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1. Methods for estimation of within population genetic variation

Author

Burger, Pamela, Colli, Licia, Curik, Ino, Danchin-Burge, Coralie, Looft, C., Mészáros, Gábor, Soelkner, J., Xu, C., Ouedraogo, D., Rosen, B.F., Utsunomiya, Y.T., and Windig, J.J.

Subjects
WIAS, Life Science, Fokkerij & Genomica, Animal Breeding & Genomics
Published
2022

2. Marker-assisted conservation of European cattle breeds: an evaluation

Author

Lenstra, J.A., Nijman, I.J., Eding, H., Engelsma, K.A., Bijma, P., Garcia, D., Canon, J., Dunner, S., Moazami Goudarzi, K., Laloe, D., Williams, J.L., Wiener, P., Burton, D., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E.M., Harlizius, B., Barre Dirie, A., Mengers, A., Looft, C., Kalm, E., Rodellar, C., Zaragoza, P., Martin Burriel, I., Sanchez, A., Ajmone Marsan, P., Negrini, R., Milanesi, E., Valentini, A., Savarese, M.C., Marchitelli, C., Zanotti, M., Ceriotti, G., Pilla, F., Bruzzone, A., Iamartino, D., Olsaker, I., Holm, L.E., Mommens, G., Dolf, G., Hiemstra, S.H., and Windig, J.J.

Subjects
Genetic Markers, Conservation of Natural Resources, Genotype, business.industry, Cattle, Conservation, Genetic diversity, Kinship, Microsatellite, Weitzman, Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico, Genetic Variation, General Medicine, Breeding, Biology, Biotechnology, Environmental protection, Genetics, Animals, Animal Science and Zoology, business, Microsatellite Repeats
Abstract

Two methods have been developed for the assessment of conservation priorities on the basis of molecular markers. According to the Weitzman approach, contributions to genetic diversity are derived from genetic distances between populations. Alternatively, diversity within and across populations is optimized by minimizing marker-estimated kinships. We have applied, for the first time, both methods to a comprehensive data set of 69 European cattle breeds, including all cosmopolitan breeds and several local breeds, for which genotypes of 30 microsatellite markers in 25-50 animals per breed have been obtained. Both methods were used to calculate the gain in diversity if a breed was added to a set of nine non-endangered breeds. Weitzman-derived diversities were confounded by genetic drift in isolated populations, which dominates the genetic distances but does not necessarily increase the conservation value of a breed. Marker-estimated kinships across populations were less disturbed by genetic drift than the Weitzman diversities and assigned high conservation values to Mediterranean breeds, which indeed have genetic histories that differ from the non-endangered breeds. Prospects and limitations of marker-assisted decisions on conservation priorities are discussed.

Published
2006
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3. Investigation on Association and Expression of ESR2 as a Candidate Gene for Boar Sperm Quality and Fertility

Author

Looft, C., Gunawan, A., Tesfaye, D., Phatsara, C., Tholen, E., Uddin, M. J., Schellander, K., Cinar, M. U., and Kaewmala, K.

Subjects
endocrine system, urogenital system
Abstract

Contents ESR2 is involved in oestrogen-related apoptosis in cell cycle spermatogenesis but their effects have not yet confirmed in pig. Therefore, this study was aimed to investigate the association of ESR2 polymorphism with sperm quality and boar fertility traits and to analyse the ESR2 mRNA and protein expressions in boar reproductive tissues. DNA samples from 203 Pietrain (PI) and 100 Pietrain x Hampshire (PIHA) pigs with records of sperm quality [sperm concentration (SCON), motility (MOT), semen volume (VOL), plasma droplet rate (PDR) and abnormal spermatozoa rate (ASR)] and fertility [non-return rate (NRR) and number of piglet born alive (NBA)] traits were available. A SNP in coding region of ESR2 g.35547A>G in exon 5 was associated with MOT and PDR in the PI and with SCON, VOL, MOT and PDR in PIHA population. For mRNA and protein expression study, a total of six boars were divided into two groups with group I (G-I) and group II (G-II) where G-I characterized for relatively a better sperm quality according to the mean of two groups. mRNA expression was higher in brain and testis than that in all parts of epididymis. Both qRT-PCR and western blot analysis revealed that the ESR2 gene expression and protein expression were significantly higher in testis collected from G-II compared with that of G-I boars. Moreover, ESR2 protein localization in germ cell, Leydig and Sertoli cells, epithelial cells and spermatozoa was remarkable, which indicated the important role of ESR2 in spermatogenesis process. These results might shed new light on the roles of ESR2 in spermatogenesis as candidate for boar fertility, but still the lack of association across populations should be considered.

