8 results on '"L., Buti"'
Search Results
2. Clinician attitudes, social norms and intentions to use a computer-assisted intervention
- Author
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Dennis McCarty, Allison L. Buti, Lynn E. Kunkel, Aisha G. Kudura, Holly E. Fussell, and Danielle Eakins
- Subjects
Adult ,Male ,Psychotherapist ,Attitude of Health Personnel ,Substance-Related Disorders ,education ,Psychological intervention ,Medicine (miscellaneous) ,Intention ,Social Environment ,Article ,Young Adult ,Social norms approach ,Sex Factors ,Intervention (counseling) ,Ethnicity ,Computer-Assisted Intervention ,medicine ,Humans ,Aged ,Internet ,Age Factors ,Health Plan Implementation ,Social environment ,Middle Aged ,medicine.disease ,Substance abuse ,Alcoholism ,Psychiatry and Mental health ,Clinical Psychology ,Socioeconomic Factors ,Models, Organizational ,Therapy, Computer-Assisted ,Educational Status ,Female ,Implementation research ,Pshychiatric Mental Health ,Psychology ,Psychosocial ,Clinical psychology - Abstract
The National Drug Abuse Treatment Clinical Trials Network (CTN) works to bridge the gap between research and practice and tested a Web-delivered psychosocial intervention (the Therapeutic Education System, TES) in 10 community treatment centers. Computer-assisted therapies, such as Web-delivered interventions, may improve the consistency and efficiency of treatment for alcohol and drug use disorders. Prior to the start of the study, we surveyed counselors ( N =96) in participating treatment centers and assessed counselor attitudes, perceived social norms and intentions to use a Web-delivered intervention. Analysis of the intention to adopt a Web-delivered intervention assessed the influence of attitudes and perceived social norms. Perceived social norms were a significant contributor to clinician intention to adopt Web-based interventions while attitude was not. To promote successful implementation, it may be helpful to create social norms supportive of computer-assisted therapies.
- Published
- 2013
3. Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2
- Author
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L Buti, C.E. Stebbins, Xin Lu, and Dragana Nesic
- Subjects
Models, Molecular ,Protein Conformation ,Virulence ,Plasma protein binding ,Biology ,digestive system ,Helicobacter Infections ,Protein structure ,Bacterial Proteins ,Humans ,CagA ,Genes, Tumor Suppressor ,Binding site ,Gene ,Genetics ,Antigens, Bacterial ,Binding Sites ,Multidisciplinary ,Helicobacter pylori ,Point mutation ,Biological Sciences ,bacterial infections and mycoses ,Molecular biology ,In vitro ,digestive system diseases ,bacteria ,Apoptosis Regulatory Proteins - Abstract
The Cytotoxin associated gene A (CagA) protein of Helicobacter pylori is associated with increased virulence and risk of cancer. Recent proteomic studies have demonstrated an association of CagA with the human tumor suppressor Apoptosis-stimulating Protein of p53-2 (ASPP2). We present here a genetic, biochemical, and structural analysis of CagA with ASPP2. Domain delineation of the 120-kDa CagA protein revealed a stable N-terminal subdomain that was used in a yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target. Biochemical experiments confirm this interaction. The cocrystal structure to 2.0-Å resolution of this N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain of CagA forms a highly specialized three-helix bundle, with large insertions in the loops connecting the helices. These insertions come together to form a deep binding cleft for a highly conserved 20-aa peptide of ASPP2. ASPP2 forms an extended helix in this groove of CagA, burying more than 1,000 Å(2) of surface area. This interaction is disrupted in vitro and in vivo by structure-based, loss-of-contact point mutations of key residues in either CagA or ASPP2. Disruption of CagA and ASPP2 binding alters the function of ASPP2 and leads to the decreased survival of H. pylori-infected cells.
- Published
- 2016
4. Herniated Lumbar Discs: Diagnosis and Management
- Author
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Rebecca L. Buti
- Subjects
Adult ,medicine.medical_specialty ,Lumbar Vertebrae ,Primary Health Care ,medicine.diagnostic_test ,business.industry ,Nurse practitioners ,Primary health care ,MEDLINE ,Physical examination ,Lumbar vertebrae ,medicine.anatomical_structure ,Lumbar ,Risk Factors ,medicine ,Physical therapy ,Humans ,Female ,Nurse Practitioners ,Medical History Taking ,business ,Physical Examination ,Intervertebral Disc Displacement ,General Nursing - Published
- 1998
5. Therapist predictors of treatment delivery fidelity in a community-based trial of 12-step facilitation
- Author
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Joseph Guydish, Barbara K. Campbell, Allison L. Buti, Priya Srikanth, Dennis McCarty, and Holly E. Fussell
- Subjects
Counseling ,Male ,Comparative Effectiveness Research ,Health Knowledge, Attitudes, Practice ,Multivariate analysis ,Medicine (miscellaneous) ,Therapist characteristics ,7.1 Individual care needs ,Psychology ,Medicine ,12 step facilitation ,media_common ,Community based ,Guideline adherence ,Substance Abuse ,Professional-Patient Relations ,Middle Aged ,Community Mental Health Services ,Psychiatry and Mental health ,Clinical Psychology ,Self-Help Groups ,Treatment delivery ,Evidence-Based Practice ,Public Health and Health Services ,Female ,Clinical Competence ,Guideline Adherence ,Substance Abuse Treatment Centers ,Adult ,medicine.medical_specialty ,Evidence-based practice ,Attitude of Health Personnel ,Substance-Related Disorders ,media_common.quotation_subject ,Clinical Trials and Supportive Activities ,treatment fidelity ,Fidelity ,behavioral disciplines and activities ,Article ,Physical medicine and rehabilitation ,Clinical Research ,Behavioral and Social Science ,Humans ,business.industry ,twelve-step facilitation ,Multivariate Analysis ,Physical therapy ,business ,Follow-Up Studies - Abstract
Background and aims: Therapist characteristics may be associated with variation in consistency, quality and effectiveness of treatment delivery. We examined associations between treatment fidelity and therapist education, experience, treatment orientation and perceived skills in a randomized, multi-site trial of Twelve Step Facilitation (TSF). Methods: Raters scored audio-recorded, TSF sessions (n = 966; 97% of TSF sessions) from 32 community-based, trained therapists for adherence, competence, empathy and global session performance. Results: Therapists with graduate degrees had significantly higher adherence and global performance fidelity ratings. Therapists reporting more positive attitudes toward 12-Step groups had lower adherence ratings. Being in recovery was associated with lower fidelity in univariate tests, but higher adherence in multivariate analysis. Fidelity was higher for therapists reporting self-efficacy in basic counseling skills and lower for self-efficacy in addiction-specific counseling skills. Fidelity was also superior in group relative to individual TSF sessions. Conclusions: Results have implications for therapist selection, training and supervision in community-based, effectiveness trials and community implementation of evidence-based treatments. To obtain high fidelity and improve outcomes, it may be preferable to choose masters level therapists who are open to learning new treatments and have good, general counseling skills. © 2013 Informa Healthcare USA, Inc.
