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Background: With rapid socioeconomic development and transition, associations between socioeconomic status (SES) and hypertension remained uncertain in China. We aimed to examine the health effects of SES on hypertension incidence and explore the sex differences among Chinese adults. Methods: We included 53 891 participants without hypertension from the China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) project. SES was evaluated by education level, occupation prestige, and household monthly per capita income, and categorized into low, medium, and high groups. Hazard ratios and their 95% CIs were calculated using Cox proportional hazards regression models. Results: Compared with high SES, participants with medium SES (hazard ratio, 1.142 [95% CI, 1.068–1.220]) or low SES (hazard ratio, 1.166 [95% CI, 1.096–1.241]) had increased risks of incident hypertension in multivariate analyses. Interactions between SES and sex on hypertension were observed, with more pronounced adverse effects of lower SES among women. The corresponding hazard ratios (95% CIs) for low SES group were 1.270 (1.155–1.397) for women and 1.086 (0.999–1.181) for men. Effects of occupation prestige on hypertension were the strongest among SES factors. Conclusions: Our study provided the compelling evidence from China that lower SES was associated with incident hypertension and women were more susceptible. These findings will have substantial implications on future hypertension prevention and management, especially among women. Sex-specific approaches are warranted to reduce socioeconomic disparities.

ObjectiveTo examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations.MethodsFine and Grey’s models were used to calculate HRs and their corresponding 95% CIs, as well as the lifetime risk of CVH metrics across Polygenic Risk Score (PRS) categories.ResultsWe included 39 755 individuals aged 30–75 years in Chinese prospective cohorts. 1275 CAD cases were recorded over a mean follow-up of 12.9 years. Compared with unfavourable CVH profile (zero to three ideal CVH metrics), favourable CVH profile (six to seven ideal CVH metrics) demonstrated similar relative effects across PRS categories, with the HRs of 0.40 (95% CI 0.24 to 0.67), 0.41 (95% CI 0.32 to 0.52) and 0.36 (95% CI 0.26 to 0.52) in low (bottom quintile of PRS), intermediate (two to four quintiles of PRS) and high (top quintile of PRS) PRS categories, respectively. For the absolute risk reduction (ARR), individuals with high PRS achieved the greatest benefit from favourable CVH, mitigating the risk to the average level of population (from 21.1% to 8.7%), and the gradient was strengthened in individuals at the top 5% of PRS. Moreover, compared with individuals at low PRS, those at high PRS obtained longer CAD-free years (2.6 vs 1.1) from favourable CVH at the index age of 35 years.ConclusionFavourable CVH profile reduced the CAD relative risk by similar magnitude across PRS categories, while the ARR from favourable CVH was most pronounced in high PRS category. Attaining favourable CVH should be encouraged for all individuals, especially in individuals with high genetic susceptibility.

We aimed to estimate the effects of indoor and outdoor temperature on wintertime blood pressure (BP) among peri-urban Beijing adults.We enrolled 1279 adults (ages: 40-89 years) and conducted measurements in two winter campaigns in 2018-2019 and 2019-2020. Study staff traveled to participant homes to administer a questionnaire and measure brachial and central BP. Indoor temperature was measured in the 5 min prior to BP measurement. Outdoor temperature was estimated from regional meteorological stations. We used multivariable mixed-effects regression models to estimate the within-individual and between-individual effects of indoor and outdoor temperatures on BP.Indoor and outdoor temperatures ranged from 0.0 to 28 °C and -14.3 to 6.4 °C, respectively. In adjusted models, a 1 °C increase in indoor temperature was associated with decreased SBP [-0.4 mmHg, 95% confidence interval (CI): -0.7 to -0.1 (between-individual; brachial and central BP); -0.5 mmHg, 95% CI: -0.8 to -0.2 (within-individual, brachial BP); -0.4 mmHg, 95% CI: -0.7 to -0.2 (within-individual, central BP)], DBP [-0.2 mmHg, 95% CI:-0.4 to -0.03 (between-individual); -0.3 mmHg, 95% CI: -0.5 to -0.04 (within-individual)], and within-individual pulse pressure [-0.2 mmHg, 95% CI: -0.4 to -0.04 (central); -0.3 mmHg, 95% CI: -0.4 to -0.1 (brachial)]. Between-individual SBP estimates were larger among participants with hypertension. There was no evidence of an effect of outdoor temperature on BP.Our results support previous findings of inverse associations between indoor temperature and BP but contrast with prior evidence of an inverse relationship with outdoor temperature. Wintertime home heating may be a population-wide intervention strategy for high BP and cardiovascular disease in China.

