1. Vertebral compression fractures may increase mortality in male patients with chronic obstructive pulmonary disease
- Author
-
Lee Sd, Yeon-Mok Oh, Tai Sun Park, Gun Woo Kim, Joo Hj, Young Ju Jung, Lee Sw, and Jung-Shin Lee
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Pulmonary disease ,Comorbidity ,Kaplan-Meier Estimate ,Risk Assessment ,Statistics, Nonparametric ,Thoracic Vertebrae ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,Age Distribution ,Internal medicine ,Cause of Death ,Fractures, Compression ,Republic of Korea ,medicine ,Humans ,Respiratory system ,Risk factor ,Sex Distribution ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,COPD ,business.industry ,Vertebral compression fracture ,Incidence ,Hazard ratio ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Survival Analysis ,respiratory tract diseases ,Surgery ,Radiography ,Infectious Diseases ,Spinal Fractures ,business ,Body mass index - Abstract
BACKGROUND Vertebral compression fracture (VCF) is frequent in chronic obstructive pulmonary disease (COPD) patients. However, little is known about whether VCF affects mortality in COPD patients. OBJECTIVE To investigate whether VCFs might increase death in COPD patients. METHODS In this retrospective cohort study, we enrolled 254 COPD patients with a recent history of hospitalisation due to respiratory problems. Patients were assessed for VCF using quantitative morphometric analyses of lateral chest radiographs; 211 patients received follow-up examinations for 2 years. RESULTS Of the 211 COPD patients analysed, 60 (28.4%) had VCF at enrolment. During the follow-up period, 33/60 (55.0%) patients with and 46/151 patients (30.5%) without VCF died (P = 0.003, log-rank test). Cox proportional hazard analysis revealed that VCF is an independent risk factor for death after adjusting for age, sex, body mass index, smoking, dyspnoea scale, forced expiratory volume in 1 sec (FEV1) and comorbidities (hazard ratio for VCF = 1.79, 95%CI 1.11-2.89, P = 0.02). CONCLUSION VCF might be an independent risk factor for death in male COPD patients.
- Published
- 2015