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Modern-day reservoir management and monitoring of geological carbon storage increasingly call for costly time-lapse seismic data collection. In this letter, we show how techniques from graph theory can be used to optimize acquisition geometries for low-cost sparse 4D seismic. Based on midpoint-offset domain connectivity arguments, the proposed algorithm automatically produces sparse non-replicated time-lapse acquisition geometries that favor wavefield recovery.

In $2011$, Herzog, Hibi, and Ohsugi conjectured that if $J$ is the cover ideal of a chordal graph, then $J^s$ is componentwise linear for all $s \ge 1.$ In 2022, H\`a and Tuyl considered objects more general than chordal graphs and posed the following problem: Let $J(\Delta)$ be the cover ideal of a simplicial tree $\Delta.$ Is it true that $J(\Delta)^s$ is componentwise linear for all $s \geq 1$? In this article, we give an affirmative answer to this problem.

In large-scale multi-agent systems like taxi fleets, individual agents (taxi drivers) are self-interested (maximizing their own profits) and this can introduce inefficiencies in the system. One such inefficiency is with regard to the "required" availability of taxis at different time periods during the day. Since a taxi driver can work for a limited number of hours in a day (e.g., 8-10 hours in a city like Singapore), there is a need to optimize the specific hours, so as to maximize individual as well as social welfare. Technically, this corresponds to solving a large-scale multi-stage selfish routing game with transition uncertainty. Existing work in addressing this problem is either unable to handle ``driver" constraints (e.g., breaks during work hours) or not scalable. To that end, we provide a novel mechanism that builds on replicator dynamics through ideas from behavior cloning. We demonstrate that our methods provide significantly better policies than the existing approach in terms of improving individual agent revenue and overall agent availability., Accepted to the 22nd International Conference on Autonomous Agents and Multiagent Systems (AAMAS-23)

Change detection for aerial imagery involves locating and identifying changes associated with the areas of interest between co-registered bi-temporal or multi-temporal images of a geographical location. Farm ponds are man-made structures belonging to the category of minor irrigation structures used to collect surface run-off water for future irrigation purposes. Detection of farm ponds from aerial imagery and their evolution over time helps in land surveying to analyze the agricultural shifts, policy implementation, seasonal effects and climate changes. In this paper, we introduce a publicly available object detection and instance segmentation (OD/IS) dataset for localizing farm ponds from aerial imagery. We also collected and annotated the bi-temporal data over a time-span of 14 years across 17 villages, resulting in a binary change detection dataset called \textbf{F}arm \textbf{P}ond \textbf{C}hange \textbf{D}etection Dataset (\textbf{FPCD}). We have benchmarked and analyzed the performance of various object detection and instance segmentation methods on our OD/IS dataset and the change detection methods over the FPCD dataset. The datasets are publicly accessible at this page: \textit{\url{https://huggingface.co/datasets/ctundia/FPCD}}

Requirements of large amounts of data is a difficulty in training many GANs. Data efficient GANs involve fitting a generators continuous target distribution with a limited discrete set of data samples, which is a difficult task. Single image methods have focused on modeling the internal distribution of a single image and generating its samples. While single image methods can synthesize image samples with diversity, they do not model multiple images or capture the inherent relationship possible between two images. Given only a handful of images, we are interested in generating samples and exploiting the commonalities in the input images. In this work, we extend the single-image GAN method to model multiple images for sample synthesis. We modify the discriminator with an auxiliary classifier branch, which helps to generate a wide variety of samples and to classify the input labels. Our Data-Efficient GAN (DEff-GAN) generates excellent results when similarities and correspondences can be drawn between the input images or classes.

Acquired aplastic anemia (aAA) is an autoimmune disease, characterized by infiltration of T lymphocytes in the bone marrow with destruction of hematopoietic stem cells by the effector cells. Interferon-gamma (IFN-γ) and perforin are important mediators of cell destruction. In this flow cytometry-based study, we have investigated the percentage of intracellular IFN-γ+ and perforin+ CD5+ T cells in peripheral blood of newly diagnosed aAA patients before and after immunosuppressive therapy (IST). Patients were categorized as per standard disease severity and response to IST. The median percentage of IFN-γ+ and perforin+ CD5+ T cells was higher in untreated patients compared to healthy controls. The percentage of these cells was also increased in untreated severe and very severe aplastic anemia when compared with non-severe aplastic anemia patients. In patients before and after IST the median percentage of T cells producing IFN-γ and perforin was elevated in non-responders as compared to partial plus complete responders. The higher percentage of IFN-γ+ and perforin+ CD5+ T cells may be useful as an early diagnostic marker for aberrant activation of immune system and predict poor response to IST in aAA patients, who will benefit from alternative therapy.

