1. Acute and subacute toxicity study of 1,8-cineole in mice
- Author
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Xu, Jiao, Hu, Zhi-Qiang, Wang, Chuan, Yin, Zhong-Qiong, Wei, Qin, Zhou, Li-Jun, Li, Li, Du, Yong-Hua, Jia, Ren-Yong, Li, Mei, Fan, Qiao-Jia, Liang, Xiao-Xia, He, Chang-Liang, and Yin, Li-Zi
- Subjects
Male ,Eucalyptol ,Dose-Response Relationship, Drug ,Administration, Oral ,Mice, Inbred Strains ,Cyclohexanols ,Endoplasmic Reticulum ,Kidney ,Mitochondria ,Mice ,Toxicity Tests, Subacute ,Liver ,Models, Animal ,Monoterpenes ,Toxicity Tests, Acute ,Animals ,Original Article ,Female - Abstract
The effects of acute and subacute toxicity of 1,8-cineole in Kunming mice were studied. After acute oral administration, the LD50 value (95% CL) was 3849 mg/kg (3488.8~4247.1 mg/kg). In the subacute toxicity study, there were no significant differences in body weight and relative organ weight between the control group and 1,8-cineole treatment groups. The histopathological examinations showed that granular degeneration and vacuolar degeneration appeared in liver and kidney tissue after administration of high dose of 1,8-cineole. Under electron microscopy, a series of ultrastructural changes were observed: The electron microscopy assays indicated that the influence of 1,8-cineole on the target organ at the subcellular level were mainly on the mitochondria, endoplasmic reticulum and other membrane type structure of liver and kidney.
- Published
- 2014