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3. A Review on the Critical Success Factors (CSF) Influencing Modular Integrated Construction

Author

null Krishnan S and null Sindhu Vaardini U

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

By sending some of the work done on-site to fabrication facilities, modularization, a new emerging approach, can improve the construction industry. Yet, there are few uses for it in the sector. To achieve higher degrees of modularization, the Engineering, Procurement and Construction (EPC) business needs new strategies. The goal of this study is to ascertain what modifications to the current EPC procedures are required to establish the ideal conditions for a wider and more efficient application of modularization. The success criteria must be understood in order to create such an atmosphere. The success factors are to be obtained from various reputed journals. With the addition of CSF enablers, a research team with expertise in this area created a comprehensive list of the most important critical success Factors. CSF enablers are extra measures that can help

Published
2023
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4. Profiling of carotenoid pigments and their antioxidant activities in ray florets of chrysanthemum (Chrysanthemum × morifolium)

Author

SHISA ULLAS P, NAMITA NAMITA, KANWAR P SINGH, ADITI KUNDU, SAPNA PANWAR, GOPALA KRISHNAN S, and GUNJEET KUMAR

Subjects
Agronomy and Crop Science
Abstract

In present study, different varieties of chrysanthemum (Chrysanthemum × morifolium Ramat) were screened for total carotenoids, phenolic content and antioxidant activities. Among the genotypes studied, variety Jubilee (32.82 mg/100g) exhibited high total carotenoids followed by varieties Haldighati (26.71 mg/100 g), Little Orange (22.25 mg/100g), Liliput (20.77 mg/100g) and Star Yellow (19.21 mg/100g). Variety Jubilee also showed highest antioxidant activities of carotenoids {CUPRAC-Cupric reducing antioxidant capacity (149.44 μmol trolox/g), FRAP- Ferrous reducing power (40.09 %), DPPH radical scavenging activity (11.24%)}. The total phenolic content varied from 1.26 mg GAE/g (Ram Lal Dada) to 31.14 mg GAE/g (Jubilee) on fresh weight basis. Further, five promising varieties having high carotenoids, were quantified for lutein and β-carotene using High Performance Liquid Chromatography (HPLC). Highest lutein content was found in variety Jubilee (19.90 μg/g) followed by varieties Haldighati (8.67 μg /g), Liliput (4.77 μg /g), Star Yellow (3.93 μg /g) and Little Orange (3.69 μg/g). Highest β-carotene content was found in Little Orange (5.51μg/g) followed by the varieties Haldighati (2.04 μg /g), Jubilee (1.77 μg /g), Liliput (0.54 μg /g) and Star Yellow (0.50 μg/g). A high correlation between carotenoids, total phenolic and antioxidant activities was observed. Variety Sadwin Yellow showed highest total carotenoid (0.48 mg/g) in leaves, whereas chlorophyll a and total chlorophyll was highest in variety Punjab Anmol (1.32 mg/g, 1.56 mg/g) and high chlorophyll b in variety Pusa Aditya (0.28 mg/g).

Published
2023
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5. Identification of early maturing and leaf determinate growth habit type accessions of cluster bean (Cyamopsis tetragonoloba L. Taub.)

Author

K Singh, VS Meena, N Shekhawat, HR Mahla, G Krishnan S, and V Gupta

Abstract

Cluster bean (Cyamopsis tetragonoloba L. Taub.), commonly known as guar, is a member of the family Papilionaceae, cultivated in the Indian Sub-continent since time immemorial. It is a drought-hardy leguminous annual crop used variously for vegetables, forage and green manure. There is tremendous variability available in Indian cluster bean germplasm. Genetic resources with their enormous variability for different characters provide the base for the improvement of crop plants. Within genetic resources, genetic stocks are expected to play a major role in future crop improvement programmes. One promising unbranched, single-stemmed and flower determinate growth habit bearing accession IC-140784P1, developed through single plant selection at ICAR-NBPGR Regional Station Jodhpur starts flowering at 23 days after sowing and flowers 50% at 32 days after sowing. This accession does mature only 82 days after sowing. These accessions mature about 10-15 days early compared to normal existing improved cultivars, which take 90-95 days for maturity. Another accession IC 569315 has been characterized as leaf determinate (in which the stem terminates into the leaf) with alternate cluster-bearing habit. The majority of the cluster bean crop is grown under rainfed conditions in the drier parts of the country. Therefore, maturity is an important trait, especially for cluster bean.

Published
2022
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6. Influence of differential root and shoot growth rate on seedling vigour index in rice

Author

Reshmi Raj KR, Gopala Krishnan S, Arun Kumar MB, and VP Bansal

Subjects
General Engineering
Abstract

Early seedling vigour is an important trait in direct seeded rice which determines the growth and yield. It is a complex trait and is found to be associated with germination and seedling growth. The rice genotypes, BPT 5204 and PB 1850-27 were screened for early seedling vigour traits and the data was recorded on germination percentage, root length, shoot length, seedling length, seedling fresh weight and seedling dry weight. The seedling vigour index I and seedling vigour index II were calculated for both the genotypes. It was observed that seedling vigour index I and II was found higher in PB 1850-27 as compared to BPT 5204. The principal component analysis was done to study differential root and shoot growth rate in F1 plants with parents. It was observed that growth rate in F1 seedlings was found higher than both the parents. The root growth in F1 plants resemble BPT 5204 during initial days of germination, while shoot growth pattern exhibited similarity only with PB 1850-27. The F2 population exhibited segregation for mean root and shoot length.

Published
2022
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7. Porkchop Plot of a Direct Earth-Mercury Trajectory using Lambert's Problem

Author

S, Gisa G, Hariprasad Thimmegowda, and Yadu Krishnan S

Subjects
Interplanetary Trajectories, Non-Hohmann Transfer, Lambert's Problem, Direct Trajectory
Abstract

Numerous space missions have minimal energy requirements, which are calculated and stated as rocket vehicle velocity requirements. This provides a quick opportunity for an impression of the ideal vehicle or an estimate of the payload capacity of a particular vehicle. As we move closer to the inner planets of the solar system, solar radiation's effects worsen and so do the energy requirements. This energy need can be reduced using flyby missions. A porkchop plot used in orbital mechanics displays contours of even characteristic energy based on numerous permutations of the date of launch and the date of arrival for a precise interplanetary voyage. The porkchop plot solutions, decide the endurance of a launch window for a particular spacecraft. In this study, the porkchop plots for the Earth-Mercury direct transfer are plotted by using the departure date, arrival date, and flight duration as fixed values in the orbital components of the solution, generally known as Lambert’s problem. For this study, non – coplanar, non – circular orbits of the planets are considered. The patched conic method is used to create mission prospects. For the years 2021- 2030, porkchop plots are produced. The simulation results utilizing Free flyer for this window are included.

Published
2023
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11. A Rare Case of Cerebral Venous Thrombosis

Author

Kumar, M.R., Kumar, N., Krishnan, S., and Reddy, S.P.

Abstract

CVST is a rather uncommon complication. A 19-year-old female developed an acute aseptic thrombosis of the parasagittal, transverse, and sigmoid sinuses. Increased intracranial pressure (ICP) due to thrombosis of the sinus with common symptoms and papilledema of both the eyes, this resulted in transitory bilateral abducents nerve palsy, as a result, horizontal diplopia in both the eyes, were among the case’s highlights. CVT has been linked to seizures. The cranial nerve function returned three to four weeks after it was first observed. The nearly complete recanalization of the cerebral venous sinus thrombosis and a favourable prognosis were aided by prompt and appropriate anticoagulant medication.

Published
2022
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12. An Interesting Case of Inflammatory Myositis

Author

Kumar, M.R., Sreelatha, N., Kumar, N., Krishnan, S., and Reddy, S.P.

Abstract

Background: Idiopathic inflammatory myopathies (IIM) are a class of long-lasting autoimmune diseases that typically affect the proximal muscles. Dermatomyositis (DM), polymyositis (PM), necrotizing autoimmune myopathy (NAM), and sporadic inclusion body myositis are the most prevalent kinds. Patients usually have subacute to chronic proximal weakness, which presents as difficulty getting out of a chair, getting up the stairs, lifting objects, and brushing their hair. They are distinguished by their clinical presentation, which includes muscular and extramuscular signs. Elevated serum creatine kinase (CK) levels and myositis-specific antibodies may help distinguish clinical phenotypes and confirm the diagnosis. Biopsy of the muscle, on the other hand, is still the gold standard for determining the cause of the problem. These disorders may be cured with proper diagnosis and treatment. The treatment’s goals are to reduce inflammation, restore muscle performance, and alleviate pain. Methods: 36-year-old man K/C/O dermatomyositis came complaints of redness swelling in the right eye for 3 months, dysphagia, easy fatiguability. Patient was neither hypertensive nor diabetic. Results: This case describes the severity of NXP2 autoantibody and a potential to be life threatening. Patient was started with immunoglobulins, monoclonal antibodies. After which patient improved from his present condition.