- Published
- 2013
6. Winter Depression: Integrating mood, circadian rhythms, and the sleep/wake and light/dark cycles into a bio-psycho-social-environmental model
- Author
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Steven C. Fiala, Alfred J. Lewy, Jonathan S. Emens, Allie L. Buti, Jeannie B. Songer, Amber Laurie, and Neelam Sims
- Subjects
medicine.medical_specialty ,Evening ,business.industry ,Chronotype ,General Medicine ,Audiology ,medicine.disease ,Article ,Melatonin ,Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Dark therapy ,medicine ,Free-running sleep ,Neurology (clinical) ,Circadian rhythm ,Bipolar disorder ,business ,Psychiatry ,medicine.drug ,Morning - Abstract
The phase shift hypothesis (PSH) states that most patients with SAD become depressed in the winter because of a delay in circadian rhythms with respect to the sleep/wake cycle: According to the PSH, these patients should preferentially respond to the antidepressant effects of bright light exposure when it is scheduled in the morning so as to provide a corrective phase advance and restore optimum alignment between the circadian rhythms tightly coupled to the endogenous circadian pacemaker and those rhythms that are related to the sleep/wake cycle. Recent support for the PSH has come from studies in which symptom severity was shown to correlate with the degree of circadian misalignment: it appears that a subgroup of patients are phase advanced, not phase delayed; however, the phase-delayed type is predominant in SAD and perhaps in other disorders as well, such as non-seasonal unipolar depression. It is expected that during the next few years the PSH will be tested in these and other conditions, particularly since healthy subjects appear to have more severe symptoms of sub-clinical dysphoria correlating with phase-delayed circadian misalignment; critically important will be the undertaking of treatment trials to investigate the therapeutic efficacy of morning bright light or afternoon/evening low-dose melatonin in these disorders in which symptoms are more severe as the dim light melatonin onset (DLMO) is delayed with respect to the sleep/wake cycle (non-restorative sleep should also be evaluated, as well as bipolar disorder). The possibility that some individuals (and disorders) will be of the phase-advanced type should be considered, taking into account that the correct timing of phase-resetting agents for them will be bright light scheduled in the evening and/or low-dose melatonin taken in the morning. While sleep researchers and clinicians are accustomed to phase-typing patients with circadian-rhythm sleep disorders according to the timing of sleep, phase typing based on the DLMO with respect to the sleep/wake cycle may lead to quite different recommendations for the optimal scheduling of phase-resetting agents, particularly for the above disorders and conditions.
- Published
- 2010
7. The phase shift hypothesis and the bio-psycho-social-environmental model
- Author
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Alfred J. Lewy, Steven C. Fiala, Amber Laurie, Jeannie B. Songer, Allie L. Buti, Jonathan S. Emens, and Neelam Sims
- Subjects
Biopsychosocial model ,Psychology ,Cognitive psychology ,Environmental model - Published
- 2009
8. GD-Workbench: A System for Prototyping and Testing Graph Drawing Algorithms
- Author
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Francesco Vargiu, Luciano Buti, Luca Vismara, Giuseppe Liotta, Emanuele Tassinari, Giuseppe Di Battista, Franz-Josef Brandenburg, L., Buti, DI BATTISTA, Giuseppe, G., Liotta, E., Tassinari, F., Vargiu, and L., Vismara
- Subjects
Diagrammatic reasoning ,Wait-for graph ,Exploit ,Graph drawing ,Computer science ,Graph editor ,Workbench ,Graph (abstract data type) ,Biconnected graph ,Algorithm - Abstract
We present a tool for quick prototyping and testing graph drawing algorithms. The user interacts with the system through a diagrammatic interface. Algorithms are visually displayed as directed paths in a graph. The user can specify an algorithm by suitably combining the edges of a path. The implementation exploits the powerful functionalities of Diagram Server and has been experimented both as a research support tool and as a back-end of an industrial application.
- Published
- 1996
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