Published
2012

4. Investigation into Association and Expression of PLCz and COX-2 as Candidate Genes for Boar Sperm Quality and Fertility

Author

Tesfaye, D., Cinar, M. U., Uddin, M. J., Grosse-Brinkhaus, C., Jonas, E., Tholen, E., Kaewmala, K., Schellander, K., Phatsara, C., and Looft, C.

Subjects
endocrine system, urogenital system
Abstract

Phospholipase C zeta (PLCz) and cyclooxygenase isoenzyme type 2 (COX-2) are important in spermatogenesis, but their effect has not yet confirmed in pigs. Therefore, this study was aimed to analyse their association with sperm quality and fertility and to identify the mRNA and protein expression in boars reproductive tissues. DNA samples from 231 Pietrain (PI) and 109 Pietrain x Hampshire (PIHA) pigs with records of sperm quality [sperm concentration (SCON), motility, semen volume, plasma droplet and abnormal spermatozoa rate] and fertility (non-return rate and number of piglet born alive) traits were available. A SNP in non-coding region of PLCz g.158 A > C was associated with SCON (p < 0.05) in PIHA population while the polymorphism of COX-2 g.68 G > A in 3' UTR was not associated with any traits. For mRNA and protein expression study, a total of six boars were divided into two groups with G-I and G-II, where G-I was characterized for relatively better sperm quality. Both genes expressed higher in reproductive tissues compared with non-reproductive tissues. Phospholipase C zeta mRNA expressed higher in testis (p < 0.01), all parts of epididymis and spermatozoa from G-I, while COX-2 expressed higher in testis (p < 0.05), head and body of epididymis (p < 0.01), and spermatozoa from G-II boar. Both proteins were localized in Leydig cells and spermatozoa. These results might shed light on roles of these genes in spermatogenesis as candidate for boar sperm quality and fertility, but still the lack of association across populations should be considered.

Published
2012

5. Mapping quantitative trait loci for innate immune response in the pig

Author

Tholen, E., Tesfaye, D., Looft, C., Uddin, M. J., Grosse-Brinkhaus, C., Juengst, H., Cinar, M. U., Schellander, K., Wimmers, K., and Phatsara, C.

Subjects
food and beverages
Abstract

P>The aim of the present study was to detect quantitative trait loci (QTL) for the serum levels of cytokines and Toll-like receptors as traits related to innate immunity in pig. For this purpose, serum concentration of interleukin 2 (IL2), interleukin 10 (IL10), interferon-gamma (IFNG), Toll-like receptor 2 (TLR2) and Toll-like receptor 9 (TLR9) were measured in blood samples obtained from F-2 piglets (n = 334) of a Duroc x Pietrain resource population (DUPI) after Mycoplasma hypopneumoniae (Mh), tetanus toxoid (TT) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccination at 6, 9 and 15 weeks of age. Animals were genotyped at 82 genetic markers covering all autosomes. QTL analysis was performed under the line cross F-2 model using QTL Express and 33 single QTL were detected on almost all porcine autosomes. Among the single QTL, eight, twelve and thirteen QTL were identified for innate immune traits in response to Mh, TT and PRRSV vaccine, respectively. Besides single QTL, six QTL were identified by a two-QTL model, of which two for TLR9_TT were in coupling phase and one for IL10_PRRSV was in repulsion phase. All QTL were significant at 5% chromosome-wide level including one and seven at 5% genome- and 1% chromosome-wide level significance. All innate immune traits are influenced by multiple chromosomal regions implying multiple gene action. Some of the identified QTL coincided with previously reported QTL for immune response and disease resistance, and the newly identified QTL are potentially involved in the immune function. The immune traits were also influenced by environmental factors like year of birth, age, parity and litter size. The results of this work shed new light on the genetic background of innate immune response and these findings will be helpful to identify candidate genes in these QTL regions related to immune competence and disease resistance in pigs.