Introduction:Healthcare scenario is fast changing all over the world. Health as a fundamental right, is gaining popularity over the last few decades and it has become a social goal. Patient satisfaction is one of the established parameters to measure success of the healthcare services that are provided in the hospitals. There are high expectations and demands from consumers because of improved socio-economic status and easy accessibility to healthcare. Successful monitoring of customer’s perception has become a simple but important strategy. The measurement of patient satisfaction is an important tool for research, administration, and planning. Objective of the study: · To study the level of satisfaction among OPD Patients · To find out the level of satisfaction among the patients regarding the behaviour of the hospital staff · To analyse the perception of patients about cleanliness in the OPD of the hospital · To find out the perception of patients about diagnostic services in the OPD of the hospital. Methodology · Study design- Cross-sectional study · Study population- The target population of this study included patients who had utilized health services at the OPD of a secondary care public hospital in Month of July 2021. · Sample size- A sample of 100 out-door patients had been taken on random basis. · Study Settings- Study had been conducted in a secondary care public hospital, Bhojpuri, Bihar,India. · Tools of Data Collection- The data had been collected by interviewing patients who had utilized health services in out-patient services (OPD). Conclusion:The study concludes the overall patient satisfaction of government hospital. The results depicted in the study are highly alarming. A government hospital with such potential cannot sustain with such dissatisfying patients. The management needs to take necessary steps in order to repair its deteriorating image in the public domain.

Malignant gliomas are the most common primary brain tumors in adults up to an extent of 78% of all primary malignant brain tumors. However, total surgical resection is almost unachievable due to considerable infiltrative ability of glial cells. The efficacy of current multimodal therapeutic strategies is, furthermore, limited by the lack of specific therapies against malignant cells, and, therefore, the prognosis these in patients is still very unfavorable. The limitation of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent to brain tumors are major reasons for this unsolved clinical problem. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents. Nanoparticles, thanks to their chemical configuration, are able to go through the blood-brain barrier carrying drugs or genes targeted against gliomas. Carbon nanomaterials show distinct properties including electronic properties, penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs. In this review we will focus on the potential effectiveness of the use of carbon nanomaterials in the treatment of malignant gliomas discussing the current progress of in vitro and in vivo researches of carbon nanomaterials-based drug delivery to brain.

There is a very popular two-zone accretion disk model that the inner part of the non-advective Keplerian disk (Shakura-Sunyaev disk) can produce hot advection-dominated accretion flow, which can generate high energy power-law radiation and outflows/jets. However, we find that this simple model is inadequate to automatically explain many properties of the sources (such as hysteresis effect, counter-clockwise traversal in a hardness-intensity diagram, peculiar variabilities, and association/non-association of jets in a black hole $X-$ray binary) without considering additional assumptions. We also find some theoretical issues in this model, such as understanding of variation of transition region and formation of an outer disk, which has only Keplerian distribution. Based on the recent theoretical studies on advective disk structures, as well as, many observational behaviors of the accreting black holes, we conclude that there should be a third component (TC) of accretion flow parallel to the two-zone disk model, which can naturally explain all above mentioned issues. Interestingly, this modified model also provides a new scenario for the jet generation and evolution with the TC flow during high energy states, which can make the jet close to the axis. We also find out an expression of jet kinetic power., 17 pages, 7 figures, comments are welcome

We investigated the possible associations between leukocyte telomere length, therapy outcomes, and clinicopathological features in patients with colorectal cancer. Aditionally, telomerase reverse transcriptase (TERT) expression was evaluated.Telomere length was measured using singleplex qPCR in 478 consecutive leukocyte DNA samples from 198 patients. Blood was drawn at diagnosis prior to any therapy, and then at 6-month intervals for 18 months.Following diagnosis, the telomeres gradually shortened during the course of the treatment regardless of the patient's age. The most pronounced decrease was observed 12 months after the diagnosis (p < 0.0001). Based on tumor localization, the decrease in telomere length one year after the diagnosis followed different trajectories (p = 0.03). In patients treated with adjuvant therapy, telomere length was correlated with the time elapsed after completion of therapy (p = 0.03). TERT expression did not correlate with the telomere length; however, it was higher in women than men (1.35-fold, 95% CI 1.11–1.65, p = 0.003) and in smokers than non-smokers (1.27-fold, 95% CI 1.01–1.61, p = 0.04).Leukocyte telomere length declines naturally during aging, but the accelerated shortening observed in our patients was age-independent. Telomere length manifestly reflected chemotherapy impact and could be linked to therapy toxicity.

