1. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors
- Author
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Sutton, L.-A. Young, E. Baliakas, P. Hadzidimitriou, A. Moysiadis, T. Plevova, K. Rossi, D. Kminkova, J. Stalika, E. Pedersen, L.B. Malcikova, J. Agathangelidis, A. Davis, Z. Mansouri, L. Scarfò, L. Boudjoghra, M. Navarro, A. Muggen, A.F. Yan, X.-J. Nguyen-Khac, F. Larrayoz, M. Panagiotidis, P. Chiorazzi, N. Niemann, C.U. Belessi, C. Campo, E. Strefford, J.C. Langerak, A.W. Oscier, D. Gaidano, G. Pospisilova, S. Davi, F. Ghia, P. Stamatopoulos, K. Rosenquist, R. the European Research Initiative on CLL
- Abstract
We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobulins in the largest cohort (n=565) studied for this purpose. By combining data on recurrent gene mutations (BIRC3, MYD88, NOTCH1, SF3B1 and TP53) and cytogenetic aberrations, we reveal a subset-biased acquisition of gene mutations. More specifically, the frequency of NOTCH1 mutations was found to be enriched in subsets expressing unmutated immunoglobulin genes, i.e. #1, #6, #8 and #59 (22-34%), often in association with trisomy 12, and was significantly different (P
- Published
- 2016