Published
2011

6. On the breeds of cattle-Historic and current classifications

Author

Felius, M., Koolmees, Peter A., Theunissen, B., Baumung, R., Manatrinon, S., Mommens, G., Holm, L. -E., Withen, K. B., Pedersen, B. V., Gravlund, P., Viinalass, H., Kantanen, J., Tapio, I., M. H., Li, Moazami-Goudarzi, K., Gautier, M., Denis, Laloë, Oulmouden, A., Levéziel, H., Taberlet, P., Harlizius, B., Simianer, H., Täubert, H., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E. -M., Medugorac, I., Medugorac, A., Förster, M., Mix, H. M., Looft, C., Kalm, E., Bradley, D. G., Edwards, C. J., Machugh, D. E., Freeman, A. R., Ajmone Marsan, P., Negrini, R., Longeri, M., Ceriotti, G., Zanotti, M., Marletta, D., Criscione, A., Valentini, A., Marchitelli, C., Pariset, L., Savarese, M. C., Pilla, F., Grislis, Z., Miceikienė, I., Nijman, I. J., van Haeringen, W., van de Goor, L., Olsaker, I., Ginja, C., Gama, L. T., Mateus, J. C., Beja-Pereira, A., Ferrand, N., Ivanova, Z., Popov, R., Ammosov, I., Kiselyova, T., Marzanov, N., Stojanovic, S., Simčič, M., Dovč, P., Kompan, D., Dunner, S., Rodellar, C., Martín-Burriel, I., Sánchez, A., Piedrafita, J., Azor, P. J., Delgado, J. V., Martínez-Martínez, A., Molina, A., Rodero, E., Dolf, G., Williams, J. L., Wiener, P., Bruford, M. W., Bray, T. C., Alderson, L., Penedo, M. C. T., Lenstra, J. A., Lenstra, Johannes A., Utrecht University [Utrecht], and European Cattle Genetic Diversity Consortium

Subjects
breeds, breed, [SDV]Life Sciences [q-bio], Ecology (disciplines), Breeds, Zoology, Ethnic origin, Subspecies, Q1, Crossbreed, 03 medical and health sciences, symbols.namesake, QH301, aurochs, auroch, lcsh:QH301-705.5, 030304 developmental biology, Nature and Landscape Conservation, 2. Zero hunger, 0303 health sciences, Genetic diversity, biology, Ecology, Ecological Modeling, Linnaean taxonomy, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Aurochs, biology.organism_classification, cattle, classification, Classification, 040201 dairy & animal science, Agricultural and Biological Sciences (miscellaneous), Breed, Ecological Modelling, lcsh:Biology (General), Evolutionary biology, symbols, Cattle
Abstract

