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34 results on '"Lockey, R."'

1. Transmission and characterisation of atypical scrapie cases from Great Britain in transgenic and wild-type mice

Author

Griffiths, PC, Spiropoulos, J, Lockey, R, Tout, AC, Jayasena, D, Plater, JM, Chave, A, Simonini, S, Dexter, I, Buschmann, A, Groschup, MH, Beringue, Vincent, Le Dur, Annick, Laude, Hubert, Simmons, MM, Hope, Jane, Inconnu, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

3. Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy?

Author

Simmons, M. M., Chaplin, M. J., Vickery, C. M., Simon, S., Davis, L., Denyer, M., Lockey, R., Stack, M. J., O'Connor, M. J., Thorne, L., Spiropoulos, J., Bishop, K., Gough, K. C., Maddison, B. C., and Fenwick, B. W.

Subjects
animal diseases, mental disorders, food and beverages, nervous system diseases
Abstract

Current European Commission (EC) surveillance regulations require discriminatory testing of all transmissible spongiform encephalopathy (TSE)-positive small ruminant (SR) samples in order to classify them as bovine spongiform encephalopathy (BSE) or non-BSE. This requires a range of tests, including characterization by bioassay in mouse models. Since 2005, naturally occurring BSE has been identified in two goats. It has also been demonstrated that more than one distinct TSE strain can coinfect a single animal in natural field situations. This study assesses the ability of the statutory methods as listed in the regulation to identify BSE in a blinded series of brain samples, in which ovine BSE and distinct isolates of scrapie are mixed at various ratios ranging from 99% to 1%. Additionally, these current statutory tests were compared with a new in vitro discriminatory method, which uses serial protein misfolding cyclic amplification (sPMCA). Western blotting consistently detected 50% BSE within a mixture, but at higher dilutions it had variable success. The enzyme-linked immunosorbent assay (ELISA) method consistently detected BSE only when it was present as 99% of the mixture, with variable success at higher dilutions. Bioassay and sPMCA reported BSE in all samples where it was present, down to 1%. sPMCA also consistently detected the presence of BSE in mixtures at 0.1%. While bioassay is the only validated method that allows comprehensive phenotypic characterization of an unknown TSE isolate, the sPMCA assay appears to offer a fast and cost-effective alternative for the screening of unknown isolates when the purpose of the investigation was solely to determine the presence or absence of BSE.

Published
2015

4. Does the presence of scrapie affect the ability of current statutory discriminatory tests to detect the presence of BSE?

Author

Simmons, M.M., Chaplin, M.J., Vickery, C.M., Simon, S., Davis, L., Denyer, M., Lockey, R., Stack, M.J., O'Connor, M.J., Bishop, Keith, Gough, Kevin C., Maddison, Ben C., Thorne, L., and Spiropoulos, J.

Subjects
animal diseases, mental disorders, food and beverages, nervous system diseases
Abstract

Current European Commission (EC) surveillance regulations require discriminatory testing of all transmissible spongiform encephalopathy (TSE)-positive small ruminant (SR) samples in order to classify them as bovine spongiform encephalopathy (BSE) or non-BSE. This requires a range of tests, including characterization by bioassay in mouse models. Since 2005, naturally occurring BSE has been identified in two goats. It has also been demonstrated that more than one distinct TSE strain can coinfect a single animal in natural field situations. This study assesses the ability of the statutory methods as listed in the regulation to identify BSE in a blinded series of brain samples, in which ovine BSE and distinct isolates of scrapie are mixed at various ratios ranging from 99% to 1%. Additionally, these current statutory tests were compared with a new in vitro discriminatory method, which uses serial protein misfolding cyclic amplification (sPMCA). Western blotting consistently detected 50% BSE within a mixture, but at higher dilutions it had variable success. The enzyme-linked immunosorbent assay (ELISA) method consistently detected BSE only when it was present as 99% of the mixture, with variable success at higher dilutions. Bioassay and sPMCA reported BSE in all samples where it was present, down to 1%. sPMCA also consistently detected the presence of BSE in mixtures at 0.1%. While bioassay is the only validated method that allows comprehensive phenotypic characterization of an unknown TSE isolate, the sPMCA assay appears to offer a fast and cost-effective alternative for the screening of unknown isolates when the purpose of the investigation was solely to determine the presence or absence of BSE.