Published
2022
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14. Ultra Wide Band MIMO Antenna for Vehicular Communication

Author

null Balayogesh R, null Chandru G, null Gokula Krishnan S, null Harisree S, and null Sobana K

Abstract

Vehicle to Vehicle (V2V) communication is continually gaining importance for road safety and different applications. so as to style economical V2V systems, associate degree understanding of realistic V2V propagation channels is needed. The Intelligent installation (ITS) initiative was invoked by congress in 1991 to advance the control systems by fostering development of Advanced Traffic Management System (ATMS). Multiple antenna systems conjointly called Multiple Input Multiple Output (MIMO) is wide wanted technology for its outstanding contribution in increasing the data rate compared to the standard approach of Single Input Single Output (SISO) systems. MIMO systems offer the pliability of antenna choice, creating the method economical and fewer advanced. A multiple-input-multiple-output (MIMO) antenna with ultra-wideband (UWB) performance is bestowed within the existing paper. The reliable Ness of the antenna within the automotive surroundings is investigated, with housing effects taken into consideration. The housing effects show that the antenna performs systematically even within the presence of an outsized metal object. Within the planned paper a UWB MIMO antenna for automotive communications is intended and developed. Stubs square measure integrated into the UWB monopole antenna part to realize resonance at three.1 GHz and one0.6 GHz. The antenna is fictional and tested for diversity performance. The planned antenna are designed, analysed victimisation 3D magnetic force simulation tools. The designed antenna are fictional and characterised for conveyance communication.

Published
2022
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15. Work Performance and Stress Alleviation in Hospitality Services

Author

Arul Krishnan S and Balaji B

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION
Abstract

The study's goal was to investigate the dynamics of workplace stress and its influence on the job performances of hospitality professionals. The hospitality sector mainly relies on services that encompass hygiene and quality rendered to the customers. Marketing of services rather than sale of products may entail large quantity of work. Increased work task fuels high responsibility and stress on the employees. Ultimately, it fosters more work pressure and directly causes depression, anxiety, strain, sleep disorders and disruptions in peace of mind of employees. This study comprises a sample of 373 employees in hospitality sector. Convenience sampling technique was employed besides a design that was descriptive in approach. Interview schedule was employed for data collection. Job dynamics such as regular tasks, human resource strategy, employee benefit, work atmosphere, supervisor support, and relations with associates have a substantial influence on the job performance of hospitality staff. Furthermore, stress coping strategies were observed to be effective for employees working in hospitality sector.

Published
2022
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16. Ameliorative Potential of Rosuvastatin on Doxorubicin-induced Cardiotoxicity by Modulating Oxidative Damage in Rats

Author

Manas Kumar Das, Narahari N. Palei, Krishnapillai Mathusoothanan, Shvetank Bhatt, Jayaraman Rajangam, Navaneetha Krishnan S, and Saumya Das

Subjects
Oxidative damage, business.industry, Pharmaceutical Science, Molecular Medicine, Medicine, Original Article, Rosuvastatin, Doxorubicin, Cardio toxicity, Pharmacology, business, medicine.drug
Abstract

OBJECTIVES: The study aimed to explore the in vivo protective potential of rosuvastatin (ROSS), an oral antihyperlipidemic drug against doxorubicin (DOXO) induced cardio toxicity in rats. MATERIALS AND METHODS: Cardiac toxicity was induced by DOXO injection (10 mg/kg, i.p.), once on the 20(th) day of the experiment. Except for the control rats, all were received DOXO and the study was continued for up to 21 days. The influence of ROSS on acute treatment was analyzed by quantification of cardiac marker enzymes such as creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and liver marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) along with the measurement of in vivo antioxidants like superoxide dismutase and catalase. To observe histological changes of myocardial tissue hematoxylin and eosin staining were used. RESULTS: Acute administration of DOXO resulted in a marked rise of cardiac marker enzymes that confirms the myocardial damage compared to control animals whereas administration of ROSS (10 mg/kg, p.o.) resulted in the significant reduction of CK-MB, LDH levels (p

Published
2022
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18. Advances and opportunities in nanoimaging agents for the diagnosis of inflammatory lung diseases

Author

Masanam, HB, Perumal, G, Krishnan, S, Singh, SK, Jha, NK, Chellappan, DK, Dua, K, Gupta, PK, and Narasimhan, AK

Subjects
0306 Physical Chemistry (incl. Structural), 1004 Medical Biotechnology, 1007 Nanotechnology, Nanoscience & Nanotechnology
Abstract

The development of rapid, noninvasive diagnostics to detect lung diseases is a great need after the COVID-2019 outbreak. The nanotechnology-based approach has improved imaging and facilitates the early diagnosis of inflammatory lung diseases. The multifunctional properties of nanoprobes enable better spatial–temporal resolution and a high signal-to-noise ratio in imaging. Targeted nanoimaging agents have been used to bind specific tissues in inflammatory lungs for early-stage diagnosis. However, nanobased imaging approaches for inflammatory lung diseases are still in their infancy. This review provides a solution-focused approach to exploring medical imaging technologies and nanoprobes for the detection of inflammatory lung diseases. Prospects for the development of contrast agents for lung disease detection are also discussed.

Published
2023

19. Amelioration of Biogas Production from Waste-Activated Sludge through Surfactant-Coupled Mechanical Disintegration

Author

Vijetha Valsa, Geethu Krishnan S, Rashmi Gondi, Preethi Muthu, Kavitha Sankarapandian, Gopalakrishnan Kumar, Poornachandar Gugulothu, and Rajesh Banu Jeyakumar

Subjects
solubilization, paper mill sludge, suspended solids, disperser, specific energy input, Plant Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), Food Science
Abstract

The current study intended to improve the disintegration potential of paper mill sludge through alkyl polyglycoside-coupled disperser disintegration. The sludge biomass was fed to the disperser disintegration and a maximum solubilization of 6% was attained at the specific energy input of 4729.24 kJ/kg TS. Solubilization was further enhanced by coupling the optimum disperser condition with varying dosage of alkyl polyglycoside. The maximum solubilization of 11% and suspended solid (SS) reduction of 8.42% were achieved at the disperser rpm, time, and surfactant dosage of 12,000, 30 min, and 12 μL. The alkyl polyglycoside-coupled disperser disintegration showed a higher biogas production of 125.1 mL/gCOD, compared to the disperser-alone disintegration (70.1 mL/gCOD) and control (36.1 mL/gCOD).

Published
2023
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20. Efficient Indirect Interatomic Coulombic Decay Induced by Photoelectron Impact Excitation in Large He Nanodroplets

Author

Ltaief, L. Ben, Sishodia, K., Mandal, S., De, S., Krishnan, S. R., Medina, C., Pal, N., Richter, R., Fennel, T., and Mudrich, M.

Subjects
FOS: Physical sciences, Physics - Atomic and Molecular Clusters, Atomic and Molecular Clusters (physics.atm-clus)
Abstract

Ionization of matter by energetic radiation generally causes complex secondary reactions which are hard to decipher. Using large helium nanodroplets irradiated by XUV photons, we show that the full chain of processes ensuing primary photoionization can be tracked in detail by means of high-resolution electron spectroscopy. We find that elastic and inelastic scattering of photoelectrons efficiently induces interatomic Coulombic decay (ICD) in the droplets. This type of indirect ICD even becomes the dominant process of electron emission in nearly the entire XUV range in large droplets with radius $\gtrsim40~$nm. Indirect ICD processes induced by electron scattering likely play an important role in other condensed phase systems exposed to ionizing radiation as well, including biological matter.

Published
2023
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23. Consequences of unrealistic optimism and pessimism for actual behavior: An experimental evidence

Author

Dr Subramanian S Iyer, Sai Krishnan S, and Sai Balaji SMR

Abstract

In this study, we performed experiments to investigate the negative consequences of unrealistic optimism and pessimism. We also attempted to extend the theory of unrealistic optimism and pessimism by investigating how past events running contrary to expectations impact unrealistic optimism and pessimism. We made participants play an insurance decision game pertaining to a gamble for two consecutive rounds while inducing unrealistic optimism and pessimism within the context of the game.