Introduction: Accuracy and total design and implementation cost of the GPS framework determine the viability of GPS based projects. As the greater part of the advanced framework including telemetry, IoT, Cloud, and AUTOSAR frameworks use GPS to get exact outcomes, finding a software-controlled error correction becomes important. The execution of open source library such as RTKLIB will help in controlling and revising GPS blunders. Methods: The project utilizes the RTKLIB along with two stations for better accuracy. The RTKGPS framework works under Linux environment, which is embedded in the Beagleboard. The communication between the GPS system is set up utilizing both serial communication protocol and TCP/IP suite. Results: To get high precision inside the network, two GPS modules are utilized. One of them will be mounted on the rover and another GPS is the base station of the setup. Both the GPS will have a double radio wire setup to increase the reception level to reduce the noise and obtain centimeterlevel precision. For long-range communication, rover utilizes Wi-Fi with TCP/IP stack protocol. In this research paper, setup is intended to accomplish the centimeter level precision through libraries in a Linux environment. Conclusion: The design will be set up and tried on a college campus under various conditions with different error parameters to acquire a low cost and centimeter level GPS accuracy.

Background: Steinstrasse, is described as array of stone pieces in the ureter following extracorporeal shock wave lithotripsy (SWL). It is well-recognized, transient event. Steinstrasse clears spontaneously, however about 6% require intervention. Spontaneous steinstrasse without prior history of SWL is a rare occurrence and only few case reports are published in literature. Objective of the study was to assess the aetiology and management issues of large spontaneous steinstrasse in our centre. Method: From February 2017 to March 2019, 684 patients underwent SWL for renal or ureteric stones. Twenty-eight patients presented with steinstrasse of which nine patients had no prior history of SWL. Detailed clinical profile and management issues have been discussed. Result: Among the nine patients of spontaneous steinstrasse, there were six males and three females. Mean age of the patients was 39 years (±13 years SD). Bilateral large spontaneous steinstrasse was seen in one out of nine patients. Seven patients had associated renal stones. Five patients presented with obstructive uropathy and three out of them had urosepsis as initial presentation. Ureterolithotomy and percutaneous nephrolithotomy were commonly performed procedures for stone clearance. Metabolic work was done in all cases in follow up period. Three patients had hypercalciuria and hypocitraturia suggestive of renal tubular acidosis. Conclusion: Large spontaneous steinstrasse is uncommon case scenario. It can be subtle in presentation and yet have significant patient consequence in terms of renal function and infection. Prompt management is essential to preclude permanent loss of renal function. Metabolic evaluation is indispensable in such cases.

Malignant gliomas are the most common primary brain tumors in adults up to an extent of 78% of all primary malignant brain tumors. However, total surgical resection is almost unachievable due to the considerable infiltrative ability of glial cells. The efficacy of current multimodal therapeutic strategies is, furthermore, limited by the lack of specific therapies against malignant cells, and, therefore, the prognosis of these in patients is still very unfavorable. The limitations of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent to brain tumors, are major reasons for this unsolved clinical problem. The major problem in brain drug delivery is the presence of the blood–brain barrier, which limits the delivery of many chemotherapeutic agents. Nanoparticles, thanks to their chemical configuration, are able to go through the blood–brain barrier carrying drugs or genes targeted against gliomas. Carbon nanomaterials show distinct properties including electronic properties, a penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, a large surface area, and easy modification with molecules, which render them as suitable candidates for deliver drugs. In this review, we will focus on the potential effectiveness of the use of carbon nanomaterials in the treatment of malignant gliomas and discuss the current progress of in vitro and in vivo researches of carbon nanomaterials-based drug delivery to brain.