Published
2015

5. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma

Author

BUSSE WW, PEDERSEN S, PAUWELS RA, TAN WC, CHEN YZ, LAMM CJ, Eckmayr J, Riedler J, Wurzinger G, Ott G, Zarkovic J, Schulheim A, Götz M, Schinko H, Thomüller I, de Backer W, van Bever H, Verleden G, de Boeck C, Aumann J, Vincken W, Dab I, de Vuyst P, de Jonghe M, Casimir G, Joos G, de Baets F, Bogaerts Y, Halloy JL, Bartsch P, Thiriaux J, Pohunek P, Rybníćek O, Skopková O, Pavelková L, Broź P, Ohnutková E, Novotná B, Baly J, Krćmová I, Kuralová Z, Koćí T, Honomichlová H, Kaśák V, Panzner P, Vondra V, Némećková J, Seberová E, Sykora T, Vít P, Turzíková J, Sörensen T, Neldam S, Peter J, Kludt J, Hansen UB, Knudsen T, Schultz PJ, Rost D, Jensen F, Kinnula V, Saarelainen P, Eho Remes M, Valovirta E, Venho KK, Kokko E, Järvinen M, Toljamo T, Taivainen A, Kava T, Herrala J, Kuusela AL, Nordgren P, Syvänen P, Godard P, Rufin P, Anton M, Aubert JP, Grosclaude M, Brambilla C, Archaud P, Racineux JL, Muir JF, Albertini M, Le Roux P, Simmons A, Bartuschka B, von Berg A, Bergmann V, Berns J, Bisping Arnold A, Blum HC, Garanin G, Brückner OJ, Burbach P, Sudhoff H, Feldmann M, Schmoller T, Wozny HW, Galaske R, Huptas M, Kaecke J, Köcher V, Laule Peschel M, Lohr E, Goldberg J, Drescher T, Reeh W, Rabe U, Rehn L, Scheffler NK, Steinmetz KO, Stutz PM, Weber HH, Uhde C, Ullner R, Vehar H, Krohn EU, Orosz M, Devai A, Uhereczky G, Rajkay K, Gönczi F, Györi E, Dobra G, Puha K, Sztancsik Z, Gömöri K, Dolinay T, Bittera I, Palinkasi S, Cseke Z, Bisits M, Bjämer D, Holme JI, Langhammer A, Hunstad K, Holmboe JH, Grangård E, Solberg DA, Grönneröd TA, Salkowitsch MB, Oymar K, Iversen K, Szczeklik A, Chyrek Borowska S, Mincewicz G, Malaczynska T, Latos T, Obtulowicz K, Emeryk A, Gorski P, Nowak D, Szmidt M, Alkiewicz J, Ziolo G, Spychalski L, Chmielewska Szewczyk D, Nowacka K, Pirozynski M, Prokurat H, Boznanski A, Malolepszy J, Rogala E, Kozielski J, Eriksson UL, Wahlestedt H, Selberg M, Larsson R, Rignér K, Alm B, Aronsson M, Winnergård I, Lagerwall M, Martinsons U, Berlin L, Rydberg B, Weston D, Johnson ME, Barrett C, Siafakas N, Mantzourani E, Orphanidou D, Trakopoulos G, Tzannes S, Kotsovoulou V, Dimadi M, Amfilochiou A, Priftis K, Papageorgiou Saxoni F, Christaki P, Tsanakas I, Paraskevi M, Bousmoukilia S, Spiropoulos K, Anthrakopoulos M, Roussos C, Bentur Alkouby L, Heimer D, Tal A, Horowitz I, Soferman R, Katz Y, Stav D, Weiler Z, Bibi H, Rottem M, Mandelberg A, Geller C, Roizin H, Weiler Ravell D, Kramer MR, Schwartz Y, Rossi A, Foresi A, Giuntini C, Bisetti A, Scoditti S, Tranfa C, Zacchello F, Giovannini M, Boner A, Fabbri LM, Girbino G, Barberio G, Cacciari E, Montefort S, Parascandalo R, Pato R, de Lourdes Chieira M, Moreira C, Chieira DS, Brito U, Borges FD, Marques AC, Figueiredo MM, Dias F, de Almeida AB, Cesar Ramos J, Valente MJ, Pereira JD, Nunes C, Riberio MF, Marques A, Carvalho MQ, de Azevedo MV, de Almeida AR, Pinto JA, Matos Mde F, Afonso A, Dos Santos JM, Fernandez CV, Agustin IC, Bejarano JM, Santos AA, Font ET, Huet EH, Lorente TL, Pujol MM, Munoz AP, Aineto PS, Forns SB, Areu JB, Casan P, Garcia JM, Rodriguez AV, Segura PA, Gil RS, Ciscar CP, Garcia JF, Jimenez TV, Gonzalez JI, Andres FQ, Bueno TA, Baticon CO, Miguel CR, Garcia FD, Hernando HV, Vina AL, Matia RA, Cumplido AS, Andueza MC, Cabra MS, Navarro PL, Rodriguez FA, Li JH, Landry D, O'Keefe D, Muram BF, Conter HS, Tweel D, Peters SD, Adelglass J, Baker JW, Berger WE, Bernstein DI, Blake KV, Amelong P, Casale TB, Charous BL, Chervinsky P, Condemi JJ, Cook D, Creticos PS, de Graff AC Jr, Smith T, Ellis MH, Grossman J, Halverson PC, Galant S, Hollingsworth H, Jackson C, Jacobs RL, Welch M, Kraemer MJ, Leflein J, Lemanske RF, Liebhaber MI, Lockey R, Kelly B, Mendelson L, Nayak A, Pearlman DS, Ruff M, Schwartz B, Scott MB, Shapiro GG, Silk HJ, Skoner DP, Stoloff S, Swamy KN, Atkins FM, Szefler SJ, Vandewalker M, Wald J, Weinstein SF, Wong DA, Wu F, Goldstein S, Murthy KC, Dolmann A, Gene R, Casas JC, Piovano C, Segal E, Balanzat AM, Taborda J, Truganti A, Teper A, Garrood J, Patel MJ, Hogan C, Russel G, Zhu YJ, Cao L, Liu SY, Miao JZ, Ding DJ, Yao WZ, Liu YN, Chen P, Kong SQ, Pang L, Sun B, Li ZM, Li GS, Chen PL, Zhu Q, Zhang TX, Wang XH, Wei S, Deng WW, Zhou X, Ji YY, Luo WT, Li Q, Zhu HR, Sheng JY, Ma JY, Zhang DP, Ji CZ, Xia XR, Zhang ZY, Yin KS, Yiang J, Li Y, Tang PW, Liu FG, Wang HP, Zhong NS, Rong ZS, Tang YC, Lin CY, Liu JS, Liu HZ, Cai DM, Yang JC, Ma QF, Mangunnegoro H, Wijono CA, Tobing NH, Rahajoe NN, Sugito, Surjanto E, Hisyam B, Alsagaff H, Santosa G, Kim YY, Park CS, Kim MK, Cho YJ, Choi DC, Jee YK, Mohan J, Yogeswery S, Wong SL, Kuan GL, Koh CT, Quah BS, de Bruyne J, Liam CK, Avila MM, Cuevas F, Chavaje N, Topete LA, Badillo I, Ponce M, Merida JC, Espinosa AG, Ledezma JM, García JA, Morales GG, Gomez JM, Martinez FJ, Ramos JE, Dorantes JR, Gonzalez CC, Vera JG, Bayardo RG, Melendez AP, Loyola CB, Suárez MA, de Guia T, Balgos A, Bautista N, Realiza T, Diaz D, Yu C, Mendoza Wi JA, Juaneza R, Bigornia R, Mansukhani P, Cacanindin DN, Wah LB, Hon YK, Yau OY, Moh CO, Tang WY, Dippenaar YD, Kirsten DL, Maraschin EF, Ossip MS, Visser SS, Mouton WL, Mercer M, Cassim KM, Macleod AH, Bateman ED, Leaver R, Morison A, Nel H, von Delft KH, Vermeulen JH, Weinberg EG, Lund RJ, Weber HC, Kuo SH, Kuo HP, Wang JL, Hsiue TR, Wang JH, Ching CD, Vangveeravong M, Pothiratana C, Trakultivakorn M, Kongpanichkul A, Thamanavat B, Fuangtong R, Suntornlohanakul S, Youngchaiyud P, Teeratakulpisarn J, Boonsawat W, Viriyachaiyo V, Direkwattanachai C, Visitsunthorn N., MIRAGLIA DEL GIUDICE, Michele, Busse, Ww, Pedersen, S, Pauwels, Ra, Tan, Wc, Chen, Yz, Lamm, Cj, Eckmayr, J, Riedler, J, Wurzinger, G, Ott, G, Zarkovic, J, Schulheim, A, Götz, M, Schinko, H, Thomüller, I, de Backer, W, van Bever, H, Verleden, G, de Boeck, C, Aumann, J, Vincken, W, Dab, I, de Vuyst, P, de Jonghe, M, Casimir, G, Joos, G, de Baets, F, Bogaerts, Y, Halloy, Jl, Bartsch, P, Thiriaux, J, Pohunek, P, Rybníćek, O, Skopková, O, Pavelková, L, Broź, P, Ohnutková, E, Novotná, B, Baly, J, Krćmová, I, Kuralová, Z, Koćí, T, Honomichlová, H, Kaśák, V, Panzner, P, Vondra, V, Némećková, J, Seberová, E, Sykora, T, Vít, P, Turzíková, J, Sörensen, T, Neldam, S, Peter, J, Kludt, J, Hansen, Ub, Knudsen, T, Schultz, Pj, Rost, D, Jensen, F, Kinnula, V, Saarelainen, P, Eho Remes, M, Valovirta, E, Venho, Kk, Kokko, E, Järvinen, M, Toljamo, T, Taivainen, A, Kava, T, Herrala, J, Kuusela, Al, Nordgren, P, Syvänen, P, Godard, P, Rufin, P, Anton, M, Aubert, Jp, Grosclaude, M, Brambilla, C, Archaud, P, Racineux, Jl, Muir, Jf, Albertini, M, Le Roux, P, Simmons, A, Bartuschka, B, von Berg, A, Bergmann, V, Berns, J, Bisping Arnold, A, Blum, Hc, Garanin, G, Brückner, Oj, Burbach, P, Sudhoff, H, Feldmann, M, Schmoller, T, Wozny, Hw, Galaske, R, Huptas, M, Kaecke, J, Köcher, V, Laule Peschel, M, Lohr, E, Goldberg, J, Drescher, T, Reeh, W, Rabe, U, Rehn, L, Scheffler, Nk, Steinmetz, Ko, Stutz, Pm, Weber, Hh, Uhde, C, Ullner, R, Vehar, H, Krohn, Eu, Orosz, M, Devai, A, Uhereczky, G, Rajkay, K, Gönczi, F, Györi, E, Dobra, G, Puha, K, Sztancsik, Z, Gömöri, K, Dolinay, T, Bittera, I, Palinkasi, S, Cseke, Z, Bisits, M, Bjämer, D, Holme, Ji, Langhammer, A, Hunstad, K, Holmboe, Jh, Grangård, E, Solberg, Da, Grönneröd, Ta, Salkowitsch, Mb, Oymar, K, Iversen, K, Szczeklik, A, Chyrek Borowska, S, Mincewicz, G, Malaczynska, T, Latos, T, Obtulowicz, K, Emeryk, A, Gorski, P, Nowak, D, Szmidt, M, Alkiewicz, J, Ziolo, G, Spychalski, L, Chmielewska Szewczyk, D, Nowacka, K, Pirozynski, M, Prokurat, H, Boznanski, A, Malolepszy, J, Rogala, E, Kozielski, J, Eriksson, Ul, Wahlestedt, H, Selberg, M, Larsson, R, Rignér, K, Alm, B, Aronsson, M, Winnergård, I, Lagerwall, M, Martinsons, U, Berlin, L, Rydberg, B, Weston, D, Johnson, Me, Barrett, C, Siafakas, N, Mantzourani, E, Orphanidou, D, Trakopoulos, G, Tzannes, S, Kotsovoulou, V, Dimadi, M, Amfilochiou, A, Priftis, K, Papageorgiou Saxoni, F, Christaki, P, Tsanakas, I, Paraskevi, M, Bousmoukilia, S, Spiropoulos, K, Anthrakopoulos, M, Roussos, C, Bentur Alkouby, L, Heimer, D, Tal, A, Horowitz, I, Soferman, R, Katz, Y, Stav, D, Weiler, Z, Bibi, H, Rottem, M, Mandelberg, A, Geller, C, Roizin, H, Weiler Ravell, D, Kramer, Mr, Schwartz, Y, Rossi, A, Foresi, A, Giuntini, C, Bisetti, A, Scoditti, S, Tranfa, C, Zacchello, F, Giovannini, M, Boner, A, MIRAGLIA DEL GIUDICE, Michele, Fabbri, Lm, Girbino, G, Barberio, G, Cacciari, E, Montefort, S, Parascandalo, R, Pato, R, de Lourdes Chieira, M, Moreira, C, Chieira, D, Brito, U, Borges, Fd, Marques, Ac, Figueiredo, Mm, Dias, F, de Almeida, Ab, Cesar Ramos, J, Valente, Mj, Pereira, Jd, Nunes, C, Riberio, Mf, Marques, A, Carvalho, Mq, de Azevedo, Mv, de Almeida, Ar, Pinto, Ja, Matos Mde, F, Afonso, A, Dos Santos, Jm, Fernandez, Cv, Agustin, Ic, Bejarano, Jm, Santos, Aa, Font, Et, Huet, Eh, Lorente, Tl, Pujol, Mm, Munoz, Ap, Aineto, P, Forns, Sb, Areu, Jb, Casan, P, Garcia, Jm, Rodriguez, Av, Segura, Pa, Gil, R, Ciscar, Cp, Garcia, Jf, Jimenez, Tv, Gonzalez, Ji, Andres, Fq, Bueno, Ta, Baticon, Co, Miguel, Cr, Garcia, Fd, Hernando, Hv, Vina, Al, Matia, Ra, Cumplido, A, Andueza, Mc, Cabra, M, Navarro, Pl, Rodriguez, Fa, Li, Jh, Landry, D, O'Keefe, D, Muram, Bf, Conter, H, Tweel, D, Peters, Sd, Adelglass, J, Baker, Jw, Berger, We, Bernstein, Di, Blake, Kv, Amelong, P, Casale, Tb, Charous, Bl, Chervinsky, P, Condemi, Jj, Cook, D, Creticos, P, de Graff AC, Jr, Smith, T, Ellis, Mh, Grossman, J, Halverson, Pc, Galant, S, Hollingsworth, H, Jackson, C, Jacobs, Rl, Welch, M, Kraemer, Mj, Leflein, J, Lemanske, Rf, Liebhaber, Mi, Lockey, R, Kelly, B, Mendelson, L, Nayak, A, Pearlman, D, Ruff, M, Schwartz, B, Scott, Mb, Shapiro, Gg, Silk, Hj, Skoner, Dp, Stoloff, S, Swamy, Kn, Atkins, Fm, Szefler, Sj, Vandewalker, M, Wald, J, Weinstein, Sf, Wong, Da, Wu, F, Goldstein, S, Murthy, Kc, Dolmann, A, Gene, R, Casas, Jc, Piovano, C, Segal, E, Balanzat, Am, Taborda, J, Truganti, A, Teper, A, Garrood, J, Patel, Mj, Hogan, C, Russel, G, Zhu, Yj, Cao, L, Liu, Sy, Miao, Jz, Ding, Dj, Yao, Wz, Liu, Yn, Chen, P, Kong, Sq, Pang, L, Sun, B, Li, Zm, Li, G, Chen, Pl, Zhu, Q, Zhang, Tx, Wang, Xh, Wei, S, Deng, Ww, Zhou, X, Ji, Yy, Luo, Wt, Li, Q, Zhu, Hr, Sheng, Jy, Ma, Jy, Zhang, Dp, Ji, Cz, Xia, Xr, Zhang, Zy, Yin, K, Yiang, J, Li, Y, Tang, Pw, Liu, Fg, Wang, Hp, Zhong, N, Rong, Z, Tang, Yc, Lin, Cy, Liu, J, Liu, Hz, Cai, Dm, Yang, Jc, Ma, Qf, Mangunnegoro, H, Wijono, Ca, Tobing, Nh, Rahajoe, Nn, Sugito, Surjanto, E, Hisyam, B, Alsagaff, H, Santosa, G, Kim, Yy, Park, C, Kim, Mk, Cho, Yj, Choi, Dc, Jee, Yk, Mohan, J, Yogeswery, S, Wong, Sl, Kuan, Gl, Koh, Ct, Quah, B, de Bruyne, J, Liam, Ck, Avila, Mm, Cuevas, F, Chavaje, N, Topete, La, Badillo, I, Ponce, M, Merida, Jc, Espinosa, Ag, Ledezma, Jm, García, Ja, Morales, Gg, Gomez, Jm, Martinez, Fj, Ramos, Je, Dorantes, Jr, Gonzalez, Cc, Vera, Jg, Bayardo, Rg, Melendez, Ap, Loyola, Cb, Suárez, Ma, de Guia, T, Balgos, A, Bautista, N, Realiza, T, Diaz, D, Yu, C, Mendoza Wi, Ja, Juaneza, R, Bigornia, R, Mansukhani, P, Cacanindin, Dn, Wah, Lb, Hon, Yk, Yau, Oy, Moh, Co, Tang, Wy, Dippenaar, Yd, Kirsten, Dl, Maraschin, Ef, Ossip, M, Visser, S, Mouton, Wl, Mercer, M, Cassim, Km, Macleod, Ah, Bateman, Ed, Leaver, R, Morison, A, Nel, H, von Delft, Kh, Vermeulen, Jh, Weinberg, Eg, Lund, Rj, Weber, Hc, Kuo, Sh, Kuo, Hp, Wang, Jl, Hsiue, Tr, Wang, Jh, Ching, Cd, Vangveeravong, M, Pothiratana, C, Trakultivakorn, M, Kongpanichkul, A, Thamanavat, B, Fuangtong, R, Suntornlohanakul, S, Youngchaiyud, P, Teeratakulpisarn, J, Boonsawat, W, Viriyachaiyo, V, Direkwattanachai, C, and Visitsunthorn, N.