Published
2021
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25. Hyphaema unmasking the underlying haemophilia‐A

Author

Dhaarani Jayaraman, Anjana Krishnan S. R., Monicka Shree G, Parveen Sen, Kannan R, Preethi P, Febe Renjitha Suman, Julius Xavier Scott, and Nataraj Palaniappan

Subjects
Oncology, Pediatrics, Perinatology and Child Health, Hematology
Published
2022
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27. Bismuth Vanadate Encapsulated with Reduced Graphene Oxide: A Nanocomposite for Optimized Photocatalytic Hydrogen Peroxide Generation

Author

Krishnan S. Raja, Nikhil Dhabarde, Siyu Tian, Orlando Carrillo-Ceja, Guoping Xiong, and Vaidyanathan Subramanian

Subjects
Nanocomposite, Materials science, Graphene, Hydrogen peroxide generation, Oxide, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, chemistry.chemical_compound, General Energy, chemistry, Chemical engineering, law, Bismuth vanadate, Photocatalysis, Physical and Theoretical Chemistry
Published
2021
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28. Carbon Ion Radiotherapy in the Management of Hepatocellular Carcinoma

Author

Abousaida B, Seneviratne D, Hoppe BS, Ko SJ, Asaithamby A, Cucinotta FA, Kirwan JM, Mody K, Toskich B, Ashman JB, Hallemeier CL, and Krishnan S

Subjects
carbon ion therapy, hypofractionation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hepatocellular carcinoma, RC254-282
Abstract

Belal Abousaida,1,* Danushka Seneviratne,1,* Bradford S Hoppe,1 Stephen J Ko,1 Aroumougame Asaithamby,2 Francis A Cucinotta,3 Jessica M Kirwan,4 Kabir Mody,5 Beau Toskich,6 Jonathan B Ashman,7 Christopher L Hallemeier,8 Sunil Krishnan1 1Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA; 2Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 3School of Integrated Health Sciences, University of Las Vegas, Las Vegas, NV, USA; 4Department of Radiation Oncology, University of Florida, Gainesville, FL, USA; 5Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA; 6Division of Interventional Radiology, Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, USA; 7Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA; 8Department of Radiation Oncology, Mayo Clinic Rochester, Rochester, MN, USA*These authors contributed equally to this workCorrespondence: Sunil KrishnanDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, 32224, USATel +1 713-202-8063Email krishnan.sunil@mayo.eduAbstract: Localized hepatocellular carcinoma (HCC) that is unresectable and non-transplantable can be treated by several liver-directed therapies. External beam radiation therapy (EBRT) is an increasingly accepted and widely utilized treatment modality in this setting. Accelerated charged particles such as proton beam therapy (PBT) and carbon ion radiation therapy (CIRT) offer technological advancements over conventional photon radiotherapy. In this review, we summarize the distinct advantages of CIRT use for HCC treatment, focusing on physical and biological attributes, and outline dosimetric and treatment planning caveats. Based on these considerations, we posit that HCC may be among the best indications for use of CIRT, as it allows for maximizing tumoricidal doses to the target volume while minimizing the dose to the organs at risk.Keywords: carbon ion therapy, hepatocellular carcinoma, hypofractionation

Published
2021

30. From farm to plate: Spatio-temporal characterization revealed compositional changes and reduced retention of γ-oryzanol upon processing in rice

Author

Ghosh, Swarnadip, Bollinedi, Haritha, Gopala Krishnan, S., Kundu, Aditi, Singh, Anupama, Bhowmick, Prolay Kumar, Singh, Archana, Nagarajan, Mariappan, Vinod, Kunnummal Kurungara, Ellur, Ranjith Kumar, and Singh, Ashok Kumar

Subjects
Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Food Science
Abstract

BackgroundAntioxidants detain the development and proliferation of various non-communicable diseases (NCDs). γ-oryzanol, a group of steryl ferulates and caffeates, is a major antioxidant present in rice grain with proven health benefits. The present study evaluated the distribution and dynamics of γ-oryzanol and its components in spatial and temporal scales and also delineated the effect of processing and cooking on its retention.MethodsSix rice varieties (four Basmati and two non-Basmati) belonging to indica group were analyzed at spatial scale in four different tissues (leaf blades, leaf sheaths, peduncle and spikelets) and temporal scale at three developmental stages (booting, milky and dough). Additionally, the matured grains were fractioned into husk, embryo, bran, and endosperm to assess differential accumulation in these tissues. Further, milling and cooking of the samples was done to assess the retention upon processing. After extraction of γ-oryzanol by solvent extraction method, individual components were identified by UPLC-QToF-ESI-MS and quantified by RP-HPLC.ResultsThe non-seed tissues were significantly different from the seed tissues for composition and quantitative variation of γ-oryzanol. Cycloartenyl caffeate was predominant in all the non-seed tissues during the three developmental stages while it showed significant reduction during the growth progression toward maturity and was totally absent in the matured grains. In contrary, the 24-methylenecycloartanyl ferulate, campesteryl ferulate and β-sitosteryl ferulate showed significant increment toward the growth progression to maturity. Milling caused significant reduction, retaining only an average of 58.77% γ-oryzanol. Cooking of brown rice in excess water showed relatively lower average retention (43.31%) to samples cooked in minimal water (54.42%). Cooked milled rice showed least mean retention of 21.66%.ConclusionThe results demonstrate prominent compositional variation of γ-oryzanol during different growth stages. For the first time, the study demonstrated that ferulate esters of γ-oryzanol were predominant in the seed tissues while caffeate esters were dominant in non-seed tissues. Basmati cultivars show differential expression of γ-oryzanol and its components compared to non-Basmati cultivars. Cooking in excess water causes maximum degradation of γ-oryzanol. Post-harvest losses due to milling and cooking indicate the necessity of biofortification for γ-oryzanol content in rice grain.

Published
2022
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31. PREGNANCY: AN OVERVIEW

Author

Abarna. S, Anu Prasad. N, Gopi Krishnan. S

Abstract

Pregnancy is the period of fetal development woman's womb or uterus when the body faces physiological and metabolic changes. Anemia remains major problem during pregnancy. About 4 hormones progesterone, estrogen, hGC, prolactin involve in pregnancy changing their concentrations during 3 trimesters. Dietary habits plays a vital role in maintaining healthy pregnancy and balancing the amount of hormones required. It is a well- understood scientific concept that the nutritional status of the pregnant woman affects the outcome of the pregnancy, especially related to birth weight. Low birth weight is associated with an increased risk for infant deaths and developmental disabilities and seen more often in children from under nourished and underweight mothers. Key words: Pregnancy, Trimester, Nutrition

Published
2022
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32. SMC protein RecN drives RecA filament translocation for in vivo homology search

Author

Afroze Chimthanawala, Jyotsana J. Parmar, Sujan Kumar, Krishnan S. Iyer, Madan Rao, and Anjana Badrinarayanan

Subjects
DNA-Binding Proteins, Rec A Recombinases, Multidisciplinary, Bacterial Proteins, DNA, Single-Stranded, Chromosomes
Abstract

While the molecular repertoire of the homologous recombination pathways is well studied, the search mechanism that enables recombination between distant homologous regions is poorly understood. Earlier work suggests that the recombinase RecA, an essential component for homology search, forms an elongated filament, nucleating at the break site. How this RecA structure carries out long-distance search remains unclear. Here, we follow the dynamics of RecA after induction of a single double-strand break on the Caulobacter chromosome. We find that the RecA-nucleoprotein filament, once formed, rapidly translocates in a directional manner in the cell, undergoing several pole-to-pole traversals, until homology search is complete. Concomitant with translocation, we observe dynamic variation in the length of the filament. Importantly in vivo, the RecA filament alone is incapable of such long-distance movement; both translocation and associated length variations are contingent on action of structural maintenance of chromosome (SMC)-like protein RecN, via its ATPase cycle. In summary, we have uncovered the three key elements of homology search driven by RecN: mobility of a finite segment of RecA, changes in filament length, and ability to conduct multiple pole-to-pole traversals, which together point to an optimal search strategy.

Published
2022
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34. Economizing marker assisted selection through cost-effective assay of sd1 gene in rice (Oryza sativa)

Author

GAURAV DHAWAN, VIJAY PRAKASH, ARUNA KUMAR, PANKAJ KUMAR, RATHOUR RAJEEV, ASHOK KUMAR SINGH, and GOPALA KRISHNAN S

Subjects
Agronomy and Crop Science
Abstract

PCR amplification and detection of GC rich sequences in DNA is a challenge due to formation of secondary structures which resist denaturation, thereby stalling Taq DNA polymerases as well as affecting primer annealing. Presently, high fidelity Taq DNA polymerase is used for amplifying long and GC-rich fragments, while dimethyl sulfoxide (DMSO) has also been suggested as an additive in Polymerase Chain Reaction (PCR) mix to avoid formation of secondary structures in templates containing high GC content. In the present study, the amplification efficiency of normal Taq DNA polymerase with 5% DMSO as compared to high fidelity Taq DNA polymerase has been applied for better amplification of fragments with high GC content of sd1 gene in rice. Normal Taq DNA polymerase with 5% DMSO displayed better and reproducible results as compared to platinum DNA polymerase for the amplification of gene sd1, thereby successfully detecting the dominant wild type allele governing tall plant height from the recessive semi-dwarf allele. There were no adverse effects of 5% DMSO in PCR amplification and the amplified fragments improved significantly indicating the improvement in amplification efficiency. The modified PCR protocol including DMSO provides a cost effective and cheaper alternative for reliable assessment of the genomic differences in GCrich regions of the gene. This will help in eliminating the need for costly high fidelity Taq DNA polymerase, thereby helping in economizing marker assisted selection.

