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Alteration in the pattern of epigenetic marking leads to cancer, neurological disorders, inflammatory problems etc. These changes are due to aberration in histone modification enzymes that function as readers, writers and erasers. Bromodomains (BDs) and BET proteins that recognize acetylation of chromatin regulate gene expression. To block the function of any of these BrDs and/or BET protein can be a controlling agent in disorders such as cancer. BrDs and BET proteins are now emerging as targets for new therapeutic development. Traditional drugs like enzyme inhibitors and protein–protein inhibitors have many limitations. Recently Proteolysis-Targeting Chimeras (PROTACs) have become an advanced tool in therapeutic intervention as they remove disease causing proteins. This review provides an overview of the development and mechanisms of PROTACs for BRD and BET protein regulation in cancer and advanced possibilities of genetic technologies in therapeutics.

Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer. Quinoline and isoquinoline derivatives have shown their possibilities to work as an antitumor agent in anticancer treatment. The members of this privileged scaffold quinoline and isoquinoline have shown their controlling impacts on cancer treatment through various modes. In particular, this review suggests the current scenario of quinoline and isoquinoline derivatives as antitumor agents and refine the path of these derivatives to find and develop new drugs against an evil known as cancer.

BackgroundMetals are one of the micro molecules required by living cell to do their biochemical functions. Out of a list of metals few are very important and useful to cells while few are required in very minute amount and their higher concentration harm or cause adverse effects on living forms. Copper and ferrous are commonly counted as essential metals to plant cells but sometimes their higher concentration is harmful to plant cells. Copper is commonly counted as important metal to plant cells but sometimes their higher concentration is harmful to plant cells.ResultsIt was found that higher concentration of copper and ferrous showed reduction in germination percentages and gemination time of investigated plant while chromium shown lethal impacts on seed germinationConclusionsIn the present study effects of copper, chromium and nickel was studied for total sugar and protein content of widely cultivated pulses i.e. Glycine max. Collectively present study showed that higher concentration of copper and nickel has adverse effects on Glycine max total sugar and protein content while chromium has lethal impacts at lower concentration also.

All the heritable alterations in gene expression and chromatin structure due to chemical modifications that do not involve changes in the primary gene nucleotide sequence are referred to as epigenetics. DNA methylation, histone modifications, and non-coding RNAs are distinct types of epigenetic inheritance. Epigenetic patterns have been linked to the developmental stages, environmental exposure, and diet. Therapeutic strategies are now being developed to target human diseases such as cancer with mutations in epigenetic regulatory genes using specific inhibitors. Within the past two decades, seven epigenetic drugs have received regulatory approval and many others show their candidature in clinical trials. The current article represents a review of epigenetic heritance, diseases connected with epigenetic alterations and regulatory approved epigenetic drugs as future medicines.

Barleria prionitis (Acanthaceae) is an important medicinal plant distributed throughout the various regions of India and useful in urinary and paralytic affection, stomach disorders, catarrh, cough and anasaraca and lacerated sole. In the present investigation an attempt was made to study the anatomy of root, stem, lamina, midrib, petiole, stomata and trichomes as well as histochemical localization of various substances viz., calcium oxalate, lignin, suberin, lipids in the organs of Barleria prionitis. The present study revealed that the plant distinguishing microcharacters viz., bicollateral vascular bundles, internal phloem, uni - biseriate xylem rays, inverted omega shape vascular bundle, diacytic stomata and eglandular as well as glandular trichomes which are useful in solving taxonomic problems and pharmacognosy. They have significance in identification of crude drugs from this taxon.