The present study was carried out to evaluate the performance of two novel gladiolus hybrid selections IIHRG-7 and IIHRG-11 along with commercial checks, for flower quality traits and Fusarium wilt resistance in completely randomized block design, during 2012-13 to 2014-15. Three years data were pooled and analyzed statistically. The hybrid selections IIHRG-7 and IIHRG-11 had been developed through hybridization by crossing Arka Meera x Picardy and Gold Medal 412 x Arka Poonam, respectively followed by selection. IIHRG-7 has novel flower colour (as per RHS Colour Chart) i.e., Red-Purple (65.B) having Red-Purple (62.A) streaks with Red-Purple (67.B) splash and spike with variegated florets, while, IIHRG-11 has novel floret colour as Red (41.C) having Red (41.A) margin. Blotch Red (46.B) with yellow (13.C) border and resistance to Fusarium wilt disease. These hybrid selections are suitable for cut-flower and flower arrangement purposes. Further, these hybrid selections will be useful for developing new gladiolus hybrid selections with novel traits and resistance to Fusarium wilt disease.

Failure of mature kidney to reach its natural location in renal fossa is termed as renal ectopia. Ectopic kidney can be found in pelvic, iliac, abdominal, and thoracic location. Pelvic ectopia has been estimated to occur in 1 of 2100 to 3000 autopsies. In contrast, ectopic ureters are commonly associated with complete renal duplication. Commonest presentation in females in continuous urinary incontinence with normal voiding habits as ectopic ureter open below the bladder neck in urethra or vagina. An ectopic kidney with ectopic ureter is extremely rare congenital anomaly. We report a 36-year-old woman presenting with left lower abdomen pain with no history of fever, dysuria, or urinary incontinence. On evaluation, she was found to have left nonfunctioning ectopic pelvic kidney with ectopic ureter opening in the vestibule of the vagina, which was managed with laparoscopic nephroureterectomy. One should suspect an ectopic ureter in a female presenting with continuous urinary incontinence since birth. However, diagnosis is challenging when clinical presentation is unusual with no urinary incontinence as seen in the index case. Detailed local examination in correlation with imaging is key for diagnosis and rule out other congenital anomalies. Laparoscopic approach in such clinical scenario is a safe and feasible option.

Nowadays there is a huge demand of High Strength Temperature Resistance (HSTR) alloys such as titanium, carbide, nimonics and ceramics in aerospace, defence and electronics. Among these alloys machining of tungsten carbide alloy is of interest, because of its numerous applications. Complex shapes of tungsten carbide are not generally made by traditional manufacturing process. To machine tungsten carbide with high accuracy, non-traditional machining process like Laser beam machining, Electron beam machining and Electrical discharge machining are a proper choice. In the present paper, the authors have machined Tungsten carbide (93% WC and 7%Co) with copper electrode. The machining is performed on EDM MODEL 500 X 300 ENC with VELVEX EDMVEL-2 as dielectric oil. The 17 experiments are carried out based on RSM (Box-Behnken) method. Further, in order to find the optimum combination grey relational approach is used. The results showed that pulse-on-time of 40μs, pulse-off-time of 2μs and current of 8A are optimum combination for machining of Tungsten carbide (93% WC and 7%Co). Lastly, the confirmation experiment has been conducted.

Cold stress adversely affects plant growth, development, and yield. Also, the spatial and geographical distribution of plant species is influenced by low temperatures. Cold stress includes chilling and/or freezing temperatures, which trigger entirely different plant responses. Freezing tolerance is acquired via the cold acclimation process, which involves prior exposure to non-lethal low temperatures followed by profound alterations in cell membrane rigidity, transcriptome, compatible solutes, pigments and cold-responsive proteins such as antifreeze proteins. Moreover, epigenetic mechanisms such as DNA methylation, histone modifications, chromatin dynamics and small non-coding RNAs play a crucial role in cold stress adaptation. Here, we provide a recent update on cold-induced signaling and regulatory mechanisms. Emphasis is given to the role of epigenetic mechanisms and antifreeze proteins in imparting cold stress tolerance in plants. Lastly, we discuss genetic manipulation strategies to improve cold tolerance and develop cold-resistant plants.

