1. Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients
- Author
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Stéphanie Bibert, Nicolas Guex, Joao Lourenco, Thomas Brahier, Matthaios Papadimitriou-Olivgeris, Lauro Damonti, Oriol Manuel, Robin Liechti, Lou Götz, Jonathan Tschopp, Mathieu Quinodoz, Peter Vollenweider, Jean-Luc Pagani, Mauro Oddo, Olivier Hügli, Frédéric Lamoth, Véronique Erard, Cathy Voide, Mauro Delorenzi, Nathalie Rufer, Fabio Candotti, Carlo Rivolta, Noémie Boillat-Blanco, Pierre-Yves Bochud, the RegCOVID Study Group, Bochud Pierre-Yves, Desgranges Florian, Filippidis Paraskevas, Guéry Benoit, Haefliger David, Kampouri Eleftheria-Evdokia, Manuel Oriol, Munting Aline, Pagani Jean-Luc, Papadimitriou-Olivgeris Matthaios, Regina Jean, Rochat-Stettler Laurence, Suttels Veronique, Tadini Eliana, Tschopp Jonathan, Van Singer Mathias, Viala Benjamin, Vollenweider Peter, RegCOVID Study Group, Pierre-Yves, B., Florian, D., Paraskevas, F., Benoit, GER, David, H., Eleftheria-Evdokia, K., Oriol, M., Aline, M., Jean-Luc, P., Matthaios, P.O., Jean, R., Laurence, R.S., Veronique, S., Eliana, T., Jonathan, T., Mathias, V.S., Benjamin, V., and Peter, V.
- Subjects
0301 basic medicine ,Immunology ,RNA-sequencing ,Context (language use) ,610 Medicine & health ,Biology ,Virus ,Transcriptome ,Pathogenesis ,03 medical and health sciences ,whole blood transcriptome ,0302 clinical medicine ,Immune system ,Influenza, Human ,medicine ,Immunology and Allergy ,Humans ,B cell ,Original Research ,SARS-CoV-2 ,immune profiling ,COVID-19 ,Cell cycle ,RC581-607 ,030104 developmental biology ,medicine.anatomical_structure ,COVID-19/immunology ,Influenza, Human/immunology ,SARS-CoV-2/immunology ,influenza ,biology.protein ,Antibody ,Immunologic diseases. Allergy ,030217 neurology & neurosurgery - Abstract
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
- Published
- 2021
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