Published
2022
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36. Study of Acute Effect of Caffeine on Cognition among Adults - A Cross Sectional Study from Puducherry, India

Author

Smisha Mohan, Manikandan S, Krishnan S, and Jeneth Berlin Raj T

Subjects
chemistry.chemical_compound, chemistry, business.industry, Cross-sectional study, Environmental health, Medicine, Acute effect, Cognition, business, Caffeine
Abstract

BACKGROUND Information processing has substantial role in performing intellectual activities such as thinking, reasoning, remembering, imagining, or learning. Caffeine being a central nervous system (CNS) stimulant, improves mental performance, especially on alertness, attention, concentration and learning depending on the quantity of intake. In the present study, an attempt was made to study the effect of caffeine on cognitive processing in healthy individuals. METHODS This cross-sectional study was conducted on 50 subjects at Mahatma Gandhi Medical College & Research Institute. Montreal cognitive assessment (MoCA) questionnaire was utilized to assess the level of cognition of each subject. Visual reaction time (VRT), auditory reaction time (ART) and critical fusion frequency (CFF) prior and after consumption of 75 mg of caffeine in 200 ml of milk, pre and post reaction time measurement were taken from the subject to address the difference in reaction time. RESULTS Both visual and auditory reaction time were significantly reduced (P < 0.001) after intake of caffeine. The ability of the subject to appreciate the flickering light stimuli to be steady (critical flicker fusion frequency) had significantly improved to 15 % after caffeine intake. CONCLUSIONS Decrease in visual and auditory reaction and increase in critical flicker fusion frequency values indicate that caffeine increases alertness thereby it may enhance performance efficiency in reasoning, planning, judgment, organizing, concept formation, and problem solving. KEY WORDS Visual Reaction Time, Auditory Reaction Time, MoCA

Published
2021
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37. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis

Author

Zhou Z., Jardine M. J., Li Q., Neuen B. L., Cannon C. P., De Zeeuw D., Edwards R., Levin A., Mahaffey K. W., Perkovic V., Neal B., Lindley R. I., Guerrero R. A. A., Aizenberg D., Albisu J. P., Alvarisqueta A., Bartolacci I., Berli M. A., Bordonava A., Calella P., Cantero M. C., Cartasegna L. R., Cercos E., Coloma G. C., Colombo H., Commendatore V., Cuadrado J., Cuneo C. A., Cusumano A. M., Douthat W. G., Dran R. D., Farias E., Fernandez M. F., Finkelstein H., Fragale G., Fretes J. O., Garcia N. H., Gastaldi A., Gelersztein E., Glenny J. A., Gonzalez J. P., Del Carmen Gonzalez Colaso P., Goycoa C., Greloni G. C., Guinsburg A., Hermida S., Juncos L. I., Klyver M. I., Kraft F., Krynski F., Lanchiotti P. V., De La Fuente R. A. L., Marchetta N., Mele P., Nicolai S., Novoa P. A., Orio S. I., Otreras F., Oviedo A., Raffaele P., Resk J. H., Rista L., Papini N. R., Sala J., Santos J. C., Schiavi L. B., Sessa H., Casabella T. S., Ulla M. R., Valdez M., Vallejos A., Villarino A., Visco V. E., Wassermann A., Zaidman C. J., Cheung N. W., Droste C., Fraser I., Johnson D., Mah P. M., Nicholls K., Packham D., Proietto J., Roberts A., Roger S., Tsang V., Raduan R. A., Da Costa F. A. A., Amodeo C., Turatti L. A. A., Bregman R., Sanches F. C. C., Canani L. H., Chacra A. R., Borges J. L. C., Vencio S. A. C., Da Silva Franco R. J., D'Avila D., De Souza Portes E., De Souza P., Deboni L. M., Filho F. F., Neto B. G., Gomes M., Kohara S. K., Keitel E., Saraiva J. F. K., Lisboa H. R. K., De Carvalho Contieri F. L., Milagres R., Junior R. M., De Brito C. M., Hissa M. N., Sabbag A. R. N., Noronha I., Panarotto D., Filho R. P., Pereira M. A., Saporito W., Scotton A. S., Schuch T., De Almeida R. S., Ramos C. S., Felicio J. S., Thome F., Hachmann J. C. T., Yamada S., Hayashida C. Y., Petry T. B. Z., Zanella M. T., Andreeva V., Angelova A., Dimitrov S., Genadieva V., Genova-Hristova G., Hristozov K., Kamenov Z., Koundurdjiev A., Lozanov L., Margaritov V., Nonchev B., Rangelov R., Shinkov A., Temelkova M., Velichkova E., Yakov A., Aggarwal N., Aronson R., Bajaj H., Cherney D., Chouinard G., Conway J., Cournoyer S., DaRoza G., De Serres S., Dube F., Goldenberg R., Gupta A., Gupta M., Henein S., Khandwala H., Leiter L., Madore F., Mc-Mahon A., Muirhead N., Pichette V., Rabasa-Lhoret R., Steele A., Tangri N., Torshizi A., Woo V., Zalunardo N., Montenegro M. A. F., Jorquera J. G. G., Farina M. M., Gajardo V. S., Vejar M., Chen N., Chen Q., Gan S., Kong Y., Li D., Li W., Li X., Lin H., Liu J., Lu W., Mao H., Ren Y., Song W., Sun J., Sun L., Tu P., Wang G., Yang J., Yin A., Yu X., Zhao M., Zheng H., Mendoza J. L. A., Arcos E., Avendano J., Ruiz J. E. A. D., Ortiz L. H. G., Gonzalez A., Triana E. H., Higuera J. D., Malaver N., De Salazar D. I. M., Rosero R., Lozano M. A. T., Cometa L. V., Valenzuela A., Alonso R. D. V., Villegas I., Yupanqui H., Bartaskova D., Barton P., Belobradkova J., Dohnalova L., Drasnar T., Ferkl R., Halciakova K., Klokocnikova V., Kovar R., Lastuvka J., Lukac M., Pesickova S., Peterka K., Pumprla J., Rychlik I., Saudek F., Tesar V., Valis M., Weiner P., Zemek S., Alamartine E., Borot S., Cariou B., Dussol B., Fauvel J. -P., Gourdy P., Klein A., Le Meur Y., Penfornis A., Roussel R., Saulnier P. -J., Thervet E., Zaoui P., Burst V., Faghih M., Faulmann G., Haller H., Jerwan-Keim R., Maxeiner S., Paschen B., Plassmann G., Rose L., Orellana R. A. G., Haase F. P., Diaz J. P. M., Roca L. A. R., Arenales J. A. S., Polo J. V. S., Juarez E. T., Csecsei G., Csiky B., Danos P., Deak L., Dudas M., Harcsa E., Keltai K., Keresztesi S., Kiss K., Konyves L., Major L., Mileder M., Molnar M., Mucsi J., Oroszlan T., Ory I., Paragh G., Peterfai E., Petro G., Revesz K., Takacs R., Vangel S., Vasas S., Zsom M., Oomman A., Raju S. B., Dewan D., Fernando M. E., Gopalakrishnan N., Gracious N., Alva H., Jain D., Keshavamurthy C. B., Khullar D., Sahay M., Peringat J., Prasad N., Rao K. S., Reddy S., Melemadathil S., Sudhakar B., Vyasam R. C., Bonadonna R., Castellino P., Ceriello A., Chiovato L., De Cosmo S., De Nicola L., Derosa G., Carlo A. D., Cianni G. D., Frasca G., Fuiano G., Gambaro G., Garibotto G., Giorda C., Malberti F., Mandreoli M., Mannucci E., Orsi E., Piatti P., Santoro D., Sasso F. C., Serviddio G., Stella A., Trevisan R., Veronelli A. M., Zanoli L., Akiyama H., Aoki H., Asano A., Iitsuka T., Kajiyama S., Kashine S., Kawada T., Kodera T., Kono H., Koyama K., Kumeda Y., Miyauchi S., Mizuyama K., Niiya T., Oishi H., Ota S., Sakakibara T., Takai M., Tomonaga O., Tsujimoto M., Wada T., Wakasugi M., Wakida Y., Watanabe T., Yamada M., Yanagida K., Yanase T., Yumita W., Gaupsiene E., Kozloviene D., Navickas A., Urbanaviciene E., Ghani R. A., Kadir K. A., Ali N., Yusof M. D. C., Gan C. L., Ismail M., Kong W. Y., Lam S. W., Lee L. Y., Lim S. K., Loh C. L., Manocha A. B., Ng K. S., Ahmad N. N. F. N., Ratnasingam V., Shudim S. S. B., Vengadasalam P., Munoz L. D. A., Salazar M. A., Cruz J. B., Soto M. B., Ramos J. C., Wong A. C., Rotter J. R. C., Escalante T. D., Sosa F. E. E., Lozano F. F., Cervera L. F. F., Baron P. F., Ballesteros C. G., Rangel J. D. G., Jimenez L. E. H., Santana S. S. I., Flores F. J., Molina H. L., Ceballos R. I. L., Del Campo Blanco B. M., Franco G. M., Loza O. T. M., Rocha C. M., Vera G. O., Castellanos R. O., Calcaneo J. P., Rosano M. A. R., Pattzi H. R., Guzman J. R., Joerg I. E. R., Sanchez S. B. S., Mijangos J. H. S., Sanson P. S., Tamayo Y Orozco J. A., Chavez E. T., Cepeda A. V., Carrillo L. V., Mesa J. V., Escobedo R. Z., Baker J., Noonan P., Scott R., Walker R., Watson E., Williams M., Young S., Abejuela Z., Agra J., Aquitania G., Caringal C., Comia R. S., Santos L. D., Gomez O., Jimeno C., Santos F., Tan G., Tolentino M., Yao C., Yap Y. E., Ygpuara M. D. L., Bijata-Bronisz R., Hotlos L., Januszewicz A., Kaczmarek B., Kaminska A., Lazuka L., Madej A., Mazur S., Mlodawska-Choluj D., Nowicki M., Orlowska-Kowalik G., Popenda G., Rewerska B., Sowinski D., Angelescu L. M., Anghel V., Avram R. -I., Busegeanu M. -M., Cif A., Cosma D., Crisan C., Demian L. D., Ferariu I. E., Halmagyi I., Hancu N., Munteanu M., Negru D., Onaca A. G., Petrica L., Popa A. R., Ranetti A. -E., Serafinceanu C., Toarba C., Agafyina A., Barbarash O., Barysheva O., Chizhov D., Dobronravov V., Dreval A., Glinkina I., Grineva E., Khirmanov V., Kolmakova E., Koroleva T., Kvitkova L., Marasaev V., Mkrtumyan A., Morugova T., Nagibovich G., Nagibovich O., Nedogoda S., Osipova I., Raskina T., Samoylova Y., Sazonova O., Shamkhalova M., Shutemova E., Shwartz Y., Uriasyev O., Vorobyev S., Zateyshchikova A., Zateyshshikov D., Zykova T., Antic S., Djordjevic M., Kendereski A., Lalic K., Lalic N., Popovic-Radinovic V., Babikova J., Benusova O., Buganova I., Culak J., Dzupina A., Dzuponova J., Fulop P., Ilavska A., Martinka E., Ochodnicka Z., Pella D., Smatanova I., Ahmed F., Badat A., Breedt J., Distiller L., Govender V., Govender R., Joshi M., Jurgens J., Latiff G., Lombard L., Mookadam M., Ngcakani N., Nortje H., Oosthuizen H., Pillay-Ramaya L., Prozesky H., Reddy J., Rheeder P., Seeber M., Chae D. -W., Cho Y. M., Jeong I. -K., Kim S. G., Kim Y. H., Kwon H. -S., Kwon M. J., Lee B. -W., Lee J., Lee M. -K., Nam M. -S., Oh K. -H., Park C. -Y., Park S. -H., Yoon K. H., Garcia P. A., Mercadal L. A., Barrios C., Castro F. C., Guldris S. C., Lopez M. D., De Los Rios J. E., Fresnedo G. F., Serrano A. G., Garcia I., Martinez F. J. G., Gimeno J. E. J., Mendoza M. L., Marin T. M., Portillo C. M., Vila M. A. M., Torres M. M., Iglesias J. N., Perez J. P., Vera M. P., Perez J. M. P., Simon M. A. Q., Canonge R. S., Gonzalez A. S., Riera M. T., Madueno F. J. T., Plaza M. V., Chang C. -T., Chuang L. -M., Hsia T. -L., Hsieh C. -H., Hwang S. -J., Lin C. -C., Lu Y. -C., Sheu W. H. -H., Barna O., Bilyk S. D., Botsyurko V., Dudar I., Fushtey I., Godlevska O., Golovchenko O., Gyrina O., Kazmirchuk A., Kolesnyk M., Komisarenko I., Korzh O., Kravchun N., Legun O., Mankovskyy B., Martynyuk L., Mostovoy Y., Pashkovska N., Pererva L., Pertseva T., Samoylov O., Smirnov I., Svyshchenko Y., Tomashkevych H., Topchii I., Tryshchuk N., Tseluyko V., Vizir V., Vlasenko M., Zlova T., Zub L., Abusnana S., Railey M., Abouglila K., Ainsworth P., Ali Z., Arutchelvam V., Barnard M., Bellary S., Davies E., Davies M., Davies S., Dawson A., Kossi M. E., English P., Fraser D., Gnudi L., Gunstone A., Hall T., Hanif W., Jackson A., Johnson A., Joseph F., Krishnan S., Kumwenda M., MacDougall I., Nixon P., O'Hare J., Philip S., Ramtoola S., Saxena M., Sennik D., Simon G., Singh B., Stephens J., Strzelecka A., Symonds R., Turner W., Wahba M., Wakeling J., Wheeler D., Winocour P., Abdallah J., Abdullah R., Abramowitz M., Acosta I., Aiello J., Akright L., Akyea-Djamson A., Alappan R., Alicic R., Al-Karadsheh A., Allison D. C., Arauz-Pacheco C., Arfeen S., Arif A., Arvind M., Atray N., Awad A., Bakris G., Barnhill P., Barranco E., Barrera C., Beacom M., Behara V., Belo D., Bentley-Lewis R., Berenguer R., Bermudez L., Bernardo M., Biscoveanu M., Bowman-Stroud C., Brandon D., Brusco O., Busch R., Canaan Y., Chilito A., Christensen T., Christiano C., Christofides E., Chuateco C., Cohen K., Cohen R., Cohen-Stein D., Cook C., Coyne D., Daboul N., Darwish R., Daswani A., Deck K., Desouza C., Dev D., Dhillon M., Dua S., Eder F., Elosegui A. M., El-Shahawy M., Ervin J., Esquenazi A., Evans J., Fishbane S., Frias J., Galindo-Ramos E., Galphin C., Ghazi A., Gonzalez E., Gorson D., Gowda A., Greco B., Grubb S., Gulati R., Hammoud J., Handelsman S., Hartman I., Hershon K., Hiser D., Hon G., Jacob R., Jaime M., Jamal A., Kaupke C., Keightley G., Kern E., Khanna R., Khitan Z., Kim S., Kopyt N., Kovesdy C., Krishna G., Kropp