Published
2008

6. The skin prick test - European standards

Author

Heinzerling, L., Mari, A., Bergmann, K. C., Bresciani, M., Burbach, G., Darsow, U., Durham, S., Fokkens, W., Gjomarkaj, M., Haahtela, T., Bom, A. T., Wohrl, S., Maibach, H., Lockey, R., and Department of Dermatology, Allergology and Venereology

Subjects
3121 General medicine, internal medicine and other clinical medicine, education
Published
2013

7. Allergic Rhinitis and its Impact on Asthma (ARIA): In collaboration with the World Health Organization

Author

Bousquet, J., Van Cauwenberge, P., Khaltaev, N., Aït Khaled, N., Annesi Maesano, I., Baena Cagnani, C., Bateman, E., Canonica, G. W., Carlsen, K. H., Demoly, P., Durham, S. R., Enarson, D., Fokkens, W. J., Gerth Van Wijk, R., Howarth, P., Ivanova, N. A., Kemp, J. P., Klossek, J. M., Lockey, R. F., Lund, V., Mackay, I., Malling, H. J., Meltzer, E. O., Mygind, N., Okuda, M., Pawankar, R., Price, D., Scadding, G. K., Simons, Estelle R., Szczeklik, A., Valovirta, E., Vignola, A. M., Wang, D. Y., Warner, J. O., Weiss, K. B., BONINI, Sergio, Bousquet, J., Van Cauwenberge, P., Khaltaev, N., Aït Khaled, N., Annesi Maesano, I., Baena Cagnani, C., Bateman, E., Bonini, Sergio, Canonica, G. W., Carlsen, K. H., Demoly, P., Durham, S. R., Enarson, D., Fokkens, W. J., Gerth Van Wijk, R., Howarth, P., Ivanova, N. A., Kemp, J. P., Klossek, J. M., Lockey, R. F., Lund, V., Mackay, I., Malling, H. J., Meltzer, E. O., Mygind, N., Okuda, M., Pawankar, R., Price, D., Scadding, G. K., Simons, Estelle R., Szczeklik, A., Valovirta, E., Vignola, A. M., Wang, D. Y., Warner, J. O., and Weiss, K. B.