The aim of this study was to explore the association of lifelong smoking status with risk of major adverse cardiovascular events (MACE) accounting for weight change in a Chinese cohort.The cohort of the People's Republic of China-United States of America (PRC-USA) Collaborative Study of Cardiovascular and Cardiopulmonary Epidemiology was established in 1983 to 1984, resurveyed during 1987 to 1988 and 1993 to 1994, and followed up to 2005. A total of 5,849 participants who survived in 1993 to 1994 were classified into never smokers, long-term quitters, short-term quitters, short-term relapsers and new smokers, long-term relapsers and new smokers, and persistent smokers according to the information on lifelong smoking status collected in all three surveys. The associations of lifelong smoking status with MACE in the subsequent 10 years were explored with Cox proportional hazards models.During a median follow-up of 10.2 years, 694 participants had MACE. Compared with persistent smokers, the multivariable-adjusted hazard ratio of developing MACE was 0.83 (95% CI: 0.61-1.12) for short-term quitters, 0.75 (95% CI: 0.54-1.02) for long-term quitters, and 0.68 (95% CI: 0.54-0.85) for never smokers (pLifelong smoking status is significantly associated with risk of MACE. As time duration increased, health benefit to quitters would become close to that of never smokers, and harms to relapsers and new smokers would become close to that of persistent smokers.

The introduction of a graphene interlayer contributes to an ultrafast and high-responsivity self-powered photodetector using a WSe2–graphene–MoTe2 van der Waals heterojunction.

Xanthene-modified cyanine dyes are considered to be an effective means to extend the emission wavelength and improve the photo-stability of cyanine dyes. However, the fluorophores obtained by this strategy generally have narrow Stokes shifts, which severely limits their application in biological imaging. Herein, a reasonable design strategy is adopted to provide an effective strategy to commendably improve the Stokes shift of xanthene-benzothiozolium fluorophores

The optimized electron transport layer by an anion–cation synergistic doping strategy has strikingly boosted the photoelectric performance of a polycrystalline CH3NH3PbCl3 device.

Circularly polarized (CP) light has attracted wide attention for its great potential in broad applications. However, it remains a challenge to generate left-handed and right-handed circularly polarized (LCP and RCP) light from cellulose nanocrystal (CNC)-based materials only with an intrinsic left-handed chiral structure, owing to the pattern of CP light emission primarily based on the chirality of materials. Herein, a separation structure of luminophore layers and chiral CNCs was provided to achieve dual-mode CP light emission by building a luminophore-chiral CNC interface. By directly exciting the back and front of two-layer films, LCP and RCP light could be easily emitted without any assisting means and specific setting angles. In addition, owing to the formation of the luminophore-chiral CNC interface, metal-enhanced fluorescence (MEF) was achieved to offset the brightness loss caused by circular polarization. By incorporating gold triangular nanoprisms in CNC chiral layers, the fluorescence enhancement of the ensemble was as high as 6.5-fold. The decisive role of the luminophore-chiral CNC interface in enhancing luminescence and dual-mode CP light emission was carefully investigated by contrasting the systems with and without luminophore-chiral CNC interfaces in this study. We believe that this dual-mode CP light emission film with MEF enables a promising approach to extending the application of CP light materials.

The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to fruit intake > 100 g/day across the genetic risk categories were observed (28–32%), but the absolute risk reductions were relatively larger in the highest genetic risk group (p for trend = 0.03). In comparison to those with a fruit intake < 200 g/week, those with a fruit intake >100 g/day in the low, intermediate, and high genetic risk groups had an average of 1.45 (95% CI, 0.61–2.31), 2.12 (1.63–2.59), and 2.19 (1.13–3.22) additional stroke-free years at aged 35, respectively. Our findings suggest that individuals with a high genetic risk could gain more absolute risk reductions and stroke-free years than those with a low genetic risk from increasing fruit intake for the stroke primary prevention.

