1. Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers
- Author
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Voisin P, Lecommandoux S, Bouchaud, Le Meins Jf, Ibarboure E, Ambikanandan Misra, Kamal Kumar Upadhyay, Schatz C, Pharm Dept, Fac Technol & Eng, Univ Baroda, University of Baroda, India, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Centre de résonance magnétique des systèmes biologiques (CRMSB), and Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)
- Subjects
polypeptide ,Polymers and Plastics ,Polymers ,Bioengineering ,Antineoplastic Agents ,block copolymer ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biomaterials ,chemistry.chemical_compound ,Cell Line, Tumor ,Hyaluronic acid ,Materials Chemistry ,Copolymer ,Humans ,Hyaluronic Acid ,targeting ,vesicle ,Polyglutamate ,Brain Neoplasms ,Vesicle ,Molecular Mimicry ,Glioma ,biomimetic ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,[CHIM.POLY]Chemical Sciences/Polymers ,Biochemistry ,chemistry ,Polyglutamic Acid ,Doxorubicin ,polysaccharide ,Drug delivery ,Polymersome ,Biophysics ,Click chemistry ,0210 nano-technology ,Drug carrier - Abstract
International audience; Using "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and as a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.
- Published
- 2009
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