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Using communications signals for localization is an important component of integrated sensing and communications (ISAC). In this paper, we propose to utilize the beam squint phenomenon to realize fast non-cooperative target localization in massive MIMO Terahertz band communications systems. Specifically, we construct the wideband channel model of the echo signal, and design a beamforming scheme that controls the range of beam squint by adjusting the values of phase shifters and true time delay lines (TTDs). By doing this, beams at different subcarriers can be aligned along different directions in a planned way. The received echo signals of different subcarriers will carry target information in different directions, based on which the targets' angles can be estimated through sophisticatedly designed algorithm. Moreover, we propose a supporting OFDM ranging algorithm that can estimate the targets' distances by comparing the theoretical phases and measured phases of the echo signals. Interestingly, the proposed localization method only needs the base station to transmit and receive the signals once, which can be termed You Only Listen Once (YOLO). Compared with the traditional ISAC method that requires multiple times beam sweeping, the proposed one greatly reduces the sensing overhead. Simulation results are provided to demonstrate the effectiveness of the proposed scheme.

Intracerebral hemorrhage (ICH) is a fatal disease with high mortality and poor prognosis that triggers multiple severe brain injuries associated with an inflammatory cascade response that cannot be treated with any effective medication. Atorvastatin (ATO) suppresses inflammation, alleviates brain trauma, and eliminates subdural hematoma. Dexamethasone (DXM) also has the capacity to inhibit inflammation. Thus, we combined ATO with low-dose DXM to treat ICH mice in vivo to examine whether the combined treatment can inhibit secondary inflammation around the cerebral hemorrhage and decrease overall mortality. Compared to the monotherapy by either ATO or DXM, the combined treatment significantly improves the survivorship of the ICH mice, accelerates their recovery of impaired neurological function, and modulates the circulating cytokines, oxidative products, and apoptosis. Moreover, the benefit of ATO-DXM combination therapy was most pronounced on day 3 after dosing compared to ATO or DXM alone. Thus, early administration of ATO combined with low-dose-DXM promotes better survival of ICH and improves neurological function by reducing neuroinflammation and brain edema in their early phase.

The beam squint phenomenon in massive multi-input and multi-output wideband communications has been widely concerned recently, which generally deteriorates the beamforming performance. In this paper, we find that with the aid of the time-delay lines (TDs), the range and trajectory of the beam squint of a near-field communications system can be freely controlled, and hence it is possible to reversely utilize the beam squint for user localization. We derive the trajectory equation for near-field beam squint points and design a way to control the trajectory of these beam squint points. With the proposed design, beamforming from different subcarriers would purposely point to different angles and different distances such that users from different positions would receive the maximum power at different subcarriers. Hence, one can simply find the different users' position from the beam squint effect. Simulation results demonstrate the effectiveness of the proposed scheme.

Objective To systematically evaluate the prognostic and clinicopathological significance of PD-L1 expression in colorectal cancer(CRC) tissues by meta-analysis. Methods PubMed, Embase, Web of Science, Cochrane Library, CNKI and Wanfang database were used to search for the studies related to PD-L1 expression and the prognosis of CRC. The search time was until June 2018. The data of survival and clinicopathological features were extracted from eligible studies and analyzed by Stata SE12.0 software. Results Eighteen studies with 5724 CRC patients were enrolled. PD-L1 expression in CRC tissues was associated with shorter overall survival (OS) (HR:1.40, 95%CI:1.02-1.93, P=0.039) and relapse-free survival (RFS) (HR:1.67, 95%CI:1.27-2.20, P=0.000), but not with disease-free survival (DFS)(P=0.933). And PD-L1 expression was significantly associated with tumor differentiation(P=0.016) and lymph node metastasis(P=0.028), but not with gender, tumor location, TNM staging, invasion depth, venous invasion, chemotherapy, MSI status or KRAS mutation. In addition, subgroup analysis showed that PD-L1 expression in tumor cells, not in tumor infiltrating immune cells (OS: P=0.991; RFS: P=0.210), was significantly associated with shorter OS(P=0.033) and RFS(P=0.001). Conclusion PD-L1 expression in CRC tissues is associated with poor prognosis. In addition, the prognostic significance of PD-L1 expression in tumor cells might be inconsistent with that in tumor-infiltrating immune cells.