Although both environmental and genetic factors were linked to coronary artery disease (CAD), the extent to which the association of air pollution exposure with CAD can be influenced by genetic risk was not well understood.A total of 41,149 participants recruited from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) were included. Genetic risk scores of CAD were constructed based on 540 genetic variants. Long-term PMDuring a median of 13.01 years of follow-up, 1,373 incident CAD events were observed. Long-term PMThis study provided evidence that long-term PM

An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). For the introduction of a preorganized isopropylamino group on the aromatic

The ambient stability and processability of organic solar cells (OSCs) are important factors for their commercialization. Herein, we selected four benzo[1,2-b:4,5-b']difuran (BDF) polymers and two electron acceptors to examine the role of photovoltaic materials in the ambient stability. The investigations revealed that the MoOx layer is the detrimental factor for the ambient stabilities. The penetration of MoOx into the active layer and their interactions will strengthen the interface and form a favorable contact, hence leading to the increased photovoltaic performance, in which the efficiency loss induced by air was balanced out. As such, these BDF polymer-based non-fullerene (NF) OSCs possessed very promising ambient stabilities even after ∼1000 h with the almost maintained power conversion efficiencies (PCEs). These results drive us to further investigate the ambient processability of these NF-OSCs. The PCEs from the devices processed under ambient condition only possessed 0.3-2% loss compared to those devices under inert conditions, which suggest the significant potentials of BDF polymers to develop highly efficient and stable NF-OSCs for the practical applications.

AIM This study aimed to determine the causal association between salt added to food and body mass index (BMI) by integrating a summary-level genome-wide association study (GWAS) data. METHODS We performed two-sample Mendelian randomisation (MR) analyses using summary statistics of GWAS. Inverse-variance weighted (IVW), maximum likelihood estimation, and random effect model were used to analyse the effect of salt added to food on BMI. A bidirectional MR analysis with BMI as the exposure and salt added to food as the outcome was also performed. RESULTS The single nucleotide polymorphisms (SNPs) were selected from the UK Biobank (n = 462 630) and a meta-analysis of 322 154 European-descent individuals. The IVW method estimate indicated that salt added to food was positively associated with BMI (β = 0.1416, SE = 0.0576, P = .0139). Results from maximum likelihood estimation (β = 0.1476, SE = 0.0363, P

In this study, we synthesized a novel benzo[1,2-b:4,5-b′]difuran (BDF) copolymer (F13-R) by introducing ester-substituted thiophene into the PDiFPBDF-TBz (F13) backbone aiming to finely tune the molecular stacking and aggregation for non-fullerene as-cast polymer solar cell (PSC) applications. Compared with F13, F13-R displayed a slight blue-shifted absorption, a deeper highest occupied molecular orbital (HOMO) energy level of −5.60 eV, and improved intermolecular stacking. In PSCs, it is found that the as-cast F13-R : IT-4F device, which does not need any solvent additive and thermal/solvent annealing, could achieve a power conversion efficiency (PCE) of 12.2% with an open-circuit voltage (Voc) of 0.904 V, a short-circuit current density (Jsc) of 17.61 mA cm−2 and a fill factor (FF) of 76.60%. The as-cast F13-R : IT-4F device is the first PSC fabricated from low-cost BDF polymers, and its performance is among the best performances in as-cast PSCs. These results demonstrate that fine-tuning the BDF polymer structure via a copolymer design could be an efficient strategy to develop low-cost and high-performance as-cast PSCs.

Semantic segmentation of remote-sensing imagery strives to assign a pixel-wise semantic label. Since encoder-decoder networks have demonstrated tremendous success in natural image semantic segmentation, the adoption and extension of this kind of method are transferring such superior performance for the problems in remote-sensing. Facing the high-altitude angle of imaging and complex and diverse ground objects of remote-sensing data, it is necessary to strengthen the features’ distinguishability by enhancing the network’s capability. Nevertheless, the existing methods suffer from the structural stereotype, leveraging the short-range and long-range contextual information insufficiently. Attempting to address the problems mentioned above, a hierarchical self-attention embedded neural network with dense connection for remote sensing image semantic segmentation (HSDCN) is proposed. In the encoder stage, multiple self-attention modules (SAM) are embedded to model pixel-wise and channel-wise relationships at various scales hierarchically, making the representations more refined and discriminative. Then the dense connections are used to fuse the heterogeneous features. Thus, the network could produce logical and reasonable clues for labeling pixels. The extensive experiments are conducted on ISPRS Vaihingen and Potsdam benchmarks. And the results reveal significant improvements in comparison with other state-of-the-art methods.

