantes de festivais de verão com as marcas, na criação de sentimentos de amor à marca. Para prosseguir este objetivo, a presente dissertação foi baseada numa abordagem qualitativa, através da realização de três focus group a participantes de festivais de verão, aliada a uma pesquisa exploratória com uma análise documental. Os resultados obtidos neste estudo sugerem a existência de uma relação entre as experiências vividas pelos participantes com as marcas e a criação de sentimentos de amor à marca, no sentido em que geram maior proximidade com os seus consumidores e criam memórias positivas. A participação ativa e o passa-palavra positivo são os principais comportamentos demonstrados pelos consumidores, ao estabelecerem este tipo de ligações experienciais com as marcas.

Articular cartilage is a highly specialized tissue found in diarthrodial joints, which is crucial for healthy articular motion. Despite its importance, articular cartilage has limited regenerative capacities, and the degeneration of this tissue is a leading cause of disability worldwide, with hundreds of millions of people affected. As current treatment options for cartilage degeneration remain ineffective, tissue engineering has emerged as an exciting approach to create cartilage substitutes. In particular, hydrogels seem to be suitable candidates for this purpose due to their biocompatibility and high customizability, being able to be tailored to fit the biophysical properties of native cartilage. Furthermore, these hydrogel matrices can be combined with conductive materials in order to simulate the natural electrochemical properties of articular cartilage. In this review, we highlight the most common conductive materials combined with hydrogels and their diverse applications, and then present the current state of research on the development of electrically conductive hydrogels for cartilage tissue engineering. Finally, the main challenges and future perspectives for the application of electrically conductive hydrogels on articular cartilage repair strategies are also discussed.

Made available in DSpace on 2021-06-25T10:24:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Knowledge of the ecological survival niches of Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff), the causal agent of bean bacterial wilt, is essential for the efficient disease management. Our study evaluated the survival of Cff in the phyllospheres and rhizospheres of barley, black oat, canola, common bean, forage turnip, maize, pearl millet, ryegrass, sorghum, soybean, sunflower, velvet bean, wheat and white oat planted in a greenhouse. The aerial parts of the plants were inoculated by spraying a bacterial suspension (107 CFU.mL−1) from the strain Feij. 2628A, which is resistant to rifampicin and pathogenic to common bean. The soil of the pots was infested with 200 mL of the same suspension. Cff survival was evaluated every seven days for 70 days, and the survival periods were confirmed by selecting strains from all samples and performing PCR with specific primers. Cff survived for at least seven days in the phyllosphere, and 21 days in the rhizosphere of all evaluated crops. Based on our results, barley, black oat, canola, forage turnip, maize, pearl millet, ryegrass, sorghum, soybean, sunflower, velvet bean, wheat and white oat can be potential asymptomatic hosts for Cff, and their cultivation in succession with common bean is not recommended in areas with a history of bacterial wilt occurrence. Department of Plant Protection São Paulo State University (Unesp) School of Agriculture, Avenida Universitária, 3780 Department of Plant Protection São Paulo State University (Unesp) School of Agriculture, Avenida Universitária, 3780 CAPES: 001

Aims Assessing reversibility of pulmonary vascular changes through vasoreactivity testing (VRT) optimizes end‐stage heart failure patient selection for heart transplant. All efforts should be made to unload the left ventricle and reduce pulmonary vascular resistance to effectively exclude irreversible pulmonary hypertension. Methods and results We reviewed our centre's cardiac transplant registry database (2009–2017) for VRT and compared haemodynamic responses with 40 ppm inhaled NO (n = 14), 14–17 μg inhaled iloprost (n = 7), and 24 h 0.1 μg/kg/min intravenous levosimendan (n = 14). Response to levosimendan was assessed by repeat right heart catheterization within 72 h. Baseline clinical and haemodynamic features were similar between groups. VRT was well tolerated in all patients. All drugs effectively reduced pulmonary artery pressures and transpulmonary gradient while increasing cardiac index, although levosimendan had a greater impact on cardiac index increase (P = 0.036). Levosimendan was the only drug that reduced pulmonary artery wedge pressure (P = 0.004) and central venous pressures (P

On July 25, 2013, the Alphasat satellite was launched, carrying the component technology test-bed (CTTB) to assess the space radiation effects in electronic components. Embedded in each of the three experimental boards of the CTTB, are radiation-sensitive metal-oxide–silicon field-effect transistors (RADFETs) to measure the radiation levels at the Alphasat geostationary orbit (GEO). In this work, values of accumulated dose are presented for the RADFETs onboard the Alphasat CTTB experiments up to July 16, 2018. These values were calculated from the threshold voltage shift and from temperature data transmitted to Earth, and using the model derived, previously, from the ESAPMOS4 RADFETs calibration campaign conducted at the European Space Research and Technology Centre (ESTEC) Cobalt-60 facility. These results show that the current accumulated doses are between 1.9 and 3.2 krad and the average dose rates are between 40 and 70 mrad/h. We also present a polynomial function that allows converting voltages into doses for a wide range of values and for different temperatures. The quality of this conversion is tested against Geant4 simulations of the expected dose in the CTTB components for the space radiation environment at the Alphasat orbit. The simulated doses were obtained for three GEO radiation models: AE8, AE9, and IGE-2006.