Subjects
Immunology
Published
2002

8. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs

Author

Bousquet, Jean, Schunemann, H. J., Samolinski, B., Demoly, Pascal, Baena-Cagnani, C. E., Bachert, C., Bonini, S., Boulet, L. P., Brozek, J. L., Canonica, G. W., Casale, T. B., Cruz, A. A., Fokkens, W. J., Fonseca, J. A., Wick, R. G. van, Grouse, L., Haahtela, T., Khaltaev, N., Kuna, P., Lockey, R. F., Carlsen, K. C. Lodrup, Mullol, J., Naclerio, R. N., O'Hehir, R. E., Ohta, K., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Pawankar, R., Price, D., Ryan, D., Simons, F. E. R., Togias, A., Williams, D. M., Yorgancioglu, A., Yusuf, O. M., Aberer, W., Adachi, M., Agache, I., Aït-Khaled, N., Akdis, C. A., Andrianarisoa, A., Annesi-Maesano, I., Ansotegui, I. J., Baiardini, I., Bateman, E. D., Bedbrook, Anna, Beghé, B., Beji, M., Bel, E. H., Kheder, A. Ben, Bennoor, K. S., Bergmann, K. C., Berrissoul, F., Bieber, T., Bindslev-Jensen, C., Blaiss, M. S., Boner, A. L., Bouchard, J., Braido, F., Brightling, C. E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Calvo, M. A., Camargos, P. A. M., Caraballo, L. R., Carlsen, K. H., Carr, W., A.M, Cepeda Sarabia, Cesario, A., Chavannes, Niels H., Chen, Y. Z., Chiriac, A. M., Pérez, T. Chivato, Chkhartishvili, E., Ciprandi, G., Costa, David J., Cox, L., Custovic, Adnan, Dahl, R., Darsow, U., Blay, F. De, Deleanu, D., Denburg, J. A., Devillier, P., Didi, T., Dokic, D., Dolen, W. K., Douagui, H. B., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., El-Meziane, A., Emuzyte, R., Fiocchi, A., Fletcher, M., Fukuda, T., Gamkrelidze, A., Gereda, J. E., Diaz, S. González, Gotua, M., Guzmán, M. A., Hellings, P. W., Hellquist-Dahl, B., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Ivancevich, J. C., Jackson, Rod T., Just, J., Kalayci, O., Kaliner, M. A., Kalyoncu, A. F., Keil, T., Keith, P. K., Khayat, G., Kim, Y. Y., N'Goran, B. Koffi, Koppelman, G. H., Kowalski, M. L., Kull, I., Kvedariene, V., Larenas-Linnemann, D., Le, Tuyen D., Lemière, C., Li, J., Lieberman, P., Lipworth, B. J., Mahboub, B., Makela, M. J., Martin, F., Marshall, G. D., Martinez, F. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Mazon, A., Melén, E., Meltzer, E. O., Mendez, N. H., Merk, H., Mihaltan, F., Mohammad, Y., Almeida, M. Morais, Muraro, A., Nafti, S., Namazova-Baranova, L., Nekam, K., Neou, A., Niggemann, B., Nizankowska-Mogilnicka, E., Nyembue, T. D., Okamoto, Y., Okubo, K., Orru, M. P., Ouedraogo, S., Ozdemir, C., Panzner, P., Pali-Schöll, I., Park, H. S., Pigearias, B., Pohl, W., Popov, T. A., Postma, D. S., Potter, P., Rabe, K. F., Ratomaharo, J., Reitamo, S., Ring, J., Roberts, R., Rogala, B., Romano, A., Rodriguez, M. Roman, Rosado-Pinto, J., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Schmid-Grendelmeier, P., Sheikh, A., Sisul, J. C., Sole, D., Sooronbaev, T., Spicak, V., Spranger, O., Stein, R. T., Stoloff, S. W., Sunyer, Jordi, Szczeklik, A., Todo-Bom, A., Toskala, E., Tremblay, Y., Valenta, R., Valero, A. L., Valeyre, D., Valiulis, A., Valovirta, E., Cauwenberge, P. Van, Vandenplas, O., Weel, C. Van, Vichyanond, P., Viegi, Giovanni, Wang, D. Y., Wickman, M., Wöhrl, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Zar, H. J., Zernotti, M. E., Zhong, N., Zidarn, M., Zuberbier, T., Ang, C. S., Baigenzhin, A. K., Boakye, D. A., Briggs, A. H., Burney, P. G., Busse, W. W., Chuchalin, Alexander G., Haddad, H., Johnston, S. L., Kogevinas, M., Levy, L. M., Mohammadi, A., Oddie, S., Rezagui, D., Terreehorst, I., Warner, J. O., Bousquet, J, Schünemann, Hj, Samolinski, B, Demoly, P, Baena Cagnani, Ce, Bachert, C, Bonini, Sergio, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, Pulmonology, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Hop Arnaud Villeneuve, INSERM, McMaster Univ, Med Univ Warsaw, Univ Hosp Montpellier, Catholic Univ, Univ Genoa, Univ Ghent, CNR, Univ Naples 2, Univ Laval, Creighton Univ, Universidade Federal da Bahia (UFBA), CNPq, Univ Amsterdam, Univ Porto, Hosp S Joao & Inst, Hosp CUF Porto, Erasmus MC, Univ Washington, Helsinki Univ Hosp, GARD ARIA Coordinator, Med Univ Lodz, Univ S Florida, James A Haley Vet Hosp, Univ Oslo, CIBERES, Univ Chicago, Alfred Hosp, Monash Univ, Teikyo Univ, EFA European Federat Allergy & Airways Dis Patien, Univ Athens, Nippon Med Sch, Univ Aberdeen, Woodbrook Med Ctr, Univ Edinburgh, Univ Manitoba, NIAID, Univ N Carolina, Celal Bayar Univ, Allergy & Asthma Inst, Med Univ Graz, Showa Univ, Transylvania Univ, Int Union TB & Lung Dis Union, Univ Zurich, Minist Hlth, Univ Paris 06, Hosp Quiron Bizkaia, Univ Cape Town, WHO, Univ Modena & Reggio Emilia, Ctr Hosp Univ Rabta, Hop Mami, Bangladesh Lung Fdn, Natl Inst Dis Chest & Hosp, Charite, Univ Med Ctr, Odense Univ Hosp, Univ Tennessee, Univ Verona, Hop Malbaie, Univ Leicester, Royal Brompton Hosp, Univ London Imperial Coll Sci Technol & Med, Ctr Med Docente La Trinidad Caracas, Univ Austral Chile, Univ Fed Sao Joao del Rei, Univ Cartagena, So Calif Res, Metropolitan Univ Barranquilla, IRCCS San Raffaele Pisana, Univ Cattolica Sacro Cuore, Leiden Univ, Capital Inst Pediat, Ctr Asthma Res & Educ, Univ Hosp, Georgian Natl Univ, Univ Montpellier I, Nova SE Univ, Univ Manchester, Aarhus Univ Hosp, Tech Univ Munich, TUM, Univ Hosp Strasbourg, Univ Med & Pharm Iuliu Hatieganu, Univ Versailles St Quentin, Ctr Hosp Reg Annecy, Univ Ss Cyril & Methodius, Georgia Hlth Sci Univ, Ctr Hosp Univ Beni Messous, Vilnius Univ, Wake Forest Univ, Ain Shams Univ, Egyptian Soc Pediat Allergy & Immunol, Soc Marocaine Malad Resp, Ctr Resp Dis & Allergy, Univ Milan, Educ Hlth, Dokkyo Med Univ, Clin Ricardo Palma, Univ Nuevo Leon UANL, Ctr Allergy & Immunol, Clin Hosp Univ Chile, Univ Hosp Leuven, Cent Reg Denmark, Allergy Ctr Vienna W, Natl Univ Ireland Univ Coll Cork, Univ Southampton, Univ Paris 11, Salvador Univ, Univ St Andrews, Univ Paris, Hacettepe Univ, George Washington Univ, Inst Asthma & Allergy, Hacettepe Univ Hosp, Hotel Dieu France, Univ St Joseph, Natl Med Ctr, Seoul Natl Univ, Korea Asthma Allergy Fdn, Ctr Hosp Univ, Univ Groningen, Karolinska Inst, Vilnius Univ Hosp Santariskiu Klinikos, Hosp Med Sur, Univ Med & Pharm, Hop Sacre Coeur Montreal, Univ Montreal, Guangzhou Med Univ, Univ Dundee, Dubai Hlth Author, Univ Sharjah, Univ Mississippi, Univ Arizona, Shahid Beheshti Univ Med Sci, Universidade Estadual de Maringá (UEM), Eduardo Mondlane Univ, Childrens Hosp La Fe, Karolinska Univ Hosp, Univ Calif San Diego, IMSS, Univ Aachen, Inst Pneumol Marius Nasta, Tishreen Univ, CUF Descobertas Hosp, Univ Padua, Mustapha Hosp, Sci Ctr Childrens Hlth RAMS, Hosp Hospitaller Bros Buda, German Red Cross Hosp Westend, Jagiellonian Univ, Kinshasa Univ, Chiba Univ Hosp, Ctr Hosp Univ Pediat Charles de Gaulle, Marmara Univ, Mem Hlth Grp, Charles Univ Prague, MESSERLI Res Inst, Med Univ Vienna, Univ Vienna, Ajou Univ, NICE, Soc Pneumol Langue Francaise, Krankenhaus Hietzing, Alexanders Univ Hosp, Groote Schuur Hosp, Grosshansdorf Clin, Hop Prive Athis Mons, Univ Wisconsin, Med Univ Silesia, Complesso Integrato Columbus, IRCCS Oasi Maria SS, Son Pisa Primary Care Ctr, Hosp Luz, Univ Missouri, Childrens Mercy Hosp, Emek Med Ctr, Technion Israel Inst Technol, Ctr Med Docente La Trinidad, UCL, Univ Zurich Hosp, Universidade Federal de São Paulo (UNIFESP), Natl Ctr Cardiol & Internal Med, Ctr ACI Immunoflow, GAAPP, Ctr Res Environm Epidemiol CREAL, Pontificia Univ Catolica RGS, Univ Nevada, Hosp Mar, CIBER Epidemiol & Salud Publ CIBERESP, Univ Pompeu Fabra UPF, Coimbra Univ Hosp, Childrens Hosp Philadelphia, Finnish Inst Occupat Hlth, Hosp Clin Barcelona, IDIBAPS, Univ Paris 13, Avicenne Hosp, Lithuanian Natl Council Childs Hlth, Terveystalo Turku, Univ Turku, Catholic Univ Louvain, Radboud Univ Nijmegen, Siriraj Hosp, Clin Physiol IFC, Natl Univ Singapore, Floridsdorf Allergy Ctr FAZ, Bradford Teaching Hosp Fdn Trust, Olmsted Med Ctr, Univ Minnesota, Harvard Univ, Cyprus Univ Technol, Catholic Univ Cordoba, Univ Clin Resp & Allerg Dis, Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute of Pharmacy, Groningen Research Institute for Asthma and COPD (GRIAC), Dermatology, Internal Medicine, Erasmus MC other, Göğüs Hastalıkları, UCL - (MGD) Service de pneumologie, and UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie

Subjects
Allergy, WORLD-HEALTH-ORGANIZATION, GUIDELINES, Medical and Health Sciences, Primary-care, 0302 clinical medicine, QUALITY-OF-LIFE, Health care, Global health, Medicine, Immunology and Allergy, 030223 otorhinolaryngology, Child, Animals, Asthma, Clinical Trials as Topic, Europe, Humans, Practice Guidelines as Topic, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, World Health Organization, Persistent types, media_common, Rhinitis, PERSISTENT TYPES, PRIMARY-CARE, Effective primary care and public health [NCEBP 7], 3. Good health, GRADE, medicine.medical_specialty, Immunology, MEDLINE, World-health-organization, CONTROLLED-TRIAL, CLASSIFICATION, 03 medical and health sciences, Quality of life (healthcare), Allergic, EUROPEAN-UNION, rhinitis, Rhinitis, asthma, Allergic Rhinitis and its Impact on Asthma, allergy, GRADE, MANAGEMENT, media_common.cataloged_instance, Controlled-trial, Allergic Rhinitis and its Impact on Asthma, allergy, asthma, European union, Seasonal, business.industry, Guideline, medicine.disease, Perennial, 2008 UPDATE, Family medicine, Quality-of-life, Clinical Medicine, business, 030215 immunology
Abstract