Background: Nephrolithiasis is a common ailment in developing countries such as India. Ureteroscopic management has superseded shockwave lithotripsy as the common treatment for upper urinary tract stones. The process of miniaturizing the instrument along with improved quality of video processor has amplified its potential application, maintaining the procedure safe and effective. However, with its extensive use, complications have risen in parallel, and one should be aware of its adverse effects. Ureteric stricture though rare is a serious problem and risks the loss of renal function. Case presentation: A 37-year-old male presented with right flank pain. On evaluation, he was diagnosed with right upper ureteric stone and left renal stone. The patient suffered ureteric perforation while the right ureterorenoscopy was being performed, and an open repair was done. On postoperative follow-up, he developed long segment ureteric stricture. Boari flap ureteroneocystostomy was done. Conclusion: Iatrogenic ureteric injury following ureterorenoscopy is common, minor and managed conservatively. Important tips to prevent major injury are: placement of the safety guide wire across the length of the ureter, small-calibre scopes during access if a tight gripping sensation is present and the use of lubricant along the length of the ureteroscope.

Objective: Optical networks exploit the Wavelength Division Multiplexing (WDM) to meet the ever-growing bandwidth demands of upcoming communication applications. This is achieved by dividing the enormous transmission bandwidth of fiber into smaller communication channels. The major problem with WDM network design is to find an optimal path between two end users and allocate an available wavelength to the chosen path for the successful data transmission. Methods: This communication over a WDM network is carried out through lightpaths. The merging of all these lightpaths in an optical network generates a virtual topology which is suitable for the optimal network design to meet the increasing traffic demands. But, this virtual topology design is an NP-hard problem. This paper aims to explore Mixed Integer Linear Programming (MILP) framework to solve this design issue. Results: The comparative results of the proposed and existing mathematical models show that the proposed algorithm outperforms with the various performance parameters. Conclusion: Finally, it is concluded that network congestion is reduced marginally in the overall performance of the network.

Aim: To report the surgical technique and early outcomes of robot-assisted ureterocalicostomy (RAUC) with near-infrared fluorescence (NIRF) in the management of secondary pelvi-ureteric junction obstruction (PUJO) in adults. Materials and Methods: The data of 6 patients who underwent RAUC using Da Vinci Xi system with NIRF technology between November 2017 and April 2019 were retrospectively reviewed. Indication was secondary PUJO due to previous failed pyeloplasty. The outcome variables evaluated include operative time (total and console), length of hospital stay, blood loss, and complications. Success was defined as the absence of pain and radionuclide scan demonstrating nonobstructive drainage and improvement/stabilization of split function of the renal moiety. Results: The mean (range) patient age was 33.7 (18-41) years. Total mean (range) operating time was 178 (140-240) minutes and mean console time was 135 minutes. Estimated mean blood loss was 115 (50-200) mL and average hospital stay was 6.1 (5-8) days. There were no conversions to open or laparoscopic surgery. Clavien-Dindo complications occurred in 2 patients. (Grade I-1 and Grade II-1). After a median (range) follow-up of 15 (6-22) months, all 6 patients had successful clinical and radiological outcomes. Conclusion: RAUC is a safe and feasible technique with acceptable outcomes in the setting of secondary PUJO. The utility of NIRF in determining vascularity of the ureter seems to be promising in this setting. Multi-institutional prospective studies with large patient cohort are necessary to validate the role of robotic platform in ureterocalicostomy in the reoperative settings.

Toxic erythema of chemotherapy is an umbrella term encompassing a range of reactions characterized by symmetric erythematous to dusky patches, which can develop oedema, desquamation and/or purpura. We describe an elderly patient with prostate cancer who developed this complication while receiving docetaxel chemotherapy, presenting with prominent mucosal and periorificial involvement, along with epidermal necrosis, closely mimicking toxic epidermal necrolysis.

Primary urinary bladder amyloidosis is a rare disease. Its importance lies in the ability of the disease to masquerade the carcinoma urinary bladder in clinical presentation and imaging but with a distinctively contrasting treatment. The commonest presentation is painless hematuria. Definitive diagnosis is made on histopathology and by ruling out systemic amyloidosis. Here, we report a 60-year-old male presenting with lower abdomen pain diagnosed with primary urinary bladder amyloidosis and discuss the management based on current literature.

Deep learning has led to many recent advances in object detection and instance segmentation, among other computer vision tasks. These advancements have led to wide application of deep learning based methods and related methodologies in object detection tasks for satellite imagery. In this paper, we introduce MIS Check-Dam, a new dataset of check-dams from satellite imagery for building an automated system for the detection and mapping of check-dams, focusing on the importance of irrigation structures used for agriculture. We review some of the most recent object detection and instance segmentation methods and assess their performance on our new dataset. We evaluate several single stage, two-stage and attention based methods under various network configurations and backbone architectures. The dataset and the pre-trained models are available at https://www.cse.iitb.ac.in/gramdrishti/.