Research methodology Analysis of public sources. Case overview/synopsis The bank named “Novo Banco” (New Bank in Portuguese) was created because of an emergency intervention by the Bank of Portugal to save the “good” assets of the once great but bankrupt Banco Espírito Santo (BES) on August 4, 2014. The toxic assets remained in BES (dubbed “bad bank”). BES was one of the biggest private banks in Portugal, with origins mounting back to the year 1869. In 2013, it was headed by the founder’s great-grandson, Ricardo Salgado, when an external audit revealed several problems with the bank’s accounting and concluded that BES had a severe financial problem (the risky credit represented 11.1% of the bank’s accounts). The bank underwent a public capital increase (endorsed by several public figures, including the Portuguese President at the time, Cavaco Silva) of €1.045m to reposition itself, which was 100% successful (demand of about 160%, with a significant part of foreign investors). However, continued amounts of suspicions led Ricardo Salgado to be replaced by Vitor Bento (via a settlement between BES’s shareholders and the Bank of Portugal) in July 2014. At the end of that same month, BES announced imparities totaling the amount of €4.2535m. This led the European Central Bank to suspend BES’s access to the financial operations, forcing it to reimburse its credit to the Eurosystem in the value of €10.000m. In two days, the stock prices dropped by 80% to around €0.03 per share. It was later proven that the administration led by Ricardo Salgado had disobeyed the Bank of Portugal 21 times between December 2013 and July 2014, apparently acting against the institution’s best interests. Some carousel schemes with companies within the Espirito Santo Group were also detected in BES’ financial movements to improve the bank’s financial statements. Complexity academic level Finance Valuation, Strategy

Recently, mobile networks have been overloaded with a considerable amount of data traffic. This paper proposes a brokerage service for mobile environments, using policies and quality metrics and ensuring better usage of network resources with more fine-grained management based on flows, and expands previous work (Silva, et al.) with the novel addition of differentiated classes of service. A closed innovative control loop included in a flexible brokerage service in the network, as well as agents at the mobile terminals, detects and counteracts an abnormal data load in any access technology. This allows the terminals to make well-informed decisions about their connections to improve the number of connected flows per technology and the individual service level offered to each flow. Simulation results indicate that the current proposed management solution optimizes the usage of available 4G/5G network resources among a high number of flows in several usage scenarios where the technologies are extremely overloaded, while at the same time, protecting the higher classes of service. info:eu-repo/semantics/publishedVersion

Background: A new computer algorithm called Express-View has recently been introduced by Mirocam, but data concerning its application and efficacy are scarce.Objective: To evaluate the lesion detec...

Gastric cancer (GC) screening is recommended in high-risk populations, although screening methods and intervals vary. In intermediate-risk populations, screening through esophagogastroduodenoscopy (EGD) may be considered depending on local resources. The aim of this study was to compare GC screening methods regarding effect on mortality, diagnostic yield and adherence. Systematic review and meta-analysis including studies evaluating population-based GC screening. Search was conducted in three online databases (MEDLINE, Scopus and clinicaltrials.gov), along with manual search. Forty-four studies were included. Studies in upper gastrointestinal series (UGIS) demonstrated that GC screening was associated with significantly lower GC mortality rates (OR 0.63, 95% CI 0.55 − 0.73). Benefits on mortality were also found in EGD and serum pepsinogen (PG) studies. EGD was associated with significantly higher GC (0.55%, 95% CI 0.39 − 0.75%) and early-GC (EGC) detection rates (0.48%, 95% CI 0.34 − 0.65%) when compared to UGIS (GC 0.19%, 95% CI 0.10 − 0.31%; EGC 0.08%, 95% CI 0.04 − 0.13%) and PG (GC 0.10%, 95% CI 0.05 − 0.16%; EGC 0.10%, 95% CI 0.04 − 0.19%). Non-invasive methods tended to higher adherence rates when compared to EGD. Regardless of the screening method, individualized recruitment performed better. Screening positively impacted GC mortality rates. EGD was associated with higher diagnostic yield, while UGIS and PG tended to higher adherence rates. Screening uptake was predominantly impacted by recruitment strategies independently of the adopted method.

Cooperative strategies amongst network players can improve network performance and spectrum utilization in future networking environments. Game Theory is very suitable for these emerging scenarios, since it models high-complex interactions among distributed decision makers. It also finds the more convenient management policies for the diverse players (e.g., content providers, cloud providers, edge providers, brokers, network providers, or users). These management policies optimize the performance of the overall network infrastructure with a fair utilization of their resources. This chapter discusses relevant theoretical models that enable cooperation amongst the players in distinct ways through, namely, pricing or reputation. In addition, the authors highlight open problems, such as the lack of proper models for dynamic and incomplete information scenarios. These upcoming scenarios are associated to computing and storage at the network edge, as well as, the deployment of large-scale IoT systems. The chapter finalizes by discussing a business model for future networks. info:eu-repo/semantics/acceptedVersion