Stallergenes ALK-Abello European Academy of Allergy and Clinical Immunology (EAACI) MSD Novartis Nycomed/Takeda PHADIA/Thermo Fischer 3M AstraZeneca GlaxoSmithKline Merck Frosst Altair Amgen Asmacure Boehringer-Ingelheim Genentech Pharmaxis Schering Wyeth Ache Brazilian Research Council Fundacao de Amparo a Pesquisa da Bahia Fundacao Ciencia e Tecnologia Sociedade Portuguesa de Alergologia e Immunologia Clinica Abdi Ibrahim OrionPharma Nasonebs Merck McNeal Chiesi Nycomed Air Liquid Healthcare Mundipharma Almirall Kyorin Teva UK National Health Service Aerocrine AKL Ltd PREDICTA Swiss National Science Foundation MeDALL Global Allergy and Asthma European Network (GA 2LEN) Christine Kuthe Center for Allergy Research and Education Faes Farma Bial Johnson Johnson Sanofi HAD treasurer Innovative Medicine Initiative (EU) Helse Sor-Ost RHF (Southern and Eastern Norway Regional Health Authority) MEDA Alcon ISTA Thermo-Fisher Airsonett Medical Research Council Moulton Charitable Trust AB Science Canadian Institutes for Health Research AllerGen NCE Merck/Schering-Plough Circassia University Hospital Medical School of Universidad Autonoma de Nuevo Leon, Mexico Children's Research Foundation (Ireland) Danone Food Standards Agency (United Kingdom) European Union (EU) DTG Netherlands Asthma Foundation Merck-Sharp-Dohme, Mexico Allerquim Mexico Abbott Apotex HRA MedImmune Schering-Plough Proctor Gamble Sunovion (Sepracor) Phadia Servier CSC JohnsonJohnson Oxygen Plus New Medics European Respiratory Society Societe de Pneumologie de Langue Francaise Asthma Ministry of Health, Welfare, and Labor Altana Takeda UCB Uriach advisory board NAPP Royal College of GPs Clinical Champion in Allergy Agency for Healthcare Research and Quality (AHRQ) AnseII Bayer Schering OST Fujisawa IHAL Henkel Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified ARas mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. in its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. (J Allergy Clin Immunol 2012;130:1049-62.) Kryolan Leti MSO Procter and Gamble Sanofi-Aventis Scientific Advisory Board for the German Society for Allergy and Clinical Immunology German Federal Ministry of Consumer Protection European Centre for Allergy Research Foundation (ECARF) Hop Arnaud Villeneuve, Dept Resp Dis, Univ Hosp, Montpellier, France INSERM, U1018, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, Villejuif, France McMaster Univ, Dept Clin Epidemiol & Biostat & Med, Hamilton, ON, Canada Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland Univ Hosp Montpellier, Hop Arnaud Villeneuve, INSERM, U657, Montpellier, France Catholic Univ, Fac Med, Res Ctr Resp Med CIMER, Cordoba, Argentina Univ Genoa, Sch Specializat, Genoa, Italy Univ Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, B-9000 Ghent, Belgium CNR, Inst Translat Pharmacol, Rome, Italy Univ Naples 2, Naples, Italy Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada Univ Genoa, Dept Internal Med, DIMI, I-16126 Genoa, Italy Creighton Univ, Dept Med, Div Allergy & Immunol, Omaha, NE 68178 USA Univ Fed Bahia, ProAR Nucleo Excelencia Asma, Salvador, BA, Brazil CNPq, Salvador, BA, Brazil Univ Amsterdam, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands Univ Porto, Sch Med, Dept Hlth Informat & Decis Sci, P-4100 Oporto, Portugal Univ Porto, Sch Med, CINTESIS, P-4100 Oporto, Portugal Hosp S Joao & Inst, Dept Allergy, Oporto, Portugal Hosp CUF Porto, Oporto, Portugal Erasmus MC, Dept Internal Med, Sect Allergol, Rotterdam, Netherlands Univ Washington, Sch Med, Seattle, WA USA Helsinki Univ Hosp, Dept Allergy, Skin & Allergy Hosp, Helsinki, Finland GARD ARIA Coordinator, Geneva, Switzerland Med Univ Lodz, Dept Internal Med Asthma & Allergy, Barlicki Univ Hosp, Lodz, Poland Univ S Florida, Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33612 USA James A Haley Vet Hosp, Tampa, FL USA Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway CIBERES, IDIBAPS, Hosp Clin, Rhinol Unit,ENT Dept, Barcelona, Spain CIBERES, IDIBAPS, Hosp Clin, Smell Clin,ENT Dept, Barcelona, Spain Univ Chicago, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol, Tokyo 173, Japan EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece Nippon Med Sch, Bunkyo Ku, Tokyo 113, Japan Univ Aberdeen, Dept Primary Care Resp Med, Aberdeen, Scotland Woodbrook Med Ctr, Loughborough, Leics, England Univ Edinburgh, Edinburgh, Midlothian, Scotland Univ Manitoba, Fac Med, Winnipeg, MB, Canada NIAID, Bethesda, MD 20892 USA Univ N Carolina, Sch Pharm, Chapel Hill, NC USA Celal Bayar Univ, Sch Med, Dept Pulmonol, Manisa, Turkey Allergy & Asthma Inst, Islamabad, Pakistan Med Univ Graz, Dept Dermatol, Graz, Austria Showa Univ, Sch Med, Div Allergol & Resp Med, Tokyo 142, Japan Transylvania Univ, Fac Med, Brasov, Romania Int Union TB & Lung Dis Union, Paris, France Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland Minist Hlth, Publ Hosp Med Serv, Antananarivo, Madagascar INSERM, EPAR U707, Paris, France Univ Paris 06, EPAR, UMR S, Paris, France Hosp Quiron Bizkaia, Dept Allergy & Immunol, Erandio Bilbao, Spain Univ Cape Town, Dept Med, Fac Hlth Sci, Div Pulmonol, ZA-7925 Cape Town, South Africa WHO, Collaborating Ctr Asthma & Rhinitis, Montpellier, France Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena, Italy Ctr Hosp Univ Rabta, Serv Pneumol Allergol, Tunis, Tunisia Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1105 AZ Amsterdam, Netherlands Hop Mami, Ariana, Tunisia Bangladesh Lung Fdn, Dhaka, Bangladesh Natl Inst Dis Chest & Hosp, Dhaka, Bangladesh Charite, Dept Dermatol, Allergy Ctr Charite, D-13353 Berlin, Germany Univ Med Ctr, Dept Dermatol & Allergy, Bonn, Germany Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA Univ Verona, Dept Paediat, I-37100 Verona, Italy Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada Hop Malbaie, La Malbaie, PQ, Canada Univ Leicester, Inst Lung Hlth, Leicester LE1 7RH, Leics, England Royal Brompton Hosp, Dept Paediat Resp Med, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sect Allergy & Clin Immunol, London, England Ctr Med Docente La Trinidad Caracas, Dept Immunol, Caracas, Venezuela Univ Austral Chile, Fac Med, Dept Pediat, Valdivia, Chile Univ Fed Sao Joao del Rei, Hlth Sci Ctr, Hlth Sci Postgrad Program, Divinopolis, Brazil Univ Cartagena, Immunol Res Inst, Cartagena de Indias, Colombia So Calif Res, Mission Viejo, CA USA Metropolitan Univ Barranquilla, Allergy & Immunol Lab, Barranquilla, Colombia IRCCS San Raffaele Pisana, Rome, Italy Univ Cattolica Sacro Cuore, Dept Thorac Surg, Rome, Italy Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands Capital Inst Pediat, Asthma Clin, Natl Cooperat Grp Pediat Res Asthma, Beijing, Peoples R China Capital Inst Pediat, Educ Ctr, Beijing, Peoples R China Ctr Asthma Res & Educ, Beijing, Peoples R China Hop Arnaud Villeneuve, Univ Hosp, Allergy Unit, Montpellier, France Univ Hosp, Dept Allergol, Sch Med CEU San Pablo Madrid, Madrid, Spain Georgian Natl Univ, AIETI Med Sch, SEU Clin, Med Ctr, Tbilisi, Rep of Georgia Univ Genoa, Dept Internal Med, IRCCS Azienda Osped Univ San Martino, I-16126 Genoa, Italy Univ Montpellier I, Primary Care Dept, Montpellier, France Nova SE Univ, Coll Osteopath Med, Davie, FL USA Univ Manchester, Manchester, Lancs, England Aarhus Univ Hosp, Dept Resp Dis, DK-8000 Aarhus, Denmark Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany TUM, Div Environm Dermatol, Munich, Germany TUM, Allergy Helmholtz Ctr, Munich, Germany Univ Hosp Strasbourg, Chest Dis Dept, Div Pulmonol Asthma & Allergol, Strasbourg, France Univ Med & Pharm Iuliu Hatieganu, Dept Allergy, Med Clin 3, Romanian Soc Allergy & Clin Immunol, Cluj Napoca, Romania McMaster Univ, AllerGen NCE, Dept Med, Hamilton, ON, Canada McMaster Univ, AllerGen NCE, Michael G DeGroote Sch Med, Div Clin Immunol & Allergy,Fac Hlth Sci, Hamilton, ON, Canada Univ Versailles St Quentin, Hop Foch, UPRES EA 220, Suresnes, France Ctr Hosp Reg Annecy, Serv Pneumol, Annecy, France Univ Ss Cyril & Methodius, Univ Clin Pulmonol & Allergy, Skopje, Macedonia Georgia Hlth Sci Univ, Augusta, GA USA Ctr Hosp Univ Beni Messous, Serv Pneumoallergol, Algiers, Algeria Vilnius Univ, Fac Med, Collaborating Ctr GA2LEN, Vilnius, Lithuania Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Ain Shams Univ, Childrens Hosp, Pediat Allergy & Immunol Unit, Cairo, Egypt Egyptian Soc Pediat Allergy & Immunol, Cairo, Egypt Soc Marocaine Malad Resp, Casablanca, Morocco Ctr Resp Dis & Allergy, Casablanca, Morocco Vilnius Univ, Fac Med, Vilnius, Lithuania Univ Milan, Sch Med, Melloni Hosp, Milan, Italy Educ Hlth, Warwick, England Dokkyo Med Univ, Mibu, Tochigi, Japan WHO, Country Off Georgia, Tbilisi, Rep of Georgia Clin Ricardo Palma, Lima, Peru Univ Nuevo Leon UANL, Hosp Univ, Fac Med, Monterrey, Mexico Ctr Allergy & Immunol, Tbilisi, Rep of Georgia Clin Hosp Univ Chile, Dept Med, Immunol & Allergol Div, Santiago, Chile Univ Hosp Leuven, Dept Otorhinolaryngol Head & Neck Surg, Louvain, Belgium Cent Reg Denmark, Ctr Publ Hlth & Qual Improvement, Aarhus, Denmark Allergy Ctr Vienna W, Vienna, Austria Natl Univ Ireland Univ Coll Cork, Dept Paediat & Child Hlth, Cork, Ireland Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England Univ Paris 11, Serv Pneumol, Hop Antoine Beclere, AP HP,INSERM,U999, Clamart, France Salvador Univ, Sch Med, Dept Immunol, Buenos Aires, DF, Argentina Univ St Andrews, St Andrews, Fife, Scotland Univ Paris, APHP, Ctr Asthme & Allergies, Grp Hosp Trousseau La Roche Guyon, F-75252 Paris, France Hacettepe Univ, Sch Med, Pediat Allergy & Asthma Unit, Ankara, Turkey George Washington Univ, Sch Med, Washington, DC USA Inst Asthma & Allergy, Chevy Chase, MD USA Hacettepe Univ Hosp, Dept Chest Dis, Adult Allergy Unit, Ankara, Turkey Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany McMaster Univ, Hamilton, ON, Canada Hotel Dieu France, Serv Pneumol & Reanimat Med, Beirut, Lebanon Univ St Joseph, Fac Med, Beirut, Lebanon Natl Med Ctr, Seoul, South Korea Seoul Natl Univ, Seoul, South Korea Korea Asthma Allergy Fdn, Seoul, South Korea Ctr Hosp Univ, Serv Malad Resp, Abidjan, Cote Ivoire Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Beatrix Childrens Hosp,Dept Pediat Pulmonol & Ped, Groningen, Netherlands Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden Vilnius Univ, Ctr Pulmonol & Allergol, Vilnius, Lithuania Vilnius Univ Hosp Santariskiu Klinikos, Vilnius, Lithuania Hosp Med Sur, Dept Allergy, Mexico City, DF, Mexico Univ Med & Pharm, Thanh Pho Ho Chi Minh, Vietnam Hop Sacre Coeur Montreal, Montreal, PQ, Canada Univ Montreal, Montreal, PQ, Canada Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China Univ Tennessee, Coll Med, Memphis, TN USA Univ Dundee, Ninewells Hosp, Asthma & Allergy Res Grp, Dundee, Scotland Dubai Hlth Author, Sharjah, U Arab Emirates Univ Sharjah, Sharjah, U Arab Emirates Univ Mississippi, Med Ctr, Div Clin Immunol & Allergy, Jackson, MS 39216 USA Univ Arizona, Coll Med, Arizona Resp Ctr, Tucson, AZ USA Univ Arizona, Inst BIO5, Tucson, AZ USA Shahid Beheshti Univ Med Sci, NRITLD, Tehran, Iran Shahid Beheshti Univ Med Sci, Chron Resp Dis Res Ctr, Tehran, Iran Charite, Dept Dermatol & Allergy, D-13353 Berlin, Germany Maputo Cent Hosp, Dept Peadiat, Maputo, Mozambique Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique Childrens Hosp La Fe, Unit Pediat Allergy & Pneumol, Valencia, Spain Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden Univ Calif San Diego, Allergy & Asthma Med Grp, San Diego, CA 92103 USA Univ Calif San Diego, Res Ctr, San Diego, CA 92103 USA IMSS, Dept Allergy & Clin Immunol, Ctr Med Nacl Siglo 21, Mexico City, DF, Mexico Univ Aachen, Dept Dermatol, Aachen, Germany Inst Pneumol Marius Nasta, Bucharest, Romania Tishreen Univ, Sch Med, Dept Internal Med, WHO EMRO Collaborating Ctr Training & Res Chron R, Latakia, Syria CUF Descobertas Hosp, Immunoallergy Dept, Lisbon, Portugal Univ Padua, Dept Pediat, Food Allergy Referral Ctr Veneto Reg, Padua, Italy Mustapha Hosp, Algiers, Algeria Sci Ctr Childrens Hlth RAMS, Moscow, Russia Hosp Hospitaller Bros Buda, Budapest, Hungary Charite, Allergie Ctr Charite ECARF, Dept Dermatol Venerol & Allergy, D-13353 Berlin, Germany German Red Cross Hosp Westend, Berlin, Germany Jagiellonian Univ, Sch Med, Dept Pulmonol, Krakow, Poland Kinshasa Univ, ENT Dept, Kinshasa, Zaire Chiba Univ Hosp, Dept Otorhinolaryngol, Chiba, Japan Nippon Med Sch, Dept Otolaryngol, Bunkyo Ku, Tokyo 113, Japan Ctr Hosp Univ Pediat Charles de Gaulle, Ouagadougou, Burkina Faso Marmara Univ, Div Pediat Allergy & Immunol, Istanbul, Turkey Mem Hlth Grp, Istanbul, Turkey Charles Univ Prague, Fac Med Plzen, Dept Immunol & Allergol, Prague, Czech Republic MESSERLI Res Inst, Vienna, Austria Med Univ Vienna, Univ Vet Med Vienna, Vienna, Austria Univ Vienna, Vienna, Austria Ajou Univ, Sch Med, Suwon 441749, South Korea NICE, Paris, France Soc Pneumol Langue Francaise, Paris, France Krankenhaus Hietzing, Karl Landsteiner Inst Expt & Clin Pneumol, Dept Pulm Med, Vienna, Austria Alexanders Univ Hosp, Clin Allergy & Asthma, Sofia, Bulgaria Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Dept Pulmonol, Groningen, Netherlands Univ Cape Town, Lung Inst, ZA-7925 Cape Town, South Africa Groote Schuur Hosp, ZA-7925 Cape Town, South Africa Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands Grosshansdorf Clin, Grosshansdorf, Germany Hop Prive Athis Mons, Serv Pneumol, Athis Mons, France Helsinki Univ Hosp, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland Tech Univ Munich, CKCARE, Dept Dermatol Allergy Biederstein, Munich, Germany Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA Med Univ Silesia, Dept & Clin Internal Dis Allergol & Clin Immunol, Katowice, Poland Complesso Integrato Columbus, Allergy Unit, Rome, Italy IRCCS Oasi Maria SS, Troina, Italy Son Pisa Primary Care Ctr, IB Salut Balear Hlth Serv, Int Primary Care Resp Grp, Palma de Mallorca, Spain Hosp Luz, Immunoallergy Dept, Lisbon, Portugal Univ Missouri, Kansas City Sch Med, Kansas City, MO 64110 USA Childrens Mercy Hosp, Kansas City, MO USA Emek Med Ctr, Afula, Israel Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel Ctr Med Docente La Trinidad, Dept Allergy & Clin Immunol, Caracas, Venezuela UCL, Royal Natl TNE Hosp, London, England Univ Zurich Hosp, Dept Dermatol, Allergy Unit, CH-8091 Zurich, Switzerland Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Allergy & Resp Res Grp, Edinburgh, Midlothian, Scotland Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil Natl Ctr Cardiol & Internal Med, Bishkek, Kyrgyzstan Ctr ACI Immunoflow, Czech Initiat Asthma, Prague, Czech Republic GAAPP, Vienna, Austria Ctr Res Environm Epidemiol CREAL, Barcelona, Spain Pontificia Univ Catolica RGS, Sch Med, Porto Alegre, RS, Brazil Univ Nevada, Sch Med, Reno, NV 89557 USA Hosp Mar, Municipal Inst Med Res IMIM, Barcelona, Spain CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain Univ Pompeu Fabra UPF, Barcelona, Spain Jagiellonian Univ, Coll Med, Krakow, Poland Coimbra Univ Hosp, Immunoallergy Dept, Coimbra, Portugal Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA Finnish Inst Occupat Hlth, Helsinki, Finland Univ Laval, Fac Med, Dept Obstet & Gynecol, Laval, PQ, Canada Med Univ Vienna, Christian Doppler Lab Allergy Res, Div Immunopathol, Dept Pathophysiol & Allergy Res,Ctr Pathophysiol, Vienna, Austria Hosp Clin Barcelona, Dept Pneumol, Allergy Unit, Immunoallergia Resp Clin, Barcelona, Spain IDIBAPS, Barcelona, Spain CIBERES, Barcelona, Spain Univ Paris 13, Bobigny, France Avicenne Hosp, AP HP, Bobigny, France Vilnius Univ, Fac Med, Dept Paediat, Vilnius, Lithuania Lithuanian Natl Council Childs Hlth, Vilnius, Lithuania Terveystalo Turku, Allergy Clin, Turku, Finland Univ Turku, Dept Lung Dis & Clin Immunol, Turku, Finland Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium Catholic Univ Louvain, Univ Hosp Mt Godinne, Yvoir, Belgium Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, NL-6525 ED Nijmegen, Netherlands Siriraj Hosp, Fac Med, Dept Pediat, Bangkok, Thailand CNR, IBIM, Palermo, Italy Clin Physiol IFC, Pisa, Italy Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore Floridsdorf Allergy Ctr FAZ, Vienna, Austria Med Univ Vienna, Dept Dermatol, DIAID, Vienna, Austria Bradford Teaching Hosp Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England Olmsted Med Ctr, Dept Res, Rochester, MN USA Univ Minnesota, Dept Family & Community Hlth, Rochester, MN USA Harvard Univ, Sch Publ Hlth, Cyprus Int Inst Environm & Publ Hlth Assoc, Limassol, Cyprus Cyprus Univ Technol, Limassol, Cyprus Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, ZA-7925 Cape Town, South Africa Catholic Univ Cordoba, Sch Med, Dept Otorhinolaryngol, Cordoba, Argentina Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China Univ Clin Resp & Allerg Dis, Golnik, Slovenia Charite, Network Excellence, Global Allergy & Asthma European Network GA2LEN, D-13353 Berlin, Germany Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil Web of Science