Chantier qualité GA Liste des auteurs de l'European Cattle Genetic Consortium, classés par pays : Austria: R. Baumung, S. Manatrinon, BOKU University, Vienna; Belgium: G. Mommens, University of Ghent, Merelbeke; Denmark: L.-E. Holm, Aarhus University, Tjele; K.B. Withen, B.V. Pedersen, P. Gravlund, University of Copenhagen, Copenhagen; Estonia: H. Viinalass, Estonian University of Life Sciences, Tartu; Finland: J. Kantanen, I. Tapio, M.H. Li, MTT, Jokioinen; France: K. Moazami-Goudarzi, M. Gautier, Denis Laloë, INRA, Jouy-en-Josas; A. Oulmouden, H. Levéziel, INRA, Limoges; P. Taberlet, Université Joseph Fourier et CNRS, Grenoble; Germany: B. Harlizius, School of Veterinary Medicine, Hannover; H. Simianer, H. Täubert, Georg-August-Universität, Göttingen; G. Erhardt, O. Jann, C. Weimann, E.-M. Prinzenberg, Justus-Liebig Universität, Giessen; I. Medugorac, A. Medugorac, M. Förster, Ludwig-Maximilians Universität, Munich; H.M. Mix, Naturschutz International, Grünheide; C. Looft, E. Kalm, Christian-Albrechts-Universität, Kiel; Ireland: D.G. Bradley, C.J. Edwards, D.E. MacHugh, A.R. Freeman, Trinity College, Dublin; Italy: P. Ajmone Marsan, R. Negrini, Università Cattolica del S. Cuore, Piacenza; M. Longeri, G. Ceriotti, M. Zanotti, Università degli Studi di Milano; D. Marletta, A. Criscione, Universita degli Studi di Catania, Catania; A. Valentini, C. Marchitelli, L. Pariset, M.C. Savarese, Università della Tuscia, Viterbo; F. Pilla, Università del Molise, Campobasso; Latvia: Z. Grislis, Latvia University of Agriculture, Jelgava; Lithuania: I. Miceikienė, Lithuanian Veterinary Academy, Kaunas; Netherlands: I.J. Nijman, Utrecht University; W. van Haeringen, L. van de Goor, Van Haeringen Laboratory, Wageningen; Norway: I. Olsaker, Norwegian School of Veterinary Science, Oslo; Portugal: C. Ginja, L.T.Gama, Instituto Nacional de Recursos Biológicos—INIA, Lisbon University, Lisboa; L.T. Gama, Instituto Nacional de Recursos Biológicos-INIA, I.P., Vale de Santarem; J.C. Mateus, Universidade de Trás-os-Montes e Alto Douro, Vila Real; A. Beja-Pereira, N. Ferrand, Oporto University; Russia: Z. Ivanova, R. Popov, I. Ammosov, Yakutian Research Institute of Agricultural Sciences, Yakutsk, Sakha; T. Kiselyova, All-Russian Research Institute for Farm Animals and Breeding, St. Petersburgh-Pushkin; N. Marzanov, All-Russian Research Institute of Animal Husbandry, Dubrovitsy; Serbia: S. Stojanovic, Ministry of Agriculture and Water Management, Belgrade; Slovenia: M. Simčič, P. Dovč, D.Kompan, University of Ljubljana, Domzale; Spain: S. Dunner, Universidad Complutense de Madrid; C. Rodellar, I. Martín-Burriel, Veterinary Faculty, Zaragoza; A. Sánchez, J. Piedrafita, Universitat Autònoma de Barcelona; P.J. Azor, J.V. Delgado, A. Martínez-Martínez, A. Molina, E. Rodero, University of Córdoba; Switzerland: G. Dolf, University of Berne; UK: J.L. Williams, P. Wiener, Roslin Institute; M.W. Bruford, T.C. Bray, Cardiff University, Cardiff; L. Alderson, Countrywide Livestock Ltd, Shrewsbury; USA: M.C.T. Penedo. University of California, Davis, CA; International audience; Classification of cattle breeds contributes to our understanding of the history of cattle and is essential for an effective conservation of genetic diversity. Here we review the various classifications over the last two centuries and compare the most recent classifications with genetic data. The classifications devised during the 19th to the late 20th century were in line with the Linnaean taxonomy and emphasized cranial or horn morphology. Subsequent classifications were based on coat color, geographic origin or molecular markers. Several theories were developed that linked breed characteristics either to a supposed ancestral aurochs subspecies or to a presumed ethnic origin. Most of the older classifications have now been discarded, but have introduced several Latin terms that are still in use. The most consistent classification was proposed in 1995 by Felius and emphasizes the geographic origin of breeds. This is largely in agreement with the breed clusters indicated by a biochemical and molecular genetic analysis, which reflect either groups of breeds with a common geographic origin or single breeds that have expanded by export and/or crossbreeding. We propose that this information is also relevant for managing the genetic diversity of cattle.