Hybrid argon plasma coagulation (hAPC) is a novel technique that combines conventional argon plasma coagulation and waterjet submucosal expansion. The aims of this metanalysis were to evaluate the efficacy and safety of hAPC in the setting of Barret’s esophagus (BE) ablation and as an adjunct to colonic endoscopic mucosal resection (EMR). Four electronic databases were searched, and the results were analyzed by two independent authors. Random-effects meta-analyses of the proportions of endoscopic and histologic remission (for BE), recurrence, and post-procedure adverse events were performed using R. Studies’ reporting quality was also assessed. From the 979 identified records, 13 studies were included (10 regarding BE and three colonic EMR). The pooled percentages of endoscopic and histologic remission after hAPC for BE were 95% (95% confidence interval [CI] 91–99, I2 = 34) and 90% (95%CI 84–95, I2 = 46), respectively, while major adverse events and recurrence were registered in 2% (95%CI 0–5, I2 = 41) and 11% (95%CI 2–27, I2 = 11), respectively. Concerning hAPC-assisted EMR, the pooled percentages of major adverse events and recurrence were 5% (95%CI 2–10, I2 = 0) and 1% (95%CI 0–3, I2 = 40). Evidence suggests that the main advantages of hAPC are the increase in safety in the setting of BE ablation and the reduction of local recurrence after colonic EMR. Trials comparing hAPC with standard strategies are required to support its use for these indications.

É cada vez, mas comum que cada influenciador digital seja "especialista" onde terá seguidores que se interesse por esse determinado assunto, mostrando sua rotina, de alimentação. Cada influenciador demonstra interesse em um assunto e irá fazer com que seu público tenha interesse nesse determinado assunto, é o que acontece com as "blogueiras fitness". O objetivo desse estudo foi verificar a relação entre a persuasão dos influenciadores digitais e o uso de redes sociais e sua influência nos hábitos alimentares e na concepção do corpo ideal. Trata-se de um estudo quantitativo, descritivo e transversal. A amostra foi constituí­da por 213 pessoas, ambos os sexos, com idade de 18 a 35 anos (22,4 ± 3,8). Para realização dessa pesquisa, foi utilizado como técnica para coleta de dados a aplicação de um questionário online. Os dados coletados foram armazenados em uma planilha do Statistical Package for the Social Sciences. Houve um predomí­nio do sexo feminino (63,8%), quando questionados sobre qual tipo de perfil você prefere seguir, a maioria dos pesquisados seguir artistas (46,9%) seguidos de Blogueiras (24,4%), e uma minoria (17,4%) afirmaram buscar por nutricionistas. Ao final foi possí­vel depreender que existe uma influência da mí­dia nos hábitos alimentares e na concepção do corpo ideal das pessoas avaliadas. It is increasingly common for each digital influencer to be an "expert" where they will have followers who are interested in that particular subject, showing their food routine. Each influencer shows interest in a subject and will make their audience interested in that particular subject, this is what happens with "fitness bloggers". The objective of this study was to verify the relationship between the persuasion of digital influencers and the use of social networks and their influence on eating habits and the conception of the ideal body. This is a quantitative, descriptive and cross-sectional study. The sample consisted of 213 people, both sexes, aged between 18 and 35 years (22.4 ± 3.8). To carry out this research, an online questionnaire was used as a technique for data collection. The collected data were stored in a Statistical Package for the Social Sciences spreadsheet. There was a predominance of females (63.8%), when asked what type of profile you prefer to follow, most respondents follow artists (46.9%) followed by bloggers (24.4%), and a minority ( 17.4%) said they looked for nutritionists. In the end, it was possible to infer that there is an influence of the media on eating habits and on the conception of the ideal body of the people evaluated. Cada vez es más común que cada influencer digital sea un “experto” donde tendrá seguidores interesados ​​en ese tema en particular, mostrando su rutina alimentaria. Cada influencer muestra interés por un tema y logrará que su audiencia se interese por ese tema en particular, esto es lo que sucede con los “fitness bloggers”. El objetivo de este estudio fue verificar la relación entre la persuasión de los influencers digitales y el uso de las redes sociales y su influencia en los hábitos alimentarios y la concepción del cuerpo ideal. Se trata de un estudio cuantitativo, descriptivo y transversal. La muestra estuvo compuesta por 213 personas, de ambos sexos, con edades comprendidas entre 18 y 35 años (22,4 ± 3,8). Para llevar a cabo esta investigación se utilizó como técnica de recolección de datos un cuestionario en línea. Los datos recolectados fueron almacenados en una hoja de cálculo del Paquete Estadístico para las Ciencias Sociales. Hubo un predominio del sexo femenino (63,8%), cuando se les preguntó qué tipo de perfil prefiere seguir, la mayoría de los encuestados siguen a los artistas (46,9%) seguidos de los blogueros (24,4%) y una minoría (17,4%) dijo buscar nutricionistas. . Al final, se pudo inferir que existe una influencia de los medios de comunicación en los hábitos alimentarios y en la concepción del cuerpo ideal de las personas evaluadas. É cada vez, mas comum que cada influenciador digital seja "especialista" onde terá seguidores que se interesse por esse determinado assunto, mostrando sua rotina, de alimentação. Cada influenciador demonstra interesse em um assunto e irá fazer com que seu público tenha interesse nesse determinado assunto, é o que acontece com as "blogueiras fitness". O objetivo desse estudo foi verificar a relação entre a persuasão dos influenciadores digitais e o uso de redes sociais e sua influência nos hábitos alimentares e na concepção do corpo ideal. Trata-se de um estudo quantitativo, descritivo e transversal. A amostra foi constituí­da por 213 pessoas, ambos os sexos, com idade de 18 a 35 anos (22,4 ± 3,8). Para realização dessa pesquisa, foi utilizado como técnica para coleta de dados a aplicação de um questionário online. Os dados coletados foram armazenados em uma planilha do Statistical Package for the Social Sciences. Houve um predomí­nio do sexo feminino (63,8%), quando questionados sobre qual tipo de perfil você prefere seguir, a maioria dos pesquisados seguir artistas (46,9%) seguidos de Blogueiras (24,4%), e uma minoria (17,4%) afirmaram buscar por nutricionistas. Ao final foi possí­vel depreender que existe uma influência da mí­dia nos hábitos alimentares e na concepção do corpo ideal das pessoas avaliadas. È sempre più comune per ogni influencer digitale essere un "esperto" in cui avrà follower interessati a quel particolare argomento, mostrando la loro routine alimentare. Ogni influencer mostra interesse per un argomento e renderà il proprio pubblico interessato a quel particolare argomento, questo è ciò che accade con i "blogger di fitness". L'obiettivo di questo studio è stato quello di verificare la relazione tra la persuasione degli influencer digitali e l'uso dei social network e la loro influenza sulle abitudini alimentari e la concezione del corpo ideale. Si tratta di uno studio quantitativo, descrittivo e trasversale. Il campione era composto da 213 persone, entrambi i sessi, di età compresa tra i 18 ei 35 anni (22,4 ± 3,8). Per svolgere questa ricerca, è stato utilizzato un questionario online come tecnica per la raccolta dei dati. I dati raccolti sono stati archiviati in un pacchetto statistico per il foglio di calcolo delle scienze sociali. C'era una predominanza di donne (63,8%), alla domanda su quale tipo di profilo si preferisce seguire, la maggior parte degli intervistati segue artisti (46,9%) seguiti da blogger (24,4%) e una minoranza (17,4%) ha detto di aver cercato nutrizionisti . Alla fine si è potuto dedurre che c'è un'influenza dei media sulle abitudini alimentari e sulla concezione del corpo ideale delle persone valutate.