Published
2012
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9. We call for iCAALL: International Collaboration in Asthma, Allergy and Immunology

Author

Lötvall, J., Pawankar, R., Wallace, D. V., Akdis, C. A., Rosenwasser, L. J., Weber, R. W., Wesley Burks, A., Casale, T. B., Lockey, R. F., Nikolaos Papadopoulos, Fineman, S. M., Ledford, D. K., University of Zurich, and Akdis, C A

Subjects
2403 Immunology, 10183 Swiss Institute of Allergy and Asthma Research, 2723 Immunology and Allergy, 610 Medicine & health
Published
2012
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10. Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper

Author

Bousquet, Jean, Schünemann, H J, Zuberbier, T, Bachert, C, Baena-Cagnani, C E, Bousquet, P J, Brozek, J, Canonica, G W, Casale, T B, Demoly, P, Gerth van Wijk, R, Ohta, K, Bateman, E D, Calderon, M, Cruz, A A, Dolen, W K, Haughney, J, Lockey, R F, Lötvall, J, O'Byrne, P, Spranger, O, Togias, A, Bonini, S, Boulet, L P, Camargos, P, Carlsen, K H, Chavannes, N H, Delgado, Lara García, Durham, S R, Fokkens, W J, Fonseca, Jun Sergio Ono, Haahtela, T, Kalayci, O, Kowalski, M L, Larenas-Linnemann, D, Li, J, Mohammad, Y, Mullol, J, Naclerio, R, O'Hehir, R E, Papadopoulos, N, Passalacqua, G, Rabe, K F, Pawankar, R, Ryan, David, Samolinski, B, Simons, F E R, Valovirta, E, Yorgancioglu, A, and Dahl, R

Subjects
Evidence-Based Medicine, Rhinitis, Allergic, Perennial, Practice Guidelines as Topic, Disease Management, Humans, Rhinitis, Allergic, Seasonal, Planning Techniques, Asthma
Abstract

The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients’ values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved.

