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While 12 years have already passed since the 2011 Tohoku-oki earthquake (M9.0), postseismic deformation of the earthquake is still ongoing. In order to detect the postseismic deformation of the Tohoku-oki earthquake, we have been performing repeating observations at seafloor sites for the GNSS-Acoustic (GNSS-A) geodetic observation technique since 2012 using both manned research vessels and an unmanned surface vehicle, called Wave Glider (WG), as a sea surface platform. We developed and tested a system to conduct the GNSS-A observations using the WG in 2019 and have continuously operated the system twice a year since 2020, visiting many (around 15) observation sites. Based on the observation data collected using research vessels and the WG, we estimated the displacement time series of the seafloor transponder array of each site. The spatio-temporal variations in seafloor crustal deformation after the 2011 Tohoku-oki earthquake indicate that the viscoelastic relaxation is the primary cause of the westward motion around the main rupture area of the M9 event, while the afterslip on the shallow plate interface played an important role in producing eastward displacements in the region south to the main rupture area. With respect to the region north to the main rupture area, no distinct spatial deformation pattern has been observed. This implies that multiple factors, i.e., viscoelastic relaxation, afterslip, interplate locking, and episodic slow slip events, are responsible for the complicated spatial deformation in this region. We will also report the current conditions of the equipment for GNSS-A observations in the presentation., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Nao Enomoto,1 Sho Nakamura,2– 4 Satoru Kanda,3– 5 Hiroko Endo,1 Emiko Yamada,1 Sachiyo Kobayashi,1 Miki Kido,1 Rina Inoue,4 Junko Shimakura,6 Hiroto Narimatsu2– 4,7 1Section of Health and Longevity Service, Takahata Town Office, Takahata, Yamagata, Japan; 2Graduate School of Health of Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan; 3Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan; 4CIKOP, Specified Nonprofit Corporation, Yamagata, Japan; 5Department of Clinical Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan; 6Section of Welfare and Child Service, Takahata Town Office, Takahata, Yamagata, Japan; 7Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, JapanCorrespondence: Hiroto NarimatsuCancer Prevention and Cancer Control Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, JapanTel +81-45-520-2222Fax +81-45-520-2216Email hiroto-narimatsu@umin.orgPurpose: A tailored approach to individual risk factors for developing lifestyle-related diseases would help induce behavioral changes toward intervention acceptability. The addition of preventive healthcare programs to nationwide specific health guidance in Japan is adapted in a given region.Patients and Methods: We conducted a prospective parallel-group comparison study on 195 eligible residents from Takahata, Japan, with a high risk of lifestyle-related diseases from 2014 to 2017 to examine whether such an intervention could improve the body mass index (BMI) and estimated glomerular filtration rate (eGFR).Results: Of the 195 enrolled residents, 117 were assigned to the control group and 78 to the intervention group. They were ≤ 65 years old and had a BMI ≥ 25 kg/m2 and an eGFR ≤ 90 mL/kg/1.73 m2. We conducted certain interventions for each group, including additional blood testing, regular health guidance, and specific health guidance. After one year, neither BMI (intervention: 26.7 ± 2.17 kg/m2 vs control: 27.3 ± 2.12 kg/m2, p = 0.076) nor eGFR (intervention: 72.2 ± 11.1 mL/kg/1.73 m2 vs control: 73.1 ± 10.5 mL/kg/1.73 m2, p = 0.608) differed significantly between groups. However, after three years, the BMI in the intervention group (26.4 ± 2.05 kg/m2) was significantly reduced compared to that in the control group (27.4 ± 2.26 kg/m2; p = 0.005).Conclusion: The additional interventions might have contributed to a reduction in metabolic syndrome.Trial Registration: This study was registered in the UMIN-Clinical Trials Registry (ID:000013581). More information: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015868. The registration date was 31/03/2014.Keywords: personalized preventive medicine, body mass index, estimated glomerular filtration rate, medical cost

1) Background: Although many studies have supported the efficacy of multi-sensory environment (MSE) in reducing behavioral and psychological symptoms, and improving quality of life for patients with disabilities and caregivers, these studies didn't offer how to identify a high-risk candidate who would harm from MSE. Thus, this study was to propose a method to classify the high-risk group of cardiac arrest during MSE interventions through the relation between QT and RR intervals (QT-RR interval). 2) Methods: Eight disabled patients were participated in experiments to experience the virtual aquarium for 15 min with a projector and music. The QT-RR relation was measured by electrocardiography, then the risk was evaluated by computing the shortest distance from the mean of QT-RR relation to the standard curve. 3) Results: It was found that the risk of original cardiac arrest for the five patients was averagely 4.7 times higher than that for the three patients. It was considered that the five patients with higher risk came from the 0.6 times slower QT interval. 4) Conclusion: It was concluded that the proposed method to classify the high-risk group through QT-RR relation was good for the prevention of cardiac arrest through the unintended sudden strong stimulation.