Novel green materials not sourced from animals and with low environmental impact are becoming increasingly appealing for biomedical and cellular agriculture applications. Marine biomaterials are a rich source of structurally diverse compounds with various biological activities. Kappa-carrageenan (κ-c) is a potential candidate for tissue engineering applications due to its gelation properties, mechanical strength, and similar structural composition of glycosaminoglycans (GAGs), possessing several advantages when compared to other algae-based materials typically used in bioprinting such as alginate. For those reasons, this material was selected as the main polysaccharide component of the bioinks developed herein. In this work, pristine κ-carrageenan bioinks were successfully formulated for the first time and used to fabricate 3D scaffolds by bioprinting. Ink formulation and printing parameters were optimized, allowing for the manufacturing of complex 3D structures. Mechanical compression tests and dry weight determination revealed young’s modulus between 24.26 and 99.90 kPa and water contents above 97%. Biocompatibility assays, using a mouse fibroblast cell line, showed high cell viability and attachment. The bioprinted cells were spread throughout the scaffolds with cells exhibiting a typical fibroblast-like morphology similar to controls. The 3D bio-/printed structures remained stable under cell culture conditions for up to 11 days, preserving high cell viability values. Overall, we established a strategy to manufacture 3D bio-/printed scaffolds through the formulation of novel bioinks with potential applications in tissue engineering and cellular agriculture.

Background and purpose Acute myocardial infarction (AMI) due to left main coronary artery (LMCA) occlusion is a rare event, often catastrophic. Limited data are available about management and outcomes of patients with acute LMCA occlusion, including those presenting with cardiogenic shock (CS) at hospital admission. This study sought to describe patients with AMI due unprotected LMCA occlusion presenting with CS and to evaluate their in-hospital outcomes and 1-year mortality. Methods In this retrospective 2-center study, we identified 7630 patients with ST-segment elevation myocardial infarction (STEMI) or hight risk non-ST segment elevation myocardial infarction who underwent to emergent coronary angiography between January 2008 and December 2020. Among this cohort, we analysed 94 patients who presented with unprotected LMCA occlusion (Thrombolysis In Myocardial Infarction – TIMI ≤2) and divided them in 2 groups according to presence of signs of cardiogenic shock at admission: CS and no-CS. Results Of 94 patients with AMI due LMCA occlusion, 52 patients presented with CS (53.3%). Mean age was 62.8±11.5 years in CS and 62.0±15.9 years in no-CS patients, p=0.766. In both groups, most patients were male. STEMI presentation was more frequent in CS group (80.4% vs. 52.4%, p=0.004). Severe systolic dysfunction of left ventricle was more frequent in CS patients (81.1% vs. 33.3%, p Conclusions Nearly half of patients with AMI due LMCA occlusion presented with CS signs at first medical evaluation. This subgroup of patients had higher in-hospital mortality compared to those without CS, despite MCS implantation. Whether the use of a specific MCS device or whether early use of MCS can change the outcome remains to be elucidated. CS patients who survive to index-hospitalization, had similar long-term outcomes compared to no-CS patients. Further studies are imperative in this population to refine initial medical treatment in order to improve their prognosis. Funding Acknowledgement Type of funding sources: None.