Published
2010
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11. Unmet needs in severe chronic upper airway disease (SCUAD)

Author

Bousquet, J, Bachert, C, Canonica, G W, Casale, T B, Cruz, A A, Lockey, R J, Zuberbier, T, University of Zurich, and Bousquet, J

Subjects
2403 Immunology, 10183 Swiss Institute of Allergy and Asthma Research, 2723 Immunology and Allergy, 10177 Dermatology Clinic, 610 Medicine & health
Published
2009

12. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)

Author

Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena-Cagnani, C. E., Canonica, G. W., van Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M. S., Bonini, S., Boulet, L.-P., Bousquet, P.-J., Camargos, P., Carlsen, K.-H., Chen, Y., Custovic, A., Dahl, R., Demoly, P., Douagui, H., Durham, S. R., van Wijk, R Gerth, Kalayci, O., Kaliner, M. A., Kim, Y.-Y., Kowalski, M. L., Kuna, P., Le, L. T. T., Lemiere, C., Li, J., Lockey, R. F., Mavale-Manuel, S., Meltzer, E. O., Mohammad, Y., Mullol, J., Naclerio, R., O'Hehir, R. E., Ohta, K., Ouedraogo, S., Palkonen, S., Papadopoulos, N., Passalacqua, G., Pawankar, R., Popov, T. A., Rabe, K. F., Rosado-Pinto, J., Scadding, G. K., Simons, F. E. R., Toskala, E., Valovirta, E., van Cauwenberge, P., Wang, D.-Y., Wickman, M., Yawn, B. P., Yorgancioglu, A., Yusuf, O. M., Zar, H., Annesi-Maesano, Isabella, Bateman, E. D., Ben Kheder, A., Boakye, D. A., Bouchard, J., Burney, P., Busse, W. W., Chan-Yeung, M., Chavannes, N. H., Chuchalin, A., Dolen, W. K., Emuzyte, R., Grouse, L., Humbert, M., Jackson, C., Johnston, S. L., Keith, P. K., Kemp, J. P., Klossek, J.-M., Larenas-Linnemann, D., Lipworth, B., Malo, J.-L., Marshall, G. D., Naspitz, C., Nekam, K., Niggemann, B., Nizankowska-Mogilnicka, E., Okamoto, Y., Orru, M. P., Potter, P., Price, D., Stoloff, S. W., Vandenplas, O., Viegi, G., Williams, D., Renseigné, Non, Dermatology, Internal Medicine, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), inconnu, Inconnu, Forschungszentrum Jülich GmbH - Projektträger BEO, GmbH, Photochimie moléculaire et macromoléculaire (PMM), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], P&A Kyriakou Children's Hospital, Forschungszentrum Karlsruhe, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'étude des textures et application aux matériaux (LETAM), Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS), Université de Poitiers, Merlin Circuit Technology LTD, Bousquet J, N Khaltaev, RG van Wijk, Kalayci O, je Agache, MA Kaliner, YY Kim, Kowalski ML, Denburg J, P Kuna, Le LT, C Lemiere, KH Carlsen, Li J, Lockey RF, Manuel-S Mavale, Khaled Aït N, EO Meltzer, Mohammad Y, Mullol J, R Naclerio, Fokkens WJ, RE O'Hehir, Chen Y, K Ohta, S Ouedraogo, S Palkonen, N Papadopoulos, C Bachert, G Passalacqua, Pawankar R, TA Popov, KF Rabe, Rosado Pinto-J, Cruz AA, Togias A, GK Scadding, FE Simons, E Toskala, E Valovirta, MS Blaiss, P Van Cauwenberge, Wang DY, M Wickman, BP Yawn, Custovic A, Yorgancioglu A, OM Yusuf, T Zuberbier, H Zar, Annesi-Maesano I, ED Bateman, S Bonini, Ben Kheder A, DA Boakye, Bouchard J, R Dahl, P Burney, WW Busse, M Chan-Yeung, Chavannes NH, Baena-Cagnani CE, Chuchalin A, WK Dolen, LP Boulet, R Emuzyte, L Grouse, Demoly P, M Humbert, C Jackson, SL Johnston, Keith PK, JP Kemp, JM Klo, GW Canonica, C Weel van, Bousquet PJ, P Camargos, H Douagui, SR Durham, and Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)

Subjects
Rhinitis, Allergic, Perennial, MESH: Asthma, Adolescent, Global Health, World Health Organization, MESH: World Health Organization, MESH: Risk Factors, Risk Factors, MESH: Child, Effective Primary Care and Public Health [EBP 3], Prevalence, Humans, Child, ComputingMilieux_MISCELLANEOUS, MESH: Prevalence, MESH: Adolescent, MESH: Humans, MESH: Rhinitis, Allergic, Perennial, Cardiovascular diseases [NCEBP 14], Rhinitis, Allergic, Seasonal, MESH: Rhinitis, Allergic, Seasonal, Effective primary care and public health [NCEBP 7], Asthma, World Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: World Health
Abstract

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an IgE-mediated inflammation of the membranes lining the nose. It is a global health problem that causes major illness and disability worldwide. Over 600 million patients from all countries, all ethnic groups and of all ages suffer from allergic rhinitis. It affects social life, sleep, school and work and its economic impact is substantial. Risk factors for allergic rhinitis are well identified. Indoor and outdoor allergens as well as occupational agents cause rhinitis and other allergic diseases. The role of indoor and outdoor pollution is probably very important, but has yet to be fully understood both for the occurrence of the disease and its manifestations. In 1999, during the Allergic Rhinitis and its Impact on Asthma (ARIA) WHO workshop, the expert panel proposed a new classification for allergic rhinitis which was subdivided into 'intermittent' or 'persistent' disease. This classification is now validated. The diagnosis of allergic rhinitis is often quite easy, but in some cases it may cause problems and many patients are still under-diagnosed, often because they do not perceive the symptoms of rhinitis as a disease impairing their social life, school and work. The management of allergic rhinitis is well established and the ARIA expert panel based its recommendations on evidence using an extensive review of the literature available up to December 1999. The statements of evidence for the development of these guidelines followed WHO rules and were based on those of Shekelle et al. A large number of papers have been published since 2000 and are extensively reviewed in the 2008 Update using the same evidence-based system. Recommendations for the management of allergic rhinitis are similar in both the ARIA workshop report and the 2008 Update. In the future, the GRADE approach will be used, but is not yet available. Another important aspect of the ARIA guidelines was to consider co-morbidities. Both allergic rhinitis and asthma are systemic inflammatory conditions and often co-exist in the same patients. In the 2008 Update, these links have been confirmed. The ARIA document is not intended to be a standard-of-care document for individual countries. It is provided as a basis for physicians, health care professionals and organizations involved in the treatment of allergic rhinitis and asthma in various countries to facilitate the development of relevant local standard-of-care documents for patients.

Published
2008
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13. Bioassay of atypical scrapie cases from Great Britain in TG338 mice provides evidence that they are indistinguishable from NOR98

Author

Griffiths, P.C., Spiropoulos, J., Lockey, R., Tout, A.C., Jayasena, D., Simonini, S., Dexter, I., Beringue, Vincent, Le Dur, Annick, Laude, Hubert, Hope, Jane, Veterinary Laboratories Agency, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Background: In Great Britain, sheep scrapie cases have been detected through active and passive surveillance programmes which do not conform to the characteristics usually associated with classical scrapie. These cases, designated as ‘atypical scrapie’, demonstrate a weak positive PrPres reaction in Bio-Rad ELISA and in histopathology produce a weak immunohistochemistry signal and demonstrate a different PrPSc distribution pattern compared to classical scrapie. Other features, such as an absence of vacuolation at the obex and a characteristic PrPres Western blotting profile are also apparent. Aim: The aim of this Defra-funded study was to determine the transmissibility of atypical scrapie cases from Britain to transgenic PrP and conventional mice, and to examine the biochemical and histopathological characteristics of the transmitted agent(s). Methods: Atypical scrapie isolates were selected from sheep carrying a range of PrP genotypes and inoculated into tg338, C57BL/6 and VM mice. Inoculated mice were clinically monitored and at termination brain samples were examined by Western blotting, lesion profiling and immunohistochemistry. Results: Eighteen atypical scrapie isolates derived from sheep of different genotypes transmitted successfully to tg338 mice at VLA and INRA. Incubation periods, lesion profiles, PrPSc distribution and Western blot profiles of the examined cases were similar, suggesting the isolation of a single strain. Furthermore, the biochemical and histopathological characteristics produced were indistinguishable from those of Nor 98 in the same transgenic mouse line. Bioassay in wild-type mice is ongoing with no TSE positive mice identified up to 431 days post-inoculation. Conclusion: Our findings suggest that the atypical scrapie cases from GB represent infection resulting from a single strain of TSE agent that is indistinguishable from Nor98.

Published
2007

14. Pharmacologic and anti-IgE treatment of allergic rhinitis ARIA update (in collaboration with GALEN)

Author

Bousquet, J, VAN CAUWENBERGE, P, AIT KHALED, N, Bachert, C, BAENA CAGNANI CE, Bouchard, J, Bunnag, C, Canonica, Giorgio, Carlsen, Kh, Chen, Yz, Cruz, Aa, Custovic, A, Demoly, P, Dubakiene, R, Durham, S, Fokkens, W, Howarth, P, Kemp, J, Kowalski, Ml, Kvedariene, V, Lipworth, B, Lockey, R, Lund, V, MAVALE MANUEL, S, Meltzer, Eo, Mullol, J, Naclerio, R, Nekam, K, Ohta, K, Papadopoulos, N, Passalacqua, Giovanni, Pawankar, R, Popov, T, Potter, P, Price, D, Scadding, G, Simons, Fe, Spicak, V, Valovirta, E, Wang, Dy, Yawn, B, and Yusuf, O.