E Compendium of invited lectures and abstracts of the National Online Training Programme on “Conservation, Management and Utilization of Horticultural Genetic Resources for Livelihood and Nutritional Security” held during November, 22-26, 2021 organized by ICAR-IIHR, Bengaluru in association with the Society for Promotion of Horticulture, Bengaluru.ISBN 978-93-5508-005-9 Rajashekaran P.E., Rajiv Kumar, Sridhar Gutam, Rohini M.R., Linta Vincent and Anushma P.L. (2021)

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.

It is generally believed that high energy radiation (power-law components) can be mostly produced by a hot corona gas in the accreting black holes. There is a very popular hybrid disk radial coupling model that the inner part of cool Keplerian disk (or Shakura-Sunyaev disk) can produce advection-dominated accretion flow or corona-like structure, which can also generate outflows/jets. Here we argue that this simple coupling model cannot explain the whole hardness-intensity diagram of the spectral states and their transitions, and associated jets of a $X-$ray binary. Based on recent theoretical works on advective disk structures around a black hole, as well as many observational behaviors of a source, we conclude that there should be a third component of hot accretion flow with the radial coupling model, which can successfully explain all the spectral states and transitions. Interestingly, this model also provides a new scenario for the jet generation, launching, and evolution during the states with help of created barrier of the inner flow. We have also find out the jet kinetic power expression with our new jet generation scenario., Comment: 8 pages, 3 figures, submitted to ApJ, comments are welcome

Additional file 6: Table S6. List of different post-translational modifications observed at peptide level using ModPred. Also, detailed list of ADP-ribosylated and phosphorylated peptides and their protein identifiers along with modified residues.

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. We project that sample sizes required to explain 80% of GWAS heritability vary from 60,000 cases for testicular to over 1,000,000 cases for lung cancer. The maximum relative risk achievable for subjects at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, ranges from 12 for testicular to 2.5 for ovarian cancer. We show that PRS have potential for risk stratification for cancers of breast, colon and prostate, but less so for others because of modest heritability and lower incidence.

The safety of optimal management of acute sub-massive or massive pulmonary embolism (PE) with thrombolytic agents remains unclear.[1][1] Thrombolytic agents reduce mortality and improve right ventricular function, but increase the risk of major haemorrhage and stroke.[2–4][2] Our project reviews

Figure S1. mRNA expression of ETS transcription factors and downstream targets in tumor tissue. Figure S2. Expression of Ets-factors and TERT in TCGA RNA sequencing data sets. Figure S3. Evaluation of TP53 and CDKN2A/Rb signaling pathways. Figure S4. Activation levels of MEK, ERK and ETS1. Figure S5. Anti-proliferative effects of BRAF inhibitors. Figure S6. Inhibition of TERT expression upon vemurafenib treatment. Figure S7. ETS1 inhibition upon vemurafenib treatment. Figure S8. Changes in expression patterns in patient tissue upon targeted treatment. Figure S9. Ectopic TERT re-expression partly rescues double-mutant glioma cells from YK-4-279- mediated cytotoxicity. Figure S10. Combined BRAF and Ets-factor inhibition. (PDF 786 kb)

In this paper, we proposed a fast recovery strategy for a dual link failure in elastic optical network. The elastic optical network is a promising solution to meet the next generation higher bandwidth demand. The survivability of high speed network is very crucial. As the network size increases the probability of the dual link failure and node failure also increases. Here, we proposed a parallel cross connection backup recovery strategy for dual link failure in the network. Proposed strategy shows lower bandwidth blocking probability (BBP), fast connection recovery, and bandwidth provisioning ratio when compared with the existing shared path protection (SPP) and dedicated path protection (DPP) approaches. Simulation is performed on ARPANET and COST239 topology networks., Comment: 12 pages, 5 figures

Let $S=\mathbb{K}[x_1,\dots, x_n]$ be a polynomial ring, where $\mathbb{K}$ is a field, and $G$ be a simple graph on $n$ vertices. Let $J(G)\subset S$ be the vertex cover ideal of $G$. Herzog, Hibi and Ohsugi have conjectured that all powers of vertex cover ideals of chordal graph are componentwise linear. Here we establish the conjecture for the special case of trees. We also show that if $G$ is a unicyclic vertex decomposable graph that does not contain $C_3$ or $C_5$, then symbolic powers of $J(G)$ are componentwise linear., Comment: Title has been changed and some figures has been added. Some minor changes are there