Introduction Acute occlusion of the unprotected left main coronary artery (LMCA) is an uncommon occurrence associated with a dismal prognosis. Whereas the role of early recruited coronary collateral circulation (CC) in prognosis of ST-segment elevation acute myocardial infarction (STEMI) patients is still controversial, it seems to be important in patients with acute LMCA occlusion. This study aimed to evaluate the coronary CC in patients with acute LMCA occlusion and its impact in short and long-term outcomes. Methods In a retrospective two-center study, we identified 7630 patients with STEMI or high-risk non-ST segment elevation myocardial infarction who underwent emergent coronary angiography between January 2008 and December 2020. Among this cohort, we analyzed 83 patients who presented with unprotected LMCA acute occlusion (Thrombolysis In Myocardial Infarction – TIMI ≤2) and classified them in 2 groups based on the degree of CC through the right coronary artery as seen in the emergent angiography: patients with no filling of collateral vessels or filling of collateral vessels without any epicardial filling of the occluded vessel [Rentrop class 0–1 (71 patients)]; and patients with partial or complete epicardial filling by collateral vessels [CC Rentrop class 2–3 (12 patients)]. Results Compared to patients with CC Rentrop 0–1, patients with CC Rentrop 2–3 presented significantly later to medical attention (symptom to coronary angiography time 8.7 vs 4.3 hours, p=0.02). Despite that, patients with CC Rentrop 2–3 had a significantly lower prevalence of cardiogenic shock at admission (16.7 vs 57.7%, p=0.01). During hospitalization, Killip class III-IV presentation (33.3 vs 88.7%, p Conclusion A well-developed coronary CC was associated to lower short-term mortality in patients presenting with acute occlusion of the unprotected LMCA. Nevertheless, in patients surviving index-event, there was no difference in the long-term outcomes. Further studies are needed to clarify if clinical approach (eg. early short-term mechanical circulatory support) of patients with CC Rentrop 0–1 should be different from those with CC Rentrop 2–3 in order to improve the outcomes of the former patients. Funding Acknowledgement Type of funding sources: None.

Millimeter-wave and terahertz technologies have been attracting attention from the wireless research community since they can offer large underutilized bandwidths which can enable the support of ultra-high-speed connections in future wireless communication systems. While the high signal attenuation occurring at these frequencies requires the adoption of very large (or the so-called ultra-massive) antenna arrays, in order to accomplish low complexity and low power consumption, hybrid analog/digital designs must be adopted. In this paper we present a hybrid design algorithm suitable for both mmWave and THz multiuser multiple-input multiple-output (MIMO) systems, which comprises separate computation steps for the digital precoder, analog precoder and multiuser interference mitigation. The design can also incorporate different analog architectures such as phase shifters, switches and inverters, antenna selection and so on. Furthermore, it is also applicable for different structures namely, fully connected, arrays of subarrays (AoSA) and dynamic arrays of subarrays (DAoSA), making it suitable for the support of ultra-massive MIMO (UM-MIMO) in severely hardware constrained THz systems. We will show that, by using the proposed approach, it is possible to achieve good trade-offs between spectral efficiency and simplified implementation, even as the number of users and data streams increases.), Comment: 16 pages 12 figures

Made available in DSpace on 2020-12-12T01:47:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This study investigated the survival of Xanthomonas campestris pv. campestris (Xcc) in the soil, under field and controlled conditions, and associated with cauliflower crop debris. Under field conditions, the soil temperature influenced the survival of Xcc, and the bacterium survived from 4 to 7 days. Under controlled conditions, the soil type and temperature influenced Xcc survival. Depending on the texture, pH and organic matter content of the soil, the bacterium survived from 10 to 24 days. Xcc survived in the soil for 14 days at 20 °C, and for 4 days when incubated at 30 °C. The soil moisture did not influence Xcc survival of 14 days at the three moisture contents evaluated. Similar behaviour was observed regarding the survival of four Xcc strains in the soil. The longest period of Xcc survival associated with cauliflower debris was 255 days. Our results suggest that the soil is not an important source of inoculum for Xcc. Considering the survival periods of Xcc in cauliflower crop residues under the Brazilian conditions studied, we recommend crop rotation with non-host species of Xcc for 1 year. This information may also be useful for the management of black rot in other brassica-producing countries. Departamento de Proteção Vegetal Faculdade de Ciências Agronômicas (FCA) Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Avenida Universitária, 3780 Departamento de Bioestatística Instituto de Biociências UNESP, P.O. Box 510 Departamento de Proteção Vegetal Faculdade de Ciências Agronômicas (FCA) Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), Avenida Universitária, 3780 Departamento de Bioestatística Instituto de Biociências UNESP, P.O. Box 510 FAPESP: 2011/18527-0 FAPESP: 2012/13298-5