Published
2006

15. Pharmacologic and anti-IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN)

Author

Bousquet, J. Van Cauwenberge, P. Aït Khaled, N. Bachert, C. Baena-Cagnani, C.E. Bouchard, J. Bunnag, C. Canonica, G.W. Carlsen, K.-H. Chen, Y.-Z. Cruz, A.A. Custovic, A. Demoly, P. Dubakiene, R. Durham, S. Fokkens, W. Howarth, P. Kemp, J. Kowalski, M.L. Kvedariene, V. Lipworth, B. Lockey, R. Lund, V. Mavale-Manuel, S. Meltzer, E.O. Mullol, J. Naclerio, R. Nekam, K. Ohta, K. Papadopoulos, N. Passalacqua, G. Pawankar, R. Popov, T. Potter, P. Price, D. Scadding, G. Simons, F.E.R. Spicak, V. Valovirta, E. Wang, D.-Y. Yawn, B. Yusuf, O.

Subjects
animal structures
Abstract

The pharmacologic treatment of allergic rhinitis proposed by ARIA is an evidence-based and step-wise approach based on the classification of the symptoms. The ARIA workshop, held in December 1999, published a report in 2001 and new information has subsequently been published. The initial ARIA document lacked some important information on several issues. This document updates the ARIA sections on the pharmacologic and anti-IgE treatments of allergic rhinitis. Literature published between January 2000 and December 2004 has been included. Only a few studies assessing nasal and non-nasal symptoms are presented as these will be discussed in a separate document. Copyright © Blackwell Munksgaard 2006.

Published
2006

16. Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI), Allergic Rhinitis and its Impact on Asthma (ARIA)

Author

Bousquet, J, Van Cauwenberge, P, Bachert, C, Canonica, Giorgio, Demoly, P, Durham, Sr, Fokkens, W, Lockey, R, Meltzer, Eo, Mullol, J, Naclerio, Rm, Price, D, Simons, Fe, Vignola, Am, Warner, Jo, European Academy of Allergy, Clinical, Immunology, Allergic, Rhinitis, and its Impact on Asthma

Published
2003

17. Optoelectronic time-division multiplexing for multicomponent laser doppler anemometry

Author

Lockey, R. A. and Tatum, R. P.

Subjects
Computer Science::Information Theory
Abstract

This thesis describes the investigation of time-division multiplexing for use in mUlticomponent laser Doppler anemometry (LDA). To make two- or three- dimensional velocity measurements of a flow, two or three separate velocity measurements in different, non-collinear or non-coplanar directions respectively must be taken from which the flow vector can be calculated. It is necessary to separate each velocity channel. Conventionally, the separation is carried out by optical techniques, such as separating the signal from each channel by wavelength or polarisation, with one detector per channel. In time division multiplexing, each channel is switched On and off in turn. A single detector records a stream of interleaved pulses, and each channel is extracted by taking every other or every third pulse. The envelope of the amplitudes of the pulses varies at the Doppler frequency. A novel system has been demonstrated which uses a single laser diode source and a single detector. The distribution of the pulses to each channel and the delay between each channel is carried out using a optical fibre network with fibre delay lines, with a consequent reduction in 'electronic complexity. The characteristics of the optoelectronic components used in the system are tested, and two signal processing schemes are investigated. A two-dimensional Doppler difference fibre-linked probe was constructed to demonstrate the technique. Hybrid instruments using two Doppler difference channels and a reference beam channel to measure orthogonal velocity components offer the possibility of avoiding the errors introduced by non-orthogonal systems. A pulsed-diode reference beam anemometer based on optical fibres and suitable for inclusion in a time-division multiplexed hybrid instrument was tested.

Published
1996

20. Letter to the editor [1] (multiple letters)

Author

Morris, D. L., Morris, M. S., Kroker, G. F., Sabnis, V. K., linda cox, Atwater Jr, J. S., Li, J. T., Lockey, R. F., Bernstein, L., Portnoy, J. M., and Nicklas, R. A.

25. EBIS preinjector construction status

Author

Alessi, J., Barton, D., Beebe, E., Bellavia, S., Gould, O., Kponou, A., Lambiase, R., Lessard, E., Lockey, R., Lodestro, V., Mapes, M., Mccafferty, D., Mcnerney, A., Masahiro Okamura, Pendzick, A., Phillips, D., Pikin, A. I., Raparia, D., Ritter, J., Scaduto, J., Snydstrup, L., Wilinski, M., Zaltsman, A., Ratzinger, U., and Schempp, A.

27. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update: In collaboration with the World Health Organization, GA(2)LEN and AllerGen | ARIA update 2008: Die allergische rhinitis und ihr einfluss auf das asthma

Author

Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W., Togias, A., Zuberbier, T., Baena-Cagnani, C., Canonica, G. W., Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M., Bonini, S., Boulet, L. -P, Bousquet, P. -J, Camargos, P., Carlsen, K. -H, Custovic, A., Chen, Y., Dahl, R., Demoly, P., Douagui, H., Durham, S., Wijk, R. G., Kalayci, O., Kaliner, M., Kim, Y. -Y, Kowalski, M. L., Kuna, P., Lemiere, C., Tuyet Lan, L. T., Li, J., Lockey, R., Mavale, S., Meltzer, E. O., Mohammad, Y., Mullol, J., Naclerio, R., Ohehir, R., Ohta, K., Ouedraogo, S., Palkonen, S., Nikolaos Papadopoulos, Passalacqua, G., Pawankar, R., Popov, T., Rabe, K., Rosado-Pinto, J., Scadding, G., Simons, F. E. R., Toskala, E., Valovirta, E., Cauwenberge, P., Wang, D. Y., Wickman, M., Yawn, B., Yorgancioglu, A., Yusuf, O., and Zar, H.

29. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update: In collaboration with the World Health Organization, GA(2)LEN and AllerGen,ARIA update 2008: Die allergische rhinitis und ihr einfluss auf das asthma

Author

Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W., Togias, A., Zuberbier, T., Baena-Cagnani, C., Canonica, G. W., Weel, C., Agache, I., Aït-Khaled, N., Bachert, C., Blaiss, M., Bonini, S., Boulet, L. -P, Bousquet, P. -J, Camargos, P., Carlsen, K. -H, Custovic, A., Chen, Y., Dahl, R., Demoly, P., Douagui, H., Durham, S., Wijk, R. G., Kalayci, O., Kaliner, M., Kim, Y. -Y, Kowalski, M. L., Kuna, P., Lemiere, C., Tuyet Lan, L. T., Li, J., Lockey, R., Mavale, S., Meltzer, E. O., Mohammad, Y., Mullol, J., Naclerio, R., Ohehir, R., Ohta, K., Ouedraogo, S., Palkonen, S., Papadopoulos, N., Passalacqua, G., Pawankar, R., Popov, T., Rabe, K., Rosado-Pinto, J., Scadding, G., Simons, F. E. R., Toskala, E., Valovirta, E., Cauwenberge, P., Wang, D. Y., Wickman, M., Yawn, B., arzu yorgancıoglu, Yusuf, O., and Zar, H.

31. IgE Isotype Switching

Author

van de Veen, W, University of Zurich, Mackay, I R, Rose, N R, Ledford, D K, Lockey, R F, and van de Veen, W

Subjects
10183 Swiss Institute of Allergy and Asthma Research, 610 Medicine & health
Published
2014
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33. Specific IgE

Author

van de Veen, W, University of Zurich, Mackay, I R, Rose, N R, Ledford, D K, Lockey, R F, and van de Veen, W

Subjects
10183 Swiss Institute of Allergy and Asthma Research, 610 Medicine & health
Published
2014
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34. Davos declaration: allergy as a global problem

Author

Thomas Bieber, Gianni Marone, A. Jung, Donald Y.M. Leung, S. T. Holgate, Jeffrey M. Drazen, Ruby Pawankar, Jean Bousquet, Harald Renz, Thomas A.E. Platts-Mills, Reto Crameri, Richard F. Lockey, Roger Lauener, Ulrich Wahn, Ernst Rietschel, S. Hildemann, Heidrun Behrendt, Günter Menz, A. Fire, J. Ring, Claudia Traidl-Hoffmann, Bruce S. Bochner, Mübeccel Akdis, Stephen J. Galli, Caroline Roduit, C. Czerkinsky, Kurt Blaser, Ulf Darsow, U. Mueller, O. de Beaumont, W. Ammann, B. Menné, E. von Mutius, Tari Haahtela, Adnan Custovic, Georg Schäppi, Carsten Schmidt-Weber, M. Kemeny, H. Koren, Patrick G. Holt, Cezmi A. Akdis, Markus Ollert, Thilo Jakob, John Bienenstock, H. zur Hausen, Liam O'Mahony, Judah A. Denburg, Martin Mempel, E. M. De Villiers, Ring, J, Akdis, C, Behrendt, H, Lauener, Rp, Schäppi, G, Akdis, M, Ammann, W, de Beaumont, O, Bieber, T, Bienenstock, J, Blaser, K, Bochner, B, Bousquet, J, Crameri, R, Custovic, A, Czerkinsky, C, Darsow, U, Denburg, J, Drazen, J, de Villiers, Em, Fire, A, Galli, S, Haahtela, T, zur Hausen, H, Hildemann, S, Holgate, S, Holt, P, Jakob, T, Jung, A, Kemeny, M, Koren, H, Leung, D, Lockey, R, Marone, Gianni, Mempel, M, Menné, B, Menz, G, Mueller, U, von Mutius, E, Ollert, M, O'Mahony, L, Pawankar, R, Renz, H, Platts Mills, T, Roduit, C, Schmidt Weber, C, Traidl Hoffmann, C, Wahn, U, Rietschel, E., and University of Zurich

Subjects
0303 health sciences, 2403 Immunology, Immunology, Declaration, Global problem, 610 Medicine & health, Global Health, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Environmental protection, 10036 Medical Clinic, 10183 Swiss Institute of Allergy and Asthma Research, Law, Political science, Hypersensitivity, 2723 Immunology and Allergy, Humans, Immunology and Allergy, 030304 developmental biology
Published
2012
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