HOBITSSIII was a 12 day (19–30 June) Wellington to Wellington RV Tangaroa voyage (TAN1607) to recover previously deployed Absolute Pressure Gauges (APGs) along the northern Hikurangi margin. APGs measure vertical displacement of the seafloor. One APG from University of Texas Institute of Geophysics, UTIG and 5 APGs from Kyoto University were recovered. Five APGs from Kyoto University were also deployed on the TAN1607 voyage and will be recovered in mid-2017. Three separate 8–12 hour GPS-Acoustic surveys were completed by Tohoku University personnel in the vicinity of 3 ocean bottom GPS-A transponders. The GPS-A surveys will be used to determine horizontal rates of motion at the offshore Hikurangi margin. Heat flow measurements were also conducted at 4 sites. Heat flow surveys add to previous measurements made on the RV Roger Revelle in May 2015. 266 km of 2.0–6.0 kHz chirp sub-bottom profiler data were acquired across the Tuaheni Landslide Complex in preparation for scientific drilling in 2017 and 2018. When TAN1607 data are added to the collective offshore geophysical datasets, they will increase the tectonic and geological knowledge of the northern Hikurangi margin.

Tesis (Cirujano Dentista, Especialización en Patología Oral) Se realizó un estudio transversal de tipo descriptivo, tomando una muestra de 200 individuos, en donde se encuestó pacientes y recolectó información de fichas clínicas para obtener los datos necesarios en relación al consumo de fármacos de los pacientes que acuden a la clínica Odontológica UNAB. El objetivo del estudio es conocer las características sobre el consumo de fármacos en los pacientes. La mayoría de los pacientes ingresados consumen algún tipo de medicamento. Y las mujeres presentan mayor tendencia a consumir con respecto a los hombres. A mayor edad tiende a ser mayor la cantidad de pacientes que consume algún fármaco, como también tiende a ser mayor los distintos tipos de fármacos que se consumen (pacientes de 50 años o más). Mientras que a menor edad, se consume generalmente un sólo tipo de fármaco. Un bajo porcentaje de pacientes relató estar automedicándose. Sin embargo, los fármacos más frecuentes al momento de realizar esta práctica fueron los analgésicos y los antibióticos. Los fármacos más consumidos por los pacientes, en orden decreciente, resultaron ser el Enalapril, Aspirina, Levotiroxina y Metformina. Es de vital importancia conocer cuáles son los medicamentos de uso más frecuente a los que nos vamos a ver enfrentados, sus potenciales efectos adversos y sus posibles interacciones con aquellos fármacos más comunes que necesitemos prescribir o administrar.

A case of pseudolymphoma occurring in a patient with Sjogren's syndrome is described. The lesion, which gave rise to intraluminal tumor masses in the airway, grew progressively, resulting in severe dyspnea. Treatment with prednisolone brought relief. The lymphoproliferative disorders, the principle clinical manifestation of which was pseudolymphoma, might have given rise to the M-component of the IgA-Ktype.

Viral-mediated gene transfer to retina, as well as to other tissues, is evolving rapidly. We have evaluated the potential of a retroviral vector with an internal opsin promoter fragment to direct gene expression to retinal photoreceptor cells.Two recombinant retroviral vectors were prepared; in each Vector, a 1.4 kb fragment of the mouse opsin promoter was placed downstream from the neoR gene in the Moloney murine leukemia virus-based vector G1Na. The opsin promoter fragment was linked either to the cDNA for mouse rod photoreceptor phosphodiesterase (PDE) beta-subunit or to the bacterial lacZ reporter gene. These vectors were tested for their ability to direct gene expression after transduction of 3T3 and Y79 cells, or of dissociated retinal cell cultures or retinal explants from neonatal mice.As expected, PDE beta-subunit and beta-galactosidase mRNAs were expressed only at low levels in 3T3 fibroblasts and Y79 retinoblastoma cells. Northern blot analysis indicated that expression was derived from the viral long terminal repeat (LTR) promoter. Infection of primary retinal cell cultures or explants from neonatal mice with BAG retrovirus, in which beta-galactosidase is driven by the viral LTR, resulted in expression in many cell types, while the opsin-lacZ vector mediated the expression of the lacZ reporter gene specifically in photoreceptor cells.The internal opsin promoter fragment appears capable of selectively directing gene expression to photoreceptor cells after retroviral-mediated gene transfer. These findings serve as a basis for future studies using the opsin promoter-beta PDE retroviral vector to rescue photoreceptor cells in the rd mutant mouse, in which the beta-PDE gene is mutated resulting in degeneration of photoreceptor cells during the early postnatal period.

This brief report describes an unusual case of a patient who had a solitary pulmonary metastasis from an intraocular tumor removed 9 years previously. He was diagnosed by bronchofiberscopy and subjected to right middle lobectomy. Pathological examination revealed that the lesion resulted from direct metastasization to the bronchial wall.