Introduction: Coronary intravascular ultrasound (IVUS) is increasingly important in catheterization laboratories due to its positive prognostic impact. This study aims to characterize the use of IVUS in percutaneous coronary intervention (PCI) in Portugal. Methods: A retrospective observational study was performed based on the Portuguese Registry on Interventional Cardiology of the Portuguese Society of Cardiology. The clinical and angiographic profiles of patients who underwent PCI between 2002 and 2016, the percentage of IVUS use, and the coronary arteries assessed were characterized. Results: A total of 118706 PCIs were included, in which IVUS was used in 2266 (1.9%). Over time, use of IVUS changed from none in 2002 to generally increasing use from 2003 (0.1%) to 2016 (2.4%). The age of patients in whom coronary IVUS was used was similar to that of patients in whom IVUS was not used, but in the former group there were fewer male patients, and a higher prevalence of cardiovascular risk factors (hypertension, hypercholesterolemia and diabetes), previous myocardial infarction, previous PCI, multivessel coronary disease, C-type or bifurcated coronary lesions, and in-stent restenosis. IVUS was used in 54.8% of elective PCIs and in 19.15% of PCIs of the left main coronary artery. Conclusion: Coronary IVUS has been increasingly used in Portugal since 2003. It is used preferentially in elective PCIs, and in patients with higher cardiovascular risk, with more complex coronary lesions and lesions of the left main coronary artery. Resumo: Introdução: A ecografia intravascular coronária tem ganho importância nos laboratórios de hemodinâmica pela evidência de impacto prognóstico positivo para os doentes. Este trabalho tem como objetivo caraterizar a utilização de ecografia intravascular em intervenções coronárias percutâneas em Portugal. Métodos: Estudo observacional retrospetivo com base no Registo Nacional de Cardiologia de Intervenção da Sociedade Portuguesa de Cardiologia. De 2002 a 2016 caraterizou-se o perfil clínico e angiográficos dos doentes submetidos a intervenção coronária percutânea, a percentagem de utilização de ecografia intravascular e as artérias coronárias avaliadas. Resultados: Foram incluídas 118 706 intervenções coronárias percutâneas, com utilização de ecografia intravascular em 2266 (19%). A evolução temporal caraterizou-se por ausência em 2002 e uma utilização maioritariamente crescente de 2003 (0.1%) a 2016 (2.4%). O grupo de doentes com utilização de ecografia intravascular coronária tinham idade semelhante ao grupo de doentes sem utilização de ecografia intravascular coronária, com uma menor prevalência de doentes do sexo masculino e uma maior prevalência de fatores de risco cardiovasculares (hipertensão arterial, hipercolesterolemia, diabetes), enfarte agudo do miocárdio prévio, intervenção coronária percutânea prévia, doença coronária multivaso, lesões coronárias do tipo C ou em bifurcação e reestenose intra-stent. A ecografia intravascular foi utilizada em 54.8% em intervenções coronárias percutâneas eletivas e em 19.15% das intervenções coronárias percutâneas do tronco comum. Conclusão: A ecografia intravascular coronária teve uma utilização crescente em Portugal desde 2003, ocorre preferencialmente em intervenções coronárias percutâneas eletivas, de doentes com maior risco cardiovascular, com lesões coronárias mais complexas e lesões do tronco comum. Keywords: Intravascular ultrasound, Percutaneous coronary intervention, Coronary disease, Cardiology, Palavras-chave: Ecografia intravascular, Intervenção coronária percutânea, Doença coronária, Cardiologia

Gastrointestinal stromal tumors account for the majority of the mesenchymal neoplasms of the gastric antrum, but other entities should also be considered. We present the case of a 70-year-old man with an ulcerated well-circumscribed polypoid submucosal mass in the gastric antrum which was proven to be a glomus tumor. CT showed progressive contrast enhancement. Magnetic resonance imaging showed a high T2 signal intensity and heterogeneous arterial contrast enhancement which became more homogeneous in later phases. We also present the case of a 50-year-old woman with a large polypoid mass occupying half the circumference of the distal gastric antrum that was proven to be a plexiform fibromyxoma. Contrast-enhanced CT and magnetic resonance imaging revealed a pattern of progressive and heterogeneous enhancement. Although gastrointestinal stromal tumors are the most frequent gastric mesenchymal neoplasms, other rare mesenchymal tumors such as glomus tumor and plexiform fibromyxoma may arise in the gastric antrum. Keywords: Gastric antrum, Glomus tumor, Plexiform fibromyxoma

Coumarins are natural 1,2-benzopyrones, present in remarkable amounts as secondary metabolites in edible and medicinal plants. The low yield in the coumarins isolation from natural sources, along with the difficulties faced by the total synthesis, make them attractive for biotechnological studies. The current literature contains several reports on the biotransformation of coumarins by fungi, which can generate chemical analogs with high selectivity, using mild and eco-friendly conditions. Prompted by the enormous pharmacological interest in the coumarin-related compounds, their alimentary and chemical applications, this review covers the biotransformation of coumarins by filamentous fungi. The chemical structures of the analogs were presented and compared with those from the pattern structures. The main chemical reactions catalyzed the insertion of functional groups, and the impact on the biological activities caused by the chemical transformations were discussed. Several chemical reactions can be catalyzed by filamentous fungi in the coumarin scores, mainly lactone ring opening, C3-C4 reduction and hydroxylation. Chunninghamella sp. and Aspergillus sp. are the most common fungi used in these transformations. Concerning the substrates, the biotransformation of pyranocoumarins is a rarer process. Sometimes, the bioactivities were improved by the chemical modifications and coincidences with the mammalian metabolism were pointed out.