J., Kumar A., Kumar J., Kumar N., Kusnir J., Lane W., Lawrence M., Lehrner L., Lentz J., Levinson D., Lewis D., Liss K., Maddux A., Maheshwari H., Mandayam S., Marar I., Mehta B., Middleton J., Mordujovich J., Moreda R., Moustafa M., Trenche S. M., Narayanan M., Narvarte J., Nassar T., Newman G., Nichol B., Nicol P., Nisnisan J., Nossuli A. K., Obialo C., Olelewe S., Oliver M., O'Shaughnessy A., Padron J., Pankhaniya R., Parker R., Patel D., Patel G., Patel N., Pavon H., Perez A., Perez C., Perlman A., Pettis K., Pharr W., Phillips A., Purighalla R., Quesada-Suarez L., Ranjan R., Rastogi S., Rendell M., Rich L., Robinson M., Rodriguez H., Rosas S., Saba F., Sankaram R., Sarin R., Schreiman R., Scott D., Sekkarie M., Sensenbrenner J., Shakeel M., Shanik M., Shaw S., Smith S., Solomon R., Sprague A., Spry L., Suchinda P., Sultan S., Surampudi P., Sussman S., Tan A., Terrelonge A., Thompson M., Trespalacios F., Trippe B., Trueba P., Twahirwa M., Updegrove J., Van Buren P., Vannorsdall M., Varghese F., Velasquez-Mieyer P., Ventrapragada S., Vukotic G., Wadud K., Warren M., Watson H., Watts R., Weiner D., Welker J., Welsh J., Williams S., Zaniewski-Singh M., Zhou, Z., Jardine, M. J., Li, Q., Neuen, B. L., Cannon, C. P., De Zeeuw, D., Edwards, R., Levin, A., Mahaffey, K. W., Perkovic, V., Neal, B., Lindley, R. I., Guerrero, R. A. A., Aizenberg, D., Albisu, J. P., Alvarisqueta, A., Bartolacci, I., Berli, M. A., Bordonava, A., Calella, P., Cantero, M. C., Cartasegna, L. R., Cercos, E., Coloma, G. C., Colombo, H., Commendatore, V., Cuadrado, J., Cuneo, C. A., Cusumano, A. M., Douthat, W. G., Dran, R. D., Farias, E., Fernandez, M. F., Finkelstein, H., Fragale, G., Fretes, J. O., Garcia, N. H., Gastaldi, A., Gelersztein, E., Glenny, J. A., Gonzalez, J. P., Del Carmen Gonzalez Colaso, P., Goycoa, C., Greloni, G. C., Guinsburg, A., Hermida, S., Juncos, L. I., Klyver, M. I., Kraft, F., Krynski, F., Lanchiotti, P. V., De La Fuente, R. A. L., Marchetta, N., Mele, P., Nicolai, S., Novoa, P. A., Orio, S. I., Otreras, F., Oviedo, A., Raffaele, P., Resk, J. H., Rista, L., Papini, N. R., Sala, J., Santos, J. C., Schiavi, L. B., Sessa, H., Casabella, T. S., Ulla, M. R., Valdez, M., Vallejos, A., Villarino, A., Visco, V. E., Wassermann, A., Zaidman, C. J., Cheung, N. W., Droste, C., Fraser, I., Johnson, D., Mah, P. M., Nicholls, K., Packham, D., Proietto, J., Roberts, A., Roger, S., Tsang, V., Raduan, R. A., Da Costa, F. A. A., Amodeo, C., Turatti, L. A. A., Bregman, R., Sanches, F. C. C., Canani, L. H., Chacra, A. R., Borges, J. L. C., Vencio, S. A. C., Da Silva Franco, R. J., D'Avila, D., De Souza Portes, E., De Souza, P., Deboni, L. M., Filho, F. F., Neto, B. G., Gomes, M., Kohara, S. K., Keitel, E., Saraiva, J. F. K., Lisboa, H. R. K., De Carvalho Contieri, F. L., Milagres, R., Junior, R. M., De Brito, C. M., Hissa, M. N., Sabbag, A. R. N., Noronha, I., Panarotto, D., Filho, R. P., Pereira, M. A., Saporito, W., Scotton, A. S., Schuch, T., De Almeida, R. S., Ramos, C. S., Felicio, J. S., Thome, F., Hachmann, J. C. T., Yamada, S., Hayashida, C. Y., Petry, T. B. Z., Zanella, M. T., Andreeva, V., Angelova, A., Dimitrov, S., Genadieva, V., Genova-Hristova, G., Hristozov, K., Kamenov, Z., Koundurdjiev, A., Lozanov, L., Margaritov, V., Nonchev, B., Rangelov, R., Shinkov, A., Temelkova, M., Velichkova, E., Yakov, A., Aggarwal, N., Aronson, R., Bajaj, H., Cherney, D., Chouinard, G., Conway, J., Cournoyer, S., Daroza, G., De Serres, S., Dube, F., Goldenberg, R., Gupta, A., Gupta, M., Henein, S., Khandwala, H., Leiter, L., Madore, F., Mc-Mahon, A., Muirhead, N., Pichette, V., Rabasa-Lhoret, R., Steele, A., Tangri, N., Torshizi, A., Woo, V., Zalunardo, N., Montenegro, M. A. F., Jorquera, J. G. G., Farina, M. M., Gajardo, V. S., Vejar, M., Chen, N., Chen, Q., Gan, S., Kong, Y., Li, D., Li, W., Li, X., Lin, H., Liu, J., Lu, W., Mao, H., Ren, Y., Song, W., Sun, J., Sun, L., Tu, P., Wang, G., Yang, J., Yin, A., Yu, X., Zhao, M., Zheng, H., Mendoza, J. L. A., Arcos, E., Avendano, J., Ruiz, J. E. A. D., Ortiz, L. H. G., Gonzalez, A., Triana, E. H., Higuera, J. D., Malaver, N., De Salazar, D. I. M., Rosero, R., Lozano, M. A. T., Cometa, L. V., Valenzuela, A., Alonso, R. D. V., Villegas, I., Yupanqui, H., Bartaskova, D., Barton, P., Belobradkova, J., Dohnalova, L., Drasnar, T., Ferkl, R., Halciakova, K., Klokocnikova, V., Kovar, R., Lastuvka, J., Lukac, M., Pesickova, S., Peterka, K., Pumprla, J., Rychlik, I., Saudek, F., Tesar, V., Valis, M., Weiner, P., Zemek, S., Alamartine, E., Borot, S., Cariou, B., Dussol, B., Fauvel, J. -P., Gourdy, P., Klein, A., Le Meur, Y., Penfornis, A., Roussel, R., Saulnier, P. -J., Thervet, E., Zaoui, P., Burst, V., Faghih, M., Faulmann, G., Haller, H., Jerwan-Keim, R., Maxeiner, S., Paschen, B., Plassmann, G., Rose, L., Orellana, R. A. G., Haase, F. P., Diaz, J. P. M., Roca, L. A. R., Arenales, J. A. S., Polo, J. V. S., Juarez, E. T., Csecsei, G., Csiky, B., Danos, P., Deak, L., Dudas, M., Harcsa, E., Keltai, K., Keresztesi, S., Kiss, K., Konyves, L., Major, L., Mileder, M., Molnar, M., Mucsi, J., Oroszlan, T., Ory, I., Paragh, G., Peterfai, E., Petro, G., Revesz, K., Takacs, R., Vangel, S., Vasas, S., Zsom, M., Oomman, A., Raju, S. B., Dewan, D., Fernando, M. E., Gopalakrishnan, N., Gracious, N., Alva, H., Jain, D., Keshavamurthy, C. B., Khullar, D., Sahay, M., Peringat, J., Prasad, N., Rao, K. S., Reddy, S., Melemadathil, S., Sudhakar, B., Vyasam, R. C., Bonadonna, R., Castellino, P., Ceriello, A., Chiovato, L., De Cosmo, S., De Nicola, L., Derosa, G., Carlo, A. D., Cianni, G. D., Frasca, G., Fuiano, G., Gambaro, G., Garibotto, G., Giorda, C., Malberti, F., Mandreoli, M., Mannucci, E., Orsi, E., Piatti, P., Santoro, D., Sasso, F. C., Serviddio, G., Stella, A., Trevisan, R., Veronelli, A. M., Zanoli, L., Akiyama, H., Aoki, H., Asano, A., Iitsuka, T., Kajiyama, S., Kashine, S., Kawada, T., Kodera, T., Kono, H., Koyama, K., Kumeda, Y., Miyauchi, S., Mizuyama, K., Niiya, T., Oishi, H., Ota, S., Sakakibara, T., Takai, M., Tomonaga, O., Tsujimoto, M., Wada, T., Wakasugi, M., Wakida, Y., Watanabe, T., Yamada, M., Yanagida, K., Yanase, T., Yumita, W., Gaupsiene, E., Kozloviene, D., Navickas, A., Urbanaviciene, E., Ghani, R. A., Kadir, K. A., Ali, N., Yusof, M. D. C., Gan, C. L., Ismail, M., Kong, W. Y., Lam, S. W., Lee, L. Y., Lim, S. K., Loh, C. L., Manocha, A. B., Ng, K. S., Ahmad, N. N. F. N., Ratnasingam, V., Shudim, S. S. B., Vengadasalam, P., Munoz, L. D. A., Salazar, M. A., Cruz, J. B., Soto, M. B., Ramos, J. C., Wong, A. C., Rotter, J. R. C., Escalante, T. D., Sosa, F. E. E., Lozano, F. F., Cervera, L. F. F., Baron, P. F., Ballesteros, C. G., Rangel, J. D. G., Jimenez, L. E. H., Santana, S. S. I., Flores, F. J., Molina, H. L., Ceballos, R. I. L., Del Campo Blanco, B. M., Franco, G. M., Loza, O. T. M., Rocha, C. M., Vera, G. O., Castellanos, R. O., Calcaneo, J. P., Rosano, M. A. R., Pattzi, H. R., Guzman, J. R., Joerg, I. E. R., Sanchez, S. B. S., Mijangos, J. H. S., Sanson, P. S., Tamayo Y Orozco, J. A., Chavez, E. T., Cepeda, A. V., Carrillo, L. V., Mesa, J. V., Escobedo, R. Z., Baker, J., Noonan, P., Scott, R., Walker, R., Watson, E., Williams, M., Young, S., Abejuela, Z., Agra, J., Aquitania, G., Caringal, C., Comia, R. S., Santos, L. D., Gomez, O., Jimeno, C., Santos, F., Tan, G., Tolentino, M., Yao, C., Yap, Y. E., Ygpuara, M. D. L., Bijata-Bronisz, R., Hotlos, L., Januszewicz, A., Kaczmarek, B., Kaminska, A., Lazuka, L., Madej, A., Mazur, S., Mlodawska-Choluj, D., Nowicki, M., Orlowska-Kowalik, G., Popenda, G., Rewerska, B., Sowinski, D., Angelescu, L. M., Anghel, V., Avram, R. -I., Busegeanu, M. -M., Cif, A., Cosma, D., Crisan, C., Demian, L. D., Ferariu, I. E., Halmagyi, I., Hancu, N., Munteanu, M., Negru, D., Onaca, A. G., Petrica, L., Popa, A. R., Ranetti, A. -E., Serafinceanu, C., Toarba, C., Agafyina, A., Barbarash, O., Barysheva, O., Chizhov, D., Dobronravov, V., Dreval, A., Glinkina, I., Grineva, E., Khirmanov, V., Kolmakova, E., Koroleva, T., Kvitkova, L., Marasaev, V., Mkrtumyan, A., Morugova, T., Nagibovich, G., Nagibovich, O., Nedogoda, S., Osipova, I., Raskina, T., Samoylova, Y., Sazonova, O., Shamkhalova, M., Shutemova, E., Shwartz, Y., Uriasyev, O., Vorobyev, S., Zateyshchikova, A., Zateyshshikov, D., Zykova, T., Antic, S., Djordjevic, M., Kendereski, A., Lalic, K., Lalic, N., Popovic-Radinovic, V., Babikova, J., Benusova, O., Buganova, I., Culak, J., Dzupina, A., Dzuponova, J., Fulop, P., Ilavska, A., Martinka, E., Ochodnicka, Z., Pella, D., Smatanova, I., Ahmed, F., Badat, A., Breedt, J., Distiller, L., Govender, V., Govender, R., Joshi, M., Jurgens, J., Latiff, G., Lombard, L., Mookadam, M., Ngcakani, N., Nortje, H., Oosthuizen, H., Pillay-Ramaya, L., Prozesky, H., Reddy, J., Rheeder, P., Seeber, M., Chae, D. -W., Cho, Y. 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Subjects
medicine.medical_specialty, Original Contributions, atrial fibrillation, canagliflozin, glomerular filtration rate, hemorrhagic stroke, ischemic stroke, Renal function, Disease, Brain Ischemia, Clinical and Population Sciences, Meta-Analysis as Topic, Internal medicine, CREDENCE Trial Investigators, Atrial Fibrillation, medicine, Diabetes Mellitus, Humans, Diabetic Nephropathies, Canagliflozin, Stroke, 1102 Cardiorespiratory Medicine and Haematology, Sodium-Glucose Transporter 2 Inhibitors, Advanced and Specialized Nursing, Neurology & Neurosurgery, business.industry, Atrial fibrillation, 1103 Clinical Sciences, medicine.disease, Diabetes Mellitus, Type 2, Meta-analysis, Cardiology, Albuminuria, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, 1109 Neurosciences, Kidney disease, medicine.drug
Abstract