Background and aims Abdominal aortic calcification (AAC) has been introduced as a good predictor of cardiovascular disease (CVD) events, but no previous study has investigated the relationship between folate levels and AAC. The present study aims to explore the relationship between red blood cell (RBC) folate, a better indicator reflecting long-term folate intake, and severe AAC in the United States (US) middle-aged and elderly population. Methods and results Cross-sectional data were derived from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 of 2818 men and women aged 40 years or older. Multivariable logistic regression models were used to determine odds ratios (ORs) and 95% confidence intervals (CIs) for severe AAC of each RBC folate quintile category. The restricted cubic spline model was used for the dose–response analysis. A U-shaped dose–response relation between RBC folate and the odds of severe AAC was found after adjustment for multiple potential confounding factors, p for nonlinear = 0.0032. With the third quintile category of RBC folate as the reference, multivariable-adjusted ORs and 95% CIs of the lowest, second, fourth, and the highest quintile categories were 2.34 (1.37–4.00), 1.24 (0.70–2.19), 1.58 (0.92–2.70), and 2.26 (1.35–3.76), respectively. Conclusions Individuals with either low or high levels of RBC folate were at increased risks of severe AAC in a representative sample of US adults. While folate deficiency is widely recognized as harmful, these results highlight the need to investigate the potential adverse health outcomes of high folate level.

Non-radiative recombination loss (ΔEnon-rad) has become the main limiting factor for the power conversion efficiency (PCE) of organic solar cells (OSCs). Herein, two benzo[1,2-b:4,5-b′]difuran (BDF) polymers (P-FT and P-FP) in combination with two electron acceptors (m-ITIC and Y6) in OSCs were employed to systemically investigate the impact of molecular orientation and interaction on energy loss in OSCs. The use of the Y6 acceptor instead of ITIC provided a reduced energy loss in OSC, regardless of the donor used, and the energy loss was lower in OSC based on P-FP, as compared to that based on P-FT. ΔEnon-rad as small as 0.23 eV was obtained in the P-FP:Y6 device, due to the small energetic disorder. In addition, the P-FP:Y6 device also possessed a promising EQEmax of 86.7%. These results provide a deep understanding of the role molecular interactions between the polymer donor and acceptor play in reducing energy loss and promoting device performance through synergic selection and optimization of donor and acceptor in OSCs.

Solvent additive (SA) treatment is the most effective strategy to obtain highly efficient non-fullerene organic solar cells (NF-OSCs). However, NF-OSCs from SA treatment usually exhibit different or even opposite effects on photovoltaic performance compared with fullerene-based OSCs. Despite the rapid progress in NF-OSCs from SA treatment, the working mechanism of SAs in the morphological optimization of NF-OSCs and their role in affecting the photovoltaic performance are still controversial, and systematic investigations are needed. In this work, two kinds of SA, non-aromatic solvent additives (NSA: DIO, DBrO) and aromatic solvent additives (ASA: DPE, CN), were applied to the benzo[1,2-b:4,5-b′]difuran-based polymer PBDF-BDD and non-fullerene acceptor IT-4F to systemically investigate their effects on photovoltaic performance and their roles in the open-circuit voltage (Voc) and fill factor (FF). The SAs have a positive impact on the power conversion efficiencies of NF-OSCs, but completely opposite trends of Voc and FF were observed for NF-OSCs processed with NSAs and ASAs. The devices with NSA obtained higher FF than devices with ASA. However, the NSA-added devices exhibited a Voc drop of about 0.1 V with a large energy loss (Eloss); in contrast, devices with ASAs showed minor change on Voc and thereby on Eloss. Further investigations indicated that NSA and ASA have different effects on inducing the crystallization of either PBDF-BDD or IT-4F, resulting in different donor/acceptor interactions and interfaces, thus producing the changes in Eg, ECT and energetic disorder, which were further investigated through GIWAXS and energy loss mechanism.

ImportanceBlood lipids are the primary cause of atherosclerosis. However, little is known about relationships between rates of blood lipid changes and age and genetic risk.ObjectiveTo evaluate associations of blood lipid change rates with age and polygenic risk.Design, Setting, and ParticipantsThis cohort is from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China, which was established from 1998 to 2008. Participants were followed up until 2020 (mean [SD] follow-up, 13.8 [4.3] years) and received 4 repeated lipid measurements. Data analysis was performed from June to August 2022. A total of 47 691 participants with available genotype data were recruited, and 37 317 participants aged 18 years or older were included in the final analysis after excluding participants who were lost to follow-up or with major chronic diseases, and those without blood lipid measurements at baseline and any follow-up survey.ExposuresAge and polygenic risk scores based on 126 lipid-related genetic variants.Main Outcomes and MeasuresThe estimated annual changes (EAC) of blood lipids in milligrams per deciliter.ResultsThis study evaluated 37 317 participants (mean [SD] age of 51.37 [10.82] years; 15 664 [41.98%] were male). The associations of EACs of blood lipids with age differed substantially between male and female participants. Male participants experienced declining change as they got older for total cholesterol (EAC, 0.34 [95% CI, 0.14 to 0.54] mg/dL for age Conclusions and RelevanceIn this cohort study, EACs of blood lipids were significantly associated with age and polygenic risk, suggesting that prevention strategies for lipids should focus on individuals with high genetic risk and in the critical age window.