Millimeter-wave (mmWave) technology is one of the most promising candidates for future wireless communication systems as it can offer large underutilized bandwidths and eases the implementation of large antenna arrays which are required to help overcome the severe signal attenuation that occurs at these frequencies. To reduce the high cost and power consumption of a fully digital mmWave precoder and combiner, hybrid analog/digital designs based on analog phase shifters are often adopted. In this work we derive an iterative algorithm for the hybrid precoding and combining design for spatial multiplexing in mmWave massive multiple-input multiple-output (MIMO) systems. To cope with the difficulty of handling the hardware constraint imposed by the analog phase shifters we use the alternating direction method of the multipliers (ADMM) to split the hybrid design problem into a sequence of smaller subproblems. This results in an iterative algorithm where the design of the analog precoder/combiner consists of a closed form solution followed by a simple projection over the set of matrices with equal magnitude elements. It is initially developed for the fully-connected structure and then extended to the partially-connected architecture which allows simpler hardware implementation. Furthermore, to cope with the more likely wideband scenarios where the channel is frequency selective, we also extend the algorithm to an orthogonal frequency division multiplexing (OFDM) based mmWave system. Simulation results in different scenarios show that the proposed design algorithms are capable of achieving performances close to the optimal fully digital solution and can work with a broad range of configuration of antennas, RF chains and data streams., Comment: preprint submitted to Elsevier Physical Communication

A cultura da seringueira com um manejo de correção do solo de qualidade expressa melhor suas características respondendo em produtividades. O cultivo do gênero Hevea brasiliensis diferentes de outras culturas não visa os frutos, mais sim o látex, que é extraído do tronco da planta. Como os procedimentos são delicados, exige-se conhecimento técnico do processo, assim, é preciso ferramentas que auxiliem na precisão e acurácia, e este processo precisa ser implantado no estabelecimento da cultura, na base, ou seja, na correção do solo, que condiciona este ambiente para as melhores expressões da planta no ambiente de produção. Nesta necessidade que entra a aplicações de ferramentas tecnológicas da agricultura de precisão aplicadas a cultura da seringueira, uma ferramenta que tem muito a contribuir no setor de produção de florestas. A aplicação da tecnologia foi totalmente realizada levando em consideração a realidade do setor da heveicultura, com uma ferramenta que auxilia na gestão dos processos por tarefas que representam tabuleiros que por sua vez são amostradas e interpoladas para fins de recomendações e confecção de mapas temáticos de correção do solo, e o conhecimento de características da variabilidade do solo.

Research methodology This study has used public sources, interview with one of the case protagonists. Case overview/synopsis This business case portrays the problems that an energy producing company faced in Portugal, in its transition from being a public company to becoming privatized. The Portuguese Government issued EDP with generous subsidies to guarantee its future profits and privatization success, but a few years later, after EDP was fully privatized, there was great political pressure to downsize such subsidies. The case describes the main steps taken by EDP from its creation and privatization, culminating at the end of 2017, where it was heavily criticized by media and political parties due to a high value of subsidies that had been granted to the company by the Portuguese Government in the past, while it was still a public company, and the renegotiation of those same subsidies after it had been privatized. EDP’s President António Mexia was under police investigation due to having led the renegotiation talks in 2007, and it was feared that EDP’s investors could refrain from investing in the company. Should EDP campaign to clear its good name, or would it be better to let the matter fall with the passing of time? Could the share value be affected? Should EDP prepare itself for loss of revenue due to an eventual downsizing of the subsidies? Complexity academic level This study covers energy sector, privatization issues and government support. The relevance of this study is good for use in Business Schools and MBA courses.

Usually, the adoption by elderly of Information and Communication Technology (ICT) products is seen as difficult and unsatisfactory. Yes, sometimes that adoption is surprisingly complete and enthusiastic, motivated by an acceptance of the use of technology in the expectation of increased continued autonomy. Identifying the factors or characteristics of products that affect that adoption is key for the development of new solutions. The Interreg SUDOE ICT4SILVER project has enabled the usability test of several technological products in senior care institutions, and created the opportunity to observe and record behavioral indicators of elderly concerning the use of technology, as well as to contribute with particular useful guidelines for the manufacturers, employing correlations and behavior observation. In this paper we describe the tests conducted on a product, we suggest an organizational pilot model, we analyze the observed behavior, we propose a reaction classification, and we register the variation with respect to the nature of the experience.

In patients with cryptogenic stroke, one of the most frequently found abnormalities is patent foramen ovale (PFO). Percutaneous 'deviceless' systems based on surgical suture-mediated PFO closure have recently been introduced and show a favorable efficacy and safety profile with clear advantages.To present procedural details of the technique and baseline characteristics of patients who underwent the procedure in our center.A single-center prospective observational registry was established between February 2020 and February 2021, to assess the safety, efficacy and possible advantages of a novel percutaneous PFO closure system (NobleStitch® EL). Patient and PFO characteristics as well as technical features were collected for analysis.Twenty-three patients were considered suitable for this technique after transesophageal echocardiography. Their mean age was 51 years and 69.5% were women. Most patients (91.3%) had a history of cryptogenic stroke. PFO closure with the NobleStitch® system was successfully performed in all patients. All procedures were performed under local anesthesia and fluoroscopic monitoring. The mean duration of the procedure was 52 min and median contrast dose used was 187 ml. Median radiation dose absorbed per patient was 61.5 Gy cmSuture-mediated PFO closure represents a valid and safe alternative to traditional umbrella-like devices, and is feasible in the majority of PFO anatomies. Follow-up information, results of larger series and clinical trials may possibly validate this technique as the first choice for PFO closure.