Supplemental Digital Content is available in the text., Background and Purpose: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. Methods: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis. Results: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55–1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61–1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19–1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20–1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53–1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82–1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89–1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30–0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49–1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71–0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (

Published
2021

38. Molecular mapping of QTLs for grain dimension traits in Basmati rice

Author

Ankit Malik, Aruna Kumar, Ranjith Kumar Ellur, Gopala Krishnan S, Deepshikha Dixit, Haritha Bollinedi, KK Vinod, M Nagarajan, PK Bhowmick, NK Singh, and AK Singh

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

Basmati rice is known for its extra-long slender grains, exceptional kernel dimensions after cooking, high volume expansion, and strong aroma. Developing high yielding Basmati rice varieties with good cooking quality is a gigantic task. Therefore, identifying the genomic regions governing the grain and cooked kernel dimension traits is of utmost importance for its use in marker-assisted breeding. Although several QTLs governing grain dimension traits have been reported, limited attempts have been made to map QTLs for grain and cooked kernel dimension traits of Basmati rice. In the current study, a population of recombinant inbred lines (RIL) was generated from a cross of Sonasal and Pusa Basmati 1121 (PB1121). In the RIL population, there was a significant positive correlation among the length (RRL: rough rice length, MRL: milled rice length, CKL: cooked kernel length) and breadth (RRB: rough rice breadth, MRB: milled rice breadth and CKB: cooked kernel breadth) of the related traits, while there was significant negative correlation between them. QTL mapping has led to the identification of four major genomic regions governing MRL and CKL. Two QTLs co-localize with the earlier reported major gene GS3 and a QTL qGRL7.1, while the remaining two QTLs viz., qCKL3.2 (qMRL3.2) and qCKL4.1 (qMRL4.1) were novel. The QTL qCKL3.2 has been bracketed to a genomic region of 0.78 Mb between the markers RM15247 and RM15281. Annotation of this region identified 18 gene models, of which the genes predicted to encode pentatricopeptides and brassinosteroid insensitive 1-associated receptor kinase 1 precursor may be the putative candidate genes. Furthermore, we identified a novel QTL qKER2.1 governing kernel elongation ratio (KER) in Basmati rice.

Published
2022
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39. A STUDY ON EARLY STAGE HEALTH TECHNOLOGY ASSESSMENT (HTA) OF MODERN BIOMEDICAL DEVICES

Author

Kumar, P., Krishnan, S., Sidheswaran, M., and Dharmalingam, M.

Abstract

Early stage Health Technology Assessment (HTA) of biomedical devices necessitates approaches separate from those used by pharmaceuticals. The Analytic Hierarchy Process (AHP) to evoke consumer requirements, and early stage economic analyses utilising Markov Models, are two approaches for early stage HTA being built in the Multidisciplinary Assessment of Technology Centre for Healthcare (MATCH) project. The spread of medical devices is accelerating at an incredible pace. The rising number of new patents issued per year shows that this trend will continue. Medical instruments, unlike medications, are inextricably linked to the context in which they are utilised and how they are managed. This provided a previously unseen global need for well-trained biomedical engineers who can assist healthcare facilities in evaluating them. The International Federation for Medical and Biological Engineering (IFMBE) is a multinational scientific society of biomedical engineers that has worked closely with the United Nations World Health Organization (WHO) to promote the involvement of biomedical engineers in health technology assessment (HTA). Summer schools, training material, an HTA eLearning platform, HTA guidelines, awards, and more are all promoted by the IFMBE Health Technology Assessment Division (HTAD), which is the IFMBE operative branch in this field, promoting studies, projects, and activities to foster the growth of this specific and very important science sector. The vision, goal, and plan of the HTAD are described in this report, with an emphasis on the outcomes and their effect on global policymaking.

Published
2022
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40. One step preparation of green reduced copper oxide nanorods using Citrus sinensis L. peel extracts and evaluation of their photocatalytic degradation of Rose Bengal dye and antibacterial activity

Author

Ayyadurai, Saranya A, Murugesan S, Ramar K, Krishnan S, and Maheshwaran P

Subjects
Copper oxide, Chemistry, Mechanical Engineering, One-Step, Condensed Matter Physics, chemistry.chemical_compound, Mechanics of Materials, Rose bengal, General Materials Science, Nanorod, Antibacterial activity, Photocatalytic degradation, Citrus × sinensis, Nuclear chemistry
Published
2021
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41. Analysis of sorbent enhanced steam assisted air gasification using biomass specific pyrolysis correlations

Author

S. Rupesh and Gokul Krishnan S

Subjects
Fuel Technology, Sorbent, Nuclear Energy and Engineering, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, Environmental science, Biomass, Char, Biomass gasification, Pulp and paper industry, Pyrolysis, Syngas
Abstract

The article presents simulation and analysis of sorbent-enhanced biomass gasification with biomass-specific pyrolysis correlations. An ASPEN plus model constituted of drying, pyrolysis, char transf...

Published
2021
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42. Challenges to adopting adiabatic circuits for systems‐on‐a‐chip

Author

Krishnan S. Rengarajan, Saroj Mondal, and Ravindra Kapre

Subjects
TK7885-7895, Adiabatic circuit, Computer Science::Hardware Architecture, Computer engineering. Computer hardware, Control and Systems Engineering, Computer science, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, Hardware_PERFORMANCEANDRELIABILITY, Electrical and Electronic Engineering, Chip, Hardware_LOGICDESIGN
Abstract

Adiabatic complementary metal–oxide–semiconductor (CMOS) circuits have been proposed as a low‐power option for CMOS systems‐on‐a‐chip (SoCs) but have not gained popularity due to practical difficulties in scaling to millions of gates. The architecture of a pipeline of stages with slow‐transitioning clock phases demands the generation and distribution of clock phases precisely and efficiently. This power must be more than offset by the power saved by using adiabatic circuits. The problems in adiabatic logic circuits are described, and solutions are proposed to address them. Three published topologies are considered, namely positive‐feedback adiabatic logic (PFAL), two‐level adiabatic logic (2‐LAL) and clocked adiabatic logic in 40 nm CMOS technology at 100 MHz. New circuit ideas for complete level restore in PFAL and avoidance of floating nodes in 2‐LAL are presented. The problem with 2‐LAL multi‐input gates is published and solved for the first time here using a modified PFAL. The conclusion is that a 3X power savings in PFAL is about the best that can be achieved in an SoC context—a low return given the required investments in area and complexity. This should motivate the future discovery of more efficient solutions.

Published
2021
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43. Assessment of the Preparedness and Planning of Academic Emergency Departments in India During the COVID-19 Pandemic: A Multicentric Survey

Author

Vivek Gopinathan, Sanjan Asanaru Kunju, Vimal Krishnan S, Freston Marc Sirur, and Jayaraj Mymbilly Balakrishnan

Subjects
Coronavirus disease 2019 (COVID-19), Specialty, COVID-19 pandemic, emergency departments, 03 medical and health sciences, 0302 clinical medicine, Pandemic, Humans, Medicine, 030212 general & internal medicine, Pandemics, Personal protective equipment, disaster preparedness, Original Research, Descriptive statistics, business.industry, Public Health, Environmental and Occupational Health, COVID-19, 030208 emergency & critical care medicine, medicine.disease, Triage, COVID-19 Drug Treatment, Cross-Sectional Studies, Preparedness, Disaster preparedness, Medical emergency, Emergency Service, Hospital, business
Abstract

Objective:Emergency medicine being a young specialty in India, we aimed to assess the level of disaster preparedness and planning strategies among various academic emergency departments (EDs) across India during the coronavirus disease 2019 (COVID-19) pandemic.Methods:A cross-sectional multicentric survey was developed and disseminated online to various academic EDs in India and followed up over a period of 8 wk. All results were analyzed using descriptive statistics.Results:Twenty-eight academic emergency medicine departments responded to the study. Compared with pre-COVID period, COVID-19 pandemic has led to 90% of centers developing separate triage system with dedicated care areas for COVID suspected/infected in 78.6% centers with nearly 70% using separate transportation pathways. Strategizing and executing the Institutional COVID-19 treatment protocol in 80% institutes were done by emergency physicians. Training exercises for airway management and personal protective equipment (PPE) use were seen in 93% and 80% centers, respectively. Marked variation in recommended PPE use was observed across EDs in India.Conclusions:Our study highlights the high variance in the level of preparedness response among various EDs across India during the pandemic. Preparedness for different EDs across India needs to be individually assessed and planned according to the needs and resources available.

