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Supplemental material, sj-docx-1-wso-10.1177_17474930231158211 for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis by Tae Jung Kim, Ji Sung Lee, Jae Sun Yoon, Mi Sun Oh, Ji-Woo Kim, Soo-Hyun Park, Keun-Hwa Jung, Hyun Young Kim, Jee-Hyun Kwon, Hye-Yeon Choi, Hahn Young Kim, Kyung Yoon Eah, Sang Won Han, Hyung-Geun Oh, Young-Jae Kim, Byoung-Soo Shin, Chang Hun Kim, Chi Kyung Kim, Jong-Moo Park, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Man-Seok Park, Jay Chol Choi, Chulho Kim, Dong-Ick Shin, Soo Joo Lee, Dong-Eog Kim, Jae-Kwan Cha, Eung-Gyu Kim, Kyung-Ho Yu, Keun-Sik Hong, Young-Seok Lee, Ju-Hun Lee, Sung Il Sohn, Hee-Joon Bae, Young-Bae Lee, Jun Hong Lee, Joung-Ho Rha, Byung-Chul Lee, Dae-Il Chang, Sang-Bae Ko and Byung-Woo Yoon in International Journal of Stroke

Supplemental material, sj-docx-1-wso-10.1177_17474930231158211 for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis by Tae Jung Kim, Ji Sung Lee, Jae Sun Yoon, Mi Sun Oh, Ji-Woo Kim, Soo-Hyun Park, Keun-Hwa Jung, Hyun Young Kim, Jee-Hyun Kwon, Hye-Yeon Choi, Hahn Young Kim, Kyung Yoon Eah, Sang Won Han, Hyung-Geun Oh, Young-Jae Kim, Byoung-Soo Shin, Chang Hun Kim, Chi Kyung Kim, Jong-Moo Park, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Man-Seok Park, Jay Chol Choi, Chulho Kim, Dong-Ick Shin, Soo Joo Lee, Dong-Eog Kim, Jae-Kwan Cha, Eung-Gyu Kim, Kyung-Ho Yu, Keun-Sik Hong, Young-Seok Lee, Ju-Hun Lee, Sung Il Sohn, Hee-Joon Bae, Young-Bae Lee, Jun Hong Lee, Joung-Ho Rha, Byung-Chul Lee, Dae-Il Chang, Sang-Bae Ko and Byung-Woo Yoon in International Journal of Stroke

Supplemental material, sj-docx-1-wso-10.1177_17474930231168742 for Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial: Rationale and design by Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Jun Yup Kim, Moon-Ku Han, Ki-Hyun Cho, Man-Seok Park, Kang-Ho Choi, Jong-Moo Park, Kyusik Kang, Yong Soo Kim, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Jin Kyo Choi, Kyungbok Lee, Kwang-Yeol Park, Hae-Bong Jeong, Jun Lee, Doo Hyuk Kwon, Yong-Jin Cho, Keun-Sik Hong, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Minwoo Lee, Dong-Eog Kim, Dong-Seok Gwak, Jay Chol Choi, Joong-Goo Kim, Chul-Hoo Kang, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Hyungjong Park, Chulho Kim, Sang-Hwa Lee, Juneyoung Lee, Philip B Gorelick, Bo Norrving and Hee-Joon Bae in International Journal of Stroke

Supplemental material, sj-docx-1-wso-10.1177_17474930231168742 for Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial: Rationale and design by Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Jun Yup Kim, Moon-Ku Han, Ki-Hyun Cho, Man-Seok Park, Kang-Ho Choi, Jong-Moo Park, Kyusik Kang, Yong Soo Kim, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Jin Kyo Choi, Kyungbok Lee, Kwang-Yeol Park, Hae-Bong Jeong, Jun Lee, Doo Hyuk Kwon, Yong-Jin Cho, Keun-Sik Hong, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Minwoo Lee, Dong-Eog Kim, Dong-Seok Gwak, Jay Chol Choi, Joong-Goo Kim, Chul-Hoo Kang, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Hyungjong Park, Chulho Kim, Sang-Hwa Lee, Juneyoung Lee, Philip B Gorelick, Bo Norrving and Hee-Joon Bae in International Journal of Stroke

Supplemental Material, ms_change_tracking for Post-Stroke Depressive Symptoms: Varying Responses to Escitalopram by Individual Symptoms and Lesion Location by Eun-Jae Lee, Jong S. Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim and Ji-Sung Lee in Journal of Geriatric Psychiatry and Neurology

Supplemental Material, supple_files for Post-Stroke Depressive Symptoms: Varying Responses to Escitalopram by Individual Symptoms and Lesion Location by Eun-Jae Lee, Jong S. Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim and Ji-Sung Lee in Journal of Geriatric Psychiatry and Neurology

ObjectivesThe purpose of this study was use molecular imaging targeting coagulation pathway and inflammation to better understand the pathophysiology of silent brain ischemia (SBI) and monitor the effects of factor XIIa inhibition.BackgroundSBI can be observed in patients who undergo invasive vascular procedures. Unlike acute stroke, the diffuse nature of SBI and its less tangible clinical symptoms make this disease difficult to diagnose and treat.MethodsWe induced SBI in mice by intra-arterial injection of fluorescently labeled microbeads or fractionated clot into the carotid artery. After SBI induction, diffusion-weighted magnetic resonance imaging was performed to confirm the presence of microinfarcts in asymptomatic mice. Molecular imaging targeting the downstream factor XIII activity (single-photon emission computed tomography/computed tomography) at 3 h and myeloperoxidase activity (magnetic resonance imaging) on day 3 after SBI induction were performed, without and with the intravenous administration of a recombinant selective factor XIIa inhibitor derived from the hematophagous insect Triatoma infestans (rHA-Infestin-4). Statistical comparisons between 2 groups were evaluated by the Student t test or Mann-Whitney U test.ResultsIn SBI-induced mice, we found abnormal activation of the coagulation cascade (factor XIII activity) and increased inflammation (myeloperoxidase activity) close to where emboli lodge in the brain. rHA-Infestin-4 administration significantly reduced ischemic damage (53% to 85% reduction of infarct volume, p < 0.05) and pathological coagulation (35% to 39% reduction of factor XIII activity, p < 0.05) without increasing hemorrhagic frequency. Myeloperoxidase activity, when normalized to the infarct volume, did not significantly change with rHA-Infestin-4 treatment, suggesting that this treatment does not further decrease inflammation other than that resulting from the reduction in infarct volume.ConclusionsFocal intracerebral clotting and inflammatory activity are part of the pathophysiology underlying SBI. Inhibiting factor XIIa with rHA-Infestin-4 may present a safe and effective treatment to decrease the morbidity of SBI.