Several gastroenterology societies have created recommendations in order to reduce nonessential exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Our aim is to evaluate the national gastroenterologists' perspective on the impact of COVID-19 and the impact of reorganization of a gastroenterology department during the COVID-19 pandemic.For the first purpose, an online survey was distributed to gastroenterologists nationwide. For the second purpose, the authors conducted an analysis of some endoscopic procedures performed at the Gastroenterology Department of the Centro Hospitalar Vila Nova de Gaia/Espinho (CHVNG/E) between March 16 and May 8 during the years 2019 and 2020.Sixty-seven gastroenterologists answered our survey. Only 14.9% were residents and 86.6% worked in a hospital with COVID-19 patients, with 16.4% assigned to assist those patients. All of the departments suffered modifications. Ninety percent of the residents affirmed that their activity had changed. Ninety-four percent declared having nonessential endoscopic procedures postponed, and 85.1% maintained in-person medical visits, 88.1% were already having remote consultations, and 11.9% did not have any clinical visit. In our gastroenterology unit, the number of endoscopic procedures decreased by 73.1% from 2019 to 2020. In 2020, the proportion of urgent procedures was higher compared to 2019.The advent of COVID-19 has led to important changes in gastroenterology activities in Portugal, and national gastroenterology units are complying with the recommendations. Furthermore, Portuguese gastroenterologists believed that the decrease in endoscopic activity can compromise residents' education and training. The gastroenterology department at CHVNG/E has shown a significant reduction in the number of endoscopic procedures.As sociedades de Gastroenterologia criaram recomendações de modo a reduzir a exposição não necessária ao vírus da síndrome respiratória aguda grave (SARS-CoV-2). O nosso objetivo é avaliar a perspectiva nacional dos gastroenterologistas sobre o impacto da COVID-19 e avaliar o impacto da reorganização do nosso serviço de Gastroenterologia durante a pandemia.Para o 1° objetivo, um inquérito online foi disponibilizado aos gastroenterologistas de todo o país. Para o 2° objetivo, os autores realizaram uma análise dos procedimentos endoscópicos do serviço de Gastroenterologia do Centro Hospitalar Vila Nova de Gaia/Espinho (CHVNG/E) entre 16 de Março e 8 de Maio durante os anos de 2019 e 2020.67 gastroenterologistas responderam o inquérito. Destes, 14.9% eram internos. 86.6% trabalharam num hospital com doentes com COVID-19, e 16.4% dos médicos prestavam cuidados a esses doentes. Todos os departamentos sofreram alterações. 90% dos internos referiram que a atividade tinha sido alterada. 94% dos médicos afirmaram que os procedimentos endoscópicos não-essenciais foram adiados. 85.1% mantinham algumas consultas médicas presenciais, 88.1% estavam a realizar consultas não presenciais, e 11.9% não tinham nenhum tipo de consulta. No nosso serviço, o número de procedimentos endoscópicos diminui em 73.1% de 2019 para 2020. Em 2020, a proporção de procedimentos endoscópicos de urgência foi superior em relação a 2019.A pandemia da COVID-19 conduziu a alterações importantes dentro das atividades da Gastroenterologia em Portugal, e os serviços de Gastroenterologia mostraram cumprir as recomendações. Além disso, os gastroenterologistas portugueses acreditam que a diminuição da atividade endoscópica dos internos pode comprometer a sua futura formação. O serviço de gastroenterologia do CHVNG/E mostrou uma redução significativa do número de procedimentos endoscópicos.

The COVID-19 pandemic has imposed an unprecedented burden on healthcare systems worldwide, changing the profile of interventional cardiology activity.To quantify and compare the number of percutaneous coronary interventions (PCIs) performed for acute and chronic coronary syndromes during the first COVID-19 outbreak with the corresponding period in previous years.Data on PCI from the prospective multicenter Portuguese Registry on Interventional Cardiology (RNCI) were used to analyze changes in PCI for ST-elevation myocardial infarction (STEMI), non-ST-elevation acute coronary syndromes (NSTE-ACS) and chronic coronary syndromes (CCS). The number of PCIs performed during the initial period of the COVID-19 outbreak in Portugal, from March 1 to May 2, 2020, was compared with the mean frequency of PCIs performed during the corresponding period in the previous three years (2017-2019).The total number of PCIs procedures was significantly decreased during the initial COVID-19 outbreak in Portugal (-36%, p0.001). The reduction in PCI procedures for STEMI, NSTE-ACS and CCS was, respectively, -25% (p0.019), -20% (p0.068) and -59% (p0.001).Compared with the corresponding period in the previous three years, the number of PCI procedures performed for STEMI and CCS decreased markedly during the first wave of the COVID-19 pandemic in Portugal.