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Allergic rhinitis (AR) is characterized by distinct clinical heterogeneity and allergic sensitization patterns. We aimed to quantify rhinitis symptoms in patients with self-reported allergic rhinitis according to the potential sensitization patterns for relevant allergens in China.We used latent class analysis (LCA; a subset of structural equation modeling) to independently cluster patients into different patterns of atopic sensitization in an unsupervised manner, based on specific immunoglobulin E tests. AR symptom severity was assessed by the visual analogue scale. We evaluated the association between the severity of AR and the allergen sensitization patterns.LCA revealed four phenotypes of atopic sensitization among 967 patients with self-report AR. We labeled latent classes as: Class 1, weed pollens and indoor sensitization (n = 74 [7.7%]); Class 2, weed pollen with low indoor sensitization (n = 275 [28.4%]); Class 3, low or no sensitization (n = 350 [36.2%]); and Class 4, house dust mite-dominated sensitization (n = 268 [27.7%]). AR was more severe in Class 2 compared to the other 3 classes, indicating that upper respiratory symptoms are more severe among patients with isolated seasonal rhinitis.We have identified four sensitization patterns in patients with self-reported AR, which were associated with different clinical symptoms and comorbidities.

Whirl flutter of a tiltrotor aircraft is a complex aeroelastic phenomenon and it can result in catastrophic consequences. The deflection of an aileron mounted on a wing has the potential to solve this fatal problem. Whirl flutter suppression using an actively controlled aileron is studied in this study. Firstly, a semi-span aeroelastic model is established for the whirl flutter problem using the Hamilton principle. This model is composed of three parts: a rigid rotor, a rigid nacelle and a flexible wing, and the effect of the aileron deflection on the aeroelastic responses is also taken into consideration through a quasi-steady aerodynamic model. In addition, the accuracy of this aeroelastic model is validated with the results of two different wind-tunnel tests. Then, an LQR controller is developed to control the dynamic deflection of the aileron, and a full-dimensional state observer is built to estimate the state of the time-invariant system of a tiltrotor aircraft. Finally, simulations are carried out using the aeroelastic model and the LQR controller at different flight conditions to study the influence of the aileron deflection on whirl flutter. The simulation results demonstrate that the flutter boundary speed can be improved by 18.1% with the active deflection of the aileron, compared with the uncontrolled condition.

Introduction: Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults. Methodology: Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively. Results: The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%). Conclusions: Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.