Published
2011
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7. Geographic Patterns of Molecular Diversity and Paternal Lineages of European cattle

Author

Lenstra, J A, Nijman, I J, Eding, H, Engelsma, K A, Bijma, P, Garcia, D, Cañón, J, Dunner, S, Moazami-Goudarzi, K, Laloe, D, Williams, J L, Wiener, P, Burton, D, Erhardt, G, Jann, O, Weimann, C, Prinzenberg, E M, Harlizius, B, Barre-Dirie, B, Mengers, A, Looft, C, Kalm, E, Rodellar, C, Zaragoza, P, Martin-Burriel, I, Sanchez, A, Ajmone-Marsan, P, Negrini, R, Milanesi, E, Valentini, A, Savarese, M C, Marchitelli, C, Zanotti, M, Ceriotti, G, Pilla, F, Bruzzone, A, Iamartino, D, Olsaker, I, Holm, Lars-Erik, Mommens, G, Dolf, G, Hiemstra, S J, and Winding, J J

Published
2009

8. Differentiation of European cattle by AFLP fingerprinting

Author

Negrini, R, Nijman, I J, Milanesi, E, Moazami-Goudarzi, K, Williams, J L, Erhardt, G, Dunner, S, Rodellar, C, Valentini, A, Bradley, D G, Olsaker, I, Kantanen, J, Ajmone-Marsan, P, Lenstra, J A, Laloë, D, Wiener, P, Burton, D, Weimann, C, Harlizius, B, Barre-Dirie, A, Mengers, A, Looft, C, Kalm, E, Cañón, J, Zaragoza, P, Martín-Burriel, I, Sanchez, A, Savarese, M C, Marchitelli, C, Zanotti, M, Pilla, F, Bruzzone, A, Iamartino, D, Holm, Lars-Erik, Eythorsdottir, E, Mommens, G, Dolf, G, Felius, M, Catholic University of the Sacred Heart, UItrecht University, Partenaires INRAE, Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), Roslin Institute, Justus-Liebig-Universität Gießen (JLU), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Trinity College Dublin, Norwegian School of Veterinary Science, Agrifood Research Finland, Faculty of Veterinary Medicine, and Utrecht University [Utrecht]

Subjects
Genotype, Introgression, Biology, Polymorphism, Single Nucleotide, amplified fragment length polymorphism, cattle, genetic diversity, introgression, zebu, Genetics, Animals, Cluster Analysis, Phylogeny, ComputingMilieux_MISCELLANEOUS, Genetic diversity, [SDV.GEN]Life Sciences [q-bio]/Genetics, Polymorphism, Genetic, General Medicine, Zebu, DNA Fingerprinting, Genetic marker, Evolutionary biology, Microsatellite, Cattle, Animal Science and Zoology, Amplified fragment length polymorphism, Genetic isolate, Microsatellite Repeats
Abstract

The Neolithic introduction of domestic cattle into Europe was followed by differential adaptation, selection, migration and genetic isolation, leading ultimately to the emergence of specialized breeds. We have studied the differentiation of European cattle by amplified fragment length polymorphism (AFLP) fingerprinting. Combining AFLP data sets from two laboratories yielded 81 biallelic polymorphic markers scored in 19-22 individual animals from 51 breeds. Model-based clustering differentiated Podolian cattle as well as French and Alpine breeds from other European cattle. AFLP genetic distances correlated well with microsatellite-based genetic distances calculated for the same breeds. However, the AFLP data emphasized the divergence of taurine and indicine cattle relative to the variation among European breeds and indicated an Eastern influence on Italian and Hungarian Podolian breeds. This probably reflects import from the East after the original introduction of domestic cattle into Europe. Our data suggest that Italian cattle breeds are relatively diverse at the DNA sequence level.