Tumor invasion, metastasis, and recrudesce remain a considerable challenge in the treatment of gastric cancer (GC). Herein, we first identified that RBFOX3 (RNA binding protein fox-1 homolog 3) was significantly up-regulated in GC tissues and negatively linked to the survival rate of GC patients. RBFOX3 promoted cell division and cell cycle progression in vitro as well as in vivo. Furthermore, RBFOX3 increased cell invasion and migration ability. Interestingly, both the suppression of GC cell multiplication and invasion moderated by the silencing of RBFOX3 was rescued by HTERT up-regulation. Additionally, RBFOX3 augmented the resistance of GC cells to 5-fluorouracil (5-Fu) by repressing RBFOX3. Mechanistically, exogenous up-regulation of RBFOX3 triggered promoter activity and HTERT expression thereby enhancing the division and development of GC cells. Importantly, our findings revealed that RBFOX3 interacted with AP-2β to modulate the HTERT expression as demonstrated by co-immunoprecipitation analysis. In conclusion, our study indicates that high expression of RBFOX3 promotes GC progression and development but predicts worse prognosis by stimulating HTERT signaling. Moreover, the results suggest that the RBFOX3/AP-2β/HTERT pathway is a novel target for the development of therapeutic agents for the prevention and treatment of GC reappearance and metastasis.

In order to obtain NiFeW alloy coating with good performance, we studied the influence of pH value, temperature, current density, and the concentration of ascorbic acid stabilizer on the composition, deposition rate, and microhardness of NiFeW alloy coating. The results show that the pH value of plating bath largely influences the concentration of W and the deposition rate of the coating; the temperature of plating bath greatly affects the deposition rate, composition, and microhardness of the coating; upon increasing the concentration of ascorbic acid, the deposition rate of the coating decreases whereas the surface morphology of coating becomes more rough. With the pH value of plating bath equal to 4, temperature of 60 °C, current density of 4 A/dm2, and ascorbic-acid concentration of 3 g/L, the deposition rate and the hardness of the coating are high. In addition, both the surface quality and the corrosion resistance of the coating are good.

Background. Many studies have shown the link between the pretreatment serum transthyretin and prognosis in gastrointestinal (GI) cancers. However, based on the conclusion, the initial findings were inconsistent. Hence, this meta-analysis was performed to identify the prognostic values of the pretreatment serum transthyretin in GI cancers. Methods. Previous studies published before November 2018 were collected from a comprehensive literature search of several databases. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were applied in the assessment of the intensity of associations. Also, the publication bias and the robustness of merged data were assessed. All statistical analyses were undertaken using STATA/SE 14.1. Results. The combined data indicated that the pretreatment serum transthyretin level was related to the prognosis in GI cancers. The group with reduced pretreatment transthyretin had a significantly worse overall survival (OS) (HR=1.71, 95% CI: 1.37-2.05). The subgroup analysis for OS further showed the predictive value of transthyretin. In addition, the low serum transthyretin level could be an unfavorable factor for recurrence-free survival (RFS) or progression-free survival (PFS) (HR=1.66, 95% CI: 1.14-2.18) in GI cancers. Conclusion. The low pretreatment serum transthyretin level implies an unfavorable prognosis for patients with GI cancers. The monitoring of pretreatment transthyretin level could contribute to the risk stratification and individualized therapy in GI cancers.

Ancient Chinese texts present an area of enormous challenge and opportunity for humanities scholars interested in exploiting computational methods to assist in the development of new insights and interpretations of culturally significant materials. In this paper we describe a collaborative effort between Indiana University and Xi'an Jiaotong University to support exploration and interpretation of a digital corpus of over 18,000 ancient Chinese documents, which we refer to as the "Handian" ancient classics corpus (H\`an di\u{a}n g\u{u} j\'i, i.e, the "Han canon" or "Chinese classics"). It contains classics of ancient Chinese philosophy, documents of historical and biographical significance, and literary works. We begin by describing the Digital Humanities context of this joint project, and the advances in humanities computing that made this project feasible. We describe the corpus and introduce our application of probabilistic topic modeling to this corpus, with attention to the particular challenges posed by modeling ancient Chinese documents. We give a specific example of how the software we have developed can be used to aid discovery and interpretation of themes in the corpus. We outline more advanced forms of computer-aided interpretation that are also made possible by the programming interface provided by our system, and the general implications of these methods for understanding the nature of meaning in these texts., Comment: 24 pages; 14 pages supplemental

Ancient Chinese texts present an area of enormous challenge and opportunity for humanities scholars interested in exploiting computational methods to assist in the development of new insights and interpretations of culturally significant materials. In this paper we describe a collaborative effort between Indiana University and Xi'an Jiaotong University to support exploration and interpretation of a digital corpus of over 18,000 ancient Chinese documents, which we refer to as the "Handian" ancient classics corpus (H��n di��n g�� j��, i.e, the "Han canon" or "Chinese classics"). It contains classics of ancient Chinese philosophy, documents of historical and biographical significance, and literary works. We begin by describing the Digital Humanities context of this joint project, and the advances in humanities computing that made this project feasible. We describe the corpus and introduce our application of probabilistic topic modeling to this corpus, with attention to the particular challenges posed by modeling ancient Chinese documents. We give a specific example of how the software we have developed can be used to aid discovery and interpretation of themes in the corpus. We outline more advanced forms of computer-aided interpretation that are also made possible by the programming interface provided by our system, and the general implications of these methods for understanding the nature of meaning in these texts., 24 pages; 14 pages supplemental