Although emerging studies from high-income countries investigated the relationship between sedentary behavior (SB) and cardiovascular risk, little evidence came from developing countries. Moreover, the benefits of reallocating time from SB to physical activity (PA) on incident cardiovascular disease (CVD) are unknown. Using three cohorts from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project, we included 93 110 adults who were free from CVD at baseline. Cox proportional hazards models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD, including stroke, coronary heart disease, and CVD death. Isotemporal substitution models were applied to estimate the per-hour effects of replacing SB with PA. After 5.8 years follow-up, 3799 CVD cases were identified. A gradient positive association between sedentary time and incident CVD was observed. Relative to those with

A new near-infrared fluorescent probe Qcy-OH with a turn-on mechanism based on a acceptor-donor-acceptor (ADA) π-electron system that can undergo an internal charge transfer to form new fluorochromes was developed for monitoring pH fluctuations in biological systems. With the pH value increases, Qcy-OH exhibited a strong pH-sensitive response from 1.1 to 9.0 (pKa = 4.41) and a good linear response from pH 3.0 to 5.5 in aqueous solution and in living cells. In addition, based on the phenolic and ketonic structure interconversions of the fluorescent backbone, Qcy-OH showed rapidly and reversibly response to pH with high selectivity. Because the introduce of two benzothiazolium units in the backbone of the probe as the electron-withdrawing group to enhance the selectivity for intracellular lysosomes, the probe had been applied successfully for tracking lysosomal pH changes and the fluorescence changes showed a good linear enhancement from pH 3.0 to 7.4 in living cells. We believe that this sulfur-driving lysosomes-targeting ability of the probe affords a guarantee for achieving long-term monitoring of lysosomal pH biology by the elimination of harmful protonating effects of the probe.

ObjectivesThis study aims to explore the associations between serum and red blood cell (RBC) folate as indicators of short- and long-term folate status, respectively, and all-cause as well as CVD mortality among hypertensive patients with elevated homocysteine.MethodsA prospective cohort study of the National Health and Nutrition Examination Survey (1999–2006) and 2015 Linked Mortality File was performed. All-cause and CVD mortality risk estimated using Cox proportional hazards models with adjusting for multiple potential covariates.ResultsA total of 1,753 hypertensive patients with elevated homocysteine [mean (SD) age, 68.5 (13.1)] were included in the analysis. During a median follow-up of 10.0 years, a total of 899 all-cause and 257 CVD deaths occurred. Compared the highest with the lowest quartile of RBC folate, the multivariable adjusted hazard ratios and 95% confidence intervals for all-cause and CVD death were 1.13 (0.92–1.39) and 1.47 (1.01–2.16) respectively. There was a significant and positive trend between RBC folate and the risk of CVD death (p for trend = 0.0196). No significant association was found between serum folate and mortality risk among the study sample.ConclusionsHigh level of RBC folate is associated with an increased risk of cardiovascular mortality among hypertensive patients with elevated homocysteine while serum folate has no such effects.

Considering the scarcity of palladium ion probes with subcellular organelle targeting, especially probes with near-infrared (NIR) emission wavelength fluorophores, our group has been working to overcome this problem and looking forward to providing potential practical tools for exploring the toxicity of palladium ions at the subcellular level. In this paper, a novel colorimetric and NIR fluorescent probe, BHCy-Pd, for the specific detection of palladium ions (Pd

Two indaceno­[1,2-b:5,6-b′]­difuran-based non-fullerene acceptors (NFAs) IDF-IC and IDF-4F were designed and synthesized. IDF-IC and IDF-4F showed strong absorptions in the visible and near-infrared (NIR) region with narrow bandgaps of 1.56–1.62 eV. The power conversion efficiencies (PCEs) of PM6:IDF-IC and PM6:IDF-4F devices were 7.80% and 7.81%, respectively, with open-circuit voltages (Voc’s) of 0.905 and 0.736 V, short-circuit current densities (Jsc’s) of 14.55 and 17.49 mA/cm2, and fill factors (FFs) of 59% and 61%. These results demonstrate that the fused-ring furan-based NFAs could be one of the promising building blocks in constructing high performance NFAs.