Published
2021
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44. Discovery of the luminous X-ray ignition eRASSt J234402.9−352640

Author

Homan, D., Krumpe, M., Markowitz, A., Saha, T., Gokus, A., Partington, E., Lamer, G., Malyali, A., Liu, Z., Rau, A., Grotova, I., Cackett, E. M., Buckley, D. A. H., Ciroi, S., Di Mille, F., Gendreau, K., Gromadzki, M., Krishnan, S., Schramm, M., and Steiner, J. F.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

In November 2020, a new, bright object, eRASSt J234402.9$-$352640, was discovered in the second all-sky survey of SRG/eROSITA. The object brightened by a factor of at least 150 in 0.2--2.0 keV flux compared to an upper limit found six months previous, reaching an observed peak of $1.76_{-0.24}^{+0.03} \times 10^{-11}$ erg cm$^{-2}$ s$^{-1}$. The X-ray ignition is associated with a galaxy at $z=0.10$, making the peak luminosity log$_{10}(L_{\rm 0.2-2keV}/[\textrm{erg s}^{-1}])$=$44.7\pm0.1$. Around the time of the rise in X-ray flux, the nucleus of the galaxy brightened by approximately 3 mag. in optical photometry, after correcting for the host. We present data from Swift, XMM-Newton, and NICER, which reveal a very soft spectrum as well as strong 0.2--2.0 keV flux variability on multiple timescales. Optical spectra taken in the weeks after the ignition event show a blue continuum with broad, asymmetric Balmer emission lines, and high-ionisation ([OIII]$\lambda\lambda$4959,5007) and low-ionisation ([NII]$\lambda$6585, [SII]$\lambda\lambda$6716,6731) narrow emission lines. Following the peak in the optical light curve, the X-ray, UV, and optical photometry all show a rapid decline. The X-ray light curve shows a decrease in luminosity of $\sim$0.45 over 33 days and the UV shows a drop of $\sim$0.35. eRASSt J234402.9$-$352640 also shows a brightening in the mid-infrared, likely powered by a dust echo of the luminous ignition. We find no evidence in Fermi-LAT $\gamma$-ray data for jet-like emission. The event displays characteristics of a tidal disruption event (TDE) as well as of an active galactic nucleus (AGN), complicating its classification. Based on the softness of the X-ray spectrum, the presence of high-ionisation optical emission lines, and the likely infrared echo, we find that a TDE within a turned-off AGN best matches our observations., Comment: 25 pages, 17 figures, 9 tables, Accepted for publication in A&A

Published
2023
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45. Development of coreset of aromatic rice (Oryza sativa L. Indica) based on molecular and morphological diversity

Author

Srsc Sekhar Maddala, Subba Rao Lv, Sathish Kumar P, Gopala Krishnan S, Akath Singh, Kuldeep Singh, Shobha Rani N, Raman Meenakshi Sundaram, Sanjeeva Rao D, Sheshu Madhav Maganti, and Praveen Kumar R

Subjects
0106 biological sciences, 0301 basic medicine, Germplasm, Oryza sativa, Plant Science, Biology, 01 natural sciences, Mean difference, Variance ratio, 03 medical and health sciences, Diversity index, 030104 developmental biology, Statistics, Genetics, Coreset, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics, Aromatic rice, 010606 plant biology & botany
Abstract

Aromatic rice (Oryza sativa L. Indica) is popular among consumers. They provide significant economic benefit to producing countries as well as farmers. Aromatic germplasm is huge and diverse in terms of agro-morphological characters, grain types and aroma content. Development of a representative coreset of aromatic germplasm can be a good source for novel alleles identification and is required for its improvement. A collection of 552 aromatic accessions were screened for 40 DUS traits and 60 SSR markers. The data were processed in PowerCore software that implements the advanced M (or maximization) strategy using a modified heuristic algorithm and a coreset of 99 accessions was identified. The average Nei diversity and Shannon–Weaver diversity indices of the coreset were 0.635 and 0.823, representing the entire diversity of the collection. Statistical parameters like mean difference and variance difference were analysed to compare the mean and variance ratio between core and entire collections. Coreset has 3.45% mean difference and 14.4% variance difference. The coreset has 99.04% coincidence rate and 106.31% variable range which indicated the optimum properties of the coreset against the entire collection. This is the first attempt of making coreset of aromatic rice from larger germplasm.

Published
2021
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46. The 2021 toolkit for emergency preparedness and mitigation to combat surge of pediatric COVID-19 patients in India: The world health organization collaborating center for emergency and trauma in South East Asia recommendations

Author

Galwankar, Sagar, Shah, Dheeraj, Gist, Ramon E., Shah, Ami P., Krishnan, S. Vimal, Arquilla, Bonnie, Batra, Prerna, Saha, Abhijeet, Bhoi, Sanjeev, Sinha, Tej Prakash, and Agrawal, Amit

Subjects
covid-19, RC86-88.9, disaster, Consensus Statement, pediatric toolkit, Medical emergencies. Critical care. Intensive care. First aid, preparedness
Abstract

The authors of this toolkit focus on children under the age of 18 comprising approximately 41% of the total population in India. This toolkit has been created with an objective to prepare, mitigate the effects of any surge of COVID-19 in our communities, and help to optimally utilize the scarce resources. The toolkit design suggests the manpower, equipment, laboratory support, training, consumables, and drugs for a 10-bedded pediatric emergency room, 25-bedded COVID pediatric intensive care unit, and 75-bedded COVID pediatric high dependency unit/ward as defined for a 100-bedded facility. A dedicated and detailed chapter is included to address the psychological needs of the children. These data can be modified for other department sizes based on the facilities, needs, local environment, and resources available.

Published
2021

48. TUG 2021 abstracts

Author

Alexáander Borbóon Alpízar, null Apu V, Robert A. Beezer, H. Andrew Black, Michael Cantino, Paulo Cereda, David Crossland, Vic van Dijk, Jonathan Fine, Michal Hoftich, Amelia Hugill-Fontanel, Rahul Jaiswal, Emílio Kavamura, Vafa Khalighi, Alexei Kolesnikov, Rahul Krishnan S, Marcel Krüger, Al Maneki, Frank Mittelbach, Ross Moore, Michael Nolan, Todd Pagano, Hugh Paterson, Simon Porter, Thomas Price, Aravind Rajendran, T. Rishi, Matheus Rocha, Volker Sorge, Paulo Ney de Souza, Suhas Chikkanaravangala Vijayakumar, and Joseph Wright

Published
2021
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49. Simulation and background characterisation of the SABRE South experiment

Author

Barberio, E., Baroncelli, T., Bignell, L. J., Bolognino, I., Brooks, G., Dastgiri, F., D Imperio, G., Di Giacinto, A., Duffy, A. R., Froehlich, M., Fu, G., Gerathy, M. S. M., Hill, G. C., Krishnan, S., Lane, G. J., Lawrence, G., Leaver, K. T., Mahmood, I., Mariani, A., Mcgee, P., Mckie, L. J., Mcnamara, P. C., Mews, M., Melbourne, W. J. D., Milana, G., Milligan, L. J., Mould, J., Nuti, F., Pettinacci, V., Scutti, F., Slavkovská, Z., Spinks, N. J., Stanley, O., Stuchbery, A. E., Taylor, G. N., Tomei, C., Urquijo, P., Vignoli, C., Williams, A. G., Zhong, Y. Y., and Madeleine Zurowski

Subjects
Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det)
Abstract

SABRE (Sodium iodide with Active Background REjection) is a direct detection dark matter experiment based on arrays of radio-pure NaI(Tl) crystals. The experiment aims at achieving an ultra-low background rate and its primary goal is to confirm or refute the results from the DAMA/LIBRA experiment. The SABRE Proof-of-Principle phase was carried out in 2020-2021 at the Gran Sasso National Laboratory (LNGS), in Italy. The next phase consists of two full-scale experiments: SABRE South at the Stawell Underground Physics Laboratory, in Australia, and SABRE North at LNGS. This paper focuses on SABRE South and presents a detailed simulation of the detector, which is used to characterise the background for dark matter searches including DAMA/LIBRA-like modulation. We estimate an overall background of 0.72 cpd/kg/keV$_{ee}$ in the energy range 1$-$6 keV$_{ee}$ primarily due to radioactive contamination in the crystals. Given this level of background and considering that the SABRE South has a target mass of 50 kg, we expect to exclude (confirm) DAMA/LIBRA modulation at $4~(5)\sigma$ within 2.5 years of data taking.

Published
2022

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