Published
2007
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10. Molecular differentiation of European Cattle breeds

Author

Lenstra, J.A., Nijman, I.J., Moazami Goudarzi, K., Laloë, D., Williams, J.L., Wiener, P., Burton, D., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E.M., Harlizius, B., Looft, C., Dunner, S., Canon, J., Rodellar, C., Zaragoza, P., Martin Burriel, I., Sanchez, A., Piedrafita, J., Ajmone Marsan, P., Negrini, R., Milanesi, E., Valentini, A., Savarese, M.C., Marchitelli, C., Zanotti, M., Ceriotti, G., Pilla, F., Bruzzone, A., Iamartino, D., Bradley, D., Machugh, D.E., Freeman, A.R., Medugorac, I., Medugorac, A., Mix, H., Förster, M., Kantanen, J., Olsaker, I., Holm, L.E., Miceikienė, I., Grislis, Z., Viinalass, H., Danell, B., Eythorsdottir, E., Mommens, G., Van Haeringen, C., Taberlet, P., Luikart, G., Beja Pereira, A., Ferrand, N., Mateus, J.C., Dolf, G., and Felius, M.

Subjects
Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico
Published
2004

11. Multiple quantitative trait loci mapping with cofactors and application of alternative variants of the false discovery rate in a enlarged granddauhgter design

Author

BENNEWITZ, J., REINSCH, N., GUIARD, V., FRITZ, Sebastien, THOMSEN, H., LOOFT, C., KUHN, C., SCHWERIN, M., WEIMANN, C., ERHARDT, G., REINHARDT, F., REENTS, R., Boichard, Didier, KALM, E., Station de Génétique Quantitative et Appliquée (SGQA), and Institut National de la Recherche Agronomique (INRA)

Subjects
bovin laitier, QTL, [SDV]Life Sciences [q-bio], PROTOCOLE PETITES-FILLES, DAIRY CATTLE, GRAND-DAUGHTER DESIGN, FALSE DISCOVERY RATE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

12. The RN gene involved in meat quality in pigs encodes a muscle specific isoform of a regulatory subunit of AMP-activated protein kinase

Author

Denis Milan, Jin-Tae Jeon, Looft, C., Amarger, V., Annie Robic, Thelander, M., Claire Rogel-Gaillard, Paul, S., Nathalie Iannuccelli, Rask, L., Ronne, H., Lundstrom, K., Reinsch, N., Joël Gellin, Kalm, E., Pascale Le Roy, Patrick Chardon, Andersson, L., Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], pig, rn gene, meat, quality, [SDV]Life Sciences [q-bio], protein, ComputingMilieux_MISCELLANEOUS
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; International audience

Published
2000

13. Exemple de cartographie fine : le cas du gène RN chez le porc

Author

Denis Milan, Annie Robic, Patrick Chardon, Nathalie Iannuccelli, Caritez, J. C., Martine Yerle, Joel Gellin, Looft, C., Andersson, L., Jean Michel Elsen, Pascale Le Roy, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unité expérimentale du GEVES du Magneraud, Institut National de la Recherche Agronomique (INRA), Christian-Albrechts University of Kiel, Swedish University of Agricultural Sciences (SLU), Station d'Amélioration Génétique des Animaux (SAGA), Station de Génétique Quantitative et Appliquée (SGQA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA)

Subjects
génétique animale, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; National audience; En 1986, un gène majeur ayant un effet défavorable sur le rendement à la cuisson de la viande de porc a été mis en évidence. La constitution de familles informatives nous a permis de cartographier ce gène appelé RN sur le chromosome 15. Pour identifier le gène RN, nous avons successivement réalisé : la cartographie génétique fine de RN, la cartographie cytogénétique de marqueurs proches, des études de carte comparée, le développement de cartes d’irradiation de la région de RN chez le porc et chez l’Homme, le développement d’un contig de BAC couvrant près de 2 Mb, le développement d’une carte du déséquilibre de liaison de la région de RN chez le porc, le séquençage d’un BAC contenant le gène RN, l’identification d’un gène encore inconnu membre d’une famille de gènes impliqués dans le métabolisme du glucose/glycogène, l’identification d’une mutation causale dans la séquence codante de ce gène.