Achieving stable deep blue organic light emitting diodes (OLEDs) with narrow full width at half maximum (FWHM) and color gamut in the range of the commission International de L’Eclairage (CIE) of y ≤ 0.10 is still challenging in display and lighting applications. In this investigation, three donor-acceptor (D-A) deep-blue emitters were designed and synthesized via integrating asymmetric quinazoline (PQ) acceptor with weak donating carbazole (Cz) donor. The effect of the position and number of Cz group in PQ unit are investigated, which is also first examples for systematic research about the effect of different position of asymmetric PQ as acceptor on deep OLEDs. Their bandgaps of 3.12∼3.19 eV and the singlet state energy levels of 3.12∼3.19 eV were found to be sufficiently large to achieve deep blue light. As expected, these emitters-based OLEDs exhibit deep blue emission with the maximum wavelength ≤ 450 nm and narrow FWHM ≈ 60 nm. Especially, a CIE of y = 0.080 was achieved for 4PQ-Cz-based OLED. Significantly, the deep blue electroluminescence (EL) spectra of these three emitters-based OLEDs are very stable and the corresponding CIE coordinates deviation (ΔCIE (x, y)) can be negligible under the applied voltage ranging from 5 V to 9 V.

Background:. The association of milk intake with cardiovascular disease (CVD) and cause-specific mortality remained controversial and evidence among the Chinese population was limited. We aimed to study the relationship between milk intake and CVDs among general Chinese adults. Methods:. A total of 104,957 participants received questionnaire survey. Results of physical examination such as anthropometric measurements and biochemical tests during 2007 to 2008, demographic data and their information on milk intake were collected through standardized questionnaires. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVD incidence, cause-specific mortality and all-cause mortality related to milk intake. Restricted cubic splines (RCSs) were applied to examine dose-response associations. Results:. Among the 91,757 participants with a median follow-up period of 5.8 years, we documented 3877 CVD cases and 4091 all-cause deaths. Compared with participants who never consumed milk, the multivariate-adjusted HRs (95% CIs) of CVD incidence for 1 to 150 g/day, 151 to 299 g/day, and ≥300 g/day were 0.94 (0.86–1.03) (P > 0.05), 0.77 (0.66–0.89) (P

In the present study, the in-situ TiB whisker was introduced into the Ti-Ni-Hf shape memory alloy composite by the in-situ reaction of the Ti-Ni-Hf alloy powder and TiB2 powders. The (Ti,Hf)2Ni phase also precipitated, accompanied with the formation of TiB phase. Moreover, the residual TiB2 particles can be observed, as the TiB2 content was higher than 0.7 wt%. Thereinto, the larger scale reinforcements constituted the quasi-continuous network structure. The smaller scale reinforcements distributed in the interior of the network structure. The two-scale reinforcements showed the uniform distribution at macroscopic level and inhomogeneous distribution at microscopic level. The single stage B19′↔B2 martensitic transformation occurred in the Ti-Ni-Hf composites. In addition, the martensitic transformation temperatures continuously decreased with the increased TiB2 content owing to the compositional and mechanical effect. The moderate TiB2 addition not noly enhanced the matrix strength, but also significantly improved the superelasticity. The excellent superelaticity with the completely recoverable strain of 4 % can be obtained in the Ti-Ni-Hf composite containing 0.7 wt% TiB2.

Single pure organic molecular white light emitters (SPOMWLEs) are of significance as a new class of material for white lighting applications; however, few of them are able to emit white electroluminescence from organic light-emitting diodes. Herein, donor-π-acceptor conjugated emitters, 2PQ-PTZ and 4PQ-PTZ, were designed and synthesized as SPOMWLEs for white light emission considering the distinct advantages of their conformation isomers. The coexistence of conformational isomers in 2PQ-PTZ, which is the first experimental evidence of the coexisting quasi-axial and quasi-equatorial conformers, provides ideal flexibility to obtain white light emission from their simultaneous and well-separated fluorescence and thermally activated delayed fluorescence. With these remarkable properties, a 2PQ-PTZ-based white light-emitting diode (LED) with a CIE of (0.32, 0.34) and color rendering index (CRI) of 89 is demonstrated. Further, the white organic light-emitting diode (OLED) of 2PQ-PTZ exhibits a high external quantum efficiency (EQE) of 10.1%, which is the reported highest performance among SPOMWLE-based OLEDs.