Cooperative Multi-agent Reinforcement Learning (MARL) is crucial for cooperative decentralized decision learning in many domains such as search and rescue, drone surveillance, package delivery and fire fighting problems. In these domains, a key challenge is learning with a few good experiences, i.e., positive reinforcements are obtained only in a few situations (e.g., on extinguishing a fire or tracking a crime or delivering a package) and in most other situations there is zero or negative reinforcement. Learning decisions with a few good experiences is extremely challenging in cooperative MARL problems due to three reasons. First, compared to the single agent case, exploration is harder as multiple agents have to be coordinated to receive a good experience. Second, environment is not stationary as all the agents are learning at the same time (and hence change policies). Third, scale of problem increases significantly with every additional agent. Relevant existing work is extensive and has focussed on dealing with a few good experiences in single-agent RL problems or on scalable approaches for handling non-stationarity in MARL problems. Unfortunately, neither of these approaches (or their extensions) are able to address the problem of sparse good experiences effectively. Therefore, we provide a novel fictitious self imitation approach that is able to simultaneously handle non-stationarity and sparse good experiences in a scalable manner. Finally, we provide a thorough comparison (experimental or descriptive) against relevant cooperative MARL algorithms to demonstrate the utility of our approach.

Table S1. Antibodies. Table S2. Primers. Table S3. Histopathological, molecular and clinical parameters of the Vienna patient cohort. (DOCX 16 kb)

Ferrari, Andrea/0000-0002-4724-0517; Pellegrini, Cristina/0000-0003-2168-8097; Migliano, Emilia/0000-0002-5316-8937; Maisonneuve, Patrick/0000-0002-5309-4704; Guida, Stefania/0000-0002-8221-6694; Pastorino, Lorenza/0000-0002-2575-8331; CARRERA, CRISTINA/0000-0003-1608-8820; Paillerets, Brigitte Bressac-de/0000-0003-0245-8608; Sekulovic, Lidija Kandolf/0000-0002-5221-5068; Caini, Saverio/0000-0002-2262-1102; Potrony, Miriam/0000-0003-2766-0765; Pizzichetta, Maria Antonietta/0000-0002-4201-8490; Little, Julian/0000-0001-5026-5531; Nagore, Eduardo/0000-0003-3433-8707; Polsky, David/0000-0001-9554-5289; Demenais, Florence/0000-0001-8361-0936; Nazzaro, Gianluca/0000-0001-8534-6497; gandini, sara/0000-0002-1348-4548; Cornelius, Lynn A/0000-0002-6329-2819; Palmieri, Giuseppe/0000-0002-4350-2276; Cotignola, Javier/0000-0003-4473-9854; Ghiorzo, Paola/0000-0002-3651-8173; Autier, Philippe/0000-0003-1538-5321; Bishop, Tim/0000-0002-8752-8785; Sera, Francesco/0000-0002-8890-6848; Newton-Bishop, Julia/0000-0001-9147-6802; Litchfield, Melisa/0000-0003-0002-7724, WOS: 000464254100018, PubMed: 30872112, Background Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods in this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1.54, 95% CI 1.02-2.33), including when analysis was restricted to patients aged 18 years or younger (1.80, 1.06-3.07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1.60, 95% CI 1.05-2.44; p=0.04) and Asp294His (2.15, 1.05-4.40; p=0.04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Copyright (c) 2019 Elsevier Ltd. All rights reserved., [AIRC-MFAG-11831]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P30CA016086, P01CA206980, P30CA016086, P30CA016086] Funding Source: NIH RePORTER, SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831.

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent melanoma GWAS meta-analysis (12,874 cases, 23,203 controls), SNPs near GPRC5A, CYP1B1, PPARGC1B, HDAC4, FAM208B, DOCK8, and SYNE2 reached global significance, and other loci, including MIR146A and OBFC1, reached a suggestive level. Overall, we conclude that most nevus genes affect melanoma risk (KITLG an exception), while many melanoma risk loci do not alter nevus count. For example, variants in TERC and OBFC1 affect both traits, but other telomere length maintenance genes seem to affect melanoma risk only. Our findings implicate multiple pathways in nevogenesis., Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count.