Published
2000

14. Positional cloning of a major gene (RN) controlling glycogen content in pig skeletal muscle

Author

Andersson, L., Denis Milan, Jin-Tae Jeon, Looft, C., Amarger, V., Annie Robic, Claire Rogel-Gaillard, Paul, S., Nathalie Iannuccelli, Kerstin Lundström, Reinsch, N., Joël Gellin, Kalm, E., Pascale Le Roy, Patrick Chardon, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], pig, rn gene, [SDV]Life Sciences [q-bio], positional cloning, mutation, ComputingMilieux_MISCELLANEOUS
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; International audience

Published
2000

15. Identification of the RN major gene influencing quality of pig meat

Author

Milan, Denis, Andersson, Leif, LOOFT, C., Amarger, Valérie, Robic, Annie, Rogel Gaillard, Claire, Iannucelli, N., CARITEZ, J.C., Yerle, Martine, Gellin, Joel, Elsen, Jean Michel, Chardon, Patrick, Le Roy, Pascale, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Génétique Expérimentale en Productions Animales (GEPA), Station d'Amélioration Génétique des Animaux (SAGA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), and Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; National audience

Published
2000

16. Development of a highly accurate DNA-test for the RN gene in the pig

Author

Looft, C., Milan, Denis, Jeon, Jin-Tae, Paul, S., Rogel Gaillard, Claire, Rey, V., Reinsch, N., Yerle, Martine, Amarger, V., Robic, Annie, Kalm, E., Chardon, Patrick, Andersson, L., Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA)

Subjects
pig, rn gene, meat, quality, [SDV]Life Sciences [q-bio], molecular typing, ComputingMilieux_MISCELLANEOUS
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; International audience

Published
1999

17. Exemple de cartographie fine : Le cas du gène RN

Author

Milan, Denis, Robic, Annie, Chardon, Patrick, Iannucelli, N., Caritez, J.C., Yerle, Martine, Gellin, Joel, Looft, C., Andersson, Leif, Elsen, Jean Michel, Le Roy, Pascale, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Génétique Expérimentale en Productions Animales (GEPA), Institut National de la Recherche Agronomique (INRA), Station d'Amélioration Génétique des Animaux (SAGA), Station de Génétique Quantitative et Appliquée (SGQA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), and Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], CARTOGRAPHIE GENETIQUE, ComputingMilieux_MISCELLANEOUS
Abstract

*INRA Station de génétique quantitative et appliquée 78352 Jouy-en-Josas (FRA) Diffusion du document : INRA Station de génétique quantitative et appliquée 78352 Jouy-en-Josas (FRA) Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; National audience

Published
1999

18. Positional cloning of a major locus controlling glycogen content in pig skeletal muscle

Author

Andersson, L., Jeon, Jin-Tae, Paul, S., Rogel-Gaillard, Claire, Wasungu, L., REINSCH, N., Yerle, Martine, Amarger, V., Robic, Annie, Le Roy, Pascale, KALM, E., Chardon, Patrick, LOOFT, C., Milan, Denis, Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
pig, [SDV]Life Sciences [q-bio], positional cloning, major gene
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access

Published
1999

19. Towards positional cloning of the RN gene in the pig

Author

Milan, Denis, Jeon, Jin-Tae, Paul, S, Rogel-Gaillard, Claire, Wasungu, L., REINSCH, N., Yerle, Martine, Amarger, V., KALM, E., Robic, Annie, Le Roy, Pascale, Chardon, Patrick, LOOFT, C., Andersson, L., Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), and Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
pig, [SDV]Life Sciences [q-bio], genetic, ComputingMilieux_MISCELLANEOUS
Abstract

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access; International audience

Published
1998

20. CaDBase - a cattle diversity database

Author

RUSSELL, G.A., SANDBERG, K., BARRE-DIRIE, A., BASEDOW, M., Blott, S.C., Dolf, Gaudenz, Dunner, Susana, Erhardt, Georg Jakob, Eythorsdottir, E., Moazami Goudarzi, Katayoun, HOLM, L.E., Kantanen, J., Laloë, Denis, LOOFT, C., Martín-Burriel, I., MOMMENS, G., Olsaker, I., ZARAGOZA, P., Zanotti, M., Williams, J.L., ProdInra, Migration, Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), and Station de Génétique Quantitative et Appliquée (SGQA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1998