This study aims to explore the association between serum cotinine and severe abdominal aortic calcification (AAC) in the US adults. We examined 2840 participants with a weighted mean age of 57.4 years from the National Health and Nutrition Examination Survey 2013-2014. Serum cotinine was analyzed as the main exposure both continuously and categorically (tertiles). Abdominal aortic calcification detected with dual-energy X-ray absorptiometry was quantified using the Kauppila score system. Severe AAC was detected in 252 (8.9%) participants. The multivariable-adjusted odds ratios and 95% confidence intervals (CIs) of the middle and top cotinine categories were 1.14 (0.79-1.64) and 1.80 (1.21-2.68), respectively, P for trend = .004. Per unit increase in log-transformed serum cotinine was associated with 10% (95% CI: 6%-15%) higher odds of severe AAC when serum cotinine was analyzed as a continuous variable. The association was consistent across sex and ethnic groups. In conclusion, elevated serum cotinine level was associated with higher odds for severe AAC in a representative sample of US adults.

Methionine sulfoxide reductases (Msrs) play special roles in protecting proteins from oxidative damage caused by reactive species and repairing MetSO residues in proteins/peptides. However, current probes for Msrs fail to target lysosomes and exhibit a relatively slow response and short emission wavelengths (less than 580 nm). Herein, we reported a novel lysosome-targeted NIR fluorescent probe RBSO for fast detection and imaging Msr A by extending the linear π-conjugated system of the probe via the SNArH reaction. As expected, RBSO exhibited high selectivity and high sensitivity for the rapid detection of Msr A in real-time via a specific Msr A-triggered methylsulfinyl reduction reaction. Importantly, RBSO was cell-membrane permeable and capable of specifically distributing in lysosomes, and thus detects Msr A in real-time there, providing a potential tool for monitoring Msr A activity in lysosomes of living cells.

Rhodamine dyes were widely developed for designing probes due to their excellent photophysical properties and biocompatibility. However, traditional rhodamine dyes still bear major drawbacks of short emission wavelengths (

We designed and synthesized a novel near-infrared (NIR) mitochondria-targeted fluorescent probe RQNA for the specific detection of mitochondrial Cu2+ because mitochondria are important reservoirs of intracellular copper. For the preparation of this probe, a novel π-extended fluorescent xanthene dye RQN was firstly synthesized via an intramolecular nucleophilic substitution of aromatic hydrogen (SNArH) strategy. Then, probe RQNA was prepared by the reaction of RQN and hydrazine hydrate, followed by treatment with acetone. RQNA exhibited selectivity, sensitivity (22 nM), and fast response time (20 s) for the detection of Cu2+via a specific Cu2+-triggered ring-opening and hydrolysis cascade reaction. RQNA is cell-membrane permeable and mitochondria-targetable, and can be used for monitoring mitochondrial Cu2+ in living cells.

In this work, a novel benzo[1,2-b:4,5-b′]difuran (BDF)-based polymer (PDiFPBDF-TBz, F13) was designed and synthesized with a wide bandgap of 1.93 eV. With the advantage of electronegative fluorine and furan unit, F13 possessed a deep HOMO level of −5.54 eV, which is favorable for higher Voc in polymer solar cells (PSCs). When F13 was blended with Y6, the device achieved a PCE of 12.7% with a Voc of 0.80 V, a Jsc of 22.61 mA cm−2 and an FF of 70.28%. More surprisingly, the unencapsulated pristine fabricated device generated a higher PCE of up to 13.34% after storing it in nitrogen or air. Further studies showed that the unencapsulated device could retain ∼92% of its original PCE even after exposure to air for ∼1150 hours and to nitrogen for ∼1370 hours, indicating quite promising stabilities. This improvement was due to the interfacial interaction of the active layer and anode layer and the stable micromorphological structure of the F13:Y6 film. The F13:Y6 device also exhibited a suppressed energy loss of 0.525 eV, which is one of the lowest among BDF polymer-based NF-PSCs. These results demonstrate that the rational design of the BDF polymer is highly critical in reaching the state-of-the-art photovoltaic performance and long-term stability.

