1. Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2
- Author
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Jamal, Alainna J, Mozafarihashjin, Mohammad, Coomes, Eric, Powis, Jeff, Li, Angel X, Paterson, Aimee, Anceva-Sami, Sofia, Barati, Shiva, Crowl, Gloria, Faheem, Amna, Farooqi, Lubna, Khan, Saman, Prost, Karren, Poutanen, Susan, Taylor, Maureen, Yip, Lily, Zhong, Xi Zoe, McGeer, Allison J, Mubareka, Samira, Coleman, Brenda L, Chen, Danny, Farshait, Nataly, Gold, Wayne, Kandel, Christopher E, Katz, Kevin, Kozak, Robert, Mazzulli, Tony, Muller, Matthew, Opavsky, Anne, Ostrowski, Mario, Plevneshi, Agron, Rau, Neil, Ricciuto, Daniel, Richardson, David, Rose, David, Sales, Valerie, and Walmsley, Sharon
- Subjects
0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Saliva ,Canada ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,Saliva sample ,medicine.disease_cause ,Real-Time Polymerase Chain Reaction ,Gastroenterology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,law ,Internal medicine ,Nasopharynx ,medicine ,Humans ,030212 general & internal medicine ,Polymerase chain reaction ,Coronavirus ,saliva ,business.industry ,SARS-CoV-2 ,Brief Report ,COVID-19 ,nasopharyngeal swab ,Reverse transcriptase ,3. Good health ,Real-time polymerase chain reaction ,Infectious Diseases ,AcademicSubjects/MED00290 ,business - Abstract
We enrolled 91 consecutive inpatients with COVID-19 at 6 hospitals in Toronto, Canada, and tested 1 nasopharyngeal swab/saliva sample pair from each patient using real-time RT-PCR for severe acute respiratory syndrome coronavirus 2. Sensitivity was 89% for nasopharyngeal swabs and 72% for saliva (P = .02). Difference in sensitivity was greatest for sample pairs collected later in illness.
- Published
- 2020