21. CadBase - a cattle diversity database

Author

Russel, G A, Sandberg, K, Barre-Dirie, A, Basedow, M, Blott, S C, Bradley, D G, Dolf, G, Dunner, S, Erhardt, G, Eythorsdottir, E, Goudarzi, K, Holm, Lars-Erik, Kantanen, J, Laloe, D, Looft, C, Loftus, R T, Martin-Burriel, I, Mommens, G, Olsaker, I, Zaragoza, P, Zanotti, M, and Williams, J L

Published
1998

22. Isolation and mapping of porcine microsatellites on chromosome 14

Author

Looft, C., Nagel, M., Renard, Christine, Chardon, Patrick, Yerle, Manon, Reinsch, N., Kalm, E., Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], CHROMOSOME 14 PORCIN, [SDV]Life Sciences [q-bio], MICROSATELLITES, CARTE GENIQUE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

23. Presence of microsatellite-SINE complex structure downstream of the swine tumor necrosis factor alpha gene

Author

LOOFT, C., Nunes, M., Chardon, Patrick, VAIMAN, M., KALM, E., Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV.GEN]Life Sciences [q-bio]/Genetics, FACTEUR DE NECROSE DE TUMEUR, [SDV]Life Sciences [q-bio], [SDV.GEN] Life Sciences [q-bio]/Genetics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1992

24. Study of mapping QTLs for milk traits on the German dairy cattle

Author

Ny, Xu, Hauke Thomsen, Reinsch N, Looft C, and Kalm E

Subjects
Male, Quantitative Trait, Heritable, Animals, Cattle, Female, Microsatellite Repeats
Abstract

A total of 1,130 bulls belonging to 20 half-sib families of German dairy cattle were genotyped for 229 microsatellite markers on 30 chromosomes. The data were used in an attempt to map quantitative trait loci applying regression as multiple-marker regression. For association analysis with a granddaughter design, the estimated breeding values for 3 milk traits were used: milk production, fat production and protein production. The empirical values of significance thresholds were determined by using a permutation test on the experimental data. Several significant QTLs were found on some chromosomes, especially on the chromosome 14. The results give a strong support for the experiments of Coppieters et al. and Ron et al.

25. Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs

Author

Ernst Tholen, Roberta Davoli, Heinz Jüngst, S. Ponsuksili, G. Gandolfi, Mehmet Ulas Cinar, Klaus Wimmers, Chirawath Phatsara, Christian Looft, Karl Schellander, D. Tesfaye, Gandolfi G, Cinar MU, Ponsuksili S, Wimmers K, Tesfaye D, Looft C, Jüngst H, Tholen E, Phatsara C, Schellander K, and Davoli R.

Subjects
Genetic Markers, Candidate gene, GENE EXPRESSION, Meat, GENES, Genotype, Swine, Biology, PIG BREEDS, Polymorphism, Single Nucleotide, MEAT QUALITY, Gene Frequency, Gene expression, Calpain small subunit 1, Animals, Cooking, RNA, Messenger, Muscle, Skeletal, Receptor, Gene, Genetics, CARCASS TRAITS, Calpain, Large white, Methylation, DNA Methylation, Hydrogen-Ion Concentration, Phenotype, Gene Expression Regulation, CpG Islands, PPARGC1A, Transcription Factors, Food Science
Abstract

This study aimed to investigate the genes PPARGC1A (peroxisome proliferator-activated receptor gamma-coactivator 1A) and CAPNS1 (calpain small subunit 1) as candidate genes affecting meat quality traits in pigs. Four polymorphisms were identified in PPARCG1A and three in CAPNS1. The PPARGC1A polymorphism c.1288T>A was associated with pH and cooking loss in a F2 Durocx Pietrain experimental cross (DuPi, n =313) and with pH values in Italian Large White (ILW, n=380) and Italian Landrace (ILA, n=158) populations (PC was associated with pH and conductivity in DuPi and with meat color in ILA (P

Published
2011

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