Fluorescent probes for the detection of acid phosphatases (ACP) are important in the investigation of the pathology and diagnosis of diseases. We reported a lysosome-targeted near-infrared (NIR) fluorescent probe SHCy-P based on a novel NIR-emitting thioxanthene-indolium dye for the detection of ACP. The probe showed a long wavelength fluorescence emission at λem = 765 nm. Due to the ACP-catalyzed cleavage of the phosphate group in SHCy-P, the probe exhibited high selectivity and sensitivity for the 'turn-on' detection of ACP with a limit of detection as low as 0.48 U L-1. The probe SHCy-P could also be used to detect and image endogenous ACP in lysosomes. In light of these prominent properties, we envision that SHCy-P will be an efficient optical imaging approach for investigating the ACP activity in disease diagnosis.

The mercury ion (Hg2+), one of the most notorious heavy metal ions, not only causes environmental pollution, but also endangers human health. There is evidence that Hg2+ tends to accumulate in the mitochondria and to induce apoptosis. However, mitochondria-targeted near-infrared (NIR) fluorescent probes with large Stokes shifts are still scarcely described for the specific detection of Hg2+. In this work, a novel near-infrared fluorescent probe JRQNS with a large Stokes shift (78 nm) was reported, and applied for sensitive and specific detection of Hg2+ in mitochondria by incorporating an additional amine group with fused rings to rhodamine dyes to enhance the electron donating ability of amine groups. As expected, the probe exhibited high selectivity and sensitivity to Hg2+ with a detection limit as low as 1.5 nM and fast response times (3 min), revealing that JRQNS could be used as a practical probe for quantitative detection of Hg2+ in real-time. Importantly, JRQNS can be used as an efficient organelle-targeting probe for imaging Hg2+ in the mitochondria of living cells, and thus detect Hg2+ in real-time there. The application of the probe for its selective localization in mitochondria along with the nanomolar level of limit of detection to Hg2+ ions provided a potential tool for studying the cytotoxic mechanisms of Hg2+.

Hypochlorous acid (HOCl) plays a crucial role in various physiological and pathological processes. However, it is still a challenge to design a xanthene-based near-infrared (NIR) fluorescent probe with a large Stokes shift for sensing HOCl. In this work, a novel mitochondria-targeted fluorescent probe, MXS, with a large Stokes shift based on a xanthene-hemicyanine dyad structure, has been successfully designed and synthesized for the specific detection of HOCl. Gratifyingly, the peak-to-peak Stokes shift of MXS was found to be 130 nm, which was obviously larger than those of conventional rhodamine dyes and most reported xanthene-based hypochlorous acid probes. As expected, MXS exhibited high selectivity, high sensitivity, and fast response time (30 s) for the detection of HOCl via a specific HOCl-promoted intramolecular charge transfer process. The detection limit of MXS for HOCl is calculated to be as low as 72 nM, enabling its use within the physiological concentration range of HOCl (5-25 μM). Importantly, MXS is able to permeate cell membranes and accumulate in the mitochondria, which is convenient for monitoring the variation of hypochlorous acid concentration in the mitochondria of living cells.

The rational molecular design and structural modification of quasi-two-dimensional fused perylene diimide (quasi-2D FPDI) acceptors have received growing attention for application in non-fullerene organic solar cells (NF-OSCs). Herein, we designed and synthesized two pairs of FPDI acceptors, one in the form of FPDI–π-bridge–FPDI with the π-bridge being either an axisymmetric thiophene (T) or a centrosymmetric thienothiophene (TT) unit, and the other being the corresponding ring-fusion counterpart. Four small molecule acceptors, namely T-FPDI, TT-FPDI, FT-FPDI and FTT-FPDI, were paired with a common PTB7-Th polymeric electron donor as active materials for a comparative study of the effects of linkers and ring fusion on their photovoltaic performances. The T-FPDI-based NF-OSC exhibited a decent power conversion efficiency (PCE) of 5.50%, while a higher PCE of 7.17% with a simultaneous enhancement in the open circuit voltage (Voc), the short-circuit current density (Jsc) and the fill factor (FF) was achieved for the TT-FPDI-based solar cells. The solar cells based on the ring-fused FT-FPDI and FTT-FPDI acceptors displayed PCEs of 6.75% and 7.66%, respectively, both higher than those of the corresponding non-fused counterparts. Notably, the trade-off between the Jsc and Voc, commonly observed in fullerene OSCs, is alleviated in these systems. It is also worth noting that the NF-OSCs based on these FPDI acceptors do not need any solvent additives. This successful molecular engineering based on novel quasi-2D FPDI building blocks may inspire the development of emergent electron acceptors for high performance additive-free NF-OSCs.