1. The Current Status and Perspectives of Delivery Strategy for Boronbased Drugs
- Author
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Yingjun Zhang, Lin Xinglong, Narayan S. Hosmane, Zhu Yinghuai, Jianlin Li, and Hongming Xie
- Subjects
inorganic chemicals ,medicine.medical_specialty ,chemistry.chemical_element ,Biochemistry ,Bone health ,Trade name ,03 medical and health sciences ,0302 clinical medicine ,Drug Discovery ,medicine ,Intensive care medicine ,Boron ,Clinical treatment ,030304 developmental biology ,Pharmacology ,0303 health sciences ,Tavaborole ,Bortezomib ,business.industry ,Organic Chemistry ,chemistry ,030220 oncology & carcinogenesis ,Anti cancer drugs ,Molecular Medicine ,business ,medicine.drug - Abstract
Boron-containing compounds are essential micronutrients for animals and plants despite their low-level natural occurrence. They can strengthen the cell walls of the plants and they play important role in supporting bone health. However, surprisingly, boron-containing compounds are seldom found in pharmaceutical drugs. In fact, there are no inherent disadvantages reported so far in terms of the incorporation of boron into medicines. Indeed, drugs based on boron-containing compounds, such as tavaborole (marked name Kerydin) and bortezomib (trade name Velcade) have been investigated and they are used in clinical treatment. In addition, following the advanced development of boron neutron capture therapy and a new emerging proton boron fusion therapy, more boron-containing medicinals are to be expected. This review discusses the current status and perspectives of delivery strategy for boron-containing drugs.
- Published
- 2019